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Covid Is Particularly Dangerous for Individuals With H.I.V., Giant Research Finds

“HIV knocks out all the brakes on the immune system, and as a consequence you get this inflammatory response that is robust and persistent – and now you still have Covid,” said Dr. Steven Deeks, an HIV expert at the University of California, San Francisco. “I would be surprised if HIV wasn’t linked to the progression of Covid-19”.

Updated

July 15, 2021, 7:14 p.m. ET

Dr. Deeks disagreed with the study researchers’ decision to adjust the calculations for the presence of other conditions such as obesity, as HIV infection itself can cause many of these diseases. “For 25 years we have argued that a history of HIV infection is an independent risk factor for the progression of heart disease, cancer and aging,” he said. Without this statistical adjustment, the increased risk of death for these patients would most likely have been higher than the 30 percent reported in the study.

Many previous studies had a bias that could have masked some of the risk: Doctors tend to hospitalize Covid-19 patients with HIV out of caution, which means patients are less sick and more likely to survive compared to those who do not having HIV.This larger number of patients would make HIV infection seem less of a problem than it is, said Dr. Matthew Spinelli, an infectious disease doctor at San Francisco General Hospital.

“Early studies may have misled people on this issue,” he said. The results of the new study are more in line with large, population-based studies from South Africa and England showing HIV infection doubles the risk of dying from Covid-19, and from a similar study in New York state, he added added.

The new findings should prompt doctors to give people with HIV quick access to monoclonal antibodies or antiviral drugs to treat Covid-19, said Dr. Deeks. The data also underscores the need to understand how HIV infection affects a person’s response to a Covid vaccine and whether some people with HIV need a booster vaccination, as many immunocompromised people do.

AIDS activists successfully campaigned for the inclusion of people with HIV in clinical trials with coronavirus vaccines, but the data are limited. A clinical study in South Africa showed the coronavirus vaccine, manufactured by Novavax, to be more effective than analysis excluded people with HIV, suggesting that HIV infection undermines the immune response to vaccines.

Out of 100 countries that have released information, 40 listed people with HIV as a priority group for Covid-19 vaccination, said Dr. Meg Doherty, WHO directs HIV programs

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Business

A dangerous bitcoin purchase in greater bull market than the cryptocurrency

All commodity markets have their leverage investment bets. Crude oil has wild exploration and production companies; Gold and precious metals let mining do the dirty work in the ground. A future commodity, bitcoin, is no exception to the rule that when there is a scarce resource in the world to be exploited and investors increasingly value it, miners will make their claim to the riches.

The recent wins on what is possibly the riskiest Bitcoin bet of all led Leeor Shimron, Vice President, Digital Asset Strategy at Fundstrat Global Advisors, to take a look at the “digital gold rush” in Bitcoin miners trading.

These mining companies are fairly new and young, they lack a track record, and some came to market through “detours” – and some of the largest, like Riot Blockchain, were scrutinized by regulators in their early days. They have also faced losses, but Shimon found they hit over $ 1 billion in market cap after investing heavily in the hardware and facilities that helped them in the current Bitcoin during the Bitcoin downturn -Bull market cycle “make it big”.

High beta, high risk bitcoin trading

Shimron described the miners in a note last week to customers who expressed interest in the rising stocks as a “high beta play” for Bitcoin. During the recent bull run for the cryptocurrency, which saw Bitcoin jump 900%, the average return among the largest publicly traded miners was 5,000%, according to his analysis.

Bitcoin miners form the core backbone of the Bitcoin blockchain, according to Shimron, as they “burn electricity to make computer-generated guesses to solve cryptographic puzzles” and generate income in the form of mined Bitcoin. While the bitcoin is being mined, the miners sell the assets to cover their expenses. Many are also choosing to keep some of their mined bitcoin on their corporate balance sheet, a trend that is gaining traction among the digitally-minded, disruptive CEO class in the broader market, like Jack Dorsey at Square and Elon Musk at Tesla . Musk just added “Technoking” to his leadership title, and Tesla’s CFO recently added “Master of Coin” to his. North American mining company Marathon Digital Holdings recently announced that it had purchased $ 150 million worth of Bitcoin to help keep it on its balance sheet.

