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World News

Shelling Cuts Off Outdoors Energy to Ukrainian Nuclear Plant

Recognition…Jim Huylebroek for the New York Times

Kyiv, Ukraine — Europe’s largest nuclear power plant was disconnected from the country’s power grid Monday after renewed shelling nearby, Ukrainian energy officials said, putting critical cooling systems once again at risk of relying solely on backup power.

Herman Galushchenko, Ukraine’s energy minister, said a fire resulting from the shelling severed the Zaporizhia power plant’s last connection to a back-up line, which was its only source of external power.

Reactor No. 6, the plant’s only functioning reactor, was still producing electricity for the plant itself, and as of Monday evening, engineers had not turned on any diesel generators, according to an official from Energoatom, the Ukrainian company responsible for running the facility.

Mr Galushchenko said it was another precarious moment made even more ominous by the fact that fire crews were unable to reach the scene of the fire.

“Repairs on the lines are now impossible,” he said. “There’s fighting all around the station.”

An International Atomic Energy Agency inspection team that had been at the facility left behind two monitors hoping they would witness unfolding events and the tensions at the facility, which was being held by Russian forces but still operated by Ukrainian engineers will, could alleviate . The greater hope had been that the shelling would stop.

The agency said that according to Ukrainian officials, the reserve line was “deliberately disconnected to put out a fire.”

“The line itself is not damaged and will be reconnected once the fire is out,” said the organization, which is part of the United Nations.

Edwin Lyman, a nuclear energy expert at the Union of Concerned Scientists, a private group in Cambridge, Mass., said the current situation – with the plant relying on one of its own reactors to power cooling systems – is ” not unique, but it is not common practice.”

He pointed out that the International Atomic Energy Agency, which sets reactor safety standards for nuclear power plants, released a technical document in 2018 detailing the backup procedure.

“Some existing nuclear power plant technologies have this capability,” says the IAEA document, “while others do not.” Even plants that do have the capability could face “a time limit of generally a few hours” for back-up power be.

Najmedin Meshkati, a professor of civil and environmental engineering at the University of Southern California, said the external power outage — which has happened at least twice at the Zaporizhia plant in recent weeks — is “one of the most horrific events that could happen at a nuclear power plant.” .”

dr Meshkati, a member of the committee appointed by the United States National Academy of Sciences to learn lessons from the disaster at Japan’s Fukushima nuclear power plant, said there was no point in running the reactor.

An engineer in contact with people at the facility and in the satellite city of Enerhodar said Monday her colleagues had reported heavy shelling in the area over the past three days.

“Dwelling houses were damaged and many more people were injured and killed than was reported in the Ukrainian media,” said the engineer, who spoke on condition of anonymity because she feared reprisals against her friends and family. “People continue to leave the city, including workers at the plant.”

Ukrainian officials tried to keep up pressure on the International Atomic Energy Agency to propose a robust assessment of both the conditions at the plant and the challenges faced by Ukrainian engineers charged with its safe operation.

Repeated shelling over the past month has damaged all of the facility’s connections to four external high-voltage power lines, forcing it to use a lower-voltage backup line to power the cooling equipment needed to avoid core meltdowns. It was this reserve line that was cut Monday.

When the main power lines and backup line were damaged by gunfire and fires on August 25, a power outage at the facility forced reliance on diesel generators to prevent a disaster.

Rafael Mariano Grossi, the director of the International Atomic Energy Agency, told a news conference on Friday that his main concern for the facility’s physical security is related to a reliable connection to external power supply.

William J. Broad contributed reporting from Brunswick, Maine.

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World News

Renewed Shelling Places Ukraine’s Zaporizhzhia Nuclear Plant at Threat

Even as hopes grew that a permanent presence of United Nations inspectors would help reduce the risk of a disaster at Ukraine’s Zaporizhia nuclear power plant, the war once again threatened the plant’s safe operation.

After Friday night’s shelling, the plant lost connection to its only remaining primary external power line, forcing it to use a lower-voltage backup line to power the cooling equipment needed to prevent core meltdowns, the International Atomic Energy Agency said in a statement on Saturday.

