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Religion, Freedom, Worry: Rural America’s Covid Vaccine Skeptics

Which trustworthy person will speak for the vaccine? Eva Fields?

She is a nurse who treated one of the first on-site patients to die of Covid. She grew up in Greeneville and has 24 relatives who had the virus.

When she asks patients if they are going to be vaccinated, about half say, “No, and I won’t.” Assuming she’s going to be angry, add, “I’m so sorry if this upsets you!”

Miss Fields replies, “That’s fine, honey. I don’t intend to. “

Her gut tells her to believe a video sent to her by someone from a far-right misinformation group jokingly said studies showed vaccines cause plaque in the brain.

Like others here, she is suspicious of Bill Gates’ involvement in vaccine development. One evening over dinner, Dr. Theo Hensley, a vaccine advocate in her office: “I don’t know Bill Gates, but I know Dolly gave Parton a million dollars.” (Ms. Parton is Northeast Tennessee’s favorite daughter.)

“Well, she’s probably fine,” admitted Miss Fields.

“When someone pushes something really hard, I sit back because I don’t like people telling me, ‘You have to do this,” said Miss Fields. Repeating to many others, she added, “I have to do my own research . “

At the moment she is not pushing or discouraging patients to get the vaccine.

The day the Fletchers, the retired couple, met their family doctor, Dr. Daniel Lewis, speaking about the vaccine, marked the one year anniversary of the day he was put on a ventilator with a severe case of Covid.

Dr. Lewis, 43, stayed in the hospital for over a month. He was so seriously ill that he recorded goodbye messages for his five children.

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Does It Matter if I Skip My Second Dose of Covid Vaccine?

It’s also not clear how long the protection of the first dose lasts without the surge of a second dose, said Dr. Fauci during a press conference at the White House in April.

Updated

April 29, 2021, 6:12 p.m. ET

“We were and still are concerned that if you look at the level of protection after a dose, you can say it’s 80 percent, but it’s a little weak 80 percent,” said Dr. Fauci. He said there was concern that more contagious variants that continue to spread around the globe might partially dodge after just one dose of vaccine-induced antibodies. “You’re in a weak zone if you don’t get the full effect of two doses,” he said.

Breakthrough infections after vaccination, while rare, do occur. A recent study of 250 people in Israel who were infected with the Pfizer vaccine after partial vaccination – between two weeks after the first dose and one week after the second dose – showed that they infected disproportionately with B.1.1.7 variant were first identified in Great Britain. The same study found that a group of 149 people infected after the second dose of vaccine developed eight infections with B.1.351 (the variant first identified in South Africa) between the seventh and 13th day after the second dose. No breakthrough infections with the South African variant were observed 14 days after the second dose. Although it was a small sample, the result suggested that full vaccination would provide more protection against the variants, said Adi Stern, the study’s lead author, a professor at Tel Aviv University’s Shmunis School of Biomedicine and Cancer Research .

Another study showing the benefits of full vaccination looked at a group of 91,134 patients previously seen by doctors at the Houston Methodist Hospital system and followed them between December and April. Most were not vaccinated, but 4.5 percent were partially immunized and 25.4 percent were fully immunized. There were 225 deaths from Covid-19 in the group and 219 (97 percent) were among the unvaccinated. However, five deaths (2.2 percent) occurred in the partially immunized. Only one person (0.004 percent) died in the fully immunized group. In this study, full vaccination was protected 96 times from hospitalization and 98.7 percent from death from Covid-19. However, the partially vaccinated were only 77 percent protected from hospitalization and 64 percent from fatal Covid-19.

The study’s lead author, Saad B. Omer, director of the Yale Institute for Global Health, said he started the research with a “neutral” view of the benefits of two doses over a single dose. But he is now convinced that the benefits of a second dose matter.

“Given the data from our study and other evidence, it doesn’t make sense for people to skip their second dose,” said Dr. Omer. “When it comes to preventing death from vaccines, the jar is 64 percent full, but wouldn’t you rather have it almost 100 percent full for a result as drastic and irreversible as death?”

Aside from the obvious health risks, skipping the second dose can also make your life more complicated if you’re traveling or visiting facilities that require proof of vaccination. “You are not considered fully vaccinated,” said Dr. Brownstein. “It can have an impact on getting back to normal. If your vaccination record or card does not show full status, there may be certain things you cannot do. You may not be able to get on a plane. “

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Shake-Up at Covid Vaccine Producer That Tossed Hundreds of thousands of Doses

The Baltimore facility is one of two federally designated locations to manufacture vaccines or therapeutics for public health emergencies. In June 2020, the Trump administration placed a $ 628 million contract with Emergent, primarily to reserve space in Baltimore for the manufacture of coronavirus vaccines.

In Washington, Emergent is known for aggressive lobbying and government relations that include both Democratic and Republican governments. The company’s board of directors is made up of former federal officials, and lobbyists include former members of Congress.

“We’ve been around as a company for 22 years,” Kramer said Thursday, adding that the company’s relationships with government agencies, including the biomedical advanced research and development agency known as BARDA, which has spent $ 628 million on the contract , “stay intact and strong.”

In June 2020, shortly after the Trump administration awarded the contract to Emergent, a top official with Operation Warp Speed, the government’s rapid vaccine initiative, warned that the company had insufficiently trained staff and was experiencing quality control issues.

A copy of the official’s assessment received from The Times named “major risks” of relying on Emergent to manufacture vaccines developed by both Johnson & Johnson and AstraZeneca at the same Baltimore facility.

Cross-contamination is a “known risk” in manufacturing two live virus vaccines, Kramer said Thursday, but the decision to manufacture both in Baltimore was with the government. There are several safeguards in place, Emergent said, although Emergent believes they “weren’t working as expected” and that the AstraZeneca virus likely contaminated the Johnson & Johnson batch.

“It’s easy to go back and rethink these decisions that were made in the early stages of the pandemic,” he said. “At the time, nobody knew how quickly we could get into a clinically viable vaccine and which candidates would be most successful.”

