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Vaccinated Folks Could Unfold the Virus, Although Hardly ever, C.D.C. Reviews

In another unexpected and unwelcome twist in the pandemic, the Centers for Disease Control and Prevention released a report on Friday strongly suggesting that fully immunized people with so-called breakthrough Delta variant infections can pass the virus on to others as easily as unvaccinated people People.

The vaccines remain highly effective against serious illness and death, and the agency said infections are comparatively rare in people who have been vaccinated. But the reveal follows a number of other recent discoveries about the Delta variant that have turned scientists’ understanding of the coronavirus on its head.

In the new report, which should explain the agency’s sudden revision of its masking recommendations for vaccinated Americans, the CDC described an outbreak in Provincetown, Massachusetts this month that rose rapidly to 470 cases in Massachusetts alone by Thursday.

Three quarters of those infected were fully immunized, and the Delta variant was found in most of the genetically analyzed samples. Vaccinated and unvaccinated people who were infected carried high levels of the virus, the agency reported.

“High viral loads indicate an increased risk of transmission and raised concerns that, unlike other variants, people infected with Delta can transmit the virus,” said Dr. Rochelle Walensky, director of the CDC, on Friday.

The viral load data shows that even fully vaccinated people can spread the virus just as easily as unvaccinated people who become infected. “We believe this can be done on an individual level, which is why we have updated our recommendation,” said Dr. Walensky in an email to the New York Times earlier this week.

An internal agency document the Times received Thursday evening indicated even greater concern among CDC scientists, raising harrowing questions about the virus and its trajectory.

The delta variant is about as contagious as chickenpox, the document says, and universal masking may be necessary. Nevertheless, according to the agency, breakthrough infections are rare overall.

On Friday, the Kaiser Family Foundation reported that the breakthrough rate among fully vaccinated people in states that store such data is less than 1 percent.

The accumulated research on the variant messes up the country’s plans to return to offices and schools this fall, and enlivens tough questions about masking, testing, and other precautions that Americans had hoped were behind them.

Government officials and scientists alike are seriously concerned that the results could shake confidence in the vaccines and shake the nation’s delayed vaccination campaign if Americans mistakenly conclude that the vaccinations are not effective.

Concerned about the delayed campaign, President Biden has ordered all federal employees to be vaccinated or tested for viruses on a weekly basis. Support for vaccination regulations is growing at some companies and in some parts of the country.

Developing research into the Delta variant has humiliated scientists around the world who are now asking themselves new questions about the virus that they had not considered.

They do not understand the circumstances that can increase the likelihood of a breakthrough infection, nor who is most at risk. They don’t know for sure that the Delta variant causes more severe illness in unvaccinated people who become infected, although early data suggests it.

“We spent so much time, energy, and treasure last year trying to figure out this damn virus and how it works and what it does,” said Dr. Robert Wachter, chairman of the Department of Medicine at the University of California. San Francisco.

To learn how differently the Delta variant differs from the original virus is “just plain staggering,” he added. “The brain doesn’t like being pushed around like that.”

While breakthrough infections are rare, the new data suggest that those who were vaccinated may contribute to an increase in new infections – albeit likely to a far lesser extent than those who were not. Breakthrough infections have always been reckoned with, but until the arrival of the Delta variant, vaccinated Americans were not seen as drivers of its spread in the community.

“Delta teaches us to expect the unexpected,” said John Moore, a virologist at Weill Cornell Medicine in New York. “There are aspects of what we now know that we don’t see coming.”

Updated

July 30, 2021, 7:36 p.m. ET

The finding is frightening, but vaccines remain the only reliable shield against the virus in whatever form. Even with the Delta variant, the vaccines largely prevent infection and significantly reduce the likelihood of serious illness or death in the event of an infection.

Nationwide, about 97 percent of people hospitalized with Covid-19 are unvaccinated, according to the CDC.

“Full vaccination is very protective, even against Delta,” said Angela Rasmussen, researcher at the Organization for Vaccines and Infectious Diseases at the University of Saskatchewan in Canada.

“Masks are a wise precaution, but most of the transmission occurs among the unvaccinated and that is still the most at risk,” she added.

The accumulated research underscores the urgency to accelerate the rate of vaccination in the United States and reduce the number of people susceptible to serious illnesses. This week, the vaccination rate in the European Union exceeded that in the US for the first time.

About 58 percent of Americans 12 years and older are fully vaccinated. The rate of vaccination has slowed to just over 500,000 people a day, although it has swung up slightly in recent weeks as infections pick up again.

In the UK, where the variant seems to have subsided after an increase, vaccinations have been introduced by age and a much higher proportion of people over 50 are vaccinated than in the United States.

Understand the state of vaccine mandates in the United States

Vaccination rates are much more inconsistent across the United States, said Bill Hanage, an epidemiologist at Harvard TH Chan School of Public Health. “The result is that what Delta is doing in the UK is not necessarily what it will be doing in places with very different vaccinations,” he said.

“Things are getting worse than they would have been,” without the variant, he added. “But they will be much better than they would have been without the vaccination.”

In its report on Friday, the CDC urged local and state officials in jurisdictions with even lower virus concentrations to consider precautions such as masking and restricting gatherings. The CDC internal document sounded more urgent, recommending that the agency “recognize that the war has changed”.

Indeed, the questions Americans now face seem almost inexhaustible, almost insoluble. Should companies allow employees to return to work when vaccinated people could occasionally spread the variant? What does this mean for shops, restaurants and schools? Are unmasked family celebrations off the table again?