The largest publicly traded mining companies the Fundstrat analyst examined include the two Nasdaq-listed companies Riot Blockchain and Marathon Digital Holdings, as well as the two over-the-counter market stocks Hive Blockchain and Hut 8.

In the past year, Bitcoin miners clearly outperformed Bitcoin, a momentum that Fundstrat Global Advisors said will continue as the bull market progresses but could turn violently downward with any correction.

Fundstrat Global Advisors

Shimron’s analysis shows that the beta that these Bitcoin mining companies have generates a return of 2.5% for every 1% movement of the cryptocurrency. While there isn’t enough historical data to draw firm conclusions, the miners’ performance is clearly tied to the price of bitcoin and their trading profile amplifies the up and down movements, he said.

It’s a “notoriously competitive industry,” as Shimron puts it, where the ability to be profitable may be due to cheap electricity and access to specialized mining hardware. As Bitcoin prices rise, “miners are building new oil rigs or upgrading their hardware with more powerful and efficient machines.”

Marathon recently closed a $ 170 million deal for 70,000 Bitmain S-19 ASIC miners that, when fully deployed later this year, will increase its mining output to 103,000 machines.

These high costs of doing business in Bitcoin mining result in low or negative free cash flow and subdued earnings, writes Shimron. However, for the time being, the mining companies have captured the growth of the current Bitcoin bull cycle due to their spending. (You also saw wild trading in the 2017 bitcoin boom.)

Now they have also caught the attention of some of the latest forces in the market, as a recent Bloomberg article on the Bitcoin miners discussion on the WallStreetBets forum on Reddit noted, which fueled the mania in GameStop stocks.

“For investors seeking exposure to miners, this beta is a great opportunity in the midst of a roaring bull market. … There are seizures and setbacks, but we still have plenty of room to grow here,” Shimron said in an interview with CNBC.

Investing in Bitcoin in 2021 and beyond

It is the broader cryptocurrency bull market that has fueled the miners, and Shimon believes it can continue in 2021, driven by macroeconomic and demographic factors. Fears of inflation will prop up bitcoin prices, and even with the recent pressure on returns from the 10-year Treasury Department that can impact cryptocurrency like tech stocks, the Fed signals suggest that the central bank intends to maintain its cautious policy in place until 2023.

Another driving force is the continued adoption of new digital technologies and digital assets among younger investors. “You can see that younger people are interested in Bitcoin and other digital currencies as opposed to gold and commodities, and that speaks for a demographic shift. … It is not crazy for them to interact with money purely digitally,” he said opposite CNBC.

Last week, Morgan Stanley became the first major Wall Street bank to offer Bitcoin to its wealthy clients. Due to the risks involved, access to customers with at least USD 2 million was restricted.

There are already other avenues into the crypto market than the underlying currencies, such as the exchanges that trade coins and that will soon be available to more investors. Coinbase was recently valued at $ 68 billion in the private market and plans to list directly on the Nasdaq.

Waiting for a Bitcoin ETF in the US

There are three Bitcoin ETFs in Canada, and at some point a Bitcoin ETF may be available in the US. The most recent attempt at the Securities and Exchange Commission was filed by VanEck ETFs in mid-March, but investors don’t have high hopes that the SEC will soon approve a Bitcoin fund. You’re looking elsewhere for cryptocurrency investment ideas that go beyond buying Bitcoin itself.

Shimon, who ran an early cryptocurrency and blockchain venture fund prior to joining Fundstrat, said he viewed the miners as the foundation of the crypto space. “The top companies will stay here,” he said, citing the economies of scale in investing in equipment that newer entrants will face tougher.

