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Health

What We Suppose We Know About Metabolism Might Be Unsuitable

Everyone knows the conventional wisdom about metabolism: people gain weight year after year from the age of 20 because their metabolism slows down, especially in middle age. Women have a slower metabolism than men. This makes it harder for them to control their weight. Menopause only makes things worse and slows women’s metabolism even more.

All wrong, according to a paper published in Science on Thursday. Using data from nearly 6,500 people aged 8 days to 95 years, the researchers discovered that there are four different stages of life when it comes to metabolism. They also found that there were no real differences between men’s and women’s metabolic rates after other factors were controlled.

The results of the research are likely to change the science of human physiology and could also have implications for some medical practices, such as determining appropriate drug doses for children and the elderly.

“It will be in textbooks,” predicted Leanne Redman, an energy balance physiologist at Pennington Biomedical Research Institute in Baton Rouge, La., Who also called it “a critical paper.”

Rozalyn Anderson, a professor of medicine at the University of Wisconsin-Madison who studies aging, wrote a perspective that accompanies the article. In an interview, she said she was “overwhelmed” with the results. “We’re going to have to revise some of our ideas,” she added.

However, the effects of the results on public health, nutrition and nutrition are currently limited as the study offers “a 30,000 foot view of energy metabolism,” said Dr. Samuel Klein, who was not involved in the study and is the director of the Center for Human Nutrition at Washington University School of Medicine in St. Louis. He added, “I don’t think you can make new clinical statements” for a person. When it comes to weight gain, the topic is the same as always: people eat more calories than they burn.

Metabolic research is expensive, and so most published studies had very few participants. But the new study’s lead researcher, Herman Pontzer, an evolutionary anthropologist at Duke University, said the project’s participating researchers agreed to share their data. There are more than 80 co-authors on the study. By pooling the efforts of half a dozen laboratories collected over 40 years, they had sufficient information to ask general questions about changes in metabolism throughout life.

All of the research centers involved in the project studied metabolic rates using a method that is considered the gold standard – double-labeled water. It measures calorie consumption by measuring the amount of carbon dioxide a person exhales during daily activities.

Investigators also had the participants’ height and weight, as well as body fat percentage, which enabled them to study basic metabolic rates. Of course, a shorter person burns fewer calories than a taller person, but to correct size and fat percentage, the group asked: Was their metabolism different?

“It was really clear that we didn’t have a good overview of how height affects metabolism or how aging affects metabolism,” said Dr. Pontzer. “These are basic fundamentals that you would think would have been answered 100 years ago.”

Central to their results was that the metabolism is different in all people in four different phases of life.

  • There are infants, up to the age of 1, when calorie burning peaks and accelerates until it is 50 percent above the adult rate.

  • Then, from the first to the 20th year of life, the metabolism gradually slows down by about 3 percent per year.

  • It remains stable between the ages of 20 and 60.

  • And from the age of 60, it drops by around 0.7 percent per year.

After checking people’s height and muscle mass, the researchers found no differences between men and women either.

As would be expected, metabolic rate patterns vary for the population, but individuals do vary. Some have a metabolic rate 25 percent below their average age and others have a metabolic rate 25 percent higher than expected. However, these outliers do not change the general pattern that is reflected in graphs that show the course of metabolic rates over the years.

The four stages of metabolic life outlined in the new paper show that “there is no constant energy expenditure per pound,” noted Dr. Redman. The price is age-dependent. This contradicts the longstanding assumptions that she and others have held in nutritional science.

The pathways of metabolism throughout life and the individuals who are outliers will raise a number of research questions. For example, what are the characteristics of people whose metabolism is higher or lower than expected and is it related to obesity?

One of the findings that Dr. Most surprising to Pontzer was the metabolism of infants. For example, he expected a newborn to have sky-high metabolism. After all, the general rule in biology is that smaller animals burn calories faster than larger ones.

Instead, says Dr. Pontzer, babies have the same metabolic rate as their mothers in the first month of life. But shortly after the baby was born, he said, “Something happens and your metabolism picks up.”

The group also expected metabolism to slow down in adults over the age of 40 or in women with the onset of menopause.

But, said Dr. Pontzer, “we just didn’t see that.”

The slowdown in metabolism that begins around the age of 60 leads to a 20 percent drop in metabolic rate by the age of 95.

Dr. Klein said that although people gained more than a pound and a half on average in adulthood, they can no longer attribute it to a slowed metabolism.