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Single dose of vaccine can virtually halve transmission

A nurse, Cindy Mendez, wearing a protective mask, holds a syringe containing a dose of Pfizer-BioNTech COVID-19 vaccine during the coronavirus disease (COVID-19) pandemic at NYC Health + Hospitals Harlem Hospital in the Manhattan neighborhood of New York City. New York, February 25, 2021.

Jeenah Moon | Reuters

LONDON – A single dose of coronavirus vaccine can cut transmission within a household by up to half, a study by Public Health England found.

People who became infected with the coronavirus three weeks after receiving a single dose of the Pfizer-BioNTech or AstraZeneca-University of Oxford vaccine were between 38% and 49% less likely to pass the virus on to their household contacts than those who weren’t vaccinated, the PHE found -Study.

Protection was observed approximately 14 days after vaccination with similar levels of protection regardless of the age of the cases or contacts.

That protection comes on top of the reduced risk that a vaccinated person will develop symptomatic infection in the first place, which is around 60% to 65% – four weeks after a dose of either vaccine, according to PHE. Both doses of a coronavirus vaccine (the delay between doses is up to 12 weeks in the UK) offer even greater protection against Covid infections.

UK Health Secretary Matt Hancock hailed the study’s results as “great news”. “We already know that vaccines save lives, and this study is the most comprehensive real-world data to show that they also reduce the transmission of this deadly virus.”

“It further underscores that vaccines are the best way out of this pandemic as they protect you and potentially prevent you from unwittingly infecting anyone in your household.”

“I urge everyone to get their vaccines as soon as they are eligible and make sure you get your second dose to ensure the best possible protection,” he added.

Both Pfizer BioNTech and AstraZeneca vaccines are used extensively in the UK, and the Moderna vaccine is now also included in the immunization program.

The introduction of vaccines was a tremendous success in the UK and a silver lining after the devastation of the pandemic that has caused over 127,000 deaths in the country to date.

In the UK, cases, hospitalizations and deaths have fallen dramatically since it was launched in December, along with strict lockdown measures. To date, nearly 34 million adults in the UK have had a first dose of vaccine and over 13 million two doses, government data shows.

The PHE study found that households are at high risk for transmission and provide early evidence of the effects of vaccines on preventing transmission. Similar results might be expected in other settings with similar transmission risks, for example in shared apartments and prisons.

The study, which is a pre-print that has not yet been peer-reviewed, included over 57,000 contacts from 24,000 households who had a laboratory-confirmed coronavirus case vaccinated, compared to nearly 1 million contacts from unvaccinated cases.

By linking case and household contact data with vaccination status, the study compared the probability of transmission for a vaccinated case with a non-vaccinated one.

PHE is also conducting separate studies on the effects of vaccination on transmission in the broader population.

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New York Will Enable Stroll-Ins at State Vaccine Websites

All state mass coronavirus vaccination centers in New York will allow people aged 16 and older to step in without an appointment and receive their first dose, starting Thursday, Governor Andrew M. Cuomo announced on Tuesday.

Walk-in vaccinations will be available at state locations in New York City like Javits Center in Manhattan and Yankee Stadium in the Bronx, as well as Long Island and upstate cities like Albany and Syracuse, the governor said.

The second dose will continue to be administered by appointment, which will be determined after the first dose has been administered.

“Just come over and roll up your sleeve and the mass vaccination centers can handle it,” Cuomo said at a press conference Tuesday.

Other types of vaccine providers in the state, such as pharmacies and locations operated by cities and counties, have the option to allow walk-ins as well, a move the governor endorsed.

New York had already started allowing some vaccinations without an appointment. Mr Cuomo announced last week that people 60 and over could come to 16 state locations for vaccination. And New York City Mayor Bill de Blasio announced last week that the city-operated vaccination centers would give anyone eligible to get a shot.

Allowing walk-ins simplifies a process that weighed on many New Yorkers earlier in the pandemic when getting a vaccine appointment was often spent hours searching online and some luck too. The new policy could also attract people who are still reluctant to get vaccinated, said Mr Cuomo.

“This is our way of saying, if you’ve been intimidated by trying to make an appointment, that’s gone,” the governor said.

He said it was feasible to allow more walk-ins as fewer vaccinations are now being given across the state – about 115,000 doses per day – than a few weeks ago when the state peaked at about 175,000 doses per day.

“Demand is decreasing, fewer people are asking for appointments,” said Cuomo.

State data shows that just under 45 percent of New Yorkers, or just over 8.9 million people, had received at least one dose of the vaccine by Tuesday morning.

Mr Cuomo also announced at the press conference that New York would adopt the new CDC guidelines that fully vaccinated people can safely do most outdoor activities without masks.

Reports of new cases and hospitalizations in the state have declined, according to a New York Times database, but the risk of infection remains high in New York City, where some problematic variants of the virus appear to be on the rise.

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Public demand for AstraZeneca vaccine falls after blood clot scares

A medical worker fills a syringe with AstraZeneca vaccine at Santa Caterina da Siena – Amendola secondary school in Salerno on March 13, 2021 in Salerno, Italy.

Francesco Pecoraro | Getty Images News | Getty Images

LONDON – Public preference for the coronavirus vaccine developed by AstraZeneca and the University of Oxford has fallen since reports surfaced suggesting it may be linked to some cases of unusual blood clotting events.

An April study of nearly 5,000 adults in the UK, with Covid vaccine uptake high and the vaccination program well established, found that public preference for the AstraZeneca Covid vaccine has declined since March and there is a belief that that he caused blood clots to have increased.

The UK academic study found that 17% of the public now say they would prefer the AstraZeneca vaccine if given a choice – up from 24% towards the end of March.

And 23% of people now believe the AstraZeneca vaccine causes blood clots – up from 13% in March. However, the public are still the most likely to say that this claim is false (39%) or that they don’t know if it is true (38%).