After taking the “smart move” during the Bitcoin bear market to build operations, the current supply chain bottlenecks in the technology sector caused by Covid may further aid these miners’ positioning after the capital they have already invested in special purpose machinery for space.

However, like many traders and hedge funds with gold miners and small cap oil explorers, he tends to trade the bitcoin miners in a bull market run rather than viewing them as long term investments.

The performance of the SPDR Gold Shares ETF compared to the VanEck ETF is an index of gold mining companies in recent history.

Shimron continues to prefer Bitcoin as a long-term investment, as well as any ETF that has ultimately been approved by the SEC for US investors. “It is only a matter of time before the SEC approves a Bitcoin ETF,” he said. “When a BTC ETF hits the market, the fees are low and it’s the safest and easiest way to get into Bitcoin using traditional rails,” he said.

The miners have been criticized for the enormous amount of electricity required to run Bitcoin, but Shimron’s view depends on financial data and market performance. (He says there is also much to be criticized about the impact of the fiat monetary system on the world.)

“It’s pretty clear that the US dollar as a global reserve currency is on its last legs and not disappearing anytime soon, but we are in the later stages of the US dollar as reserve currency and decentralized is the next stage.”

While Bitcoin mining stocks pose too high a risk for most investors, he is confident that everyone should be talking about the cryptocurrency world. “This is where everything runs. Finances were the last holdover that the internet didn’t touch,” said Shimron.

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German Covid circumstances rising ‘exponentially’ amid dangerous vaccine pause

A health care worker will take care of a Covid 19 patient in the intensive care unit of the Robert Bosch Hospital in Stuttgart on Tuesday, January 12, 2021.

Bloomberg | Bloomberg | Getty Images

It’s no secret that Germany has seen a sharp rise in coronavirus cases in recent weeks, but a leading health expert in the country is now warning of an “exponential growth” in the number of infections.

It does so at a time when the country has stopped using the AstraZeneca University of Oxford’s coronavirus vaccine.

Epidemiologist Dirk Brockmann, an expert at the Robert Koch Institute for Infectious Diseases, said a recent relaxation of Covid restrictions has allowed a faster spread of a more virulent variant of the virus that was discovered in the UK late last year.

“We are exactly on the flank of the third wave. That can no longer be denied. And at this point in time we relaxed the restrictions and that accelerates the exponential growth,” Brockmann told the German ARD on Tuesday.

“It was completely irrational to relax here. It just powers this exponential growth,” he said.

Germany has been praised for its initial response to the pandemic, which has managed to lower cases through an effective track and tracing regime and keep the death rate lower thanks to its modern hospital infrastructure.

But over the past few months, over the winter, and with new, more virulent variants of the virus, it has seemed difficult to contain infections. The slow adoption of vaccines in the EU has not helped. The block has been criticized for its slower procurement and slower use of vaccines. The introduction of vaccinations in Germany faced several hurdles that frustrated officials and health professionals in the country.

Chancellor Angela Merkel and heads of state agreed earlier this month to gradually ease restrictions and an “emergency brake” that would allow authorities to reverse course if the number of infections rises above 100 per 100,000 for three consecutive days.

According to the government, the emergency brake is intended “in the event of exponential growth” in the cases. Merkel and the regional leaders are expected to review the measures on March 22nd and decide whether or not to proceed with the next step of reopening.

The number of cases per 100,000 reported Tuesday was 83.7 down from 68 a week ago, and the RKI has said the metric could hit 200 by the middle of next month, Reuters said in a report on Tuesday.

The lockdown in Germany is currently expected to last at least until March 28th, but some restrictions have already been relaxed. Schools, daycare centers and hairdressers will reopen at the beginning of the month.

Then a week ago, bookshops and florists were allowed to reopen and some museums too. However, regional rules may vary, with states being given discretion as to how and when to reopen certain case rates.

