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Eye Drops Had been Speculated to Assist Her Imaginative and prescient. Why Did It Really feel Worse?

She immediately emailed Bicket informing the doctor that she would stop the medication and just take the others. Perhaps it was this drug that caused the photophobia, the dry eyes, and now the burning sensation.

“I am fine with any short-term IOP dropping experiment you choose to conduct,” Bicket wrote back. But the symptoms the patient was experiencing did not match the usual side effect profile of the medications she was taking. There is another possibility, added Bicket: Maybe it’s not a single drop, but all of them. They all contain a preservative called benzalkonium chloride (BAK). “If you don’t tolerate this,” Bicket wrote, “stopping one agent against another won’t help.”

The patient decided to stop them all, she wrote to Bicket. It was a risky move because the drops were important to keep pressure down and avoid further damage. But the pain and sensitivity to light were unbearable.

The patient had her answer three days later. Her eyes felt so much better without the drops. The gloomy feeling when she blinked was gone. Likewise the photophobia. It had to be the BAK. The patient turned to PubMed for information. There was a lot. Preservatives were essential in preventing bacteria from growing in medicine bottles that contained more than a single dose, and BAK was the most commonly used preservative in both over-the-counter and prescription eye drops.

She found that the patient’s complaints were not due to an allergy to the preservative, but to the way BAK worked. This compound kills germs by dissolving the lipid layer that forms their outer protective covering. Here’s the problem: the eyes are kept from drying out by a similar protective coat – from tears. Tears consist of a thin layer of fluid from the lacrimal gland (lacrimal gland), which in turn is covered by a layer of oil formed by the meibomian glands. BAK breaks down this outer protective lipid layer and exposes the salty liquid to the air. For many people with dry eyes, the unprotected fluid evaporates and the patient’s eyes become even drier. Eye drop users who produce enough tears are not affected, but many are not. Aging also reduces this protective layer, which puts older users of BAC-containing drugs at greater risk of eye drying. Eventually, the dryness can lead to permanent damage to the cornea, the clear outermost layer of the eye.

The patient immediately switched to single-dose bottles of the drops; these do not need any preservatives at all. With this change, her eyes began to heal. It’s been five years and she still can’t see well with her left eye, and she now has glaucoma in her right eye too. But she has figured out how to work with her vision and her glaucoma is well under control.

Bicket, now at the University of Michigan, was intrigued by the difference between real-world visual acuity and the patient’s own eyesight. Research she and her colleagues recently published shows that this can lag behind the visual acuity tested by weeks or sometimes months. The first question anyone undergoing eye surgery will ask themselves, Bicket told me, is how long it will take them to recover enough to go back to work, read, or drive. “The simple answer,” she says, “is, we just don’t know.” But Billet is working hard to find out.

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Health

The Pandemic Appears to Have Made Childhood Weight problems Worse, however There’s Hope

But while it has been possible to identify ways that schools can help prevent B.M.I. increases, it has been harder to figure out how to replicate those conditions when classes aren’t in session. For example, only about three million of the 22 million children who receive free or reduced-price lunch during the school year get the meals they’re eligible for over the summer. Those meals are typically more balanced nutritionally than the cheaper, calorie-dense fare that families resort to when food is scarce. Inconsistent access to food can also cause physiological changes that heighten the risk of obesity; school closures and job losses during the pandemic greatly increased the number of children without a stable source of nutrition. In June 2020, more than 27 percent of U.S. households with children were experiencing food insecurity; in about two-thirds of them, there was evidence that the children, in addition to adults, weren’t getting enough to eat — more than 5.5 times the number who reported those circumstances in all of 2018, according to the Brookings Institution. In addition, many families with sufficient resources were buying more ultraprocessed, shelf-stable foods for comfort and in preparation for possible lockdowns or supply shortages.