With the number of daily cases averaging nearly 72,000 on Friday, the new data suggests vaccinated people with young children, aging parents, or friends and family with weak immune systems may need to wear masks to protect those around them – even in Communities with lower infection rates.

The Provincetown, Massachusetts outbreak germinated this month after more than 60,000 revelers celebrated the July 4th gathering in crowded bars, restaurants, guest houses and rental apartments, often indoors.

On July 3, there were no cases in the city or the surrounding district. By July 10, officials saw an increase and by July 17 there were 177 cases per 100,000 people. The outbreak has since spread to nearly 900 people across the country.

“Vaccines are like waders,” said Dr. Rasmussen. “They keep you dry when you wade through a river, but when you get too deep, water starts flowing over it. That seems to have happened with the Massachusetts eruption. “

Three-quarters of citizens linked to the outbreak reported a cough, headache, sore throat, or fever – symptoms of an upper respiratory tract infection – and 74 percent were known to be fully immunized.

Of the five people hospitalized, four were fully vaccinated – one with the Pfizer BioNTech vaccine and three with the Johnson & Johnson vaccine. Two of the vaccinated patients had previous illnesses. The genetic analysis of 133 cases identified the delta variant in 119 cases and a closely related virus in another case.

Scientists even warned last year that the vaccines may not completely prevent infection or transmission. However, experts didn’t expect these infections to play a significant role in the fight against the virus, nor did they anticipate how quickly the Delta variant would rip across the country.

“Two months ago I thought we were over the top,” said Dr. Guardian. In San Francisco, the most heavily vaccinated city in the country, 77 percent of people over the age of 12 are vaccinated.

And yet the hospital he works in has grown significantly, from a Covid-19 case on June 1 to 40 now. 15 of the patients are in intensive care.

“When a 70 or 75 percent immunity doesn’t protect the community, I think it’s very difficult to extrapolate what happens to a place that is 30 percent vaccinated,” said Dr. Guardian. “Humility is perhaps the most important thing here.”

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CDC research reveals 74% of individuals contaminated in Massachusetts Covid outbreak had been absolutely vaccinated

Boston EMS medics work to resuscitate a patient on the way to the ambulance amid the coronavirus disease (COVID-19) outbreak in Boston, Massachusetts, April 27, 2020.

Brian Snyder | Reuters

About three-fourths of people infected in a Massachusetts Covid-19 outbreak were fully vaccinated against the coronavirus, according to new data published Friday by the Centers for Disease Control and Prevention.

The new data, published in the U.S. agency’s Morbidity and Mortality Weekly Report, also found that fully vaccinated people who get infected carry as much of the virus in their nose as unvaccinated people, and could spread it to other individuals.

“This finding is concerning and was a pivotal discovery leading to CDC’s updated mask recommendation,” CDC Director Dr. Rochelle Walensky said in a statement. “The masking recommendation was updated to ensure the vaccinated public would not unknowingly transmit virus to others, including their unvaccinated or immunocompromised loved ones.”

On Tuesday, the CDC reversed course on its prior guidance and recommended fully vaccinated Americans who live in areas with high Covid infection rates resume wearing face masks indoors. The guidelines cover about two-thirds of the U.S. population, according to a CNBC analysis.

While the delta variant continues to hit unvaccinated people the hardest, some vaccinated people could be carrying higher levels of the virus than previously understood and are potentially transmitting it to others, Walensky told reporters on a call Tuesday. She added the variant behaves “uniquely differently from past strains of the virus.”

A CDC document that was reviewed by CNBC warned that the delta variant sweeping across the country is as contagious as chickenpox, has a longer transmission window than the original Covid strain and may make older people sicker, even if they’ve been fully vaccinated.

Delta, now in at least 132 countries and already the dominant form of the disease in the United States, is more transmissible than the common cold, the 1918 Spanish flu, smallpox, Ebola, MERS and SARS, according to the document. Only measles appears to spread faster than the variant.

The data published Friday was based on 469 cases of Covid associated with multiple summer events and large public gatherings held in July in Barnstable County, Mass., according to the CDC. The events were held in an unnamed town in Barnstable, which encompasses Cape Cod and is just outside Martha’s Vineyard. Approximately three quarters, or 74%, of the cases occurred in fully vaccinated people who had completed a two-dose course of the mRNA vaccines or received a single dose of Johnson & Johnson’s.

Overall, 274 vaccinated patients with a breakthrough infection were symptomatic, according to the CDC. The most common side effects were cough, headache, sore throat, muscle pain and fever. Among five Covid patients who were hospitalized, four were fully vaccinated, according to the agency. No deaths were reported.

Testing identified the delta variant in 90% of specimens from 133 patients.

The CDC the data has limitations. The agency noted that as population-level vaccination coverage increases, vaccinated persons are likely to represent a larger proportion of Covid cases. Additionally, asymptomatic breakthrough infections might be underrepresented because of detection bias, the agency said.

The CDC also said the report is “insufficient” to draw conclusions about the effectiveness of the authorized vaccines against Covid, including the delta variant, during this outbreak.

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Health

Behind the Masks, a Thriller: How Usually Do the Vaccinated Unfold the Virus?

The recommendation that vaccinated people dust their masks off in some parts of the country was based, according to Dr. Rochelle Walensky, director of the Centers for Disease Control and Prevention, is largely based on a problematic finding.

New research showed that vaccinated people infected with the Delta variant carry tremendous amounts of the virus in their noses and throats, she said in an email in response to questions from the New York Times.

The finding contradicts what scientists had observed in vaccinated people who were infected with previous versions of the virus and who mostly appeared unable to infect others.