On March 22nd, Germany’s five-point reopening plan had envisaged that some restaurants, theaters and outdoor cinemas could be reopened. But the rising number of infections could derail that schedule.

Vaccine suspension

The epidemiologist’s key comments come from the fact that Germany and a handful of other European countries have decided to suspend the use of the coronavirus vaccine developed by AstraZeneca and the University of Oxford amid concerns about reports of blood clots in a handful of people who have been vaccinated.

The move has baffled experts around the world as the World Health Organization and the European Medicines Agency (both of which are conducting a safety review of the vaccine) insist that all available evidence shows that the vaccine is safe and effective, rather than asking for a higher one Risk of blood clots, which are common in the general population.

The vaccine manufacturer itself has highlighted that the data shows that the number of blood clots in the vaccinated population was actually lower than expected.

WHO and EMA, due to release the results of their safety review Thursday, say the vaccine’s benefits outweigh the risks and that countries shouldn’t interrupt their vaccination programs. Nevertheless, more than a dozen European countries have stopped using it. According to experts, this could lead to a dangerous increase in infections and deaths.

“Latest figures suggest 40 fatal cases for every 20 million cases vaccinated with Astra-Zeneca shocks. Every single case is always terrible, but that percentage is statistically insignificant. Instead, vaccination delays cost Europe about 2,000 more deaths a day – and tens of billions of euros for closings, closed shops, “said Guido Cozzi, professor of macroeconomics at the University of St. Gallen, in a note on Tuesday.

Even though public health authorities like WHO and EMA reiterated on Thursday that the vaccine is safe, experts fear that more damage has already been done to the vaccine’s reputation.

AstraZeneca’s vaccine has already faced several hurdles ranging from question marks about trial methods and data to false hesitation about the vaccine’s effectiveness in those over 65 and disputes over delays in delivery to the EU. Real-world data shows the vaccine is extremely effective at preventing severe Covid cases, hospitalizations and adult deaths.

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Health

WHO scientist warns world is at ‘very dangerous’ stage as Covid instances rise

The world needs to step up its efforts to fight Covid-19 – and countries must not give up their vigilance, the World Health Organization’s chief scientist warned on Monday as coronavirus cases rise around the world.

“We are in a very risky phase,” said Dr. Soumya Swaminathan from the World Health Organization. “We have to double up, this is not the time to slack off.”

The WHO warned last week that the number of new Covid-19 cases is increasing with declines worldwide after six consecutive weeks. More than 2.6 million new cases were reported in the last week of February, a 7% increase from the previous week, according to the health department.

The Eastern Mediterranean, Southeast Asia, Europe and America all recorded increases of between 6% and 14%.

Although vaccines are on the rise for us in the nation, we cannot give up our vigilance.

Julie Morita

Robert Wood Johnson Foundation

“This is partly due to lockdown fatigue, you know. It’s because people … may loosen up believing vaccines are on the way,” Swaminathan told CNBC’s Squawk Box Asia on Monday. New variants could also play a role, she added.

“We have to … do everything we know to keep these viruses under control, keep transmission under control until we have enough vaccines,” she said, warning health systems could become overloaded again.

“Health workers around the world are exhausted, they have been battling it for over a year now,” she added.

Other health professionals have also suggested that it is not time to get complacent.

Julie Morita, executive vice president of the Robert Wood Johnson Foundation, said it was important to realize that infections, hospitalizations and deaths are still high even after falling from their peaks in the US

“It is still necessary that we wear our masks, social distance, avoid large crowds while we are vaccinated,” she told CNBC’s Street Signs Asia on Monday.

“Although vaccines are on the rise for us in the nation, we cannot give up our vigilance,” she said. “It’s way too early to relax.”

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Retailers signal extra short-term leases in a dangerous wager for mall homeowners

Shoppers walk through the King of Prussia shopping mall in King of Prussia, Pennsylvania.