The study, conducted April 1–16 by the University of Bristol, King’s College London, and the NIHR Health Protection Unit for Emergency Preparedness and Relief, found a “big difference” in beliefs before and after MHRA ( the UK Medicines Agency) announced on April 7th that there is a possible link between the vaccine and extremely rare blood clots.

The study found that 17% of respondents in the first week of this month thought this claim was true, compared with 31% who were asked about it.

Why autumn

Since the first clinical data was published, the vaccine has shown an average effectiveness rate of 70% (subsequent studies in the US have shown an effectiveness rate of 79%, and other studies have shown that the effectiveness rate increases with a larger gap between the first and second doses ) The fate of the AstraZeneca vaccine is mixed to say the least.

Continue reading: Dates, Doubts, and Disputes: A Timeline for AstraZeneca’s Covid Vaccine Problems

One of the recent hurdles for the AstraZeneca vaccine was a small number of reports of unusual, sometimes fatal, blood coagulation events that occurred in post-vaccinating people in Europe in February, causing several countries to suspend use of the vaccine.

The UK and EU drug regulators (the UK Medicines and Health Products Regulatory Authority and the European Medicines Agency) examined the reports and said that while there is a possible link between the vaccine and low incidence of blood clotting, the benefits of the vaccine are significant outweighing them Risks.

The Anglo-Swedish vaccine maker, British government and experts largely defended the vaccine, saying it protected millions of people by reducing Covid cases, hospitalizations and deaths.

In addition, experts tried to correlate the risk, saying the number of reported rare blood clotting cases with low platelets was about one case in 250,000 people vaccinated and one death in one million.

Britain is fortunate that it has traditionally received high levels of public support for vaccination. The vaccine preference survey found that, despite the growing belief that it was associated with blood clots, the AstraZeneca vaccine did not affect general confidence in vaccines in general. 81% say vaccines are safe, compared to 73% who said so in late 2020.

Similarly, views on how well vaccines work have changed: 86% say they are effective, up from 79% in November and December 2020.

However, surveys have shown that the public perception of the AstraZeneca vaccine has deteriorated in mainland Europe, and there is scattered evidence that people in the EU are using the AstraZeneca vaccine (referred to as the “Aldi” vaccine after the low-cost food chain will) because in favor of the coronavirus vaccine from Pfizer-BioNTech, which also prevails when EU vaccinations are introduced.

Continue reading: “The damage is done”: Europe’s caution against the AstraZeneca vaccine could have far-reaching consequences

Moderna’s shot and Johnson & Johnson’s shot have also been approved for use in the EU and the UK, but have been less widely used, EU vaccination data show.

Hesitation to vaccinate can apparently work both ways. A British doctor reported in the Evening Standard newspaper in January that some of his patients had turned down the opportunity to receive the Pfizer vaccine, saying they would “wait for the English one.”

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Can You Have Alcohol After the Covid Vaccine?

After a long year and much anticipation, receiving the Covid-19 vaccine can be cause for celebration, which for some could mean pouring a drink and toasting their new immunity. But can alcohol affect your immune response?

The short answer is that it depends on how much you drink.

There is no evidence that a drink or two could affect the effectiveness of the current Covid vaccines. Some studies have even found that, over the longer term, small or moderate amounts of alcohol can actually support the immune system by reducing inflammation.

On the other hand, heavy drinking, especially in the long run, can suppress the immune system and potentially affect your vaccination response, experts say. Since it can take weeks after a Covid shot for the body to generate protective antibodies against the novel coronavirus, anything that disrupts the immune response is cause for concern.

What you need to know about the Johnson & Johnson US vaccine break

    • On April 23, an advisory panel to the Centers for Disease Control and Prevention voted to lift a hiatus on Johnson & Johnson Covid vaccine and put a label on an extremely rare but potentially dangerous bleeding disorder.
    • Federal health officials are expected to officially recommend states lift the hiatus.
    • The vaccine was recently discontinued after reports of a rare bleeding disorder surfaced in six women who received the vaccine.
    • The overall risk of developing the disorder is extremely small. Women between the ages of 30 and 39 appear to be most at risk, with 11.8 cases per million doses. There were seven cases per million doses in women between 18 and 49 years of age.
    • Almost eight million doses of the vaccine have now been given. There was less than one case per million doses in men and women aged 50 and over.
    • Johnson & Johnson had also decided to postpone the launch of its vaccine in Europe for similar reasons, but later decided to continue its campaign after the European Union Medicines Agency announced the addition of a warning. South Africa, devastated by a contagious variant of the virus, also stopped using the vaccine, but later continued to use it.

“If you are really a moderate drinker, there is no risk of having a drink at the time of your vaccine,” said Ilhem Messaoudi, director of the Center for Virus Research at the University of California at Irvine, who has conducted research on the effects of alcohol on the immune response. “But be very aware of what moderate drinking really means. Drinking large amounts of alcohol is dangerous because the effects on all biological systems, including the immune system, are quite severe and appear fairly quickly after leaving this temperate zone. “

Moderate drinking is generally defined as no more than two drinks per day for men and a maximum of one drink per day for women, while heavy drinking is defined as four or more drinks per day for men and three or more drinks for women. Remember that a “standard” drink is considered to be 5 ounces of wine, 1.5 ounces of distilled spirits, or 12 ounces of beer.

Some of the first concerns about alcohol and Covid vaccinations came after a Russian health official warned in December that people should abstain from alcohol for two weeks before vaccination, and then abstain for 42 days afterwards. According to a Reuters report, the official claimed that alcohol could affect the body’s ability to develop immunity to the novel coronavirus. Your warning sparked a violent backlash in Russia, which has one of the highest drinking rates in the world.

Updated

April 27, 2021, 7:34 a.m. ET

In the United States, some experts say they heard similar concerns about whether it is safe to drink at the time of vaccination. “We have received a lot of questions from our patients about this,” said Dr. Angela Hewlett, an associate professor of infectious diseases who leads the Covid Infectious Diseases team at the University of Nebraska Medical Center. “Understandably, people who receive these vaccines want to make sure they are doing the right things to maximize their immune response.”