This conclusion dealt a severe blow to Americans: people with what are known as breakthrough infections – cases that occur despite being fully vaccinated – of the Delta variant can be just as contagious as unvaccinated people, even if they have no symptoms.

This means that fully vaccinated people with young children, aging parents, or friends and family with weak immune systems need to renew their vigilance, especially in communities with high transmission. Vaccinated Americans may need to wear masks not only to protect themselves but everyone around them.

In the US, there are an average of 67,000 new cases per day as of Thursday. If vaccinated people transmit the Delta variant, they can contribute to the increases – albeit likely to a far lesser extent than those who were not vaccinated.

The CDC has not yet released its data, frustrating experts who want to understand the basis for the change of heart with masks. But four scientists familiar with the research said it was imperative, and based the CDC’s advice, that those vaccinated again wear masks in public indoor spaces.

The study was conducted by a group outside the CDC, the scientists said, and the agency is working quickly to analyze and publish the results.

It is still unclear how common breakthrough infections are and how long the virus stays in the body in these cases, said Dr. Walensky. Breakthroughs are rare and unvaccinated people are responsible for the majority of virus transmission, she said.

Regardless, the data the CDC is reviewing suggests that even fully immunized people can be unwilling vectors for the virus. “We believe this can be done on an individual level, which is why we have updated our recommendation,” said Dr. Walensky in her email to the Times.

The conclusion also suggests that vaccinated people exposed to the virus should get tested even if they feel fine. (In the UK, vaccinated individuals who come into contact with a known case are required to isolate themselves for 10 days.)

The new data doesn’t mean the vaccines are ineffective. The vaccines are still effective in preventing serious illness and death as they were intended, and people with breakthrough infections very rarely end up in hospital.

Updated

July 29, 2021, 5:53 p.m. ET

According to data from the CDC, around 97 percent of people hospitalized with Covid-19 are unvaccinated. (Immunity to a natural infection can offer even less protection.)

Earlier versions of the virus rarely broke the immunization barrier, prompting the CDC to advise in May that vaccinated people could go mask-free indoors. But the usual rules don’t seem to apply to the delta variant.

The variant is twice as contagious as the original virus, and one study found that the amount of virus in unvaccinated people infected with Delta could be a thousand times higher than in people infected with the original version of the virus. The CDC data support this finding, said an expert familiar with the results.

Anecdotes of clusters of breakthrough infections are becoming more common, with groups of those vaccinated reporting runny nose, headache, sore throat, or loss of taste or smell – symptoms of an upper respiratory infection.

The overwhelming majority, however, do not need intensive care because the immune system created by the vaccine destroys the virus before it can reach the lungs.

Understand the state of vaccine mandates in the United States

“We’re still going to see a huge, huge impact on disease severity and hospitalization,” said Michal Tal, an immunologist at Stanford University. “That’s what the vaccine was really made for.”

The coronavirus vaccines are injected into the muscle, and most of the antibodies produced in response remain in the blood. Some antibodies can get into the nose, the main entry point for the virus, but not enough to block it.

“The vaccines – they’re beautiful, they work, they’re amazing,” said Frances Lund, a viral immunologist at the University of Alabama in Birmingham. “But they won’t give you that local immunity.”

When people are exposed to a respiratory pathogen, it can gain a foothold in the lining of the nose – without causing any further damage. “If you walked down the street and wiped people, you’d find people with viruses in their lining that were asymptomatic,” said Dr. Michael Marks, epidemiologist at the London School of Hygiene and Tropical Medicine. “Our immune systems fight these things most of the time.”

But the Delta variant seems to thrive in the nose, and its abundance could explain why more people than scientists expected are experiencing breakthrough infections and cold-like symptoms.

However, when the virus tries to snake its way into the lungs, the immune cells in vaccinated people are fired up and quickly clear the infection before it does any major damage. That means vaccinated people should be infected and contagious for a much shorter period of time than unvaccinated people, said Dr. Lund.

“But that doesn’t mean they can’t pass it on to someone else for the first few days when they’re infected,” she added.

To stop the virus right where it enters, some experts have recommended nasal spray vaccines that would prevent the intruder from entering the upper respiratory tract. “Vaccine 1.0 is designed to prevent death and hospitalization. Vaccine 2.0 should prevent transmission, ”said Dr. Valley. “We just need one more iteration.”

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C.D.C. Says Some Vaccinated Individuals Ought to Put on Masks Once more

Revising a decision made just two months ago, the Centers for Disease Control and Prevention said on Tuesday that people vaccinated against the coronavirus should resume wearing masks in public indoor spaces in parts of the country where the virus is surging.

C.D.C. officials also recommended universal masking for teachers, staff, students and visitors in schools, regardless of vaccination status and community transmission of the virus. With additional precautions, schools nonetheless should return to in-person learning in the fall, according to agency officials.

The recommendations are another baleful twist in the course of America’s pandemic, a war-weary concession that the virus is outstripping vaccination efforts. The agency’s move follows rising case counts in states like Florida and Missouri, as well as growing reports of breakthrough infections of the more contagious Delta variant among people who are fully immunized.

“The Delta variant is showing every day its willingness to outsmart us,” Dr. Rochelle Walensky, director of the C.D.C., said at a news briefing on Tuesday.

C.D.C. officials were persuaded by new scientific evidence showing that even vaccinated people may become infected and may carry the virus in great amounts, perhaps even similar to those in unvaccinated people, Dr. Walensky acknowledged at the news briefing.

Data from several states and other countries show that the variant behaves differently from previous versions of the coronavirus, she added: “This new science is worrisome and unfortunately warrants an update to our recommendation.”