Jennah Moon | Bloomberg | Getty Images

Retailers and their landlords are currently embroiled in a high stakes risk game. And it will be a few years before we find out which party is on the winning side.

As thousands of retail leases need to be renewed, their term continues to shrink as companies grapple with an unpredictable future and seek ways to cut costs, remain flexible, and maintain leverage with their landlords even after the health crisis subsides.

However, the risk is a one-way street. For one thing, malls and shopping malls owners could have the opportunity to turn the tables in two or three years by increasing rents or outfitting retailers for another tenant. However, shorter-term deals could also result in landlords having even more vacancies across the board.

Best Buy chief executive Corie Barry said Thursday that the big box retailer’s average rental length is definitely decreasing.

She said the company has about 450 leases due to be renewed over the next three years, or an average of 150 a year. The electronics retailer has closed around 20 of its large-format stores in each of the past two years, but expects to close even more in 2021, she said.

“In the short term, there will be higher lease renewal thresholds as we assess the role of each store in its market, the investments required to meet our customer needs, and the expected return on investment based on a new retail landscape,” Barry said during a conference call with analysts .

The trend is spreading far across the retail landscape and in shopping malls. Apparel companies are increasingly rethinking whether it makes sense to be in an enclosed mall anchored by department stores struggling to attract shoppers and increase sales.

According to VF Corp., owner of Vans and Timberland, the leases for its stores have been shorter for years. They will get out of the pandemic even shorter thanks to recent and ongoing negotiations, according to the company’s CFO. VF Corp. makes the switch to allow the freedom to close deals faster.

“The way we structure our rental agreements allows us to be quite nimble and agile and … we can turn around as consumer behavior changes,” CFO Scott Roe said in a recent telephone interview.

The retailer’s average rental period is around four years, according to Roe and will soon be even shorter as new contracts are signed.

“The landlords have been cooperative and have worked with us,” added Steven Rendle, CEO of VF Corp.. “We both have the same goal, which is to be viable and productive.”

There is plenty of freedom

While it has traditionally been in a landlord’s best interest to get a long term tenancy or 20 year lease in order to limit risk and fill a room for as long as possible, many succumb to the pressures that have been placed in the past 12 months.

With lots of vacant space in many markets across the country, tenants such as retailers and restaurateurs are in a greater position of power. It’s a trend that many real estate experts expect will only multiply from here and become the norm.

According to a follow-up from real estate services company CoStar Group, leases for approximately 1.5 billion square feet of retail space in the US expire this year. That’s around 14% of the retail market. Either these leases will not be renewed and additional retail stores will be closed, or these contracts will be renegotiated.

“We agree with that.”

While short-term leases can pose a higher risk for landlords who then grapple with unpredictable waves of renters moving in and out, they go both ways. Retailers could get a short-term lease, and rents could be higher in the future as the market strengthens.

David Simon, CEO of mall owner Simon Property Group, told analysts during a conference call in early February that tenants were interested in a “slightly shorter term”. Simon is currently signing another three-year leases, he said.

“We are okay with this because in two or three years I would rather negotiate,” than not filling a shop at all, he said. “I think that might be in our best interests too, because … we’re not entirely able to refer to sales to increase the rent,” he said.

“It’s actually a one-way street and it works fine for the vast majority of our retailers,” said Simon.

Beth Azor, CEO of retail property management and development firm Azor Advisory Services, said she worked on a number of short-term super deals during the pandemic. Azor, often referred to as the “canvassing queen” by her social media peers, is helping leasing agents fill vacancies across the country by working with a number of publicly traded real estate mutual funds (REITs).

She recently took up service on the emerging social network Clubhouse, where she has set up spaces for entrepreneurs to set up their business in, and landlords with free space can overhear. The rental contracts have a term of three months to one year. and sometimes that’s rent-free. She calls it “Space Tank”, a piece from ABC’s “Shark Tank”.

