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Signs, unfold and what to look out for

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The Covid-19 Delta variant originally discovered in India is now spreading around the world and becoming the dominant strain in some countries like the UK and likely to become so in others like the US

On Wednesday, the World Health Organization announced that the variant has been detected in more than 80 countries and continues to mutate as it spreads.

The variant now accounts for 10% of all new cases in the US, up from 6% last week. Studies have shown that the variant is even more transferable than other variants.

Scientists have warned that the data suggest the Delta variant is about 60% more transmissible than the “Alpha” variant (formerly known as the UK or Kent variant, which itself was much more transmissible than the original version of the virus) and more likely to result in hospital admissions, as has been observed in places like the UK

WHO officials said Wednesday there are reports that the Delta variant also causes more severe symptoms, but that more research is needed to confirm these conclusions.

Still, there are indications that the Delta variant could produce different symptoms than the ones we should look out for with Covid-19.

What do you have to pay attention to?

Throughout the pandemic, governments around the world have warned that the main symptoms of Covid-19 are fever, persistent cough, and loss of taste or smell with some domestic variations and supplements as we learned more about the virus.

The updated list of CDC symptoms includes, for example, fatigue, muscle or body aches, headache, sore throat, constipation or runny nose, nausea or vomiting, and diarrhea as possible symptoms of infection. There are of course the millions of people who have had Covid-19 without symptoms, with the extent of asymptomatic transmission still being studied by scientists.

But the delta variant appears to provoke a different set of symptoms, according to experts.

Tim Spector, Professor of Genetic Epidemiology at King’s College London, leads the Zoe Covid Symptom study, an ongoing study in the UK that allows the public to enter their Covid symptoms into an app when scientists can then analyze the data.

“Covid is behaving differently now,” Spector stated in a YouTube briefing last week. “It’s more like having a bad cold in this younger population and people don’t realize it and that hasn’t come up in any of the government reports.”

“We’ve been looking at the top symptoms among app users since early May and they’re not the same anymore,” he said. “Symptom number one is a headache, followed by a sore throat, runny nose and fever.” “More traditional” Covid symptoms like coughing and loss of smell are now much less common, he said, and younger people are much more likely to have a bad cold or a “strange feeling”.

First discovered in the UK, the alpha variant illustrated the appearance of a wider range of symptoms.

A study of over a million people in England as part of the REACT study (which tracks community transmission of the virus in England), which was carried out between June 2020 and January 2021 – over a period in which the alpha – Variant spread and became dominant – showed additional symptoms associated with the coronavirus, including chills, loss of appetite, headaches and muscle aches, in addition to the “classic” symptoms.

Worrying variant

This week, the Centers for Disease Control and Prevention rated the Delta variant as a “variant of concern” based on increasing evidence that the Delta variant spreads more easily and compared to other variants, including B. 1.1.7 (Alpha), “it said in a statement to NBC News.

Dr. Scott Gottlieb, a former commissioner for the Food and Drug Administration, said the Delta variety is likely to become the dominant strain in the US and “could spark a new epidemic in the fall,” during an interview with CBS “Face the Nation” Sunday .

In the UK, where the Delta variant is now responsible for the majority of new infections, cases have increased in young people and unvaccinated people, leading to an increase in hospital admissions in these cohorts. The spread of the variant has also caused Great Britain to postpone the further relaxation of the Covid-19 restrictions.

There is hope that Covid-19 vaccination programs can stop the wild spread of the Delta variant, so the race is to protect younger people who may not be fully vaccinated. An analysis published by Public Health England on Monday showed that two doses of the Pfizer BioNTech or Oxford AstraZeneca Covid-19 vaccines are highly effective against hospitalizations from the Delta variant.

The situation in Great Britain shows how quickly the delta variant can quickly become dominant and the USA is certainly watching this with concern.

Dr. Anthony Fauci, chief medical adviser to the president, noted last week that “we cannot allow this to happen in the United States” when he urged more people to be vaccinated, especially young adults.

The latest study on the spread of the virus in England alone cannot allay experts’ concerns. The latest REACT study results, released Thursday, warned that cases were increasing “exponentially” and said the “resurgence” of Covid-19 infections in England was “with an increased frequency of the Delta variant connected”.

The study estimates that about 1 in 670 people have the virus, a sharp increase compared to previous study’s results when 1 in 1,000 people had the virus on May 3. The results were released Thursday and are based on nearly 110,000 home swab tests performed between May 20 and June 7.

Led by Imperial College London, the scientists estimate that the number of reproductions in England is now 1.44, meaning that 10 infected people would, on average, pass the virus on to 14 others, “leading to rapid growth of the epidemic”.

Professor Paul Elliott, Director of the REACT Program at the Imperial School of Public Health, said, “We found strong evidence of exponential growth in infection from late May to early June … These data are consistent with the dominance of the Delta variant and show how It is important to continue to monitor infection rates and worrying variants in the community. “

Most infections occur in children and young adults, but they are also increasing in the elderly, the study found.

While the link between infections, hospital admissions and deaths had weakened since February, suggesting that infections resulted in fewer hospital admissions and deaths due to the vaccination program, the trend reversed for hospital admissions since late April.

– CNBC’s Rich Mendez contributed to coverage of this story.

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WHO says delta Covid variant has now unfold to 80 nations and it retains mutating

A mobile Covid-19 vaccination centre outside Bolton Town Hall, Bolton, where case numbers of the Delta variant first identified in India have been relatively high.

Peter Byrne | PA Images | Getty Images

The delta Covid variant, first detected in India, has now spread to more than 80 countries and it continues to mutate as it spreads across the globe, World Health Organization officials said Wednesday.

The variant now makes up 10% of all new cases in the United States, up from 6% last week. Studies have shown the variant is even more transmissible than other variants. WHO officials said some reports have found that it also causes more severe symptoms, but more research is needed to confirm those conclusions.

The WHO is also tracking recent reports of a “delta plus” variant. “What I think this means is that there is an additional mutation that has been identified,” said Maria Van Kerkhove, the WHO’s Covid-19 technical lead. “In some of the delta variants we’ve seen one less mutation or one deletion instead of an additional, so we’re looking at all of it.”

The United Kingdom recently saw the delta variant become the dominant strain there, surpassing its native alpha variant, which was first detected in the country last fall. The delta variant now makes up more than 60% of new cases in the U.K.

Dr. Anthony Fauci, chief medical advisor to the president, said last week that “we cannot let that happen in the United States,” as he pushed to get more people vaccinated, especially young adults.

The Centers for Disease Control and Prevention designated the delta variant as a variant of concern in the U.S. on Tuesday. The WHO designated the delta variant as a variant of concern in early May.

The WHO on Tuesday also added another Covid mutation, the lambda variant, to its list of variants of interest. The agency is monitoring more than 50 different Covid variants, but not all become enough of a public health threat to make the WHO’s formal watchlist. The lambda variant has multiple mutations in the spike protein that could have an impact on its transmissibility, but more studies are needed to fully understand the mutations, Van Kerkhove said.

The lambda variant has been detected by scientists in South America, including in Chile, Peru, Ecuador and Argentina, thanks to increased genomic surveillance.

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Extra younger folks hospitalized as extra contagious variants unfold

A paramedic takes a patient to an emergency room at Hackensack Meridian Health Palisades Medical Center in North Bergen, New Jersey on December 11, 2020.

I have Betancur | AFP | Getty Images

Dr. Paul Offit, a doctor at Philadelphia Children’s Hospital, said he is now seeing more patients with a rare inflammatory disease, a complication of Covid-19, than he has seen since the pandemic began.

In Texas, Dr. James McDeavitt, Dean of Clinical Affairs at Baylor College of Medicine, said he and his colleagues are noticing an increase in the admissions of young people with Covid-19, although he did not yet have accurate dates to support the anecdotal evidence.

Both doctors attributed the increase in hospital visits by teenagers and young adults, at least in part, to B.1.1.7, the coronavirus variant first identified in the UK, which, according to health authorities, is currently the most common variety circulating in the US The variant is highly contagious and is believed to be about 60% more transmissible than the original virus strain.

“I think they’ll get infected more often because of the virus they’ve got,” said Offit, a health expert in virology and immunology who also serves on advisory boards for the Centers for Disease Control and Prevention and the Food and Drug Administration. “Because of this, I think you will see and see more diseases” in children and young adults.

CDC director Dr. Rochelle Walensky said earlier this month that more and more younger adults are being admitted to hospitals with Covid-19 as new, more contagious variants of the virus spread faster than ever. The number of 18- to 64-year-olds who visit emergency rooms with Covid is increasing nationwide, while the number of visits to patients aged 65 and over is decreasing. This emerges from a slide that Walensky presented at a press conference last week.

“Cases and emergency rooms are on,” said Walensky. “We are seeing this increase in younger adults, most of whom have not yet been vaccinated.”