The energy needs of the heart, liver, kidneys, and brain make up 65 percent of resting metabolic rate, even though they make up only 5 percent of body weight, said Dr. Small. A slower metabolism after age 60 could mean that important organs function less well as you get older. This could be one reason why chronic diseases are most common in the elderly.

Even college students could see the effects of the metabolic shift around the age of 20, said Dr. Small. “When you finish college, you burn fewer calories than you did when you started.”

And by the age of around 60, young people, no matter what they look like, change fundamentally.

“There is a myth about keeping youth,” said Dr. Anderson. “Biology doesn’t say that. At the age of 60 things start to change. “

“There comes a time when things are no longer the way they used to be.”

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Health

The place Covax, the Huge World Vaccine Program, Went Improper

Dr. Seth Berkley, the chief executive of Gavi, the nonprofit at Covax’s heart, said insufficient early financing made supply shortages inevitable. When distribution problems of the type in Chad and Benin emerge, Covax tries to “move those vaccines to other countries, but then to work with those countries to try to improve capacity,” he said.

Supporters and critics agree that the program must improve, rapidly. As of early July, confidential Covax documents indicated that 22 nations, some with surging fatalities, reported being nearly or entirely out of doses from the program.

“The way Covax was packaged and branded, African countries thought it was going to be their savior,” said Dr. Catherine Kyobutungi, who directs the African Population and Health Research Center. “When it didn’t meet expectations, there was nothing else.”

In the frantic early months of 2020, health experts strategized on how to equitably inoculate the world. Covax was the answer, bringing together two Gates-funded nonprofits, Gavi and the Coalition for Epidemic Preparedness Innovations, or CEPI; the World Health Organization; and UNICEF, which would lead delivery efforts. It hoped to be a major global vaccine buyer, for both rich and poor nations, giving it the clout to bully vaccine makers.

But if rich nations pledged donations, they did not make obliging partners. Britain negotiated for wealthier participants to be given a choice of vaccines to purchase through Covax, creating delays, said Kate Elder, senior vaccines policy adviser for Doctors Without Borders’ Access Campaign.

Most important, rich nations became rivals in a vaccine-buying race, paying premiums to secure their own shots while slow-walking financial pledges that Covax needed to sign deals.

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Health

Wall Road is flawed to be bullish on European shares, strategist says

A photo taken on December 29, 2020 shows the skyline of Frankfurt am Main, western Germany, with (RtoL) the Frankfurt Cathedral, the Main Tower with the Helabas head office, and the Commerzbank Tower.

DANIEL ROLAND | AFP | Getty Images

LONDON — Not everyone is bullish on Europe for the remainder of the year.

Peter Toogood, chief investment officer at financial services firm Embark Group, believes European stocks may well keep pace with U.S. stocks in the coming months, but that’s not to say he shares Wall Street’s optimism for the region.

Analysts at Morgan Stanley say Europe is well-placed to outperform all major regions this year for the first time in more than two decades. The investment bank believes U.S. markets are likely to be “choppier” in the months ahead, citing rising inflation, growing pressure on profit margins and a possible slowing of quantitative easing.

Meanwhile, there is a “compelling” case for Europe to be the best-performing region due to attractive valuations, stronger earnings-per-share growth and the launch of the EU’s massive post-Covid recovery fund.

Separately, analysts at Goldman Sachs have identified “inexpensive” stocks in Europe for the rest of the year, while JPMorgan has named “cheap” stocks to buy in the region if the market dips.

When asked whether he agreed with the view that European equities could soon decouple from the U.S., Toogood told CNBC’s “Squawk Box Europe” on Friday: “No I don’t … I’m not buying it this time.”

“I’ll happily acknowledge that we’ll keep up … There’s going to be a Covid bounce, notionally, they are getting their act together, there is the recovery coming but it is going to be very late. We are going to be into the autumn and winter soon where I’m sorry (but) Covid is not going to go away,” he continued.

“So, no, I’m not buying it. I think they have come too late to the party in terms of the vaccines; very sadly, and therefore the recovery is delayed,” Toogood said.

To date, around 33% of EU citizens have received at least one dose of a Covid vaccine, according to statistics compiled by Our World in Data. By contrast, nearly 48% of the U.S. population has received at least one vaccine dose.

‘What are you buying when you buy in Europe?’