“This is not a decision we at C.D.C. have made lightly,” Dr. Walensky added. “This weighs heavily on me.” Americans are tired and frustrated, she said, and mental health challenges are on the rise.

Jen Psaki, the White House press secretary, said at a news conference on Tuesday that changing the masking guidance was crucial to “battling an ever-evolving virus,” and that the Biden administration supported the effort.

“The virus is changing, we are dealing with a dynamic situation,” said Dr. Anthony S. Fauci, the Biden administration’s top pandemic adviser. The C.D.C. is correct to revisit its recommendations as the research evolves, he said.

“I don’t think you can say that this is just flip-flopping back and forth,” he added. “They’re dealing with new information that the science is providing.”

The vaccines remain remarkably effective against the worst outcomes of infection with any form of the coronavirus, including hospitalization and death. But the new guidelines explicitly apply to both the unvaccinated and vaccinated, a sharp departure from the agency’s position since May that vaccinated people do not need to wear masks in most indoor spaces.

Those recommendations, which seemed to signal a winding down of the pandemic, were based on earlier data suggesting that vaccinated people rarely become infected and almost never transmit the virus, making masking unnecessary.

But that was before the arrival of the Delta variant, which now accounts for the bulk of infections in the United States. And it may be followed by others. “The big concern is that the next variant that might emerge — just potentially a few mutations away — could evade our vaccine,” she said.

Some public health experts welcomed the agency’s decision to revise its guidelines. Based on what scientists are learning about the Delta variant’s ability to cause breakthrough infections, “this is a move in the right direction,” said Dr. Celine Gounder, an infectious disease specialist at Bellevue Hospital Center in New York.

The American Federation of Teachers and the National Education Association, the two leading teachers’ unions, strongly endorsed the C.D.C.’s move to universal masking in schools.

“Masking inside schools, regardless of vaccine status, is required as an important way to deal with the changing realities of virus transmission,” said Randi Weingarten, president of the A.F.T. “It is a necessary precaution until children under 12 can receive a Covid vaccine and more Americans over 12 get vaccinated.”

Whether state and local health officials are willing to follow the agency’s guidance is far from certain. And there is sure to be resistance from pandemic-fatigued Americans, particularly in regions of the country where vaccination rates are low and concerns about the virus are muted.

Some jurisdictions, like Los Angeles County and St. Louis County, Mo., have already reinstated mask mandates in response to rising cases. But officials some communities in Los Angeles County have said they will not enforce a mandate. Arkansas, one of the states with the highest numbers, has retained a ban on mask mandates even as vaccination rates lag.

Updated 

July 27, 2021, 4:16 p.m. ET

Businesses, too, are likely to find that new mask recommendations complicate return to office plans in places where the virus is spreading and may necessitate mandates for employees to receive vaccines.

The Washington Post, for example, on Tuesday said it would require proof of vaccination as a condition of employment when workers return to the office in September, after hearing concerns from many employees about the emergence of coronavirus variants.

If businesses believe that such mandates would be beneficial, “we encourage them to do so,” Dr. Walensky said at the news briefing. “We’re encouraging, really, any activities that would motivate further vaccination.”

As recently as last week, a C.D.C. spokesman said that the agency had no plans to change its masking guidance, unless there were a significant change in the science. But researchers have begun to turn up disturbing data.

The Delta variant is thought to be about twice as contagious as the original version of the virus. Some research now suggests that people infected with the variant carry about a thousandfold more virus than those infected with other variants, and may stay infected for longer.

C.D.C. officials were swayed by new research showing that even vaccinated people may carry great amounts of the variant virus in the nose and throat, hinting that they also may spread it to others.

Large so-called viral loads may help explain reports of breakthrough infections in groups of vaccinated people. For example, an outbreak that began in Provincetown, Mass., after Fourth of July festivities there has grown to include at least 765 cases, according to Steve Katsurinis, chair of the Provincetown Board of Health.

Of the 469 cases reported among Massachusetts residents alone, 74 percent were in people who were fully immunized, Mr. Katsurinis said.

Smaller clusters of breakthrough infections have been reported after weddings, family reunions and dinner parties. Some of the infected had symptoms, but the vast majority were not seriously ill, suggesting that immunity produced by the vaccines quickly curbs the virus.

Vaccines “are not a force field,” said Jennifer Nuzzo, an epidemiologist at Johns Hopkins University’s Bloomberg School of Public Health. Instead, vaccination trains the immune system to recognize cells that become infected with the virus.

Understand the State of Vaccine Mandates in the U.S.

“The term breakthrough infection is probably a bit misleading,” she said. “It’s probably more realistic that we talk about breakthrough disease and how much of that is occurring.”

Dr. Walensky on Tuesday again urged people to get vaccinated, noting that the rise of cases and hospitalizations is greatest in places with low vaccination rates and among unvaccinated people.

She acknowledged that some vaccinated people can become infected with the Delta variant and may be contagious, but maintained that it was a rare event. So far vaccinated people account for just 3 percent of hospitalizations, officials have found.

The C.D.C. is not routinely tallying breakthrough infections unless they lead to hospitalization or death among vaccinated Americans. But the agency is tracking more than 20 groups of Americans to see how often breakthrough infections occur and under what circumstances.

Dr. Gounder and other experts said that it is unclear how often vaccinated people transmit the virus to others, but it may be more common than scientists had predicted as the original virus spread last year.

