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C.D.C. to Suggest Some Vaccinated Folks Put on Masks Indoors Once more

Reversing a decision made just two months ago, the Centers for Disease Control and Prevention is expected to recommend on Tuesday that people vaccinated for the coronavirus resume wearing masks indoors in certain areas of the country.

The change follows reports of rising breakthrough infections with the Delta variant of the virus in people who were fully immunized, and case surges in regions with low vaccination rates. The vaccines remain effective against the worst outcomes of infection with the virus, including those involving the Delta variant.

But the new guidance, the details of which are expected later Tuesday, would mark a sharp turnabout from the agency’s position since May that vaccinated people do not need to wear masks in most indoor spaces.

As recently as last week, an agency spokesman said that the C.D.C. had no plans to change its guidance, unless there were a significant change in the science. Federal officials met on Sunday night to review new evidence that may have prompted the reversal, CNN reported on Tuesday.

“I think that’s great,” said Dr. Celine Gounder, an infectious disease specialist at Bellevue Hospital Center in New York. Based on what scientists are learning about the Delta variant’s ability to cause breakthrough infections, she said, “this is a move in the right direction.”

The C.D.C.’s initial guidance in May said people fully protected from the coronavirus could go mask-free indoors in most scenarios, but recommended that unvaccinated people still wear masks. Those recommendations drew sharp criticism from some experts, who said it was premature given the vast swaths of unvaccinated people in the country.

Dr. Rochelle Walensky, the C.D.C.’s director, at the time pointed to two scientific findings as significant factors. Few vaccinated people become infected with the virus, and transmission seems rarer still, she noted; and the vaccines appear to be effective against all known variants of the coronavirus.

A day after the announcement, the agency released results from a large study showing that the mRNA vaccines made by Pfizer-BioNTech and Moderna were 94 percent effective in preventing symptomatic illness in those who got two doses, and 82 percent effective in those who had received one dose.

But those data, and the C.D.C.’s decision, were based on infections of previous versions of the virus before the Delta variant began sweeping through the country. Reports of clusters of infections among fully immunized people have suggested that the variant may be able to break through the vaccine barrier more often than previous iterations of the virus.

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CDC group says there is not sufficient information but to suggest booster pictures

A group of Centers for Disease Control and Prevention scientists said Wednesday that currently there isn’t enough data to support recommending Covid-19 booster shots to the general population but that more-vulnerable groups, such as elderly people or transplant recipients, may need an extra dose.

The Covid-19 working group of the CDC’s Advisory Committee on Immunization Practices didn’t rule out the possibility that the general population eventually may need booster shots if immunity from the vaccines wanes or a variant reduces the effectiveness of current shots.

“Boosters may be required for a broad population. However, it could also be that the need for boosters of Covid vaccine may only be demonstrated in some populations,” said Dr. Sarah Oliver, co-lead of the working group and a medical epidemiologist with the CDC’s National Center for Immunization and Respiratory Diseases.

A recent study by researchers at Johns Hopkins University published in the Annals of Internal Medicine showed that booster shots may be beneficial for people with weakened immune systems. Oliver said the agency should monitor residents of long-term care facilities, elderly people, health-care workers and immunocompromised people.

The working group recommended that the CDC consider booster shots only “after evidence of declining protection,” Oliver said, meaning if the vaccines became less effective over time or antibodies guarding against Covid waned over time. The agency could also consider using booster shots if a variant emerged that substantially reduced the effectiveness of the vaccine.

Vials with Pfizer-BioNTech and Moderna coronavirus disease (COVID-19) vaccine labels are seen in this illustration picture taken March 19, 2021.

Dado Ruvic | Reuters

“I would have to agree with the interpretation of the working group in the sense that there’s no data to support recommendations to support boosters at this time,” said Dr. Sharon Frey, a member of ACIP and clinical director of the Center for Vaccine Development at Saint Louis University Medical School. “There’s no evidence against declining protection at this time.”

But Frey said she would be open to giving a third shot to transplant patients or if infections rise in the general population, indicating a lot of breakthrough cases in fully vaccinated individuals. So far, there have been at least 3,729 breakthrough infections in the U.S. that resulted in hospitalization or death, according to CDC data.

“I think the only thing we can do at this moment is, if we start to see an uptick in reinfection in people or new infections in people who have been vaccinated, that’s our clue that we need to move quickly,” Frey said.

Dr. Grace Lee, who chairs the ACIP safety group and is a professor of pediatrics at Stanford University School of Medicine, also said she would like to see more evidence of breakthrough cases before recommending a booster shot.

“I would want greater certainty on the safety data if we’re talking about boosting before it’s clear what the risk data will look like,” Lee said. “If we’re seeing severe breakthrough cases then I think the decision-making moves forward even if there’s uncertainty with the safety data.”

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FDA advisory panel meets at this time to vote on whether or not to advocate approval of Pfizer’s Covid vaccine

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A panel from the Food and Drug Administration will meet Thursday to vote on whether to recommend Pfizer and BioNTech’s emergency approval of the coronavirus vaccine.

Prior to voting by the Agency’s Advisory Committee on Vaccines and Related Biological Products, the independent panel of medical experts will evaluate the Pfizer clinical trial data and provide their opinion on the vaccine, including whether the benefits outweigh the risks in an emergency .

The FDA is not required to follow the advice of the advisory group, but it often does.

A recommendation from the advisory committee is the final step before the FDA is likely to give final OK to the distribution of the potentially life-saving doses in the United States. The vaccine would be the first to be approved for use in the United States

Read CNBC’s live updates for the latest news on the Covid-19 outbreak.