In New York City, Governor Andrew Cuomo said last week the state was seeing an increase in the rate of Covid positivity in people aged 18 to 24. In Michigan, where Covid-19 cases and hospital stays are increasing rapidly, case rates are at an all-time high for those ages 19 and younger, according to state data released April 6. Hospital admissions are increasing for all age groups, with the largest increase occurring in people between the ages of 40 and 49, according to the state.

Health experts say the problem is diverse: older teens and young adults were among the last to be preferred to the Covid-19 vaccines, and many of them haven’t got a chance yet. In addition, young adults are believed to be involved in higher-risk behaviors, such as: B. Sports in close contact, going out in bars, attending unmasked meetings or traveling.

According to health experts, these factors in connection with the highly contagious variant B.1.1.7 should lead to an increase in young people going to the hospital.

We are “seeing less disease in the elderly due to vaccination, so we will now see proportionally more disease in young adults,” said Dr. Stephen Schrantz, an infectious disease expert at UChicago Medicine, added that it is still unclear how much of the increase is due to strain B.1.1.7 alone.

Isaac Bogoch, an infectious disease specialist at the University of Toronto, said there was evidence that B.1.1.7 caused more symptoms and more severe illness. He said health officials in the US and other countries where exposure is prevalent could see a shift towards unvaccinated young people ending up in hospitals or even in intensive care units.

“There are things that are not currently working in our favor, namely B.1.1.7 and other worrying variants,” he said.

Even if more young people could get sick, Schrantz of UChicago doesn’t expect many of them to get seriously ill, especially school-age children. He said young adults with comorbidities like obesity, high blood pressure and diabetes are likely to be most at risk.

“The severity of the disease depends mainly on two factors – the virus and the host,” said Schrantz.

“As the virus changes, I don’t think the mutations in the spike protein will have increased virulence in children because their bodies, and especially their immune systems, will be less responsive to the virus. In other words, I think the host is the more important variable compared to changes in the virus, “he said.

Offit said he expected the situation to improve as the US vaccinates more adults regardless of age. It also makes it more difficult for the virus to spread from one person to the next as more people have antibodies.

As of Thursday, more than 125 million Americans had received at least one dose of a Covid-19 vaccine, according to the CDC. That’s roughly 37% of the total US population.

Young people “live in the herd,” Offit said. “The more the herd is vaccinated, the less the virus can spread.”

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Can Vaccinated Individuals Unfold the Virus? We Don’t Know, Scientists Say.

The Centers for Disease Control and Prevention responded Thursday to controversial comments from their director, Dr. Rochelle P. Walensky, back and suggested that people vaccinated against the coronavirus never get infected or pass the virus on to others.

The claim challenged the precautions the agency had urged vaccinated individuals to take just last month, such as wearing masks and collecting only in limited circumstances with unvaccinated individuals.

“DR. Walensky spoke broadly during this interview,” an agency spokesman told The Times. “It is possible that some people who are fully vaccinated will get Covid-19. The evidence is not clear as to whether they have the virus others can transfer. We continue to evaluate the evidence. “

The agency responded in part to criticism from scientists who found that current research is nowhere near enough to suggest that vaccinated people cannot spread the virus.

The data suggests that “vaccinated people are much harder to get infected, but don’t think for a second they can’t get infected,” said Paul Duprex, director of the Center for Vaccine Research at the University of Pittsburgh.

In a television interview with MSNBC’s Rachel Maddow, Dr. Walensky responded to data released by the CDC showing that one dose of the Moderna or Pfizer BioNTech vaccine was 80 percent effective and two doses were 90 percent effective.

This certainly indicated that transmission from vaccinated people might be unlikely, but Dr. Walensky’s comments indicated that the protection was complete. “Our data from the CDC today suggests that vaccinated people do not carry the virus and do not get sick,” she said. “And not only in clinical studies, but also in real data.”

Dr. Walensky also stressed the importance of continuing to wear masks and taking precautions, including for people who have been vaccinated. However, the brief comment has been widely interpreted to mean that the vaccines provide complete protection against infection or transmission.

In a pandemic that regularly leads to scientific misunderstandings, experts said they sympathized with Dr. Walensky and her obvious desire that Americans continue to take precautionary measures. It was only Monday when she said the rising number of cases left her feeling “impending doom”.

“If Dr. Walensky had said that most people who were vaccinated don’t carry the virus, we wouldn’t be having this discussion,” said John Moore, a virologist at Weill Cornell Medicine in New York.

“What we do know is that the vaccines are very effective against infections – there is more and more data on them – but nothing is 100 percent,” he added. “It is an important public health message that needs to be properly understood.”

Updated

April 1, 2021, 6:59 p.m. ET

A misinterpretation could disrupt the agency’s urgent requests for vaccination, some experts said. By Wednesday, 30 percent of Americans had received at least one dose of vaccine and 17 percent were fully immunized.

“There can be no daylight between what the research shows – really impressive, but incomplete protection – and the description,” said Dr. Peter Bach, director of the Center for Health Policies and Results at Memorial Sloan Kettering Cancer Center in New York.

“This opens the door to the skeptics who believe the government is glossing over science,” said Dr. Bach, “completely undermines any remaining argument as to why people should continue to wear masks after vaccination.”

All coronavirus vaccines spectacularly prevent serious illness and death from Covid-19, but how well they prevent infection is less clear.

Clinical trials with the vaccines should only assess whether the vaccines prevent serious illness and death. The CDC’s research on Monday brought the welcome conclusion that the vaccines are also extremely effective at preventing infection.

3,950 healthcare workers, rescue workers and other people at high risk of infection took part in the study. Participants wiped their noses and sent in samples for testing each week, which allowed federal researchers to track any symptomatic or non-symptomatic infections. Two weeks after vaccination, the vast majority of people vaccinated remained virus-free, the study found.

Follow-up data from clinical studies support this finding. For example, in the results published Wednesday by Pfizer and BioNTech, 77 people who received the vaccine had coronavirus infection compared to 850 people who received a placebo.

“It is clear that some vaccinated people will be infected,” said Dr. Duprex. “We stop the symptoms, we keep people out of hospitals. But we’re not making them completely resistant to infection. “

The number of vaccinated people who become infected is likely to be higher among those who received Johnson & Johnson and AstraZeneca vaccines, which are less effective, experts say. (Still, these vaccines are worth taking because they consistently prevent serious illness and death.)

Infection rates can also be higher in people exposed to a variant of the virus that the immune system can bypass.

Cases across the country are on the upswing again and threaten a new upswing. Dr. Walensky’s comment came just a day after she emotionally urged the American public to continue taking precautionary measures.

“I ask you to hold on just a little longer to get the vaccine if you can, so that all of the people we all love will stay here when this pandemic ends,” she said.

With numbers soaring, it’s especially important that immunized people continue to protect those who have not yet been immunized against the virus, experts say.

“People who have been vaccinated shouldn’t throw away their masks at this point,” said Dr. Moors. “This pandemic is not over yet.”

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Double mutation Covid variant in India might unfold to different nations, physician says

The double mutation of a Covid-19 variant discovered in India is extremely worrying – and, according to Dr. Kavita Patel, a non-resident Brookings Institution scholar, spread to other countries.

“It’s something that should be watched very closely and that won’t be limited to India. It’s something that we will likely see around the world, as we have with other variants,” she told CNBCs on Monday “Street Signs Asia”.

The Indian Ministry of Health said last week that a variant with two mutations – known as E484Q and L452R – was found in the country. The mutations aren’t new, but the variant in India carries both – something that has not been seen in other variants.

The mutations could make the virus more contagious and better bypass the body’s defenses.

A health worker delivers a dose of COVID-19 vaccine at a clinic in Bhopal, India on March 25, 2021.

STR | Xinhua News Agency | Getty Images

“This double mutation, number one, is incredibly serious. Number two, it’s probably just the tip of the iceberg in what we’d be concerned about in Asia,” said Patel, who is also a former Obama administration official.

She said the mutations could lead to re-infections because the body’s immune system doesn’t recognize them and therefore can’t fight them effectively.

Patel also said she would be concerned about the effects of the mutation if she were an Asian health agency and think about ways to get vaccines as many people as possible.

Indian authorities said that Covid variants, including the double mutation strain, have not been detected in large enough numbers to explain the increase in new infections.

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WHO says most areas of the globe are seeing a rise in circumstances as variants unfold

Paramedics lower a patient from an ambulance outside the Emergency Room at Royal London Hospital in London, England on January 26, 2021.

David Cliff | NurPhoto | Getty Images

There is an increase in new Covid-19 cases in most regions of the world as highly contagious variants continue to spread, the World Health Organization said on Monday.

Dr. Maria Van Kerkhove, technical director of the agency for Covid-19, told reporters during a press conference that the number of new cases worldwide has increased by 8% in the past week.