“We’ve seen increasing numbers of breakthrough infections, and it seems like most of those may be happening in places where people are exposed to a lot of Covid,” said Dr. Scott Dryden-Peterson, an infectious disease physician and epidemiologist at Brigham & Women’s Hospital in Boston, who has been reviewing breakthrough infections in Massachusetts.

Vaccinated people — particularly those with weak immune systems or otherwise at high risk — should consider wearing masks even in areas of low transmission, he said: “Masks can effectively reduce the amount of virus that we breathe in and prevent us from getting sick, and so they augment the impact of our vaccine. Almost everywhere in the U.S., it’s a good idea.”

Infections have been rising swiftly in the United States, to more than 56,000 daily cases on average, as of Tuesday, more than four times the number a month ago. Hospitalizations have also been ticking up in nearly all states, and deaths have risen to an average of 275 per day.

“Given what we’re seeing, that’s absolutely needed right now to slow and curb transmission,” Dr. Robby Sikka, a physician who worked with the N.B.A.’s Minnesota Timberwolves, said of the new masking guidance.

“Not everyone who has a breakthrough infection will be at risk for transmission, but it’s imperative to note that there is a risk of transmission,” he said.

But Dr. Sikka noted that relying on states or localities to set masking rules will require more testing than is being done now to identify people with mild or asymptomatic infections. “That’s something that we’re probably not totally prepared to do,” he said.

Given that the virus seems likely to become endemic, permanently embedded in American life, federal officials need to articulate an even clearer plan for long-term masking, Dr. Nuzzo said.

“The question is, what are the off ramps for masking? It’s really important for us to define that,” she said. “If we want to continue to ask people to step up, we need to give them a vision of what we’re working toward.”

The C.D.C. should have simply made a universal recommendation and told all Americans to wear masks indoors, said Ali Mokdad, an epidemiologist at University of Washington and former C.D.C. scientist.

“The director said the guidance is for people in areas of high transmission, but if you look at the country, every state is seeing a rise in transmission,” Dr. Mokdad said. “So why not say, ‘Everybody in the U.S. should be wearing a mask indoors?’ The whole country is on fire.”

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Entertainment

Metropolis Plans Central Park Live performance for the Vaccinated: LL Cool J, Santana and Extra

LL Cool J, Elvis Costello, Andrea Bocelli, Carlos Santana and the New York Philharmonic, along with Bruce Springsteen and other artists, will be at the starry Central Park concert next month, which the city plans to announce its comeback from the pandemic, Mayor Bill announced de Blasio on Tuesday.

The mayor said that concert-goers would need to show a vaccination card.

“We want this to be a concert for the people,” said Mr. de Blasio at a video press conference, announcing additional headliners – and the name – of the We Love NYC: The Homecoming Concert, which will take place on August 21st take place on the Great Lawn. “But I would also like to make it clear: it has to be a safe concert. It has to be a concert that will help us advance our recovery. “

“So if you want to go to this concert, you must have a vaccination card,” he added.

The line-up includes artists and music icons from a range of eras, genres, and styles, including the Killers; Earth, wind; Wyclef Jean; Barry Manilow and the previously announced cast including Paul Simon, Jennifer Hudson and Patti Smith.

While 80 percent of the tickets are free, proof of vaccination is required to participate. (Adequate accommodation would be provided for those unable to be vaccinated because of a disability, the city said in a press release.) Masks will be optional due to the vaccination requirement and the fact that it takes place outdoors.

Free tickets will be released to the public in batches from Monday at 10 a.m. on nyc.gov/HomecomingWeek. Others will be available for purchase on Monday.

Gates will open at 3 p.m. on August 21 for the concert produced in partnership with Live Nation, and the show will start at 5 p.m. CNN will also broadcast the event live worldwide, including on CNN en Español.

The venerable music producer Clive Davis, a native of Brooklyn, has been working on the concert since May. He had lived in New York for most of his life, he said at the press conference, but he had never seen anything like the events of the past year and a half.

“As a born, raised, and true New Yorker, I know exactly how resilient we are and how New York keeps coming back,” said Mr. Davis. “And yes, ladies and gentlemen, we’ll be back. And I really can’t think of a more fitting way to celebrate this than an unforgettable concert in one of the most extraordinary places in the world: the Great Lawn at Central Park. “

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CDC to reverse indoor masks coverage, saying totally vaccinated folks ought to put on them indoors in Covid sizzling spots

The Centers for Disease Control and Prevention is expected to recommend Tuesday that fully vaccinated people return to wearing masks indoors in locations with high Covid-19 transmission rates, according to those familiar with the matter.

According to the sources, federal health officials still believe that fully vaccinated individuals represent a very low level of transmission. Still, some people vaccinated could carry higher amounts of the virus than previously thought and potentially pass it on to others, they said.

The CDC is expected to hold a briefing on Tuesday at 3 p.m. ET.

The updated guidelines come before the fall season, when the highly contagious Delta variant is expected to lead to a further surge in new coronavirus cases and many large employers plan to bring workers back to the office. In mid-May, the CDC announced that fully vaccinated people would not need to wear masks in most environments, whether indoors or outdoors.

Continue reading: Americans will need masks indoors as the US is heading for a “dangerous fall” with a surge in Delta Covid cases

Health experts fear that Delta, already the dominant form of the disease in the US, hits states with low vaccination rates. These states are now being forced to reintroduce mask rules, capacity limits and other public health measures that they have largely withdrawn in recent months.

White House senior medical advisor Dr. Anthony Fauci said Sunday that the CDC was considering revising mask guidelines for vaccinated Americans, saying it was “in active consideration”.

“It’s a dynamic situation. It’s in the works, it’s developing like so many other areas of the pandemic, “Fauci, also director of the National Institute of Allergies and Infectious Diseases, told CNN. “You need to look at the data.”

