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How Weight Coaching Burns Fats

Before and after that process, the researchers drew blood, biopsied tissues, centrifuged fluids and microscopically searched for vesicles and other molecular changes in the tissues.

They noted plenty. Before their improvised weight training, the rodents’ leg muscles had teemed with a particular snippet of genetic material, known as miR-1, that modulates muscle growth. In normal, untrained muscles, miR-1, one of a group of tiny strands of genetic material known as microRNA, keeps a brake on muscle building.

After the rodents’ resistance exercise, which consisted of walking around, though, the animals’ leg muscles appeared depleted of miR-1. At the same time, the vesicles in their bloodstream now thronged with the stuff, as did nearby fat tissue. It seems, the scientists concluded, that the animals’ muscle cells somehow packed those bits of microRNA that retard hypertrophy into vesicles and posted them to neighboring fat cells, which then allowed the muscles immediately to grow.

But what was the miR-1 doing to the fat once it arrived, the scientist wondered? To find out, they marked vesicles from weight-trained mice with a fluorescent dye, injected them into untrained animals, and tracked the glowing bubbles’ paths. The vesicles homed in on fat, the scientists saw, then dissolved and deposited their miR-1 cargo there.

Soon after, some of the genes in the fat cells went into overdrive. These genes help direct the breakdown of fat into fatty acids, which other cells then can use as fuel, reducing fat stores. In effect, weight training was shrinking fat in mice by creating vesicles in muscles that, through genetic signals, told the fat it was time to break itself apart.

“The process was just remarkable,” said John J. McCarthy, a professor of physiology at the University of Kentucky, who was an author of the study with his then graduate student Ivan J. Vechetti Jr. and other colleagues.

Mice are not people, though. So, as a final facet of the study, the scientists gathered blood and tissue from healthy men and women who had performed a single, fatiguing lower-body weight workout and confirmed that, as in mice, miR-1 levels in the volunteers’ muscles dropped after their lifting, while the quantity of miR-1-containing vesicles in their bloodstreams soared.

Of course, the study mostly involved mice and was not designed to tell us how often or intensely we should lift to maximize vesicle output and fat burn. But, even so, the results serve as a bracing reminder that “muscle mass is vitally important for metabolic health,” Dr. McCarthy said, and that we start building that mass and getting our tissues talking every time we hoist a weight.

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Business

Health corporations see surge in demand as Individuals rush to lose Covid weight

The economy opens up again quickly. Restaurants, sports arenas, and even offices are filling up again as pandemic restrictions are lifted. And that means a lot of people who have been confiscated from their homes in the past year are heading out even if they don’t look exactly alike.

The stressful and sedentary nature of life during the coronavirus pandemic caused many to drop out of their fitness routines and gain weight. According to a recent survey by the American Psychological Association, 42% of adults in the United States reported unwanted weight gain due to Covid. Average gain: 29 pounds.

“Sourdough bread was fun making. Banana bread was fun making, but the result is not great,” said Jim Rowley, CEO of Crunch Worldwide.

On the flip side, 18% reported unwanted weight loss, possibly due in part to muscle loss from all that sitting around. It’s no wonder, profit or loss, that fitness companies are suddenly seeing a new surge in activity.

“We now have a lot of people who haven’t seen us over the winter who are ready and realizing this is a long time coming,” said Lucy Ballentine, gym manager at Orangetheory Fitness in Washington, DC I told her, “It It’s been over a year since I’ve done any kind of training and I’m really desperate to get back in shape. “

An employee wearing a protective mask disinfects a treadmill between classes at an Orange Theory gym in Atlanta, Georgia, United States on Wednesday, May 27, 2020.

Elijah Nouvelage | Bloomberg | Getty Images

While the demand for home fitness has spiked over the past year, benefiting big names like Peloton, Beachbody, and The Mirror, the urge to get back in shape is now clearly felt as Americans come out of hiding.

That was the overwhelming feeling of an outdoor orange theory class in a DC parking lot.

“Do you think I have to go back to the closet that I no longer fit? Yes,” said Stacey Weinstock, who has been working from home since the pandemic began.

“We’re getting a little closer to where everything will open up, and we want to do our best and feel our best,” Rachel Robins said as she prepared for class.

Both gyms and streaming fitness companies are suddenly seeing a surge in new demand and overall workout. Nationwide Orange Theory memberships rose 17% in the first quarter of this year, with the biggest jump in March, up 9%.

Crunch reports that member visits in March were up 30% compared to February. Despite having a huge presence in major cities that still have severe gym restrictions, such as New York, Los Angeles, and San Francisco, the company had its strongest new member sales in a year.