Clinical trials of Covid vaccines currently approved by the Food and Drug Administration did not specifically look at whether alcohol had an effect on the vaccines’ effectiveness, said Dr. Hewlett. It is possible that there will be more information on this in the future. Most of what is known, however, comes from previous research, including studies looking at how alcohol affects the immune system in humans and whether it interferes with the immune response in animals that have received other vaccines.

Studies have shown that heavy alcohol consumption impairs the immune response and increases your susceptibility to bacterial and viral infections. It prevents immune cells from reaching foci of infection and performing their tasks, e.g. B. the destruction of viruses, bacteria and infected cells. makes it easier for pathogens to enter your cells and causes a variety of other problems.

In contrast, moderate drinking does not seem to have this effect. In one study, scientists exposed 391 people to five different respiratory viruses and found that moderate drinkers are less likely to develop colds, but not if they are smokers.

In another study, Dr. Messaoudi and colleagues gave rhesus monkeys access to alcoholic beverages for seven months and then studied how their bodies reacted to a vaccine against the smallpox virus. Much like humans, some rhesus monkeys enjoy alcohol and drink a lot, while others show less interest and limit themselves to small amounts. The researchers found that the animals that chronically drank heavily had a poor response to the vaccine. “They had almost no immune response,” said Dr. Messaoudi.

However, the animals that consumed moderate amounts of alcohol responded the most to the vaccine, even compared to the tea totalers who did not consume alcohol at all. Studies in rats have found a similar pattern: those who consume large amounts of alcohol have poor immune responses to infections compared to animals who have been given moderate amounts or no alcohol. Other studies have found that people who drink moderately seem to lower the markers of inflammation in their blood.

Another reason to moderate your alcohol consumption is that heavy drinking – along with the resulting hangover – can potentially exacerbate all of the Covid vaccine side effects, including fever, malaise, or body ache, and make you feel worse, said Dr. Hewlett from the University of Nebraska Medical Center. Dr. Hewlett chose not to drink after receiving the Covid vaccine. But she said people should feel free to drink as long as they drink within reason.

“A glass of champagne is unlikely to inhibit an immune response,” she said. “I think having a festive drink in moderation is fine.”

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Covid-19 and Vaccine Information: Dwell International Updates

Here’s what you need to know:

Credit…Atul Loke for The New York Times

As a second wave of the pandemic rages in India, which set a global record new cases for the fifth consecutive day on Monday, countries around the world are trying to help. But their efforts to send oxygen and other critical aid are unlikely to plug enough holes in India’s sinking health care system to end its deadly catastrophe.

The Indian health ministry reported almost 353,000 new cases and 2,812 deaths on Monday. Enormous funeral pyres have spilled into parking lots and city parks. Experts say that India’s reported overall toll of more than 195,000 deaths could be a vast undercount.

The emergency in India, where a worrying virus variant is spreading rapidly, has global implications for potential infections worldwide, as well as for countries relying on India for the AstraZeneca vaccine, millions of doses of which are manufactured there.

“It’s a desperate situation out there,” said Ramanan Laxminarayan, the founder and director of the Center for Disease Dynamics, Economics & Policy, adding that donations will be welcome, but may make only a “dent on the problem.”

Scientists fear that part of the problem is the emergence of a virus variant known as the “double mutant,” B.1.617, because it contains genetic mutations found in two other difficult-to-control versions of the coronavirus. One of the mutations is present in the highly contagious variant that ripped through California earlier this year. The other mutation is similar to one found in the variant dominant in South Africa and is believed to make the virus more resistant to vaccines.

Still, scientists caution it is too early to know with certainty how pernicious the new variant emerging in India really is.

In the early months of 2021, the government of Prime Minister Narendra Modi acted as if the coronavirus battle had been won, holding huge campaign rallies and permitting thousands to gather for a Hindu religious festival.

Now, Mr. Modi is striking a far more sober tone. He said in a nationwide radio address on Sunday that India has been “shaken” by a “storm.” And countries, companies and powerful members of the diaspora have pledged to pitch in.

Patients are suffocating in the capital, New Delhi, and other cities because hospitals’ oxygen supplies have run out. Frantic relatives have appealed on social media for leads on intensive-care-unit beds and experimental drugs. The government has extended New Delhi’s lockdown by another week.

India’s Supreme Court last week ordered the government to come up with a “national plan” for distributing oxygen supplies.

The problems in India’s hospitals go beyond oxygen shortages. In the western state of Gujarat, more than a dozen patients were evacuated from a hospital on Sunday night after an air-conditioning unit caught fire, the Press Trust of India reported, the third accident involving virus patients in India in the past seven days.

Mr. Modi appears to be looking to the rest of the world to help India quell the wave. Saudi Arabia and the United Arab Emirates have promised oxygen generators. The United States has pledged raw material for coronavirus vaccines and intends to share up to 60 million doses of the AstraZeneca vaccine with other nations, so long as the doses clear a safety review conducted by the Food and Drug Administration, officials said Monday. Indian-American businessmen have pledged millions in cash from the companies they lead.

At a news conference on Monday, Dr. Tedros Adhanom Ghebreyesus, the director general of the World Health Organization, called the situation in India “beyond heartbreaking.” He said the organization has deployed 2,600 staff to India to provide surveillance and vaccination help.

A global coronavirus surge, driven largely by the devastation in India, continues to break daily records and run rampant in much of the world, even as vaccinations ramp up in wealthy countries. More than one billion shots have now been administered globally.

On Sunday, the world’s seven-day average of new cases hit 774,404, according to a New York Times database, higher than the peak average during the last global surge, in January. Despite the number of shots given around the world, far too small a percentage of the global population of nearly eight billion have been vaccinated to slow the virus’s steady spread.