The CDC guidelines are just a recommendation, leaving it up to state and local officials to reintroduce their masking rules for specific individuals. But even before the CDC’s expected guidelines on Tuesday, some regions reintroduced mask mandates and notices as Covid cases rose again.

Several California and Nevada counties are now advising all residents to wear masks in public indoor spaces, regardless of whether they are vaccinated or not. In Massachusetts, Provincetown officials advised everyone to return to wearing masks indoors after the July 4 celebrations resulted in an outbreak of new cases.

Experts say Covid prevention strategies remain critical to protecting people from the virus, especially in areas with medium to high transmission rates in the community.

Dr. Paul Offit, a pediatrician and vaccine advocate who served on advisory boards for both the CDC and the Food and Drug Administration, told CNBC earlier this month that the US is still “undervaccinated” and about half the population is not fully vaccinated be .

Even people who are fully protected have cause for concern when it comes to variants of Covid, Offit said. While the vaccines protect well against serious illness and death, they may not protect as well against minor illness or the spread of Covid to others, he said. No vaccine is 100% effective, he noted.

“It is not a bold prediction to believe that SARS-CoV-2 will be circulating in two or three years. I mean, there are 195 countries out there, most of which haven’t received a single dose of vaccine. ”“ Offit said. “Will it still be circulating in the United States? I think that would be very, very likely.”

Israel released preliminary data last week showing that the Pfizer vaccine was only 39% effective against the virus there, which officials attributed to the rapidly spreading Delta variant. Its effectiveness against serious illness and death remained high, the data showed. US and World Health officials said they would look at Israeli research, which was non-peer-reviewed and had few details.

Pfizer, Moderna, and Johnson & Johnson executives have stated that they expect Americans to need booster vaccinations, and Pfizer has announced it will ask the FDA to approve booster vaccinations as it sees signs of waning immunity. Federal health officials say that otherwise healthy people don’t currently require booster doses of the vaccines, although they may recommend it for the elderly or those with compromised immunity.

– CNBC’s Meg Tirrell and The Associated Press contributed to this report.

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C.D.C. to Suggest Some Vaccinated Folks Put on Masks Indoors Once more

Reversing a decision made just two months ago, the Centers for Disease Control and Prevention is expected to recommend on Tuesday that people vaccinated for the coronavirus resume wearing masks indoors in certain areas of the country.

The change follows reports of rising breakthrough infections with the Delta variant of the virus in people who were fully immunized, and case surges in regions with low vaccination rates. The vaccines remain effective against the worst outcomes of infection with the virus, including those involving the Delta variant.

But the new guidance, the details of which are expected later Tuesday, would mark a sharp turnabout from the agency’s position since May that vaccinated people do not need to wear masks in most indoor spaces.

As recently as last week, an agency spokesman said that the C.D.C. had no plans to change its guidance, unless there were a significant change in the science. Federal officials met on Sunday night to review new evidence that may have prompted the reversal, CNN reported on Tuesday.

“I think that’s great,” said Dr. Celine Gounder, an infectious disease specialist at Bellevue Hospital Center in New York. Based on what scientists are learning about the Delta variant’s ability to cause breakthrough infections, she said, “this is a move in the right direction.”

The C.D.C.’s initial guidance in May said people fully protected from the coronavirus could go mask-free indoors in most scenarios, but recommended that unvaccinated people still wear masks. Those recommendations drew sharp criticism from some experts, who said it was premature given the vast swaths of unvaccinated people in the country.

Dr. Rochelle Walensky, the C.D.C.’s director, at the time pointed to two scientific findings as significant factors. Few vaccinated people become infected with the virus, and transmission seems rarer still, she noted; and the vaccines appear to be effective against all known variants of the coronavirus.

A day after the announcement, the agency released results from a large study showing that the mRNA vaccines made by Pfizer-BioNTech and Moderna were 94 percent effective in preventing symptomatic illness in those who got two doses, and 82 percent effective in those who had received one dose.

But those data, and the C.D.C.’s decision, were based on infections of previous versions of the virus before the Delta variant began sweeping through the country. Reports of clusters of infections among fully immunized people have suggested that the variant may be able to break through the vaccine barrier more often than previous iterations of the virus.

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As Virus Instances Rise, One other Contagion Spreads Among the many Vaccinated: Anger

As coronavirus cases resurface across the country, many vaccine Americans are losing patience with vaccine holdouts who they believe neglect a civic duty or cling to conspiracy theories and misinformation, even as new patients arrive in emergency rooms and the nation renews mask recommendations.

The pandemic appeared to be leaving the country; Almost a month ago there was a feeling of celebration. Now many of the vaccinated fear for their unvaccinated children and fear that they themselves are at risk for breakthrough infections. Rising case numbers are turning plans to reopen schools and workplaces upside down and threaten another wave of infections that could overwhelm hospitals in many communities.

“It’s like the morning sun came up and everyone was arguing about it,” said Jim Taylor, 66, a retired civil servant in Baton Rouge, LA, a state where fewer than half of adults are fully vaccinated.

“The virus is here and killing people, and we have a proven way to stop it – and we’re not going to. That is rude.”

The rising sentiment adds support for further coercive measures. Scientists, business leaders, and government officials are demanding vaccine mandates – if not from the federal government, then from local jurisdictions, schools, employers, and corporations.

“I’ve gotten angrier over time,” said Doug Robertson, 39, a teacher who lives outside of Portland, Oregon and has three children too young to be vaccinated, including a toddler with serious health.