The crisis did force federal, state and local agencies to improvise novel ways of getting more balanced meals to children outside a school setting. To limit infection risk and reach more students, for instance, the U.S.D.A. offered waivers to what is known as its “congregant feeding” requirement that children eat on-site. This allowed caregivers to pick up multiple days’ worth of meals; some districts converted school buses running along their regular routes into a food-delivery service. The agency also made all children eligible for free lunch through September 2021, eliminating the paperwork required to qualify and the stigma that often comes with it, says Eliza Kinsey, a professor of epidemiology at the Mailman School of Public Health and an author of the Obesity paper. Such “program flexibility,” she points out, “could be applied in other, non-Covid contexts,” such as during the summer or for other disruptions like hurricane and wildfire closures.

It stands to reason that broadening access to nutritious foods would help prevent childhood obesity going forward. But schools also play a central role in the collection of nationally representative health data for children, a process that has been disrupted by school closures. We don’t know yet if the nearly 2 percentage point increase observed in the Philadelphia area will be similar across the country — or how much expanded feeding programs have mitigated the many and varied risk factors for obesity imposed by the pandemic.

Still, other pediatric hospital networks have reported worrying increases not just in obesity but also in the conditions that go with it. In a study published in April in the journal Diabetes Care, researchers noted a sharp increase in 2020, compared with previous years, of the number of children who showed up at Children’s Hospital Los Angeles with a severe form of new-onset Type 2 diabetes called diabetic ketoacidosis. That might be because children were eating poorer-​quality food and moving less, according to the lead author, Lily Chao, interim medical diabetes director at the hospital. It could also be that worries about the coronavirus induced families to delay seeking treatment for their children’s symptoms until they were in diabetic ketoacidosis.

A better understanding of how and why the pandemic affected children — not just physically but also emotionally and academically — would improve the ability of pediatricians, parents and policymakers to facilitate their recovery. Unfortunately, what is clear is that for children whose B.M.I. increased, “there are no magic bullets,” Black says. And, she adds, “it’s not healthy for kids to think about losing weight.” Rather than try to undo a past B.M.I. increase, a better strategy is to try to slow future ones and establish healthy habits. There is some good news in the fact that children tend to experience a growth spurt during puberty, says Risa Wolf, a pediatric endocrinologist at the Johns Hopkins Hospital; this can enable them to redistribute added weight on a taller frame. Wolf suggests parents focus on trying to build physical activity into their kids’ daily routine; the C.D.C. recommends 60 minutes for school-age children. And cutting fruit juice and soda from children’s diets is an easy way to significantly reduce sugar and calorie intake, Chao says.

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Health

CDC examine finds nursing dwelling residents have been reinfected with worse case of Covid

A general overview of the Centers for Disease Control and Prevention (CDC) headquarters in Atlanta.

Tami Chappell | Reuters

A new CDC study found that some elderly people who appeared to have recovered from the coronavirus later had a second, even worse case – suggesting that asymptomatic or mild cases may not offer much protection against re-infection with Covid- 19 offer.

The study, published Thursday in the Centers for Disease Control and Prevention’s Weekly Report on Morbidity and Mortality, looked at two separate outbreaks that occurred three months apart in a qualified care facility in Kentucky. According to the study, 20 residents and five health care workers tested positive for the virus between mid-July and mid-August.

The second outbreak, between late October and early December, was worse: 85 residents and 43 healthcare workers tested positive for the virus. Among residents who tested positive during the first outbreak and were still living at the facility, five tested positive a second time more than 90 days after their first positive test.

Although Covid-19 reinfections do occur, they are generally rare.

Through frequent monitoring after the initial outbreak, all five residents had at least four negative tests between outbreaks, suggesting that they may have been re-infected with the virus later. Reinfection means that a person who had Covid-19 recovered and then got it again, according to the CDC.

“The history of exposure, including when the roommate infections occurred and symptoms recurred during the second outbreak, suggests that the second positive RT-PCR results represented new infections after the patients appeared to clear the first infection,” wrote Alyson Cavanaugh , one of the researchers who led the study.

While only two of the five residents showed mild symptoms during the first outbreak, all five potentially reinfected residents showed signs of illness the second time. The two residents who reported symptoms during the first outbreak “experienced more severe symptoms during the second infectious episode, according to the study.” One resident was hospitalized and subsequently died.