The International Monetary Fund said last month that Europe’s economic recovery from the coronavirus pandemic was on track to return to pre-crisis levels in 2022. The forecast was conditional on the region’s Covid-19 vaccine campaign, and as uncertainty persists over how the health crisis will evolve.

“I think the second problem remains: What are you buying when you buy Europe?” Toogood said, noting possible exceptions in the region among some “very strong” consumer brands.

“The banking sector? No, not really. I don’t see interest rates going anywhere in Europe for a very long time and they’ve been withdrawing globally, if anything. Most of the Europeans, in terms of banks and activities, are heading inward.”

Read more about China from CNBC Pro

“There’s a massive discount gap but that’s because a lot of the stocks in the U.S. are priced more highly because they simply grow better. There are no FAANGs in Europe I’m afraid,” he continued, referring to the acronym for Facebook, Amazon, Apple, Netflix and Google-parent Alphabet.

“So, there is trouble for the indices in Europe and the U.K. … That’s the reality. We haven’t got the disruptors and we don’t have the exciting industries. It’s Asia and America where that action sits,” Toogood said.

— CNBC’s Lucy Handley contributed to this report.

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Entertainment

Shakespeare, Swing and Louis Armstrong. So What Went Mistaken?

“It’s almost like some kind of crime thriller,” said Kwame Kwei-Armah with apparent pleasure. “The piece was butchered by the press and somehow the body disappeared.”

The case referred to by the Artistic Director of London’s Young Vic Theater is a Broadway show called “Swingin ‘the Dream”. This “musical variation of Shakespeare’s” A Midsummer Night’s Dream “, as it was billed, was set in Louisiana in 1890 and ran on Broadway for only 13 performances at the end of 1939 and was then sunk without a trace. The script itself is lost, except for a few pages from the Pyramus and Thisbe sections.

So one has to wonder why prominent institutions – the Royal Shakespeare Company and the Young Vic in the UK and the New York Theater for New Audiences – would band together to reconsider a footnote on a long-term project that begins Jan. 9 a livestream concert of popular jazz tunes that included the score.

Once you start digging, however, you have to wonder how not to be drawn to “Swingin ‘the Dream” which is at the center of an intricate network of racial and cultural influences.

Let’s start with an integrated cast of about 110 – you read that right – that had Louis Armstrong as the bottom; Butterfly McQueen and Oscar Polk, fresh from the set “Gone with the Wind”, as puck and flute; the comedian Moms Mabley as a quince; the singer Maxine Sullivan as Titania; and future Oscar nominee Dorothy Dandridge as an elf. The Benny Goodman Sextet and Bud Freeman’s Summa Cum Laude Orchestra completed the pit musicians. (According to Ricky Riccardi’s most recent book, Heart Full of Rhythm, Armstrong and Goodman argued over who would get the highest bill and ended up sharing it equally.)

And there was more: Agnes de Mille took care of the choreography; The sets were inspired by Walt Disney cartoons. and the score burst with popular jazz melodies as well as new ones like “Darn That Dream” by Jimmy Van Heusen and Eddie de Lange.

However, this abundance of talent did not guarantee success. The reviews were mixed at best and didn’t help fill the 3,500 seats at the Center Theater – even with the top ticket price dropped to $ 2.

The show was quickly forgotten, although “Darn That Dream” has become a concert favorite, sung by Billie Holiday and Nancy Wilson, among others.

It will be part of the concert, which includes a cast of RSC ensemble members and jazz performer Zara McFarlane.

“‘Darn that Dream’ is a really important jazz standard that I play and with which I accompany people. It was really surprising not to know its roots in a very important production that they put so much money into”, said Peter Edwards, the concert’s music director, who didn’t hear about “Swingin ‘the Dream” when the RSC contacted him.

The project was launched long before the pandemic and the directors of the three theaters are unsure of what it will be like this weekend after the concert. However, a complete remount of the show sounds less likely than a forensic dive – think “CSI: Times Square”. The George C. Wolfe meta show “Shuffle Along or Making of the Musical Sensation from 1921 and All That Followed,” which had a short but acclaimed Broadway run in 2016, could provide a possible direction.

“I just want to know what happened, why this cast crashes, and then why the show seems to go so completely,” said Gregory Doran, artistic director of the Royal Shakespeare Company.

At the time, black newspapers were among those shared on the show. An article in The Pittsburgh Courier praised a “powerful blend of music, serenity, and gentle reflection”; Another pointed out the many employment opportunities for black artists.