United States › United StatesOn Apr. 25 14-day change
New cases 33,662 –16%
New deaths 282 –3%
World › WorldOn Apr. 25 14-day change
New cases 378,263 +15%
New deaths 7,655 +4%

U.S. vaccinations ›

Where states are reporting vaccines given

People getting vaccinated at a government hospital in Mumbai, India, this month.Credit…Atul Loke for The New York Times

President Biden, under intense pressure to do more to address the surging pandemic abroad, including a humanitarian crisis in India, intends to make up to 60 million doses of the AstraZeneca vaccine available to other countries, so long as federal regulators deem the doses safe, officials said Monday.

The announcement came after Mr. Biden spoke with Prime Minister Narendra Modi of India and the two pledged to “work closely together in the fight against Covid-19.” It is a significant, albeit limited, shift for the White House, which has until now been reluctant to make excess doses of coronavirus vaccine available in large amounts.

But the commitment is a tricky one to make: The AstraZeneca doses are manufactured at the Baltimore plant owned by Emergent BioSolutions, where production has been halted amid fears of contamination. The New York Times has reported extensively on problems at the plant, which had to throw out millions of doses of AstraZeneca vaccine between October and January, and later discarded up to 15 million doses of the vaccine developed by Johnson & Johnson, also because of concern about possible contamination.

AstraZeneca’s vaccine, unlike those of Pfizer, Moderna and Johnson & Johnson, has also not been granted emergency use authorization by the Food and Drug Administration. And the administration would not specify which countries will receive the vaccine.

Jen Psaki, the White House press secretary, cautioned at a news conference that the donations of doses would not happen right away. She said about 10 million doses could be released “in the coming weeks” if the F.D.A. determines that the vaccine meets “our own bar and our own guidelines,” and that another 50 million doses are in various stages of production.

“Right now we have zero doses available of AstraZeneca,” Ms. Psaki said.

In a statement, a spokesperson for AstraZeneca said that the company would not comment on specifics but that “the doses are part of AstraZeneca’s supply commitments to the U.S. government. Decisions to send U.S. supply to other countries are made by the U.S. government.”

Correction: April 26, 2021

An earlier version of this article referred incorrectly to a safety review that the Food and Drug Administration is required to conduct before AstraZeneca coronavirus vaccine doses are shared with other nations. The doses themselves must clear an F.D.A. safety review, not the plant where the doses are manufactured.

A Sputnik V vaccine production line in Saint Petersburg, Russia in February. Brazil’s health regulator rejected the Sputnik Covid-19 vaccine on Monday, citing safety concerns.Credit…Emile Ducke for The New York Times

Brazil’s health authority, Anvisa, said late on Monday that it would not recommend importing Sputnik V, the Covid-19 vaccine developed by Russia.

Anvisa said that important safety tests had not been performed, and that questions remained about the vaccine’s development, safety and manufacturing.

Data about the vaccine’s efficacy were “uncertain,” Gustavo Mendes Lima Santos, Anvisa’s manager of medicine and biological products, said in a lengthy presentation explaining the health authority’s decision.

A tweet from the official Sputnik V Twitter account — in Portuguese — pushed back on Monday, saying that the vaccine’s developers had shared “all the necessary information and documentation” with Anvisa. In another tweet, it urged Anvisa that “we have no time to waste — let us start saving lives in Brazil. Together.”

Russia is using Sputnik V in its mass vaccination campaign, and the vaccine has been approved for emergency use in dozens of other countries. Its rollout has been entangled in politics and propaganda, with President Vladimir V. Putin announcing its approval for use even before late-stage trials began. For months, it was pilloried by Western scientists.

The Gamaleya Research Institute, part of Russia’s Ministry of Health, developed the vaccine, also known as Gam-Covid-Vac. A peer-reviewed study published in The Lancet in February said the vaccine had an efficacy rate of 91.6 percent.

Skepticism from Western experts has focused mostly on its early approval, not the vaccine’s design, which grew out of decades of research on adenovirus-based vaccines. Other Covid-19 vaccines are also based on adenoviruses, such as one from Johnson & Johnson using Ad26, and one by the University of Oxford and AstraZeneca using a chimpanzee adenovirus.

While Sputnik V’s developers have yet to release detailed data on adverse events observed during the trials, the Russian government has been using the vaccine to inoculate its own citizens for months. Russia has also exported Sputnik V to Belarus, Argentina and other countries, suggesting that any harmful side effects overlooked during trials would by now have come to light.

As vaccine supply woes in Europe worsened, the European Union’s drug regulator announced last month that it was reviewing the Sputnik V vaccine after member nations began announcing they would acquire the shot on their own.

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E.U. Sues AstraZeneca

The European Union has sued AstraZeneca over its failure to deliver hundreds of millions of Covid vaccination doses by the end of June as promised.

Indeed, the commission has started last Friday a legal action against the company AstraZeneca on the basis of breaches of the advance purchase agreement. The reason indeed being that the terms of the contract or some terms of the contract have not been respected, and the company has not been in a position to come up with a reliable strategy to ensure the timely delivery of those. What matters to us in this case is that we want to make sure that there’s a speedy delivery of a sufficient number of doses that the European citizens are entitled to and which have been promised on the basis of the contract. So the commission has indeed started legal action on its own behalf and on behalf of the 27 member states that are fully aligned in their support for this procedure.

Video player loadingThe European Union has sued AstraZeneca over its failure to deliver hundreds of millions of Covid vaccination doses by the end of June as promised.CreditCredit…Alessandro Grassani for The New York Times

The European Union has sued AstraZeneca over what the bloc has described as delays in shipping hundreds of millions of doses of coronavirus vaccines, a sharp escalation of a longstanding dispute between the bloc and the maker of one of the world’s most important vaccines.

AstraZeneca has said that it would be able to deliver only a third of the 300 million doses that European officials had been expecting by the end of June. As a result, European officials said on Monday that they believed AstraZeneca had broken its contract, and that they were seeking speedier deliveries than the company said it could muster.

The two sides’ relationship had grown acrimonious in January when AstraZeneca slashed its expected deliveries for the first quarter of the year, setting back the bloc’s vaccination campaign by weeks as cases picked up across the continent and political leaders faced scorching criticism for inadequate planning.