“We predict the big boom will be in September when we’re through the summer and the kids are back to school. It’s normal for businesses to reopen, especially in urban centers like Manhattan and San Francisco,” Rowley said.

According to Barry’s Bootcamp, the number of studio goers in March increased 31% from February and 48% from January. The new streaming workouts are also available.

The presence in the class is increasing thanks to relaxed restrictions and increased vaccinations.

“I feel more comfortable being closer to people and sharing air with people after I’m vaccinated,” said Rachel Weiss, another client at Orangetheory.

A person works out on an elliptical trainer at a crunch gym in Burbank, California, the United States, on Tuesday, June 23, 2020.

Patrick T. Fallon | Bloomberg | Getty Images

However, that doesn’t necessarily mean an end to the new boom in streaming and home fitness. Crunch, for example, has been streaming for more than a decade.

“I can tell you that during the shutdown we spent money improving our lighting, sound, camera, and digital presence,” said Rowley, who argues that those who focus on fitness always have multiple options have used. “They were the first to buy the thigh master, the Ab Cruncher. So it’s not unique to say, ‘Oh, I have a gym membership and a peloton.'”

Peloton, which has seen phenomenal growth in its streaming fitness platform and bike and treadmill sales over the past year, doesn’t seem to be losing steam right now. While the publicly traded company wouldn’t release the latest numbers on streamed workouts, CEO John Foley recently said he wasn’t worried about a return to the gym.

“I can commit to hypergrowth,” said Foley. “What we’re seeing is a shift in which people want to exercise at home … it’s the future of fitness, Covid or not.”

Cari Gundee rides her peloton exercise bike at her home in San Anselmo, California on April 6, 2020.

Ezra Shaw | Getty Images

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Business

NCAA weight room discrepancy displays continual gender inequality

The NCAA has a chronic problem with undervalued women, writer and presenter Jemele Hill said Friday – and the recent controversy over weight room discrepancies highlights that inequality.

“This has long been a consistent issue when it comes to the lack of equity between men’s and women’s sports,” Hill said. “This should let everyone know who is seeing and hearing this story that it was about the fact that they didn’t think they were worth it to begin with.”

A Stanford University athletic performance coach posted photos on Twitter Thursday exposing inequalities between the weight rooms of women and men.

Photos of Ali Kershner, a coach for the Stanford women’s basketball and golf teams, showed the women’s weight room in the NCAA bubble in San Antonio – a dumbbell rack and some yoga mats. The men’s weight room in their NCAA bubble in Indianapolis. was decked out with equipment worth a gym.

On a Friday morning call to Zoom, NCAA senior vice president of basketball Dan Gavitt promised to do better.

“I apologize to the students, coaches and the women’s committee for dropping the ball on the San Antonio weight room issue. We’ll fix it as soon as possible,” said Gavitt.

NCAA vice president for women’s basketball Lynn Holzman said later Friday the organization is looking at ways to adjust square footage and provide more exercise opportunities.

Hill told CNBC’s The News with Shepard Smith on Friday that the rapid response was indicative.

“When they were caught and this video went viral, they suddenly had a change of heart within 24 hours,” said Hill, who hosts the Spotify podcast. “Jemele Hill is undisturbed.” “The money was always there. The money isn’t the problem. The problem is they don’t believe these women are worth it.”

ESPN signed a 14-year $ 500 million contract with the NCAA in the 2023/24 academic year to expand rights to 24 college championships, including continued coverage of the Women’s Division I basketball tournament.

Hill told host Shepard Smith that going forward, the NCAA “must do everything it can to show that they take women’s sport seriously because it looks worse as the background to this is that it is the month of women’s history.”

NCAA officials were not immediately available Friday to respond to Hill’s comments.

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Health

Semaglutide Brings Vital Weight Loss in Overweight Sufferers

For the first time, a drug has been shown to be so effective against obesity that patients can avoid many of its worst effects, including diabetes, researchers reported Wednesday.

Novo Nordisk’s drug Semaglutide is already marketed for the treatment of type 2 diabetes. In a clinical study published in the New England Journal of Medicine, researchers at Northwestern University in Chicago tested semaglutide at a much higher dose as an anti-obesity drug.

Nearly 2,000 participants in 129 centers in 16 countries injected semaglutide or a placebo weekly for 68 weeks. Those who received the drug lost an average of nearly 15 percent of their body weight, compared with 2.4 percent of those who received the placebo.

More than a third of the participants who received the drug lost more than 20 percent of their weight. Symptoms of diabetes and pre-diabetes improved in many patients.