Still, the agency’s director, Rafael Mariano Grossi, expressed cautious optimism that a plan to indefinitely station two nuclear experts at the facility would help reduce the risk of a disaster.

“We think it was important for the agency to be there permanently,” he said. “The difference between being there and not being there is like night and day.”

The decision to monitor the facility despite the obvious risks underscored what Mr. Grossi described as the “unprecedented” danger of the moment. He added that having independent nuclear experts at the plant will allow for real-time, unbiased reports on conditions.

“Now if there is a claim that something happened at the plant, you can contact us,” he said, rather than weighing the conflicting claims of Russia and Ukraine.

Mr Grossi, who has avoided blaming either the Russians or the Ukrainians for the shelling, said on Friday that it appeared the power plant’s power supply was being deliberately attacked.

“It is clear that those who have these military targets know very well that the way to cripple or do more damage is not to look inside the reactors, which are enormously robust and robust,” he said . Instead, the rig gets hit where it hurts — the power lines that are essential to its operation.

On Saturday, Mr Grossi said the presence of the agency’s inspectors, who were able to confirm the damage to the external power line, had already proved valuable.

“Our on-site team received direct, fast and reliable information on the latest significant developments affecting the power plant’s external power supply and the operational status of the reactors,” he said.

One of the plant’s six reactors is currently operational, the agency said, producing electricity for both cooling and other vital safety functions at the site, as well as for Ukrainian homes and factories.

The UN’s move to keep two inspectors at the facility comes as fighting rages on in southern and eastern Ukraine. The facility is perilously close to some of the most intense combat.

Late last month, the Ukrainian military launched a counter-offensive in the south, including the area directly opposite the nuclear power plant in the western Kherson region. On Saturday, British military intelligence said Ukraine’s advance on three fronts was likely “to have generated a degree of tactical surprise; Exploitation of poor logistics, administration and leadership in the Russian Armed Forces.”

But military analysts have dampened expectations for Ukraine’s push, saying between 15,000 and 25,000 Russian troops are stationed in fortified defenses west of the Dnieper.

Jack Watling, a research fellow and specialist in land warfare at the Royal United Services Institute in Britain, wrote that unless Russian forces collapse from abysmal morale – which he says is “possible, but not something assumed in the planning can be” – then anything Success on the battlefield for the Ukrainians would take time.

On another front in the Ukraine war, German officials expressed cautious confidence their country could survive a winter without Russian energy after Russia indefinitely postponed gas supplies to the country.

Aware of President Vladimir V. Putin’s history of using energy supplies as a foreign policy tool, Berlin has been bracing for months for the possibility that Russia could cut gas supplies in retaliation for European resistance to Moscow’s invasion of Ukraine.

The German government has imposed tough energy-saving measures, and the ministry responsible for gas supplies found that Germany’s gas storage facilities are already nearly 85 percent full, a target set for early October.

And while Germany got 55 percent of its natural gas from Russia in February when Russia invaded Ukraine, Russian gas made up only about 10 percent of Germany’s on Tuesday — the last full day that gas flowed through the Nord Stream 1 pipeline gas mixes. thanks to months of gas procurement from other countries.

Gazprom, the Russian-owned energy giant, was scheduled to resume gas flow through the Nord Stream 1 pipeline on Saturday after three days of maintenance. But hours earlier, on what a European Union official called “false pretexts,” it said it found oil leaks around a turbine used to pressurize the pipeline, forcing it to restart cancel. There was no schedule for the reboot.

In Washington on Friday, the Biden administration asked Congress for $13.7 billion in additional aid to Ukraine, underscoring its commitment to supporting the war-torn country even as the conflict shows little sign of abating .

As part of Ukraine’s funding request, $7.2 billion would be used to give the country new weapons and military equipment, replenish US stockpiles and provide other defense-related support, government officials said. Another $4.5 billion would support the Ukrainian government and $2 billion would be used to offset the impact of the Russian invasion on energy supplies.