For AstraZeneca, whose cheap and easy-to-store shot is being used by 135 countries, the lawsuit could create further difficulties in a bruising stretch. No company had been as instrumental in the race to vaccinate poorer countries around the world, but AstraZeneca has been buffeted in recent weeks by the discovery of an exceedingly rare, though serious, side effect that has prompted restrictions on its use in parts of Europe.

At issue in the legal dispute was whether AstraZeneca had done everything in its power to meet its delivery schedule. Pascal Soriot, the company’s chief executive, has said that the contract required only that it make its “best efforts” to deliver the purchased doses on time.

Vaccine production is a notoriously fickle science, with live cultures needing time to grow inside bioreactors, for instance. In an effort to supply doses not only to richer nations that had purchased them well in advance, but also to poorer nations, AstraZeneca had partnered with manufacturing sites around the world, rather than relying on only a few factories, as Pfizer and Moderna have.

AstraZeneca, which developed the vaccine with the University of Oxford, has also said that the European Commission, the bloc’s executive branch, finalized its contract months after Britain did, giving the company less time to iron out any manufacturing difficulties.

Legal experts said that the “best efforts” language in the contract raised the burden on the Europeans to prove that AstraZeneca did not act diligently enough to supply the promised doses. But they also said that it did not entirely insulate the company from being deemed in breach of contract.

GLOBAL ROUNDUP

Men walk on an empty street after a coronavirus curfew in Istanbul, Turkey, on Thursday.Credit…Chris Mcgrath/Getty Images

President Recep Tayyip Erdogan of Turkey ordered a national lockdown for three weeks, closing nonessential businesses and sending all students home, as the nation struggles to contain the latest surge in cases of the coronavirus.

Turkey ranks fourth in the world in new daily cases per person, averaging 63 cases per 100,000 people, according to a New York Times database. Its seven-day average for deaths ranks 11th in the world.

The lockdown starts on April 29 and will end on May 17, coinciding with Eid al-Fitr, the end of the holy month of Ramadan, Mr. Erdogan said after meeting with his cabinet. Schools and restaurants will close and travel within Turkey will require a permit, he said. Government employees will either work from home or in shifts. Essential businesses like those in the food, manufacturing and health sectors will be exempt, Mr. Erdogan said.

“In a period where Europe is opening up, we have to pull the number of cases’’ lower, Mr. Erdogan said. “Otherwise, it would be inevitable to face a heavy cost from tourism to trade to education.’’

So far, about 16 percent of its total population has received at least one dose of the vaccine from Sinovac or Pfizer-BioNTech, according to data from the Our World in Data project at the University of Oxford.

Turkey reported about 63,000 new cases on April 16, its highest daily tally since the start of the pandemic.

In other updates from around the world:

  • Brazil’s health regulator rejected the use of Russia’s Sputnik V vaccine late on Monday, citing “inherent risks” and a lack of information about the vaccine’s safety and quality, Reuters reported.

  • The governments of Singapore and Hong Kong said on Monday that a long-delayed travel bubble between the two Asian financial centers would begin next month, allowing travelers on designated flights to bypass quarantine. The travel arrangement, which was originally supposed to begin last November, was suspended at the last minute when Hong Kong experienced a sudden surge in cases.

  • The Philippines surpassed the one million mark on Monday in the total number of coronavirus cases it has reported, as the country struggles with newer, deadlier forms of the virus. The Philippines reported very few cases last year, and did not see a significant surge until recently. In response, Manila and four other suburbs went into lockdown earlier this month.

  • For the first time in nearly nine months, Portugal’s health authority on Monday reported no coronavirus-related deaths in the last 24 hours, according to Reuters. Portugal has reported nearly 17,000 Covid-19 deaths and more than 830,000 cases.

  • Health authorities in Germany will allow all adults to sign up for vaccine appointments beginning in June, Chancellor Angela Merkel said on Monday. The announcement came after a meeting with lawmakers to discuss lifting social restrictions for fully vaccinated people, a sign that Germany may be moving closer to emerging from its latest lockdown.

  • More than 78,000 people attended an Australian rules football match in Melbourne on Sunday night in what is believed to be the world’s biggest crowd at a sporting event since the coronavirus pandemic began. Just three days earlier, the government of the state of Victoria, of which Melbourne is the capital, had increased the attendance cap for the 100,000-capacity venue, the Melbourne Cricket Ground, to 85 percent from 75 percent.

A pub in Glasgow, Scotland on Monday.Credit…Andy Buchanan/Agence France-Presse — Getty Images

Scotland and Wales reopened restaurants, cafes, and nonessential shops on Monday, marking the next phase of a gradual relaxation of coronavirus restrictions that have been in place for months.

In Scotland, restaurants can serve food but not alcohol indoors until 8 p.m., and they can serve food and alcohol outdoors without restrictions. Stores, beauty salons, museums and galleries also reopened, and people are permitted to book travel in the rest of Britain.

The first minister of Scotland, Nicola Sturgeon, said she was hopeful that the country would continue its progress and lift more restrictions by the summer. But she cautioned that the virus was more infectious now than it had been in earlier waves and, therefore, “We must stick to the rules.” Free rapid tests will be available to the public.

In Wales, places of worship and retail stores reopened, and restaurants resumed outdoor service. Outdoor wedding receptions with up to 30 people can take place.

Cases remain low in Britain, with more than 40 percent of the population having received at least one dose of a vaccine. On Sunday, the country reported just over 1,700 new cases and 11 deaths, according to a New York Times database.

Health care workers prepared doses of a Covid-19 vaccine in Buffalo, W.Va., last month. Gov. Jim Justice announced a plan to give savings bonds to young people who get vaccinated.Credit…Stephen Zenner/Getty Images

West Virginia will give $100 savings bonds to 16- to 35-year-olds who get a Covid-19 vaccine, Gov. Jim Justice said on Monday.

There are roughly 380,000 West Virginians in that age group, many of whom have already gotten at least one shot, but Mr. Justice said he hoped the money would motivate the rest to get inoculated, as “they’re not taking the vaccines as fast as we’d like them to take them.”