These results far exceed the weight loss seen in clinical trials with other anti-obesity drugs, experts say. The drug is a “game changer,” said Dr. Robert F. Kushner, an obesity researcher at Northwestern University’s Feinberg School of Medicine, who led the study. “This marks the beginning of a new era of effective obesity treatments.”

Dr. Clifford Rosen of the Maine Medical Center Research Institute, who was not involved in the study, said, “I think it has great potential for weight loss.” The gastrointestinal symptoms among the participants were “really marginal – nothing like weight loss drugs in the past,” added Dr. Rosen, editor of the New England Journal of Medicine and co-author of an editorial that accompanied the study.

For decades, scientists have been looking for ways to help a growing number of people with obesity. Five obesity drugs currently available have side effects that limit their use. The most effective phentermine causes an average weight loss of 7.5 percent and can only be taken for a short time. After stopping, this amount of weight is also regained.

The most effective treatment to date is bariatric surgery, which allows people to lose an average of 25 to 30 percent of their body weight, noted Dr. Louis Aronne, an obesity researcher at Weill Cornell Medicine in New York, who advises Novo Nordisk and studies semaglutide.

However, surgery is an invasive solution that permanently changes the digestive system. Only 1 percent of those who qualify do the procedure. Instead, most obese people try diet after diet with disappointing results.

The semaglutide study confirms what scientists already know, said Dr. Kushner: Willpower is not enough. In the new study, the participants who received the placebo and the diet and exercise counseling could not find any significant difference in weight.

In general, insurers have refused to pay for the weight loss drugs on the market. Semaglutide is likely to be expensive. The lower dose used to treat diabetes has an average retail price of nearly $ 1,000 per month. (Insurers usually pay for diabetes medication, Dr. Kushner noted.)

Dr. Caroline Apovian, co-director of the Center for Weight Management and Wellness at Brigham and Women’s Hospital and a member of the Novo Nordisk advisory board, said semaglutide’s effectiveness is “phenomenal” and the trial results may lead insurers to cover it.

Semaglutide is a synthetic version of a naturally occurring hormone that acts on appetite centers in the brain and intestines, causing feelings of satiety. A high-dose regimen of the drug hasn’t been studied long enough to see if it has serious long-term effects.

And it is expected that patients will have to take it for a lifetime to prevent weight loss from returning.

Qiana Mosely, who lives in Chicago, has tried dieting and drugs for years to lose weight, but to no avail. Then Ms. Mosely took the semaglutide study and lost 40 pounds, about 15 percent of her weight.

Ms. Mosely did not know until recently whether she was receiving the drug or the placebo. Although she tried to eat well and exercise, her weight “dropped too quickly,” she said. “It had to be the drugs.”

She said she didn’t experience any side effects. But when the study ended and she stopped receiving the drug, the weight came back. “I was so sad,” she said. She will endeavor to resume taking the medicine as soon as it becomes available.

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Health

Extra Weight Throughout Being pregnant Tied to Fertility Points in Sons

Overweight mothers may be more likely to have infertile sons, Danish researchers report.

Their study included 9,232 men and women aged 31 to 34 years. In this group, 10 percent of underweight mothers were born with a body mass index below 18.5. 77 percent of mothers of normal weight; and 13 percent for overweight or obese mothers with a pre-pregnancy BMI over 25.

When examining the records of the diagnosis and treatment of infertility, the researchers found that sons of overweight mothers were 40 percent more likely to be infertile than sons of mothers of normal weight. Sons with underweight mothers did not have increased infertility rates, and a mother’s weight did not affect her daughters’ fertility. The study, published in AOGS, controlled maternal age, smoking, alcohol consumption, socio-economic status, and other factors.

The reason for the association is unknown, but the authors suggest that obesity is an indication of a hormonal imbalance that could affect prenatal development of the male reproductive system.

The lead author, Dr. Linn H. Arendt, obstetrician at Aarhus University in Denmark, said that being overweight in pregnancy is unhealthy for several reasons, and that most women are aware that obesity is a risk. She said this is the first study to show an association between maternal BMI and infertility in adult sons, but that it would not warn women about the problem.

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Health

Kim Chernin, Who Wrote About Ladies, Weight and Id, Dies at 80

Kim Chernin, a feminist writer and counselor who wrote compassionately about female body dysmorphism and its cultural causes, and about her own upbringing as the daughter of a fiery communist organizer incarcerated for her belief, died on December 17 in a Marin County hospital , California. She was 80 years old.

Your wife, Renate Stendahl, said the cause was Covid-19.

Ms. Chernin’s mother was Rose Chernin, a labor organizer and Communist Party leader who was convicted with others during the McCarthy era for attempting to overthrow the government (the government would also try twice to deport her to her native Russia) . In a landmark case in 1957, the Supreme Court overturned the convictions and ruled that it was not a crime to merely encourage people to believe a certain doctrine.