“Now there’s a vaccine and a light at the end of the tunnel and some people choose not to go to it,” he said. “You are making it darker for my family and others like mine by making this decision.”

On Monday, New York City Mayor Bill de Blasio ordered all city workers to be vaccinated against Covid-19 or subjected to weekly tests until schools reopen in mid-September. Officials in California followed hours later with a similar mandate that covered all government employees and health care workers.

The Department of Veterans Affairs on Monday called for 115,000 local health care workers to be vaccinated over the next two months, becoming the first federal agency to mandate a mandate. Nearly 60 major medical organizations, including the American Medical Association and the American Nurses Association, called for mandatory vaccination of all health care workers on Monday.

“It is time to blame the unvaccinated people, not the ordinary people,” a frustrated Governor Kay Ivey, Republican of Alabama, told reporters last week. “It’s the unvaccinated people who fail us.”

There is no doubt that the United States has reached a turning point. According to a New York Times database, 57 percent of Americans 12 and older are fully vaccinated. Eligible Americans receive an average of 537,000 doses per day, down 84 percent from the high of 3.38 million in early April.

Infections are on the rise as a result of delayed vaccinations and lifted restrictions. As of Sunday, the country recorded 52,000 new cases a day, an average of 170 percent more than the previous two weeks. Hospital stays and death rates are also increasing, though not as rapidly.

Communities from San Francisco to Austin, Texas recommend that people who have been vaccinated wear masks again in public indoor spaces. Citing the spread of the more contagious Delta variant of the virus, Los Angeles and St. Louis, Missouri counties have mandated indoor masking.

For many Americans who were vaccinated months ago, the future looks bleak. Frustration strains relationships even within close-knit families.

Josh Perldeiner, 36, a Connecticut public defender who has a 2-year-old son, was fully vaccinated in mid-May. But a close relative who visits frequently refused to get the syringes, even though he and other family members urged them to do so.

She recently tested positive for the virus after traveling to Florida, where hospitals are filling up with Covid-19 patients. Now Mr Perldeiner is concerned that his son, too young to have a vaccine, might be exposed.

“It’s beyond risk,” he said. “People with privileges are opposed to the vaccine, and it affects our economies and continues the cycle.” As infections rise, he added, “I feel like we are on the same precipice as we were a year ago, when People don’t care if more people die. “

Hospitals have become a particular focus. Vaccination remains voluntary in most facilities and is not required for nursing staff in most hospitals and nursing homes. Many large hospital chains are just beginning to require their employees to be vaccinated.

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As New York begins its post-pandemic life, we are investigating the ongoing effects of Covid on the city.

Despite being fully vaccinated, Aimee McLean, a nurse case manager at the University of Utah Hospital in Salt Lake City, is concerned that she will contract the virus in a patient and accidentally pass it on to her father, who has a severe chronic condition Suffers from lung disease. Less than half of Utah’s population is fully vaccinated.

“The longer we get near that number, the more it feels like there is a decent percentage of the population that honestly doesn’t care about us as healthcare workers,” said Ms. McLean, 46.

She suggested that health insurers link hospital bills to vaccination. “If you choose not to be part of the solution, you should be responsible for the consequences,” she said.

Many schools and universities will resume classroom teaching as early as next month. With the increase in the number of infections, the tensions between vaccinated and unvaccinated people have also risen in these settings.

Recommendations from the Centers for Disease Control and Prevention to reopen K-12 schools are tied to community virus transmission rates. In communities where vaccination is delayed, these rates are rising and vaccinated parents are again concerned about school outbreaks. The vaccines are not yet approved for children under 12 years of age.

The American Academy of Pediatrics has recommended that children wear masks in class when schools reopen. School districts from Chicago to Washington began enacting mandates on Friday.

Universities, on the other hand, can often require students and staff to be vaccinated. But many don’t have what frustrates the vaccinated.

“If we respect the rights and freedoms of the unvaccinated, what happens to the rights and freedoms of the vaccinated?” Said Elif Akcali, 49, who teaches engineering at the University of Florida at Gainesville. The university doesn’t require students to be vaccinated, and as rates rise in Florida, it worries about exposure to the virus.

Some even wonder how much sympathy they should have for fellow citizens who are not acting in their own interests. “I feel like if you decide not to have a vaccination and now you get sick, it’s kind of bad,” said Lia Hockett, 21, the manager of Thunderbolt Spiritual Books in Santa Monica, California.

Understand the state of vaccine mandates in the United States

As the virus spreads again, some vaccinated people believe the federal government should start using sticks instead of carrots, like lottery tickets.

Carol Meyer, 65, of Ulster County, NY, suggested withholding incentive payments or tax credits from vaccine objectors. “I have a feeling that in this country we have a social contract with our neighbors, and people who can get vaccinated and choose not to get vaccinated are breaking it,” said Meyer.

Bill Alsstrom, 74, a retired innkeeper in Acton, Massachusetts, said he would not support measures that would directly affect individual families and children, but asked if states that do not meet vaccination goals are withholding federal government funding should be.

Perhaps the federal government should require employees and contractors to be vaccinated, he thought. Why shouldn’t federal funding be withheld from states that don’t meet vaccination goals?

Although it is often viewed as a conservative phenomenon, hesitant and refused vaccination occurs in the United States for a variety of reasons across the political and cultural spectrum. No argument can address all of these concerns, and rethinking is often a slow, individual process.

Pastor Shon Neyland, who regularly pleads with members of his Portland, Oregon church to get Covid-19 vaccines, estimates that only about half of the members of the Highland Christian Center church have been injected. There was tension in the community over vaccination.