Cases in Europe where the highly contagious variant B.1.1.7 spreads rapidly increased by 12%, Kerkhove said. WHO also saw cases increase in the Southeast Asia region by 49% and in the east by 8% Mediterranean basin and a 29% increase in the western Pacific, driven by increases in infections in the Philippines and Papua New Guinea, she said.

America and Africa saw “a slight decline,” Kerkhove said, but added that overall case numbers were “worrying”.

“In many of these countries there is pressure to open up and there is difficulty for people, individuals and communities to adhere to best practice controls,” she said, adding that the number of deaths has “increased slightly” around the world. “We also see that the distribution of vaccinations is uneven and uneven.”

WHO comments come as public health officials around the world are increasingly concerned that reopening too quickly in the face of new, highly contagious variants could reverse the progress of the global pandemic. Some countries, including the United States, have seen an increase in new Covid-19 cases despite vaccinating millions of their citizens every day.

Around 82.7 million Americans have received at least one dose of a Covid-19 vaccine, and more than 44.9 million are fully vaccinated, according to the Centers for Disease Control and Prevention.

According to a CNBC analysis of data compiled by Johns Hopkins University, the 7-day average of new cases in 27 states rose 5% or more on Sunday. The nation recorded an average of 54,308 new cases per day for the past week – a 1% increase from the previous week after months of rapidly declining case numbers, according to the Hopkins data.

Earlier Monday, New Jersey Governor Phil Murphy had said the state would likely suspend its reopening plans as Covid-19 cases there pick up again.

Also on Monday, CDC Director Dr. Rochelle Walensky urges all Americans to remain “vigilant” as officials fight to vaccinate the majority of Americans.

“We are at a critical point in this pandemic,” Walensky said during a press conference at the White House. “I worry that if we don’t take the right action now, we will see another avoidable surge, as we are seeing in Europe right now.”

Kerkhove urged the public to continue to take safety measures, including social distancing, wearing masks, washing hands and avoiding crowded rooms. She also called on world leaders to make vaccination of the most vulnerable people a priority.

“There’s a lot more we can do at the individual level, at the community level as government leaders,” she said.

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Texas Gov. Abbott blames Covid unfold on immigrants, criticizes Biden’s ‘Neanderthal’ remark

Texas governor Greg Abbott Thursday criticized President Joe Biden for calling his decision to lift Covid-19 restrictions and masking mandates earlier this week “Neanderthal thinking,” making undocumented immigrants for the persistent Outbreak of the state responsible.

Abbott’s comments come after its much-criticized decision on Tuesday to lift most of the state’s Covid-19 restrictions, including a statewide mask mandate. Texas businesses will be allowed to open “100%” starting March 10, he said. Mississippi Governor Tate Reeves took a similar move around the same time.

Biden on Wednesday hit governors for a “big mistake”, adding that “the last thing we need is Neanderthal thinking”.

Abbott told CNBC’s “Squawk Box” that the comment was “not the kind of word a president should use” and accused immigrants crossing the southern border of spreading the coronavirus. The Republican governor said the Biden government “refused to test them for the virus.”

“The Biden government has released immigrants in South Texas who exposed Texans to Covid. Some of those people were put on buses and took that Covid to other states in the United States,” Abbott told CNBC. “This is a Neanderthal approach to dealing with the Covid situation.”

While the Republican governor failed to provide details, Telemundo reported Tuesday that some migrants released by Border Patrol in the Texas city of Brownsville subsequently tested positive for Covid-19. Since testing began in the city on January 25, 108 migrants have tested positive for Covid-19, which corresponds to 6.3% of all test subjects, according to the report.

“The Biden government must stop importing Covid into our country,” Abbott said.

Senior U.S. health officials have repeatedly urged states not to lift Covid-19 restrictions as statewide coronavirus cases and deaths stall and highly communicable variants threaten to “hijack” the recent decline in infections.

Abbott, however, defended his decision to repeal the state’s mask requirements, claiming that Texans already know that “the safe standard is to wear a mask, among other things.”

“Do you really need the state to tell you what you already know for your personal behavior?” Abbott told CNBC.

The governor added that the state’s coronavirus infections are “at a four-month low” and Texas hospitals stand ready to treat an influx of patients if needed. According to a CNBC analysis of the CNBC analysis compiled by Johns Hopkins University, Texas reports a daily average of around 7,265 new cases over the past week. That’s a decrease from the high of more than 20,400 daily cases the state reported in January.

However, new infections are creeping back across the state, with the average daily new cases increasing nearly 13% from a week ago.

Abbott said most of the state’s coronavirus that spread over the holidays was being driven by indoor gatherings, not restaurants and other businesses. The newly lifted restrictions “aren’t really that transformative” because the state’s mask mandate was not enforced and businesses were already 75% busy, he said.

“Maybe it seems like a big difference to the people in New York,” Abbott said.

– CNBC’s Will Feuer contributed to this report.

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Covid-19: Restaurant Eating and Lack of Masks Mandates Are Every Linked to U.S. Virus Unfold, C.D.C. Says

Here’s what you need to know:

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C.D.C. Warns Against Repealing Virus Restrictions

At a Friday briefing, the Centers for Disease Control and Prevention warned of the link between repealing mask mandates, indoor dining and increased coronavirus cases. This is after many states have announced plans to decrease virus restrictions.

“Increases in both daily death rates and Covid cases and deaths slowed significantly within 20 days of putting mask mandates into place, and protective effective mask mandates grew stronger over time. In contrast, increases in daily death rates of Covid-19 cases and deaths grew more quickly within 40 to 80 days, following restaurants being allowed to resume on-premises dining.” “It may seem tempting in the face of all of this progress to try to rush back to normalcy as if the virus is in the rearview mirror. It’s not. Now, years of watching football on TV has shown me that it’s better to spike the football once you’re safely in the end zone, not after you’ve made a couple of completions.”

At a Friday briefing, the Centers for Disease Control and Prevention warned of the link between repealing mask mandates, indoor dining and increased coronavirus cases. This is after many states have announced plans to decrease virus restrictions.CreditCredit…Kendrick Brinson for The New York Times

As officials in Texas and Mississippi lifted statewide mask mandates, researchers at the Centers for Disease Control and Prevention offered fresh evidence of the importance of mask use in a new study on Friday. Wearing masks, the study reported, was linked to fewer infections with the coronavirus and Covid-19 deaths in counties across the United States.

The researchers also found that counties opening restaurants for on-premises dining — indoors or outdoors — saw a rise in daily infections about six weeks later, and an increase in Covid-19 death rates about two months later.

The study does not prove cause and effect, but the findings square with other research showing that masks prevent infection and that indoor spaces foster the spread of the virus through aerosols, tiny respiratory particles that linger in the air.

“You have decreases in cases and deaths when you wear masks, and you have increases in cases and deaths when you have in-person restaurant dining,” Dr. Rochelle Walensky, the director of the C.D.C., said on Friday. “And so we would advocate for policies, certainly while we’re at this plateau of a high number of cases, that would listen to that public health science.”

The findings come as city and state officials nationwide grapple with growing pressure to reopen schools and businesses amid falling rates of new cases and deaths. Officials recently began allowing limited indoor dining at New York City restaurants. And on Thursday, Connecticut’s governor said the state would end capacity limits on restaurants, gyms and offices later this month. Masks will still be required in both places.

Coronavirus cases and deaths are down significantly across the country compared to the devastating peaks around the holidays. But as more cases of worrisome virus variants have been detected and the U.S. vaccination campaign continues, President Biden and his team have stressed in recent days that now is not the time for Americans to relax, particularly on wearing masks.

The seven-day average of new cases was about 61,000 per day as of Friday, the lowest average since October, according to a New York Times database. But that number was still close to last summer’s highest peak.

Fatalities are falling, too, in part because of vaccinations at nursing homes. Yet the nation is still routinely reporting 2,000 deaths in a single day.

Mr. Biden on Wednesday criticized the decisions by the governors of Texas and Mississippi to lift statewide mask mandates and reopen businesses without restrictions, calling the plans “a big mistake” that reflected “Neanderthal thinking.”

The president, who has asked the American people to wear a mask for his first 100 days in office, said it was critical for public officials to follow the guidance of doctors and public health leaders as the vaccination campaign gains momentum.

According to the C.D.C., about 54 million people had already received at least one dose of a Covid-19 vaccine as of Thursday. Mr. Biden’s power to enforce mask-wearing is limited to the federal sphere; he has ordered a mask requirement for anyone on federal property, and his administration is asking people to wear masks regardless of local mandates.

“It may seem tempting, in the face of all of this progress, to try to rush back to normalcy as if the virus is in the rear view mirror. It’s not,” Andy Slavitt, a White House pandemic adviser, said on Friday. “Why somebody wouldn’t take advantage of a small intervention to save people’s lives, that would be surprising.”

