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Health

A Altering Intestine Microbiome Might Predict How Properly You Age

About 900 of these people were seniors who were regularly examined in medical clinics to assess their health. Dr. Gibbons and his colleagues found that middle-aged people from around 40 years of age showed significant changes in their microbiomes. The strains that were most dominant in their guts tended to decrease while other, less common strains were more common, causing their microbiomes to diverge and become increasingly different from others in the population.

“We have found that people drift apart in the different decades of their lives – their microbiomes are becoming more and more unique,” said Dr. Gibbons.

People with the most changes in their microbial makeup tended to have better health and longer lifespans. They had higher levels of vitamin D and lower levels of LDL cholesterol and triglycerides, a type of fat in the blood. They needed less medication and had better physical health, faster walking speeds, and greater mobility.

The researchers found that these “unique” individuals also had higher levels in their blood of several metabolites produced by gut microbes, including indoles, which have been shown to reduce inflammation and maintain the integrity of the barrier that lines the gut and protects. In some studies, scientists have found that giving indoles to mice and other animals helps them stay youthful so that they are more physically active, more mobile, and more resistant to disease, injury, and other stresses in old age. Another metabolite identified in the new study was phenylacetylglutamine. It is not exactly clear what this connection does. However, some experts believe this promotes longevity, as research has shown that centenarians in northern Italy tend to have very high levels.

Dr. Wilmanski found that people whose gut microbiomes had barely changed with age were in poorer health. They had higher levels of cholesterol and triglycerides, and lower levels of vitamin D. They were less active and couldn’t run as fast. They took more medication and died almost twice as often during the study period.

The researchers speculated that some intestinal bugs, which might be harmless or even beneficial in early adulthood, might become harmful in old age. For example, the study found that healthy people who saw the most dramatic changes in their microbiome composition dropped sharply in the prevalence of bacteria called Bacteroides, which are more common in developed countries, where people eat many processed foods full of fat, sugar, and salt and less common in developing countries, where people tend to eat higher fiber diets. When fiber isn’t available, according to Dr. Gibbons like to “mucus,” including the protective layer of mucus that lines the intestines.

“Maybe that’s good if you’re 20 or 30 years old and you have a lot of mucus in your gut,” he said. “But as we get older, our mucus layer gets thinner, and maybe we need to suppress these flaws.”

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Business

Drive-Throughs That Predict Your Order? Eating places Are Considering Quick

Starbucks has employees in hundreds of busy locations strolling down car lines taking handheld orders so customers can get their caffeine fix a few seconds faster. Shake Shack, which has long insisted that it pays to wait a few minutes longer for quality ingredients, will soon have its first drive-through window. And the vast majority of new Chipotles this year will have “Chipotlanes” where customers can pull up to a window and have pre-ordered meals in less than a minute.

With dining room restrictions in place throughout much of the country during the pandemic, drive-through and pick-up windows have become a crucial way for a variety of restaurants to stay afloat.

Now that the hospitality industry is facing a post-pandemic world, many companies are counting on digital ordering and pass-throughs to remain an integral part of their success. And the basic experience of sitting in a single row of cars, speaking into a sometimes mangled intercom, and pulling up to a window to pay for your meal before driving away is likely to change for the first time in decades.

A number of restaurants are moving quickly to improve their online ordering and app skills, change their physical design, or add two or three drive-through lanes. Some are testing artificial intelligence systems to make suggestions for people who get to the menu bar.

“The transit was one of those places that hasn’t changed in decades,” said Ellie Doty, Burger King’s North American marketing director. “But with Covid we are seeing the dramatic acceleration of the directions in which we have already gone.”

Taco Bell, who last year announced plans to test a restaurant design with stadium seating so players can play against each other, has placed a heavy emphasis on creating smaller restaurants with two thoroughfares and one roadside pickup. Applebee’s is testing its first drive through in Texarkana, Texas. Shake Shack is experimenting with a number of new designs and plans, including walk-in windows and curbside pickups. It will open its first transit this year in Orlando, Florida, with plans for five to eight more by 2022.

“We had started working on some formats before the pandemic,” said Andrew McCaughan, Shake Shack’s chief development officer. “But we saw a massive accelerator and catalyst to go faster and really get the drive going.”

While several chains claim to have invented the drive through, many say it dates back to the 1930s when a Texas chain’s Los Angeles franchise, the Pig Stand, allowed customers to order and collect their food from a window . In the late 1940s, California chain In-N-Out Burger introduced the two-way squawk box. But the phenomenon really increased in the 1970s when McDonald’s installed drive-throughs.

As more families had two working parents and the demand for quick and easy meals increased, drive-throughs became mainstream. But they also became a source of ridicule and exhilaration. In “Wayne’s World 2” from 1993, the characters Garth and Wayne intentionally cut out their voices while giving their orders, suggesting a broken intercom. The server repeats the order back perfectly.