The state will use federal funds from the CARES Act to pay for the bonds, Mr. Justice, a Republican, said at a news conference, adding that he had “vetted this every way that we possibly can” to ensure that the unconventional use of the funds was allowed.

The bonds will be also be available to anyone in that age group who has already been vaccinated, Mr. Justice said.

West Virginia has the 16th highest rate of new coronavirus cases per person among U.S. states and ranks 12th in hospitalizations, according to a New York Times database.

Mr. Justice said the state needed to stop the virus “dead in its tracks,” and that if it did, “these masks go away, the hospitalizations go away, the death toll and the body bags start to absolutely become minimal.”

Earlier this year, at the start of the country’s vaccination effort, West Virginia had stood out for its success in vaccinating its residents. At one point, it had administered second doses to more of its population than any other state; it was also behind only Alaska for the percent of its residents that had received a first dose.

But now West Virginia is fallen behind, ahead of only nine states for the portion of its residents that have had a first dose, according to a New York Times database tracking vaccines.

Mr. Justice said that young West Virginians could “always stand an extra dose of patriotism.” He urged them to “accept that wonderful savings bond” — which will allow the recipient to retrieve the $100, plus interest, at a later date — adding, “I hope that you keep it for a long, long, long time.”

State Senator Lora Reinbold of Alaska in Juneau in March.Credit…Pool photo by Becky Bohrer

Alaska Airlines has suspended an Alaska state lawmaker from its flights for violating its mask policies, the company said.

Lora Reinbold, a Republican state senator, was arguing with employees at Juneau International Airport about the airline’s mask rules, according to footage posted on Twitter.

“We need you to pull the mask up, or I’m not going to let you on the flight,” an employee is heard saying to Ms. Reinbold on the videos, which were posted on Thursday.

“It is up,” Ms. Reinbold responds.

“It is not,” an employee says. “It’s down below your nose. We can’t have it down.”

The airline said it had told Ms. Reinbold that she was “not permitted to fly with us for her continued refusal to comply with employee instruction regarding the current mask policy,” adding that the suspension is being reviewed.

The clash over the company’s rule was the latest to surface in the country about masks during the pandemic. Mask mandates have become a rallying cry for some activists and a divisive political talking point. Disputes about the rules have sometimes led to angry confrontations.

The European Union will ease travel restrictions for vaccinated Americans.Credit…Charlie Riedel/Associated Press

U.S. airlines have been bolstered by the return of customers eager to travel within the country or just outside its borders, but the nation’s largest carriers are still lamenting the loss of two particularly lucrative parts of the business: international and corporate travel. At least one of those could rebound this summer.

In an interview with The New York Times over the weekend, Ursula von der Leyen, the president of the European Commission, said she expected the European Union to ease travel restrictions for vaccinated American tourists, a move that could let the airline industry cash in during the year’s busiest travel season.

“Long-haul international flying represents a significant opportunity for United,” Andrew Nocella, the chief commercial officer for United Airlines, told investors last week. “We have seen in recent weeks that immediately after a country provides access with proof of a vaccine, leisure demand returns to the level of 2019 quickly.”

American Airlines and United said this month that international travel remained about 80 percent lower than in 2019. They and other airlines expect strong demand for domestic flights this summer, and the restoration of trans-Atlantic travel could provide the industry a much-needed boost as it works to generate profits again.

American, Delta Air Lines and United each reported a loss of more than $1 billion in the first three months of the year. Southwest Airlines reported a small profit, of $116 million, though its chief executive said the airline would have lost $1 billion without federal aid.

The news of the E.U. reopening to vaccinated American tourists was also welcomed by Willie Walsh, the director general of the International Air Transport Association, a global airline industry group, who said it could bode well for carriers elsewhere, too.

He said in a statement that coordination between the European Commission and the industry was essential “so that airlines can plan within the public health benchmarks and timelines that will enable unconditional travel for those vaccinated,” not just Americans but passengers from other countries as well.

A small number of guests enjoying the pool at a resort in Phuket, Thailand, this month.Credit…Adam Dean for The New York Times

Only a few weeks ago, Phuket seemed poised for a comeback. After a year of practically no foreign tourists arriving in Thailand, the national government decided that Phuket would start welcoming vaccinated visitors in July, without requiring them to go through quarantine. The project was called Phuket Sandbox.

But Thailand is now gripped by its worst Covid-19 outbreak since the pandemic began, spread in part by the well-heeled Thais who partied in Phuket and Bangkok with no social distancing. The confirmed daily caseload — albeit low by global standards — has increased from 26 on April 1 to more than 2,000 three weeks later, in a country that in early December had about 4,000 cases total.

The opening that Phuket had planned for July 1 now appears unlikely, Thailand’s tourism minister acknowledged this month.

“If you ask me how optimistic I am, I cannot say,” said Nanthasiri Ronnasiri, the director of the tourism authority’s Phuket office. “The situation changes all the time.”

The virus’s resurgence after so many months of economic hardship is devastating for the majority of Phuket’s residents, who depend on foreign tourists for their livelihoods.

Centner Academy in Miami sent teachers a letter repeating false claims that being vaccinated made people a health risk. People waited to receive a shot at Miami Dade College.Credit…Lynne Sladky/Associated Press

A private school in the fashionable Design District of Miami sent its faculty and staff a letter last week about getting vaccinated against Covid-19. But unlike institutions that have encouraged and even facilitated vaccination for teachers, the school, Centner Academy, did the opposite: One of its co-founders, Leila Centner, informed employees “with a very heavy heart” that if they chose to get a shot, they would have to stay away from students.

In an example of how misinformation threatens the nation’s effort to vaccinate enough Americans to get the coronavirus under control, Ms. Centner, who has frequently shared anti-vaccine posts on Facebook, claimed in the letter that “reports have surfaced recently of non-vaccinated people being negatively impacted by interacting with people who have been vaccinated.”