In the latest study, C.D.C. researchers examined the association between mask mandates and indoor or outdoor restaurant dining and the number of coronavirus infections and deaths last year between March 1 and Dec. 31. The agency relied on county-level data from state government websites and measured daily percentage growth in coronavirus cases and deaths.

Infections and deaths declined after counties required mask use, the agency found. Daily infections rose about six weeks after counties allowed restaurants to open for dining on the premises, and death rates followed two months later.

Mask mandates were linked to statistically significant decreases in coronavirus cases and death rates within 20 days of implementation, the report’s authors concluded. On-premises dining, whether indoors or outdoors, at restaurants was associated with increases in case and death rates within 41 to 80 days after reopenings.

“State mask mandates and prohibiting on-premises dining at restaurants help limit potential exposure to SARS-Cov-2, reducing community transmission of Covid-19,” the authors wrote.

Shortly after publishing the report, the C.D.C. amended it to urge restaurants that resume on-premises dining to follow the C.D.C.’s guidelines for reducing transmission in restaurant settings.

That includes “everything from having staff stay home when they show signs of Covid or have tested positive or been in contact with someone who has Covid, and requiring masks among employees as well as customers who are not actively eating or drinking,” said Gery P. Guy, a health scientist with the C.D.C.’s Covid response team and the study’s corresponding author.

Other steps that can be taken are ensuring adequate ventilation, providing options to eat outdoors, spacing customers six feet apart, encouraging hand washing and frequent sanitizing of surfaces that are touched a lot, such as cash registers, pay terminals, door handles and tables.

“The message is, if restaurants are going to open for on-premise dining, it’s important to follow C.D.C. guidelines to do so safely and effectively,” Dr. Guy said.

Eileen Sullivan contributed reporting.

United States › United StatesOn March 5 14-day change
New cases 65,681 –12%
New deaths 2,483 –5%
World › WorldOn March 5 14-day change
New cases 442,743 +4%
New deaths 10,771 –12%

U.S. vaccinations ›

Where states are reporting vaccines given

A health club in Scottsdale, Ariz., in December. Gov. Doug Ducey announced on Friday a loosening of Covid-19 restrictions but said mask use is still recommended in the state.Credit…Adriana Zehbrauskas for The New York Times

Gov. Doug Ducey of Arizona signed an executive order on Friday that ends capacity limits on businesses, but he said that they were still required to follow health and safety guidance, including mask use, from the state’s Department of Health.

By ending occupancy restrictions on businesses, Mr. Ducey, a Republican, has joined a growing number of governors who are lifting measures even as the Centers for Disease Control and Prevention continues to warn officials that doing so could be premature.

Also on Friday, Gov. Henry McMaster of South Carolina signed an executive order lifting the state’s mask mandate in government buildings. Mr. McMaster, a Republican, cited vaccines and lower infection rates in the state as reasons to lift the mandate. Mr. McMaster recommended in his order that restaurants and other food establishments continue to require mask use and social distancing.

The California Department of Public Health also loosened some restrictions Friday saying amusement parks and outdoor sports and live events at stadiums can restart on April 1, with reduced capacity and mandatory masks.

Like many states, Arizona has recorded a steep decline in coronavirus cases since they peaked in January, according to a New York Times database. Mr. Ducey’s decision on Friday to ease some restrictions comes after his Republican peers in Texas and Mississippi lifted their state’s mask mandates, despite pleas from the Biden administration that it was critical that people continue wearing masks and as a new report from the C.D.C. found that counties that allowed restaurants to open for in-person dining had a rise in daily infections weeks after. The study also said that counties that issued mask mandates reported a decrease in virus cases and deaths within weeks.

The question of when it’s safe for states to reopen has been complicated by the emergence of more contagious and possibly more lethal variants in the United States, like B.1.1.7, originally identified in Britain. In Carver County, Minn., which has a population of about 91,000, at least 68 cases of the variant have been linked to participants in both school-sponsored and club sports activities, according to the Minnesota Department of Public Health. High schools and middle schools in Minnesota began opening up for some in-person learning in February.

Govs. Kay Ivey of Alabama and Mike DeWine of Ohio, both Republicans, are also taking more measured approaches. Ms. Ivey announced on Thursday that she was extending her state’s mask order until April 9. Mr. DeWine said on the same day that he would lift all public health measures aimed at curbing the virus in Ohio once new cases drop to a certain threshold.

This week, Mr. Ducey also issued an executive order requiring schools to offer in-person learning no later than March 15. According the C.D.C., 12 of Arizona’s 15 counties, including the state’s two largest counties — Maricopa and Pima, are in phases where all schools are safe to reopen.

Over the summer, when Arizona led the nation in the number of cases per person, Mr. Ducey gave city and county officials the green light to order residents to wear masks. It was a reversal for Mr. Ducey, who had been among a cadre of Republican governors who bucked mask-wearing, seeing it as a violation of individual liberties.

At the time, Mr. Ducey also rolled back earlier reopenings, and he directed bars, indoor gyms, water parks and movie theaters to shut down again.

About a month after Mr. Ducey embraced mask use, the number of Arizonans hospitalized with the virus started to decline.

The latest Arizona order states that mayors and local entities cannot put into effect measures that shut down businesses, and that major league sports can start up again if they get approval from the state’s Department of Health Services.

“Today’s announcement is a measured approach; we are not in the clear yet,” Mr. Ducey said in a statement on Friday. “We need to continue practicing personal responsibility. Wear a mask. Social distance. Stay home when you’re sick and wash your hands frequently.”

Disneyland in Anaheim, Calif., has been closed since March 14.Credit…Mario Tama/Getty Images

The teacups could soon be spinning again: Disneyland, which has been closed for a year, is poised to reopen this spring.

California officials announced on Friday that theme parks in the state could reopen on a limited basis as soon as April 1. Eligibility, however, will depend on coronavirus transmission statistics in individual counties.

For instance, theme parks in counties where the virus threat remains the most severe (in the purple tier under the state’s system) must remain closed. But parks in areas where the threat of infection has eased somewhat (red tier) will be allowed to reopen at 15 percent capacity. Even less threat (orange tier) will allow for 25 percent capacity.

Attendance will be limited to in-state visitors.

Disneyland is in Orange County, which is in the purple tier. But if coronavirus cases continue to decline in Southern California at the current pace, the county could fall within the orange tier by late April. The Walt Disney Company said last year that reopening a park at less than 25 percent capacity would not make economic sense. A Disney spokeswoman declined to comment on a specific reopening timeline on Friday.

“We are encouraged that theme parks now have a path toward reopening this spring, getting thousands of people back to work,” Ken Potrock, Disneyland’s president, said in a statement.

Disney has said it would take at least four weeks to rehire employees and train them on new coronavirus safety procedures. Before the pandemic, roughly 32,000 people worked at the 486-acre Disneyland Resort, which includes two separately ticketed theme parks, three Disney-owned hotels and an outdoor shopping mall. Most of the Anaheim complex has been closed for a year.

Disney had hoped to reopen its California attractions in July. But unions representing Disneyland employees criticized that timetable as too fast and pressured Gov. Gavin Newsom to withhold approval. He sided with the unions, prompting fans to attack him online. (“Open Disney, or we are taking away your hair gel.”)

In contrast, Florida allowed Disney to reopen its Orlando parks in July. The company endured withering criticism for doing so, but stringent safety procedures, including mandatory masks, resulted in a safer-than-expected environment.

“It has been a success story,” Julee Jerkovich, a United Food & Commercial Workers official, said in October. “As a union rep, I do not say that lightly.”

In addition to Disneyland, theme parks in California include Universal Studios Hollywood, Six Flags Magic Mountain, Knott’s Berry Farm and the Santa Cruz Boardwalk.

Workers checking syringes at a factory in Ballabgarh, India, last month.Credit…Rebecca Conway for The New York Times

As countries jostle to secure enough vaccine doses to help put an end to the pandemic, a new competition is unfolding: for syringes to administer them with.

There is simply not enough of them.

Officials in the United States and the European Union have said they need more. And in January, Brazil restricted exports of syringes and needles when its vaccination efforts fell short.

Further complicating the challenge, not just any syringe will do the trick.

Japan revealed last month that it might have to discard millions of doses of the Pfizer-BioNTech vaccine if it couldn’t secure enough syringes able to draw out a sixth dose from vials. In January, the Food and Drug Administration advised health care providers in the United States that they could extract more doses from the Pfizer vials after hospitals there discovered that some contained enough for a sixth — or even a seventh — shot.

“A lot of countries were caught flat-footed,” said Ingrid Katz, the associate director of the Harvard Global Health Institute.

The world needs between eight billion and 10 billion syringes for Covid-19 vaccinations alone, experts say.