In fact, drive through can be stressful. Other customers honk their horns occasionally to encourage you to expedite your order. After shouting “No cucumbers!” Again and again in the intercom, you sometimes get a burger with three cucumbers on it. And lines can extend through parking lots and onto the street, especially during the pandemic. Chick-fil-A has been sued by neighboring companies that the long thoroughfares are blocking their customers’ access.

For most restaurants, the solution consists of many parts. First, more and more customers are trying to use ordering apps, which improve the accuracy of orders, and are often associated with loyalty programs that give them points for free food. They are also trying to figure out how best to speed up consumers through the drive-through or pick-up process without disrupting traffic patterns or other businesses.

Updated

March 8, 2021, 9:50 p.m. ET

Drive-through times average 4 minutes and 15 seconds, according to Bluedot, a geolocation company. Like a Daytona 500 pit crew, restaurants are always looking for ways to save minutes or even seconds.

To be competitive in this race, Chipotle, whose digital orders soared from 20 percent of its sales to up to 70 percent at the height of the pandemic, installed a second assembly line in many of its kitchens, where employees put together tacos or burrito bowls exclusively for mobile and mobile phones Online orders.

The chain also expects 70 percent of its restaurants opening this year to have dedicated chipotlanes for online ordering.

“In the traditional drive-through experience, you wait in line to order, you wait in line to pay and collect, you wait in line for your food to be prepared,” said Jack Hartung, Chipotle’s chief financial officer. “We try to hit our service time from the time you drive to the restaurant, pick up your food and drive to 40 or 50 seconds.”

Others, like McDonald’s and Burger King, add multiple thoroughfares, which were a feature of some busy fast-food places like Chick-fil-A, but are becoming more common. Burger King is running three-lane tests in the US, Brazil and Spain. In the USA and Spain, the third lane is “Express” for pre-orders via the app. In Brazil, the lane brings the deliverers to a pick-up area with food cupboards or shelves.

Burger King would like to use an artificial intelligence system similar to Big Brother, Deep Flame, to advance its passages into the future.

Currently, roughly half of Burger King’s passages with digital menu boards use Deep Flame’s technology to suggest foods that are particularly popular in the area that day. External factors such as the weather are also used to highlight elements such as an iced coffee on a hot day.

This year, Burger King is testing Bluetooth technology that can identify customers in Burger King’s loyalty program and view their previous orders. If a customer ordered a small sprite and a whopper of cheese hold the pickles, the last three visits, Deep Flame calculates that the chances are high the customer will want the same order again.

It’s unclear whether the technology will pay off. McDonald’s is moving in a similar direction. The fast food giant acquired the Israeli artificial intelligence company Dynamic Yield in 2019 to drive sales through personalized digital promotions for customers.

Restaurant Brands International – the parent company of Burger King, Tim Hortons, and Popeyes – hopes to have the predictive personalized systems in more than 10,000 locations of its restaurants in North America by mid-2022.

“We’re taking an outdated, old, static sales channel and bringing it to the forefront of the industry,” said Duncan Fulton, chief corporate officer of Restaurant Brands International. Now customers have the ability to “automatically rearrange things and pay for the items on the board, ultimately reducing window time and allowing you to collect your groceries and be on your way.”

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Health

Will Tiger Woods Play Golf Once more? Medical doctors Predict a Troublesome Restoration

The severe lower leg injuries Tiger Woods sustained in a car accident on Tuesday usually lead to a long and dangerous recovery that, according to medical experts who have treated similar injuries, calls into question his ability to return to professional golf.

Athletes with severe leg injuries believed to ruin their careers have returned – quarterback Alex Smith returned to play football after a cruel broken leg last season, and golfer Ben Hogan returned after a car accident decades ago .

But Woods’ injuries are more extensive and his path to recovery is littered with serious obstacles. Infection, inadequate bone healing, and in Woods’ case, previous injuries and chronic back problems can make months or even years of recovery even more difficult and reduce the chances of him playing again.

In the accident near Los Angeles, Woods’ right lower leg was bruised, his right foot was badly injured, and his leg muscles became so swollen that surgeons had to cut open the tissue covering them to relieve the pressure, Dr. Anish Mahajan, the chief physician at Harbor-UCLA Medical Center where Woods, 45, was treated, wrote in a Twitter message on Wood’s account.

Doctors also inserted a bar into Wood’s shin and screws and pins into his foot and ankle. Doctors familiar with these types of injuries described the complications that they typically pose.

The injuries are common among drivers involved in car accidents, said Dr. R. Malcolm Smith, chief of orthopedic trauma at Massachusetts General Hospital in Boston. Usually they happen when the driver desperately hits the brakes while a car is spiraling out of control.

When the front end of the car is smashed, immense force is transferred to the driver’s right leg and right foot. “This happens every day with car accidents in this country,” said Dr. Smith.