The New York Amsterdam News, on the other hand, wondered if promoting a below-average effort would only delay the day when Negro actors and Negro art are recognized without ridicule and burlesque.

“The critics tell us that it didn’t hold together, that the mash-up didn’t work,” said Kwei-Armah. “I’m interested in why it didn’t work. Just because they said it didn’t work doesn’t mean it didn’t! “

The locomotive that pulled the train and its many, many cars was Erik Charell, a gay, Jewish director and producer of revues who had relocated to the United States after fleeing Nazi Germany and was a fascinating character himself. His Broadway directorial debut in 1936 was an adaptation of his successful Berlin operetta “White Horse Inn” with 145 actors – no wonder that he was nicknamed “Ziegfeld of the German musical comedy stage”.

Charell may have wanted to capitalize on the success of “The Swing Mikado” (1938) and “The Hot Mikado” (1939), two jazz-flavored adaptations of the operettas Gilbert and Sullivan, but he wasn’t quite ready for the delicate subjects and challenges that came through an integrated show in America before World War II.

“Obviously he’s the man of the moment, he has the Midas touch,” said Doran of Charell. “But is what he’s doing an exploitation of that talent or a visionary mindset?”

Because, as a preview in The New York Times put it, Charell was “a stranger to our mother tongue,” and co-wrote the American critic Gilbert Seldes, an early advocate of popular culture.

For Jeffrey Horowitz, the founding artist of Theater for New Audiences, it was a big missed opportunity not to bring in a black co-writer. “There isn’t a person on this writing team who knows anything about African American culture and jazz,” he said. “You could have had Langston Hughes, you could have had Zora Neale Hurston. I don’t think they thought of that. “

The racial and artistic dynamics in “Swingin ‘the Dream” provides valuable insight into the everyday misunderstandings and problems that shaped American culture in the early 20th century. For example, the white cast played the aristocrats and lovers, while the black cast handled the fairies and mechanics – comic entertainers, not romantic leads.

Another fascinating juxtaposition took place with dancing, as de Mille’s choreography was complemented by jitterbugs developed by the ballroom of the King of Harlem, Herbert White, who brought his troupe with him.

Most of the reviews complained that there was too much Shakespeare and too little swing, with Armstrong being wasted in a role where he didn’t have to blow his horn. The producers desperately tried to adapt, eventually giving their star more time on the trumpet. Unfortunately nothing worked and “Swingin ‘the Dream” was closed.

Now all that remains is a seductive riddle, the making-of story of which has become more compelling than the final product.

“Even if the script came up tomorrow, we wouldn’t be interested,” said Horowitz. “It’s really about something else – it’s about race and context and who’s telling whose story.”

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Health

A vacation all about ingesting and reveling with mobs of strangers — what might go fallacious?

First there was Thanksgiving when some families who gathered for the turkey and stuffing also shared the coronavirus, causing a surge in cases in some places and further straining the country’s already overburdened hospitals.

Then there was a Christmas weekend when Americans overcrowded airports in numbers that have not been seen since the pandemic began. Anyone who contracted the virus at the time is likely still in the incubation phase or just beginning to experience symptoms. So it’s too early to appreciate the full impact of people’s Christmas activities.

Now comes New Year’s Eve, an opportunity to celebrate, drink, indulge in large crowds, often among strangers, and to utter a primal scream when the clock strikes twelve.

In other words, it’s a vacation that is tailored precisely to super-spreader events. And it is just arriving as the first cases of a new, contagious variant of the virus were discovered in the United States, suggesting that it is already widespread.

“It’s in a small community south of Denver, so it’s reasonable to believe it could already be in New York City,” said Dr. Bill Hanage, Associate Professor of Epidemiology at Harvard TH Chan School of Public Health.

New Year’s Eve, he said, “risks accelerating the rollout of variants that are more communicable in communities, and we have reason to believe that these are emerging.”

The risk of transmission increases with the size of the congregation, of course, but also with the amount of alcohol consumed, said Dr. Hanage.

People who drink “become disinhibited,” he noted, “and when they become disinhibited, they are more likely to be risky.”

The safest way to see the New Year is at home when there is no one outside of your household, said Dr. Hanage. However, as more people gather around, they can reduce the risk a bit by doing it outdoors and wearing masks.

“It doesn’t sound very fun or easy to drink champagne,” he said, “but wearing a mask will be another barrier to possible transmission.”