In previous years, only 5 percent to 10 percent of the estimated 16 billion syringes used worldwide were meant for vaccination and immunization, said Prashant Yadav, a senior fellow at the Center for Global Development, a think tank in Washington, and an expert on health care supply chains.

Wealthier nations like the United States, Britain, France and Germany pumped billions into developing the vaccines, but little public investment has gone into expanding manufacturing for syringes, Mr. Yadav said.

The industry has ramped up to meet demand.

Becton, Dickinson and Company, which is the world’s largest manufacturer of syringes and is based in New Jersey, said it was producing 2,000 each minute to meet orders of more than a billion.

The United States is the world’s largest syringe maker by sales, according to Fitch Solutions, a research firm. The United States and China are neck and neck in exports, with combined annual shipments worth $1.7 billion.

While India is a small player globally, Hindustan Syringes & Medical Devices in Ballabgarh, one of the world’s largest syringe makers, sunk millions of dollars into preparing its syringe factories for the vaccination onslaught.

Rajiv Nath, the company’s managing director, added 500 workers to his production lines, which crank out more than 5,900 syringes per minute at factories spread over 11 acres in a dusty industrial district outside New Delhi. With Sundays and public holidays off, the company churns out nearly 2.5 billion a year, and plans to scale up to three billion by July.

Mr. Nath has sold 50 million to the Japanese government, he said, and over 400 million to India for its Covid-19 vaccination drive, one of the largest in the world.

More are waiting in line, including UNICEF. In November, the United Nations agency for children reached out to say that it was desperately seeking syringes. And not just any would do. They had to be smaller than usual, and break if used a second time, to prevent spreading disease through accidental reuse.

Most important: UNICEF needed them in vast quantities. Now.

“I thought, ‘No issues,’” said Mr. Nath. “We could deliver it possibly faster than anybody else.”

The company is set to begin shipping 3.2 million of those syringes soon, UNICEF said, provided they clear another quality check. And Mr. Nath has offered to produce about 240 million more.

Credit…

The images above tell a story of disparity of the starkest sort.

“People of color are getting vaccinated at rates below their representation of the general population,” Dr. Marcella Nunez-Smith, the chair of President Biden’s coronavirus equity task force, said at a recent forum on the vaccine. “This narrative can be changed. It must be changed.”

In recent days, The New York Times’s graphics team set out to measure how equitably Covid-19 vaccines were being distributed across the United States.

The data is imperfect. As of March 3, only 38 states publicly shared race and ethnicity data for vaccinated people.

Further complicating the task, different jurisdictions define race and ethnicity categories in slightly different ways — and with different levels of completeness. In some states, as much as a third of vaccinations were missing race and ethnicity data.

But a disturbing portrait nevertheless emerged.

Communities of color, which have borne the brunt of the Covid-19 pandemic in the United States, have also received a smaller share of available vaccines. The vaccination rate for Black Americans is half that of white people, and the gap for Hispanic people is even larger, The Times analysis found.

Dr. Eva Galvez prepares to test patients for Covid-19 at a clinic in Hillsboro, Ore.Credit…Ruth Fremson/The New York Times

Scientists in Oregon have identified a homegrown version of a fast-spreading variant of the coronavirus that first surfaced in Britain — but this one has a mutation that may make the variant less susceptible to vaccines.

The researchers have so far found just a single case of this formidable combination, but genetic analysis suggested that the variant had been acquired in the community and did not arise in the patient.

“We didn’t import this from elsewhere in the world — it occurred spontaneously,” said Brian O’Roak, a geneticist at Oregon Health and Science University who led the work. He and his colleagues participate in the Centers for Disease Control and Prevention’s effort to track variants, and they have deposited their results in databases shared by scientists.

The variant originally identified in Britain, called B.1.1.7, has been spreading rapidly across the United States, and accounts for at least 2,500 cases in 46 states. This form of the virus is both more contagious and more deadly than the original version, and is expected to account for most infections in America in a few weeks.

The new version that surfaced in Portland has the same backbone as B.1.1.7, and the mutation it carries — E484K, or “Eek” — is one seen in variants of the virus circulating in South Africa, Brazil and New York City.

Lab studies and clinical trials in South Africa indicate that the Eek mutation renders the current vaccines less effective by blunting the body’s immune response. (The vaccines still work, but the findings are worrying enough that Pfizer-BioNTech and Moderna have begun testing new versions of their vaccines designed to defeat the variant found in South Africa.)

The B.1.1.7 variant with Eek also has emerged in Britain, but the virus identified in Oregon seems to have evolved independently, Dr. O’Roak said.

Dr. O’Roak and his colleagues found the B.1.1.7 variant with Eek among coronavirus samples collected by the Oregon State Public Health Lab from an outbreak in a health care setting. Of the 13 test results they analyzed, 10 turned out to be B.1.1.7 alone, and one the combination.

Experts said the discovery was not surprising, because the Eek mutation has arisen in forms of the virus all over the world. But the mutation’s occurrence in B.1.1.7 is worth watching, they said.

Gov. Philip D. Murphy of New Jersey applauded as the state’s first doses of the Johnson & Johnson vaccine were administered at the Union Plaza Apartments in Union City, N.J., on Friday. Credit…Bryan Anselm for The New York Times

Vaccine hesitancy has been a concern among U.S. public health experts for months now. But evidence increasingly suggests that as vaccination rates increase, many unvaccinated Americans are becoming more comfortable with the idea of receiving the shot themselves.

The proportion of adults in the country who intend to get vaccinated has increased significantly over the last several months, according to a survey released Friday by the Pew Research Center. Sixty-nine percent of the public now plans to get vaccinated — or already has — up from 60 percent who said in November that they intended to pursue it.

The issue has become more partisan over time, however. The new survey finds a 27-percentage point political gap, with 83 percent of Democrats saying they plan to get the vaccine or have already received it, compared to just 56 percent of Republicans.

Despite the divides, the new survey bolsters optimism that overall, Americans are increasingly open to receiving the vaccine. About 54 million people — 16 percent of the population — had received at least one dose of a Covid-19 vaccine as of Thursday, according to the Centers for Disease Control and Prevention.

The survey also notes that 47 percent of Black Americans plan to get vaccinated and 15 percent say they already have been. Taken together, that is a sharp increase from the 42 percent who said in November they intended to be vaccinated.

Black and Latino people in the United States are being vaccinated at lower rates in part because they face obstacles like language barriers and inadequate access to digital technology, medical facilities and transportation. Mistrust in government officials and doctors also plays a role, experts say, and is fed by misinformation that is spread on social media. President Biden has made equity a major focus of his pandemic response, saying he wants pharmacies, mobile vaccination units and community clinics that help underserved communities to help increase the pace of vaccinations.

Overall, those surveyed by Pew who say they do not plan to get the vaccine cite reasons including concerns about side effects and a feeling that the vaccines were developed too quickly. Others say they are waiting for more information about how well they work.

The Pew results echo a survey released last week from the Kaiser Family Foundation that found vaccine hesitancy declining among most demographic groups. That survey also found a significant political gap, but noted that both Democrats and Republicans were significantly more likely to say they intended to get the vaccine now than in December.

Credit…Timothy A. Clary/Agence France-Presse — Getty Images

Since Johnson & Johnson revealed data showing that its vaccine, while highly protective, had a slightly lower efficacy rate than the ones produced by Moderna and Pfizer-BioNTech, health officials have feared that the new shot might be viewed by some Americans as the inferior choice.

But the early days of its rollout suggest something different: Some people are eager to get it because they want the convenience of a single shot.

And public health officials are enthusiastic about how much faster they can get the single-shot doses distributed, particularly in vulnerable communities that might not otherwise have access to vaccine.

“This is a potential breakthrough,” said Dr. Joseph Kanter, the top health official in Louisiana.

With its first allotted doses, that state is holding a dozen large Johnson & Johnson vaccination events at civic centers and other public places, modeled after what has worked for flu vaccines.

Only four million doses were shipped this week, and the company’s manufacturing lags mean that it will be at least a month before states start receiving significant supplies. But as Johnson & Johnson ramps up production over the next few months, Dr. Kanter said, the vaccine will allow his state to slash costs for staffing and operations related to second doses.

“The J. & J. vaccine brings a lot to the table,” he said.

Judged by how well it prevents severe disease, hospitalization and death, the Johnson & Johnson shot is comparable to those made by Moderna and Pfizer-BioNTech. And although it has a lower overall efficacy rate in the United States — 72 percent, compared with roughly 95 percent for the others — experts say that comparing those numbers is problematic because the companies’ trials were conducted in different places and at different times.

Besides being a single-dose shot, the Johnson & Johnson vaccine offers another benefit: It can be kept at normal refrigeration temperatures for three months. That makes it ideal for distribution at nonmedical sites such as stadiums and convention centers. The vaccine has caused a surge of excitement at small, independent pharmacies, too.