Such lower leg fractures occasionally bring “massive disabilities” and other serious consequences, said Dr. Smith. “A very rough estimate is that there is a 70 percent chance that it will heal completely,” he added.

The crash caused a cascade of injuries. It shattered Woods’ tibia with primary fractures in the upper and lower portions of the bones and a scattering of bone fragments. When the bones in Wood’s shin burst, they damaged muscles and tendons; Pieces protruded from his skin.

The trauma caused bleeding and swelling in his leg and threatened his muscles. Surgeons had to quickly cut into the thick layer of tissue covering his leg muscles to relieve the swelling. If it hadn’t been for them, the tissue covering the swelling muscle would have acted like a tourniquet, restricting blood flow. The muscle can die within four to six hours.

It is possible that a muscle may have died between the accident and the operation anyway. Dr. Smith said, “Once you’ve lost it, you can’t get it back.”

Patients who are used this procedure must be hospitalized until the muscle swelling subsides. This can take a week or more. Sometimes, even after a few weeks, the swelling has not gone down enough to close the wound, requiring surgeons to transplant skin over the opening.

Dr. Kyle Eberlin, a reconstructive surgeon at Massachusetts General Hospital, said doctors often need to transplant skin from the thigh or back to plug the holes where bones protrude from the skin. This is known as a free flap. They cut pieces of skin the size of a football and carefully use a microscope to connect tiny blood vessels about a millimeter in diameter from the skin graft to the blood vessels near the wounds.

Infection is a risk with fractures that break through the skin and insert chopsticks and pens into the bones after surgery, with an amputation in the worst case, said Dr. Smith. The likelihood of infection depends on the level of contamination and the size of the wound.

In car accidents, gravel and sometimes dirt can get into wounds and increase the chances of infection, said Dr. Eberlin.

Opening the muscle shell can increase the risk of infection, said Dr. Reza Firoozabadi, an orthopedic trauma surgeon at Harborview Medical Center in Seattle.

In large trauma centers like Massachusetts General or UCLA, the free flap procedures are performed within 48 hours. However, it is more typical to operate within a week of the injury, said Dr. Eberlin.

Rehabilitation will be long and arduous. If Woods needed a free valve – which trauma surgeons say is likely – “it will be months and months before he can put weight back on his leg,” said Dr. Eberlin.

Woods also risks fractures that do not heal or grow together very slowly, said Dr. Firoozabadi. “To heal things, you need good blood circulation,” he said. “With such an injury, the blood flow is disturbed.”

As a result, Wood’s lower leg bones could take five to 14 months to grow together, provided they do so at all.

The biggest hurdle will be his foot and ankle injuries, said Dr. Firoozabadi and others. Restoring mobility and strength can take three months to a year. Depending on the extent of these injuries, Woods can barely walk even after rehabilitation.

His rehabilitation can be made more difficult by a back operation in December. Woods also went to rehab for an addiction to pain medication; Managing pain while he is recovering can now be difficult.

Still, some athletes have returned from serious injuries. Smith, the Washington Football Team quarterback, had a similar leg injury and returned to play in October. But it took two years and 17 operations, and along the way he developed infection of the wounds and sepsis, a life-threatening condition. And Smith had no injuries to his foot or ankle.

Golfer Ben Hogan broke his collarbone, pelvis, left ankle, and a rib. The injuries were severe but not comparable to Woods’ injuries.

With his foot and ankle injuries and severe injuries to his leg, “Woods may never play golf again,” said Dr. Smith.

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Health

Coronavirus Will Resemble the Widespread Chilly, Scientists Predict

Other experts said this scenario is not only plausible, it is likely.

“I fully agree with the overall intellectual construct of the paper,” said Shane Crotty, a virologist at the La Jolla Institute of Immunology in San Diego.

If the vaccines prevent people from transmitting the virus, “it’s much more like the measles scenario where you vaccinate everyone, including children, and the virus really doesn’t infect people,” said Dr. Crotty.

It’s more plausible that the vaccines prevent disease – but not necessarily infection and transmission, he added. And that means the coronavirus will continue to circulate.

“The vaccines we currently have are unlikely to offer sterilizing immunity,” said Jennifer Gommerman, an immunologist at the University of Toronto.

A natural infection with the coronavirus leads to a strong immune response in the nose and throat. But with the current vaccines, Dr. Gommerman: “You don’t get a natural immune response in the actual upper airways, you get an injection in your arm.” This increases the likelihood that infections will still occur after vaccination.

Ultimately, Dr. Lavine’s model on the assumption that the new coronavirus is similar to the common cold coronavirus. That assumption might not be true, however, warned Marc Lipsitch, an epidemiologist at Harvard TH Chan School of Public Health in Boston.

“Other coronavirus infections may or may not be applicable because we haven’t seen what these coronaviruses can do to an elderly, naive person,” said Dr. Lipsitch. (Naive refers to an adult whose immune system has not been exposed to the virus.)