It was a seismic moment for the country and for Rose’s daughter, who struggled to define herself in relation to her mother – the “Red Leader,” as the newspapers liked to call Rose – and instilled a lifelong dislike for the younger Mrs. Chernin Advertising.

In 1980, Ms. Chernin was an unpublished poet when Ticknor & Fields purchased her book The Obsession: Reflections on the Tyranny of Slenderness. The seven-year manuscript was rejected by 13 publishers.

Anorexia and bulimia were little discussed diseases at the time; However, there was an emerging crisis among young women on the college campus, and when Ms. Chernin’s book appeared she became a sought-after speaker on television and on the college campus. The book, which had a limited edition, sold out quickly.

“Obsession” was the first of a trilogy about women’s appetite and identity. In it, Ms. Chernin wrote about her own obsession with weight and her attempts to equate food with care. She used a variety of lenses – cultural, feminist, anthropological, spiritual, and metaphorical – to discover why so many women felt alienated from their bodies.

“Many of the emotions in life – from loneliness to anger, from love for life to falling in love – can be experienced as appetites,” she wrote. “And some would explain the obsession with weight in these simple, familiar terms. But there are deeper levels of understanding to guide. That night, for example, when I was standing in front of the refrigerator, I realized that my hunger was for bigger things, for identity, for creativity, for power and for a meaningful place in society. The hunger that most women experience, which leads them to eat more than they need, is satisfied through self-development and expression. “

She argued that the physical ideal for an American woman was a man’s body – lean and wiry, not soft and round – and if so, she asked what did that say about society?

Updated

Jan. 3, 2021, 5:36 p.m. ET

“There is a poetic truth at the heart of ‘The Obsession’,” wrote Christopher Lehmann-Haupt in his 1981 New York Times review of the book. “Eloquently written, passionate in its rhetoric and consistently receptive, it becomes a seemingly trivial subject from the inside out to uncover unconfirmed attitudes and prejudices. We Americans are probably far too worried about fat and its appearance. Perhaps Miss Chernin is right, when she argues that the problem is not the superficiality of our perceptions, but the depth of our feelings. “

Elaine Kusnitz, known as Kim, was born in the Bronx on May 7, 1940. Her father, Paul Kusnitz, was a civil engineer trained at the Massachusetts Institute of Technology. Her mother, Rose Chernin Kusnitz, using her maiden name, had graduated from high school early and worked in a factory to support her parents and sisters.

Both of Kim’s parents were Russian-born Jews and committed Marxists. Before Kim was born, they returned to Russia for some time, where Mr. Kusnitz was working on plans for the Moscow subway.

When Kim was 4 years old, her older sister and carer Nina died of Hodgkin’s lymphoma. Rose moved the family to Los Angeles and began working as an organizer to advocate farm labor and housing rights for their black and Latin American neighbors.

Kim grew up attending Communist Party rallies, initially in her stroller. From a young age she read Marx, Lenin, and reports on the trial of the Scottsboro Boys, the nine black teenagers falsely accused of rape in Alabama. Kim fought bitterly with her mother, who she also adored.

At the Yiddish school, which was sponsored by a left-wing Jewish organization, which she visited briefly, Kim quacked like a duck when she was spoken to in that language. But when her mother was imprisoned for five months at the age of eleven, she was desolate. And when she wrote her memoir “In My Mother’s House” in 1983, in which she interwoven her own story with that of her mother, she recorded her mother’s unmistakable, Yiddish-influenced voice: “You want to fly? Grow wings. Don’t like things the way they are? To tell a story.”

Ms. Chernin studied English at the University of California at Berkeley, where she met David Netboy. The two were married, had a daughter, Larissa, who she survived, and soon divorced. Her marriage to Robert Cantor also ended in divorce. After that, she took her mother’s maiden name as her own, as did Larissa.

Ms. Chernin met Ms. Stendhal, a journalist and author, in a café in Paris. They married together since 1985 in 2014. They were, among other things, collaborators and editors of each other’s letter and co-authors of “Lesbian Marriage: A Love & Sex Forever Kit”.

After “Obsession,” Ms. Chernin published nearly 20 books, but her aversion to advertising and marketing increased with age, Ms. Stendhal said, and her latest writings were donated directly to her archive in the Schlesinger Library at Harvard University.

Ms. Chernin, who was in psychoanalysis for 25 years and began counseling women with eating disorders after the publication of “Obsession”, did her doctorate in spiritual psychology, as did Ms. Stendhal, in the mid-1990s, which combines the spiritual teachings of all creeds with conventional psychotherapy .