“It is disappointing because I was trying to show them that their life is in danger and that this is a serious threat to humanity,” he said.

Shareese Harris, 26, who works in the Grace Cathedral International office in Uniondale, NY, has not been vaccinated and is “taking my time” with it. She fears that the vaccines may have long-term side effects and that they have been brought to market.

“I shouldn’t be convicted or forced into a decision,” said Ms. Harris. “Society will just have to wait for us.”

Rising resentment among vaccinated people may well lead the public to support stronger coercive action, including mandates, but experts warn that punitive action and social exclusion can backfire and end dialogue and outreach.

Elected officials in several communities in Los Angeles County, for example, are already refusing to enforce the county’s new mask mandate.

“Anything that limits the opportunity for honest dialogue and persuasion is not a good thing,” said Stephen Thomas, professor of health policy and management at the University of Maryland School of Public Health. “We are already in isolated, isolated information systems where people are in their own echo chambers.”

Gentle persuasion and persistent urging convinced Dorrett Denton, a 62-year-old home nurse in Queens, to get vaccinated in February. Her employer repeatedly urged Ms. Denton to get vaccinated, but in the end it was her doctor who persuaded her.

“She says to me: ‘You have been coming to me since 1999. How many times have I operated on you and your life was in my hands? You trust me with your life, don’t you? ”Ms. Denton recalled.

“I said, ‘Yes, Doctor.’ She said, ‘Well, trust me on this.’ “

Giulia Heyward contributed the coverage from Miami, Sophie Kasakove from New York and Livia Albeck-Ripka from Los Angeles.

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World News

N.Y.C. to Require Metropolis Staff to Be Vaccinated by Mid-September

Attempts to get Americans vaccinated accelerated on Monday when the most populous state and largest city in the United States announced it would require its employees to be vaccinated against the coronavirus or have frequent testing.

All New York City urban workers, including police officers and teachers, as well as all state and local public and private health workers in California, must be vaccinated or tested at least weekly.

The Department of Veterans Affairs also became the first federal agency to order some of its employees vaccinated on Monday.

The mandates are the most dramatic response yet to the sluggish pace of vaccination across the country given the highly contagious Delta variant ripping through communities with low vaccination rates and one by federal health officials as a “pandemic of the unvaccinated.”

According to federal data, only 49 percent of people in the United States are fully vaccinated.

Misinformation and skepticism have haunted the launch of the vaccine, and in recent weeks coronavirus infections and hospital admissions have risen, with the number of new cases per day quadrupling in the past month.

Yet all three indicators are well below last winter’s devastating winter peaks, and vaccines have proven to be very effective protection against the coronavirus. Cities, private employers and other institutions are increasingly turning to mandates to ensure that more people are vaccinated.

Hospitals and health systems like New York-Presbyterian and Trinity Health have announced vaccination mandates and in some cases sparked union protests. The National Football League announced that it would punish teams with players who fail to be vaccinated. Delta Air Lines requires that new employees be vaccinated, but not current employees. And last week, a federal judge ruled that Indiana University could require vaccinations for students and staff.

New York City will require its approximately 340,000 urban workers to be vaccinated against the coronavirus or undergo weekly tests until schools reopen in mid-September, Mayor Bill de Blasio said.

The new California requirement, which will apply to approximately 246,000 state workers and many more healthcare workers, will be implemented by Aug. 23, Governor Gavin Newsom said.

At the VA, one of the largest federal employers and the largest integrated health system in the country, government officials said 115,000 frontline health workers will have to get vaccinated over the next two months. “I’m doing this because it’s the best way to protect our veterans, period,” said Denis McDonough, the veterans affairs secretary, in a telephone interview on Monday.

Eliza Shapiro, Dan Levin and Shawn Hubler contributed to the coverage.

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Health

Why Vaccinated Folks Are Getting ‘Breakthrough’ Infections

Whether a vaccinated person ever becomes infected may depend on how high antibodies spiked after vaccination, how potent those antibodies are against the variant, and whether the level of antibodies in the person’s blood has waned since immunization.

In any case, immune defenses primed by the vaccines should recognize the virus soon after infection and destroy it before significant damage occurs.

“That is what explains why people do get infected and why people don’t get seriously ill,” said Michel C. Nussenzweig, an immunologist at Rockefeller University in New York. “It’s nearly unavoidable, unless you’re going to give people very frequent boosters.”

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Understand the State of Vaccine Mandates in the U.S.

There is limited evidence beyond anecdotal reports to indicate whether breakthrough infections with the Delta variant are more common or more likely to fan out to other people. The C.D.C. has recorded about 5,500 hospitalizations and deaths in vaccinated people, but it is not tracking milder breakthrough infections.

Additional data is emerging from the Covid-19 Sports and Society Workgroup, a coalition of professional sports leagues that is working closely with the C.D.C. Sports teams in the group are testing more than 10,000 people at least daily and sequencing all infections, according to Dr. Robby Sikka, a physician who worked with the N.B.A.’s Minnesota Timberwolves.

Breakthrough infections in the leagues seem to be more common with the Delta variant than with Alpha, the variant first identified in Britain, he said. As would be predicted, the vaccines cut down the severity and duration of illness significantly, with players returning less than two weeks after becoming infected, compared with nearly three weeks earlier in the pandemic.

But while they are infected, the players carry very high amounts of virus for seven to 10 days, compared with two or three days in those infected with Alpha, Dr. Sikka said. Infected players are required to quarantine, so the project has not been able to track whether they spread the virus to others — but it’s likely that they would, he added.