Occupancy pays off

Azor says landlords shouldn’t view short-term leases as negatively, especially given the retail location. A tenant – period – increases occupancy, she said, which can come in handy when other businesses are knocking on the door asking for rent relief.

During the health crisis, companies at the national and local levels came to malls and malls owners to try to renegotiate their rents, Azor said. And when a property is full, albeit with some short term leases, it’s harder for a company to argue that their rent should go down. So the occupancy can literally pay off.

Outlet owner Tanger Factory Outlets has also done more short term deals. Currently, about 7% of tenants’ leases are categorized as fixed-term when they are typically between 4.5% and 5.5%, CEO Stephen Yalof told analysts during a conference call earlier this month.

“A number of deals that actually started out as pop-up or short-term leases … we extended the duration of those leases,” he said. “So that seems to be a trend.”

He went on to explain that the REIT preferred to maintain a high occupancy with shorter-term deals over charging rents in 2020.

“We’ll see a lot more local and [temporary] Leasing probably in the first half of the year, “he said.” But we are very proactive with our long-term leasing to replace this tenancy and expand our permanent leasing base. “

However, not all properties seem suitable for pop-ups.

For example, according to Jerome Barth, president of the Fifth Avenue Association, New York’s glitzy Fifth Avenue neighborhood is still largely populated by tenants with long-term leases.

“These will be premium leasing contracts, no matter what … because this is still the world’s leading market,” said Barth. “I think leases will keep moving, and that will be a constant. But people know the avenue will be an exciting place for years to come.”

Disclosure: CNBC owns the exclusive off-network cable rights to “Shark Tank”.

– CNBC’s Melissa Repko contributed to this report.

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‘Dangerous’ to delay second Covid vaccine photographs within the UK: ex-FDA director

Postponing the second dose of Covid-19 vaccines is “very risky” because the efficacy data was based on a specific dosage schedule, a former FDA director told CNBC on Thursday.

His comments came after the UK’s decision to give a second shot of the coronavirus vaccine 12 weeks after the first dose, contrary to vaccine manufacturers’ recommendations. Germany is reportedly considering a similar move, while Denmark approves a six-week gap between doses.

The vaccines approved for use in the UK both require two doses.

American pharmaceutical company Pfizer and German biotechnology company BioNTech recommended giving the second dose of their vaccine 21 days after the first. British-Swedish pharmaceutical company AstraZeneca said the vaccine, jointly developed with Oxford, requires two doses to be given one month apart. The UK initially said it would follow this timetable.

It’s a very risky endeavor because if it fails, you will be worse off.

Norman Baylor

Former FDA director

Any decision to change dosing schedules should be based on data, said Norman Baylor, a former director in the US Food and Drug Administration’s bureau of vaccine research and testing.

“It is very risky to try to extend [the gap between two doses] or give a dose if there is no data, “he told CNBC’s Street Signs Asia on Thursday.

“I can see some reasons for this, but again, it’s not really data-driven,” said Baylor, who is also president and chief executive officer of Biologics Consulting. “It’s a very risky endeavor because if it fails, you will be worse.”

The UK’s controversial decision came as the country continued to grapple with a new strain of the coronavirus that is spreading faster, despite no evidence that it is more severe or deadly. 62,322 cases were reported on Wednesday, and more than 2.8 million people have tested positive for the virus to date, according to government figures.

A nurse prepares the Oxford-AstraZeneca vaccine at Pontcae medical practice in Merthyr Tydfil, Wales on January 4, 2021.

Matthew Horwood | Getty Images News | Getty Images

Delaying the second dose of the vaccine means more people can get their first dose. However, Baylor said it was ideal to follow the dosing regimen from the vaccine’s effectiveness studies.

“If you don’t have the data, you are taking a risk there,” he said. “That is the point, the risk you are taking.”

Weigh vaccine manufacturers