Many state health officials said they were focused on getting the vaccine to people who might be harder to reach for a second dose, such as those who are homeless or on the verge of release from prison.

Patricia Cooper, a teacher in Washington, D.C., said that President Donald J. Trump’s efforts to claim credit for a vaccine last year and the label “emergency use authorization” had suggested to her that the federal government may have rushed its reviews of vaccines. That left her feeling jittery about their safety.

But Ms. Cooper said she was eager to get a shot, especially the Johnson & Johnson one.

“This one is more appealing to me,” she said. “Who likes to get stuck more than once?”

Pope Francis in the Our Lady of Salvation church in Baghdad on the first day of his papal visit to Iraq.Credit…Ivor Prickett for The New York Times

Pope Francis made an audacious return to the world stage in the midst of the pandemic on Friday when he became the first leader of the Roman Catholic church to visit Iraq, seeking to help heal a nation uniquely wounded by violent sectarianism, foreign adventurism and the persecution of minority populations, including his own Christian flock.

“I’m happy to travel again,” Francis, who has been vaccinated against the coronavirus, said after taking off his blue surgical mask to address reporters on the papal plane.

The pope’s trip sent a message that, after a year of being cooped up in Rome and fading from public consciousness, Francis wanted to elevate his profile and spend his time with those who have suffered the most.

The pope’s visit coincided with a recent return of suicide bombings, increased rocket attacks and renewed geopolitical tensions, and some of Francis’ admirers worry that his whirlwind four-day visit will exacerbate a recent spike in the country’s coronavirus cases by drawing crowds.

But his advisers and Iraq’s top prelates insisted social distancing measures would be followed and argued the trip was necessary to show Francis’ closeness to a flock that had suffered terribly. The pope’s predecessors dreamed of visiting, but those aspirations were dashed by tensions and conflict.

The pope called for an equitable distribution of vaccines to countries already scarred by “fragility and instability.” A vaccination program began just this week in Iraq, where social distancing restrictions are largely ignored.

Credit…Ivor Prickett for The New York TimesGov. Andrew M. Cuomo at a briefing on the pandemic a year ago. His thorough, sometimes folksy daily updates drew national attention. Credit…Cindy Schultz for The New York Times

Top aides to Gov. Andrew M. Cuomo were alarmed: A report written by state health officials had just landed, and it included a count of how many nursing home residents in New York had died in the pandemic.

The number — more than 9,000 by that point in June — was not public, and the governor’s most senior aides wanted to keep it that way. They rewrote the report to take it out, according to interviews and documents reviewed by The New York Times.

The extraordinary intervention, which came as Mr. Cuomo was starting to write a book on his pandemic achievements, was the earliest act yet known in what critics have called a monthslong effort by the governor and his aides to obscure the full scope of nursing home deaths in the state. The episode reflects the lengths to which Mr. Cuomo has gone to control data, brush aside public health expertise and bolster his position as a national leader in the fight against the coronavirus.

The details contradict the timeline and motivation Mr. Cuomo offered in recent weeks, when he released the complete data after the state attorney general, Leticia James, revealed that thousands of deaths of nursing home residents had been undercounted, Mr. Cuomo said he had withheld the information out of concern that the Trump administration might pursue a politically motivated inquiry into the state’s handling of the outbreak in nursing homes.

But the rewriting of the report came well before requests for data arrived from federal authorities, and was accompanied by Cuomo aides’ battles with top state health officials, according to documents and interviews with six people with direct knowledge of the discussions, who requested anonymity to describe the closed-door debates.

The aides involved in changing the report included Melissa DeRosa, the governor’s top aide; Linda Lacewell, the head of the state’s Department of Financial Services; and Jim Malatras, a former top adviser to Mr. Cuomo brought back to work on the pandemic. None had public health expertise.

In response to a detailed list of questions from The Times sent on Tuesday, the governor’s office responded with a statement Thursday night from Beth Garvey, a special counsel, who said “the out-of-facility data was omitted after D.O.H. could not confirm it had been adequately verified.” She added that the additional data did not change the conclusion of the report.

Senator Joe Manchin walks to the Senate Chambers on Friday.Credit…Anna Moneymaker for The New York Times

Top Democrats reached a deal late Friday to scale back weekly unemployment payments in President Biden’s $1.9 trillion stimulus plan, working to preserve moderate support for the package by dropping their effort to increase those payments to $400 and agreeing on a $300 supplement instead.

The agreement came about nine hours after Senator Joe Manchin III of West Virginia, a centrist Senate Democrat, created an impasse by raising concerns that an overly generous benefit could discourage people from returning to work. The impasse paralyzed efforts to move Mr. Biden’s stimulus bill through the Senate, and the vote dragged on past midnight.

By late Friday, Democrats had reached a compromise that appeared to satisfy Mr. Manchin, a crucial swing vote in an evenly divided Senate. While Mr. Manchin is a Democrat, his state is decidedly not (former President Donald J. Trump won nearly 70 percent of the vote in the 2020 election). As a result, Mr. Manchin is among the most centrist Democrats in the party.

The amendment ultimately passed, 50 to 49, just before 1:30 a.m. Saturday as the Senate barreled through a stretch of amendment votes that would modify the legislation even further. Most of the amendments failed on party lines.

The agreementwould extend the existing $300 jobless benefit through Sept. 6, and make up to $10,200 of unemployment benefits received last year tax-free for households with incomes less than $150,000. It would also extend tax rules regarding excess business loss limitations for one additional year, through 2026.

“The president has made it clear we will have enough vaccines for every American by the end of May, and I am confident the economic recovery will follow,” Mr. Manchin said in a statement. “We have reached a compromise that enables the economy to rebound quickly while also protecting those receiving unemployment benefits” from being hit with unexpected tax bills.

Top Democrats had initially planned to drop their effort to increase the payments to $400 but extend them for an additional month, through Oct. 4. The agreement reached with Mr. Manchin shaves one month off that extension.

The impasse had halted the measure just as the Senate began voting on proposed changes. What was supposed to have been a 15-minute vote on a minimum-wage increase stretched for hours as Democrats stalled for time, huddling on the Senate floor in search of a solution.

The White House declined to say whether Mr. Biden had reached out to Mr. Manchin to try to secure his support.

In a statement, Jen Psaki, the White House spokeswoman, said that Mr. Biden “supports the compromise agreement.”

The proposal was one of dozens that the Senate considered in a marathon session of rapid-fire votes that was delayed by the impasse. The vote-a-rama, as it is known, stretched past midnight and would pave the way for a Senate vote to pass the stimulus plan as early as Saturday.

Democrats are racing against the clock, as some Americans have already begun to file their taxes and unemployment benefits are set to begin lapsing next weekend. Once the legislation clears the Senate, it will have to be approved for a second time in the House before it heads to Mr. Biden’s desk.

The compromise was aimed at appeasing centrist Democrats who might otherwise have been tempted to vote for a Republican amendment by Senator Rob Portman of Ohio to keep the unemployment benefit at $300 per week — extending it until July but omitting any tax sweeteners — thus sapping support for the bill among other Democrats.

Republican efforts to slow action on the Senate floor were expected to have little effect on the final legislation. Another wrinkle arose late Friday when Senator Dan Sullivan, Republican of Alaska, left the Capitol to catch a flight to Fairbanks and attend his father-in-law’s funeral.

A spokesman, Nate Adams, confirmed the senator’s departure and said Mr. Sullivan “intended to vote against final passage of the bill and made his opposition clear” by voting against advancing the measure.

In an evenly divided Senate, Mr. Sullivan’s absence could give Democrats an extra vote of leeway as they haggle over last-minute changes to the $1.9 trillion package.

Each party holds 50 seats in the chamber, giving Democrats a one-vote margin of control thanks to Vice President Kamala Harris’s power to break ties. Senate Democrats, having already made significant revisions to the text the House approved over the weekend, are working to remain united. Republicans are expected to oppose the bill en masse, arguing that it is too costly and not targeted enough.

VideoVideo player loadingPrime Minister Justin Trudeau announced on Friday that Canada’s health regulator had authorized the use of Johnson & Johnson’s single-dose vaccine, giving the country a fourth vaccine option.CreditCredit…Paul Chiasson/The Canadian Press, via Associated Press

Canada’s health regulator on Friday authorized the use of Johnson & Johnson’s single-dose vaccine. The move now gives the country, which has experienced a slow start to vaccinations, four inoculations to choose from.

“This is great news,” Prime Minister Justin Trudeau said at a news conference. He offered no projected date for the first deliveries.

Health Canada officials said that the vaccine has an overall effectiveness of 66.9 percent, much lower than the efficacy rates reached by Pfizer and Moderna vaccines. But it is similar to those vaccines in having a powerful ability to prevent severe disease, hospitalizations and death.