“Even among our own population, we have at least three women with menstrual cycles impacted after having spent time with a vaccinated person,” she wrote, repeating a false claim that vaccinated people can somehow pass the vaccine to others and thereby affect their reproductive systems. (They can do neither.)

In the letter, Ms. Centner gave employees three options:

  • Inform the school if they had already been vaccinated, so they could be kept physically distanced from students;

  • Let the school know if they get the vaccine before the end of the school year, “as we cannot allow recently vaccinated people to be near our students until more information is known”;

  • Wait until the school year is over to get vaccinated.

Teachers who get the vaccine over the summer will not be allowed to return, the letter said, until clinical trials on the vaccine are completed, and then only “if a position is still available at that time” — effectively making teachers’ employment contingent on avoiding the vaccine.

Credit…Romain Maurice/Getty Images for Haute Living

Ms. Centner required the faculty and staff to fill out a “confidential” form revealing whether they had received a vaccine — and if so, which one and how many doses — or planned to get vaccinated. The form requires employees to “acknowledge the School will take legal measures needed to protect the students if it is determined that I have not answered these questions accurately.”

Ms. Centner directed questions about the matter to her publicist, who said in a statement that the school’s top priority throughout the pandemic has been to keep students safe. The statement repeated false claims that vaccinated people “may be transmitting something from their bodies” leading to adverse reproductive issues among women.

“We are not 100 percent sure the Covid injections are safe and there are too many unknown variables for us to feel comfortable at this current time,” the statement said.

The Food and Drug Administration, the Centers for Disease Control and Prevention, the World Health Organization and many other authorities have concluded that the coronavirus vaccines now in emergency use in the United States are safe and effective.

The Centner Academy opened in 2019 for students in prekindergarten through eighth grade, promoting itself as a “happiness school” focused on children’s mindfulness and emotional intelligence. The school prominently advertises on its website support for “medical freedom from mandated vaccines.”

Ms. Centner founded the school with her husband, David Centner, a technology and electronic highway tolling entrepreneur. Each has donated heavily to the Republican Party and the Trump re-election campaign, while giving much smaller sums to local Democrats.

In February, the Centners welcomed a special guest to speak to students: Robert F. Kennedy Jr., the prominent antivaccine activist. (Mr. Kennedy was suspended from Instagram a few days later for promoting Covid-19 vaccine misinformation.) This month, the school hosted a Zoom talk with Dr. Lawrence Palevsky, a New York pediatrician frequently cited by anti-vaccination activists.

Kitty Bennett contributed research.

Teenagers in Scampia, a district on the outskirts of Naples, Italy.Credit…Gianni Cipriano for The New York Times

The number of students that dropped out of school in Italy because of the coronavirus pandemic is rising, aggravating what was already a crisis before the disease spread across the nation.

Italy had among the worst dropout rates in the European Union, and the southern city of Naples was particularly troubled by high numbers. When the coronavirus hit, Italy shuttered its schools more than just about all the other European Union member states, with especially long closures in the Naples region, pushing students out in even higher numbers.

While it is too early for reliable statistics, principals, advocates and social workers say they have seen a sharp increase in the number of students falling out of the system. The impact on an entire generation may be one of the pandemic’s lasting tolls.

Italy closed its schools — fully or in part — for 35 weeks in the first year of the pandemic — three times longer than France, and more than Spain or Germany.

And experts say that by doing so, the country, which has Europe’s oldest population and was already lagging behind in critical educational indicators, has risked leaving behind its youth, its greatest and rarest resource for a strong post-pandemic recovery.

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Health

Covid-19 Vaccine ‘Passports,’ Passes and Apps Across the Globe

Isn’t the European Union also developing a system? Yes. The EU is expected to introduce a certificate called the Digital Green Pass on June 21st to allow people vaccinated against the coronavirus to travel more freely. According to the proposed rules, each nation within the block could decide which travel restrictions, such as B. the compulsory quarantine, owners of Digital Green should do without. But many countries, including Denmark, say they can’t afford to wait for the Digital Green Pass and are developing their own versions.

Name of the card: The green pass

Could it bring you an indoor table? Yes.

How about a concert or a sports game? That too.

Anything else? The pass allows you to enter many businesses including swimming pools, gyms, theaters and wedding halls, as well as cultural events such as concerts, sports games and religious gatherings. The passport can also mean that you may not need to be quarantined for 10-14 days after international travel.

How does it work? In late February, the Israeli Ministry of Health began offering the Green Pass to fully vaccinated residents and people who have recovered from Covid-19. When booking a table in a restaurant, many companies would ask, “Do you have a Green Pass?” Israelis can print out their certificates with a QR code, download the code to their phones or flash the app themselves.

What about this family? The app and other Green Pass materials include an animated representation of a family of three. The man is wearing shorts, a backpack and a camera around his neck, suggesting that he is on vacation. His son and wife wear masks, but their demeanor is relaxed as they pull their suitcases.

Aparna Nair, a professor of the history of science at the University of Oklahoma who maintains a collection of vaccination certificates from the 1820s, said this detail was noteworthy: “They use the vaccination card design to make visual connections to life after the pandemic is in Essentially the vaccine as a literal passport to the rest of the world. “

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Health

CDC panel debates J&J Covid vaccine after uncommon blood clot challenge

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An advisory panel from the Centers for Disease Control and Prevention is holding an emergency meeting Friday to discuss Johnson & Johnson’s Covid-19 vaccine and its use after six women developed a rare but potentially life-threatening bleeding disorder called the one left dead.

A positive recommendation from the CDC Advisory Committee on Immunization Practices could pave the way for US regulators to lift the recommended hiatus for the use of the J&J shot earlier this weekend.

The CDC panel decided to postpone a decision on the vaccine last week while officials continued to investigate cases of six women who developed cerebral sinus thrombosis (CVST) within about two weeks of receiving the shot.

Earlier this week, J&J announced that it would restart its vaccine rollout in Europe after regulators there backed the single vaccine by recommending adding a warning to the label. The European Medicines Agency has examined all available evidence, including reports from the United States.