According to the study’s researchers, this was “noteworthy” as it suggests the possibility that people who show mild to no symptoms when they first become infected are “not creating a sufficiently robust immune response to prevent re-infection”. The results “suggest the possibility that the disease may be more severe during a second infection.”

“The results of this study underscore the importance of maintaining public health mitigation and protection strategies that reduce the risk of transmission, even in those with a history of COVID-19 infection,” wrote Cavanaugh.

Some limitations were noted in the study. Because the samples were not stored, the researchers were unable to perform genome sequencing, a laboratory technique that breaks down the virus’ genetic code to confirm re-infection. “There are no additional test results to prove the initial test result is really positive,” they said during the initial outbreak.

It is believed that the risk of re-infection for the general population is still low, but nursing home residents may be particularly at risk due to their coexistence and high number of exposures, according to the study.

“Qualified care facilities should employ strategies to reduce the risk of SARS-CoV-2 transmission in all residents, including those previously diagnosed with COVID-19,” Cavanaugh wrote.

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World News

Former ambassador warns expiration of key nuclear treaty with Russia would make the U.S. ‘worse off’

The Biden government has urged the renewal of the new Strategic Arms Reduction Treaty (New START) with Russia for five years, which expires on February 5. The nuclear deal regulates and limits how many nuclear weapons each country can have. Russian officials said Friday they welcomed the news.

Michael McFaul told CNBC’s “The News with Shepard Smith” that the expiry of New START with Russia would “put the US in a worse position”.

“We would lose our ability to review, look inward and look at the Russian nuclear arsenal,” said McFaul, who served as US ambassador to Russia from 2012 to 2014. “Do you remember Ronald Reagan always saying,” Trust but check? “I say don’t trust, just check, and the new START contract allows us to do that. I think it’s the right decision by the new Biden team to renew it.”

Joel Rubin is a former Deputy Assistant Secretary of State for Legislative Affairs, where he has worked with members of Congress on various national security issues, including nuclear safety. He agreed with McFaul and told The News with Shepard Smith that the deal would stabilize relations between the two nuclear powers.

“The Trump administration has tried to leverage the delay in the renewal of the treaty but has received nothing in return, which puts the entire treaty at risk,” said Rubin, who was also the policy director for Plowshares Fund, the country’s leading nuclear security company Foundation, endowment. “We need stability between the US and Russia, which together own more than 90% of the world’s nuclear weapons. The renewal of New START will do that.”

Relations between Moscow and the US have been shaped by massive cyberattacks against federal authorities, interference in US elections and the recent arrest of Russian opposition leader Alexie Navalny. President Joe Biden will ask his Director of National Intelligence, Avril Haines, to review Russia’s interference in the 2020 election, according to the Washington Post.

McFaul told host Shepard Smith that he believes the reaction against Russia will likely be sanctions, but that the Biden administration has a choice when it comes to penalties against Russia.

“The simple thing is to sanction a number of unnamed colonels, FSB, the successor group to the KGB, and tick the box,” McFaul said. “The bolder move would be to sanction some of those who make the Putin regime possible, including some economic oligarchs who support Putin.”

Rubin added that the US should also work closely with European and Asian allies to pressure Russia to change and address its internal repression and aggressive international behavior, “rather than pushing them away and easing diplomatic pressure on Russia, like the Trump administration did. “”

McFaul told Smith he wasn’t sure President Joe Biden would want to spend the political capital to toughen up on Russia as the U.S. faces domestic political issues, including Covid and an economic crisis. McFaul added, however, that he believes Biden could do both.

“I think you could run and chew gum at the same time. I think you should be able to do both at the same time, but we’ll have to wait and see what they do,” McFaul said.

Rubin told The News with Shepard Smith that the time had come for the US to be “persistent” on Russia and President Vladimir Putin.

“We should not be afraid of Moscow, nor should we go to Moscow, nor should we expect that we can improve relations between the US and Russia through the diplomacy of children’s gloves,” said Rubin.