The United States and Bahrain have also authorized the Johnson & Johnson vaccine.

Production delays with the Pfizer and Moderna vaccines, combined with relatively modest initial shipments, have led to frustration among many Canadians — and put political pressure on Mr. Trudeau as Canada’s vaccination rate fell far behind that of the United States, Britain and other countries. As of Friday, 2.86 percent of all Canadians have received at least one dose.

Canada has ordered 10 million doses of the Johnson & Johnson vaccine and has options for another 28 million, a combined number that is slightly higher than the country’s population.

Depending on its arrival and combined with the need to only administer a single shot, the new vaccine may help significantly boost the country’s vaccination rate. The Johnson & Johnson vaccine also does not require extremely low storage temperatures, as the Pfizer vaccine does, making it easier to distribute to remote communities in Canada’s north.

Mr. Trudeau said that Pfizer would send 1.5 million doses, originally scheduled for delivery in the summer, over the next two months. Canada also received its first shipment this week of a version of the AstraZeneca vaccine, developed by the Serum Institute of India.

The Canadian government had initially promised to obtain six million doses of vaccines by the end of March. The new Pfizer schedule combined with AstraZeneca shipments, officials said, will raise that figure to eight million.

President Biden visiting a Covid-19 vaccination center in Bethesda, Md. Credit…Oliver Contreras for The New York Times

President Biden is enjoying a level of popularity his poll-obsessed predecessor never came close to achieving — a 60 percent approval rating — with 70 percent of Americans expressing support for his handling of the coronavirus pandemic, according to a new poll.

Despite enduring and stark partisan divisions, 44 percent of Republicans approve of Mr. Biden’s actions prioritizing the fight against the virus, according to an Associated Press-NORC Center for Public Affairs Research poll released early Friday.

As a temperature check of the current national mood, the poll suggests that Republican lawmakers in Washington, who have united to oppose Mr. Biden’s $1.9 trillion coronavirus relief bill, are not swaying public opinion, despite their efforts to alter or delay its passage.

In all, 22 percent of Republicans approve of Mr. Biden’s performance, suggesting small but substantial gains among his most hard-core opponents that could give him added political leverage, paving the way for the possibility of a big bipartisan deal on infrastructure.

Mr. Biden’s overall approval among Democrats is a solid 94 percent, despite recent criticism from progressives.

Mr. Trump sustained a similar level of support from his base, but is the only president in the history of modern polling to never post an aggregate approval rating above 50 percent. His level of support has sunk, to an average of about 38 percent, after the Jan. 6 attack on the Capitol.

Friday’s poll is a bit sunnier than other recent national surveys that show a slight decrease in support for Mr. Biden as the fight over his relief package heats up on Capitol Hill. A RealClearPolitics aggregation of polls put his approval rating at 53.4 percent, not factoring in the A.P. poll.

Mr. Biden’s grades on the economy were lower than his ratings on other issues, the poll found. His approval on pocketbook issues was 55 percent. Only 17 percent of Republicans, a group that gave former President Donald J. Trump high marks for his handling of the economy even during the pandemic-related downturn, approved of Mr. Biden’s approach to the economy.

The A.P. poll, unsurprisingly, found that the atmosphere of hyper partisanship exacerbated by Mr. Trump’s four years of provocation is not subsiding under Mr. Biden, and that people in both parties tend to interpret fact through the filter of ideology.

Americans’ views on the economy have shifted dramatically even though many basic economic statistics have budged little, if at all.

In December, 67 percent of Republicans and just 15 percent of Democrats described the economy as “good,” according to an A.P. poll taken at the time. Now, 35 percent of Republicans and 41 percent of Democrats describe the economy in positive terms.

The poll, which surveyed 1,434 adults between Feb. 23 and March 1, has an overall sampling error of plus or minus 3.4 percentage points.

A beach in Limassol, Cyprus, on Thursday. Some European nations with economies that are heavily reliant on tourism have pushed for a vaccine certificate program to help open up international travel.Credit…Petros Karadjias/Associated Press

Cyprus has announced a plan to allow vaccinated residents of Britain to visit the island beginning in May, a further signal that countries, particular those dependent on tourism, could resort to inoculation certificates to reopen their borders.

Savvas Perdios, the deputy tourism minister for Cyprus, told the Cyprus News Agency that, as of May 1, British citizens who had received two doses of a vaccine approved by the European Union’s drug regulator would be allowed to travel to the Mediterranean island without having to be tested for the coronavirus or to isolate on arrival.

Some European nations with economies that are heavily reliant on tourism, such as Spain, have advocated for a vaccine certificate program to be created at the European Union level but have also said that they could adopt bilateral systems if no broader agreement is reached. The European Commission, the bloc’s executive arm, this week announced plans to create a “digital green pass” to facilitate safe travel among member nations, though that system is expected to take at least three months.

The British authorities have said that talks on opening up travel are underway with a number of countries, including some in the European Union.

Matt Hancock, the British health secretary, said this week, “If another country wants to say that you need to have been vaccinated with a recognized vaccine to travel there, we want to enable Brits to be able to take that journey.”

More than a million travelers from Britain visited Cyprus in 2019, representing by far the highest number of international tourists to the island, according to official statistics.

Despite the green light from Cyprus, international travel from Britain is forbidden for leisure purposes until at least May 17 under the current lockdown rules, and it is unclear how many British residents will have received two vaccine doses by then. Fewer than a million people in Britain have so far been fully vaccinated.

In other news around the world:

  • South Korea’s drug safety agency approved the Pfizer-BioNTech vaccine on Friday and doses for about 23 million people are expected to begin arriving this month, the news agency Yonhap reported. The country, which has a population of about 51 million, began its vaccination program last week as part of a plan to achieve herd immunity by November. South Korea approved the Oxford-AstraZeneca vaccine in February and expects to receive more than two million doses through Covax, an international group that has negotiated for coronavirus shots.

  • Prime Minister Jacinda Ardern of New Zealand has said that a snap lockdown imposed last week on the country’s largest city, Auckland, will end on Sunday morning. Social gatherings will be capped at 100 people and other restrictions will remain in place. The lockdown was imposed after the authorities discovered an untraceable case. They have since conducted more than 50,000 tests and tracked more than 6,000 contacts.

  • Japan has extended its state of emergency for the greater Tokyo metropolitan area until March 21, the government announced on Friday, according to the national broadcaster NHK. Emergency orders were lifted in six other prefectures. The restrictions, which include an order for restaurants and bars to close by 8 p.m., had been scheduled to end on Sunday.

Some gorillas in a troop at the San Diego Zoo tested positive for the coronavirus in January. Zoo officials have been using an experimental vaccine on other apes, like orangutans and bonobos. Credit…Ken Bohn/San Diego Zoo Global, via, via Reuters

The San Diego Zoo has given nine apes an experimental coronavirus vaccine developed by Zoetis, a major veterinary pharmaceuticals company.

In January, a troop of gorillas at the zoo’s Safari Park tested positive for the virus. All are recovering, but even so, the zoo requested help from Zoetis in vaccinating other apes. The company provided an experimental vaccine that was initially developed for pets and is now being tested in mink.

Nadine Lamberski, a conservation and wildlife health officer at San Diego Zoo Global, said the zoo vaccinated four orangutans and five bonobos with the experimental vaccine, which is not designed for use in humans. Among the vaccinated orangutans was an ape named Karen, who made history in 1994 when she became the first orangutan to have open-heart surgery.

Dr. Lamberski said one gorilla at the zoo was also scheduled to be vaccinated, but the gorillas at the wildlife park were a lower priority because they had already tested positive for infection and had recovered. She said she would vaccinate the gorillas at the wildlife park if the zoo received more doses of the vaccine.

Mahesh Kumar, senior vice president of global biologics for Zoetis, said the company is increasing production, primarily for its pursuit of a license for a mink vaccine, and will provide more doses to the San Diego and other zoos when possible. “We have already received a number of requests,” he said.

Infection of apes is a major concern for zoos and conservationists. They easily fall prey to human respiratory infections, and common cold viruses have caused deadly outbreaks in chimpanzees in Africa. Genome research has suggested that chimpanzees, gorillas and other apes will be susceptible to SARS-CoV-2, the virus that has caused the pandemic. Lab researchers are using some monkeys, like macaques, to test drugs and vaccines and develop new treatments for the virus.

Scientists are worrying not just about the danger the virus poses to great apes and other animals, but also about the potential for the virus to gain a foothold in a wild animal population that could become a permanent reservoir and emerge at a later date to reinfect humans.

Infections in farmed mink have produced the biggest scare so far. When Danish mink farms were devastated by the virus, which can kill mink just as it kills people, a mutated form of the virus emerged from the mink and reinfected humans. That variant showed resistance to some antibodies in laboratory studies, raising suspicion that vaccines might be less effective against it.

That virus variant has not been found in humans since November, according to the World Health Organization. But other variants have emerged in people in several countries, proving that the virus can become more contagious and in some cases can diminish the effectiveness of some vaccines.

Denmark ended up killing as many as 17 million mink — effectively wiping out its mink farming industry. In the United States, thousands of mink have died, and one wild mink has tested positive for the virus.

Although many animals, including dogs, domestic cats, and big cats in zoos, have become infected by the virus through natural spread, and others have been infected in laboratory experiments, scientists say that widespread testing has yet to find the virus in any animal in the wild other than the one mink.

National Geographic first reported the vaccination of the apes at the San Diego Zoo.

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Health

The Virus Unfold The place Eating places Reopened or Masks Mandates Have been Absent

Even as officials in Texas and Mississippi lifted statewide mask mandates, researchers from the Centers for Disease Control and Prevention provided new evidence on the importance of face covering, reporting that mask mandates were associated with fewer infections with the coronavirus and Covid. 19 deaths in counties in the United States.

Federal researchers also found that districts that opened restaurants for on-site meals – indoors or outdoors – saw an increase in daily infections about six weeks later and an increase in death rates from Covid-19 about two months later.

The study doesn’t establish cause and effect, but the results agree with other research showing that masks prevent infection and that indoor spaces encourage the spread of the virus through aerosols, tiny particles of breath that linger in the air.

“You have fewer cases and deaths when you wear masks, and you have more cases and deaths when you dine in person,” said Dr. Rochelle P. Walensky, director of the CDC, on Friday. “And so we would advocate for policy, certainly while we are on this plateau of high numbers of cases hearing this public health science.”

On Friday evening, the National Restaurant Association, which represents one million restaurants and restaurants, criticized the CDC study as “an ill-informed attack on the industry hardest hit by the pandemic”. It was suggested that the researchers failed to control factors other than restaurant food – such as shop closures and other policies – that may have contributed to coronavirus infections and deaths.

“If a positive correlation is found between ice cream sales and shark attacks, it would not mean ice cream is causing shark attacks,” the association said in a statement.

The group also accused federal researchers of failing to measure compliance with safe operating protocols, noting that the investigation did not distinguish between indoor and outdoor dining, nor did it determine whether restaurants had followed removal recommendations or had adequate ventilation decreed.

“It is irresponsible to limit the spread of Covid-19 to a single industry,” said the association.

The findings come from city and state officials nationwide grappling with growing pressure to reopen schools and businesses amid falling rates of new cases and deaths. Officials recently allowed limited indoor dining in New York City. On Thursday, the Connecticut governor said the state would end capacity restrictions on restaurants, gyms and offices later this month. Masks are still required in both regions.

“The study isn’t surprising,” said Joseph Allen, associate professor at Harvard’s TH Chan School of Public Health and director of the university’s healthy buildings program. “What is surprising is that we see some states ignoring all evidence and are quick to open up, removing mask mandates and opening up full meals.”

Other researchers said the new study confirms the idea that transmission of viruses is often through the air, that physical distancing may not be enough in some situations to stop the spread, and that masks at least partially block airborne particles.

President Biden’s health advisors have said over the past few days that this is not the time to relax. According to a New York Times database, the seven-day average of new cases on Thursday was 62,924 per day.

While that number is down 14 percent from two weeks earlier, new cases remain near the peaks reported last summer. Although the death toll has declined in part due to vaccination campaigns in nursing homes, it remains routine for 2,000 deaths to be reported in a single day.

Mr Biden on Wednesday criticized the decisions of Texas and Mississippi governors to lift statewide mask mandates and reopen businesses without restrictions, calling the plans “a major mistake” reflecting “Neanderthal thinking”.

The president, who asked Americans to wear masks during his first 100 days in office, said it was vital for officials to follow directions from doctors and public health executives as the coronavirus vaccination campaign picks up . By Thursday, around 54 million people had received at least one dose of a Covid-19 vaccine.

Updated

March 5, 2021, 7:20 p.m. ET

“With all this progress, it may seem tempting to try and get back to normal as if the virus was in the rearview mirror,” Andy Slavitt, White House advisor on the pandemic, said Friday. “It is not.”

CDC researchers examined the links between mask mandates, indoor or outdoor restaurants, and coronavirus infections and deaths in the past year between March 1 and December 31. The agency relied on county-level data from state government websites and measured the daily percentage change in coronavirus cases and deaths.

Infections and deaths declined after counties mandated the use of masks, the agency found. Daily infections rose about six weeks after the counties allowed restaurants to dine on the premises, and death rates followed two months later.

The report’s authors concluded that mask mandates were associated with a statistically significant decrease in coronavirus cases and death rates within 20 days of implementation. Eating in indoor or outdoor restaurants was linked to rising fall and death rates 41 to 80 days after reopening.

“Government mask mandates and the ban on dining in on-site restaurants help limit potential exposure to SARS-CoV-2 and reduce community transmission of Covid-19,” the authors wrote.

Shortly after the report was released, the CDC amended it, urging facilities resuming serving guests to follow authorities’ guidelines on reducing broadcast in restaurants.

What you need to know about the vaccine rollout

“The message is that it is important to follow CDC guidelines if restaurants are to be opened for on-site dining,” said Gery P. Guy, researcher on the CDC’s Covid Response Team and co-author of the study.

This includes “everything from employees who stay at home if they show signs of Covid or have tested positive or have been in contact with someone who has Covid, and masks for both employees and customers who are not actively eating or drink, are required, “Dr. Guy said.

Other steps include adequate ventilation, outdoor dining, a two-meter distance from customers, frequent hand washing and disinfection of surfaces that are touched frequently, such as cash registers or payment terminals, door handles and tables.

Even when restaurants limit capacity, an aerosol virus can build up if there is insufficient ventilation, said Dr. All.

“It doesn’t really matter if it’s a restaurant, spin class, gym or choir practice. If you’re inside with no masks, little or no ventilation, we know it’s a higher risk,” he said. “Aerosols for the airways are formed indoors. It’s that simple. This is a real problem for restaurants. “

Linsey Marr, an aerosol delivery expert at Virginia Tech, said Americans couldn’t be expected to follow the latest science and so many simply rely on what is open or closed as an indicator of what for sure is.

But indoor dining is especially risky, she added. People typically sit in a restaurant for an hour or more and don’t wear masks while eating, which makes them susceptible to viruses in the air.

“Limiting capacity will help reduce the risk of transmission, but eating indoors is still a high-risk activity until more people are vaccinated,” she said.

Restaurant workers are particularly exposed. While they can wear masks, guests don’t, reducing protection from the virus. And workers spend many hours indoors on each shift, said Dr. All.

He recommended that restaurant staff wear a double mask, wear a surgical mask covered with a cloth mask, or buy highly efficient masks like N95, which are usually reserved for healthcare workers, or KN95 or KF94 masks to make sure that they are not fake.

“This is not the time to let go of our watch and take back controls when we are so close that many people are being vaccinated,” said Dr. All.

Eileen Sullivan contributed to the coverage.

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Health

Altria asks FDA to unfold the phrase that nicotine does not trigger most cancers

A Marlboro cigarette.

Daniel Acker | Bloomberg | Getty Images

Marlboro’s parent, Altria, has asked the Food and Drug Administration to help spread the word that nicotine doesn’t cause cancer.

CNBC received a copy of a letter Altria sent to the FDA on Thursday asking the agency to spread the word about nicotine as part of a proposed publicity campaign about the risks of tobacco use.

“We received the letter and we will respond directly to the company,” FDA spokeswoman Alison Hunt told CNBC in an email.

Altria was not immediately available to comment on the matter.

In the February 25 letter signed by Paige C. Magness, senior vice president of Regulatory Affairs, Altria cited government studies on misperceptions about nicotine. It was said that eliminating such misperceptions would help traditional smokers switch to non-flammable methods of using nicotine, which may be less risky than products containing smoke.

Bloomberg News first reported the letter Thursday.

While the vast majority of Altria’s revenue comes from the sale of cigarettes and cigars, the company is also involved in vaping firm Juul and the nicotine pouch brand On! Involves and markets IQOS, a smokeless tobacco product that heats tobacco instead of burning it in the United States

There are at least 60 carcinogens in cigarette smoke, but these newer products deliver nicotine without the smoke.

As the regulator of Altria, the FDA can determine what claims it can make of its products. The FDA has allowed Altria to market IQOS in a way that would reduce the exposure of users to harmful chemicals than cigarette smoke.

Nicotine is the addicting ingredient to tobacco and it can have other negative health effects. In its report, Bloomberg said studies have shown that nicotine can affect brain development and birth outcomes, and in large doses acts as an agricultural poison.