Marc Santora reported from Kyiv and Andrew E. Kramer from Zaporizhzhia, Ukraine. Reporting was provided by Christopher F. Schuetze from Berlin, Michael D. Shear from Washington and Dan Bilefsky from Montreal.

Categories
Health

Moderna, Canada agree on constructing manufacturing plant

Justin Trudeau, Canada’s Prime Minister, listens during a press conference in Ottawa, Ontario, Canada on Friday June 4, 2021. Trudeau said 65% of eligible Canadians received a first dose of the Covid-19 vaccine.

David Kawai | Bloomberg | Getty Images

Moderna said Tuesday it had reached an agreement with the Canadian government to build a “state-of-the-art” manufacturing facility in Canada to manufacture Covid vaccines and possibly vaccines for other respiratory viruses after the country suffered from supply shortages earlier this year.

The facility is designed to give Canadians access to domestically manufactured mRNA vaccines against respiratory viruses, including Covid, seasonal influenza, respiratory syncytial virus and possibly other vaccines, pending approval, the U.S. drugmaker said.

It is also to be used “urgently” to aid the country with health emergencies with direct access to vaccines, the company said.

Moderna said it was in talks with other governments about similar collaborations.

“We are very excited to expand our presence and continue our long-term relationship with Canada,” said Patricia Gauthier, Moderna’s head of Canadian business, in a statement. “With our industry-leading mRNA technology platform and rapid drug development capabilities, we look forward to being an active participant in Canada’s robust life science ecosystem.”

Canada has suffered repeated delays and supply shortages of Covid vaccines this year as it struggled to get the vaccines from other countries that manufactured them. The problem forced the government to postpone the second vaccinations for up to 16 weeks and advise residents to “mix and match” vaccines.

The Biden government, under pressure from allies worldwide to share vaccines, announced plans in March to ship about 4 million doses of AstraZeneca’s Covid vaccine that it was not using to Mexico and Canada.

Vaccine supplies and the pace of vaccinations have increased since then, Canadian health officials said, and residents have since received their second doses.

Moderna shares fell about 3% on Tuesday just before the announcement. The stock is up more than 360% since the beginning of the year.

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Politics

California shuts down main hydroelectric plant amid extreme drought

In this aerial view, houseboats sit on Lake Oroville at low tide as the California drought emergency worsens in Oroville, California on July 25, 2021.

Robyn Beck | AFP | Getty Images

SANTA MONICA, Calif. – California closed a large hydropower plant on Lake Oroville when the water level fell near the minimum required to generate electricity, state water authorities said.

It is the first time since the power plant opened in 1967 that the state has shut down the Hyatt power plant due to a lack of water.

The blackout could trigger even more blackouts this summer as the state grapples with a historic drought and record-breaking heat waves.

Officials said the record low water level at Lake Oroville, an artificial water reserve in Northern California, was due to the drought aggravated by climate change.

Though California is experiencing constant drought, climate change has fueled high temperatures and arid soils, which significantly reduced water runoff to the reservoirs this spring, resulting in the lowest levels ever recorded at Lake Oroville, officials said Thursday.

“This is just one of many unprecedented impacts we are experiencing in California as a result of our climate-induced drought,” Karla Nemeth, director of the state’s water resources division, said in a statement.

Nemeth said the department anticipated the shutdown and planned a loss of water and network management. Officials have warned that the facility will no longer be able to generate electricity if the water level drops below 640 feet above sea level.

Dry land is visible in a section that is usually underwater on the shores of Lake Oroville, which is the second largest reservoir in California and has a capacity of nearly 35, according to daily reports from the state Department of Water Resources near Oroville, California % hat, 06/16/2021.

Aude Guerrucci | Reuters

Lake Oroville’s water levels are expected to reach 620 feet above sea level by the end of October. Nemeth said the state’s water board was working to “save as much water as possible”.

Although the facility is no longer generating electricity, officials said they will dump some water from the dam into the Feather River to help maintain the river’s temperature requirements.

Governor Gavin Newsom urged California residents in July to reduce household water use by 15% in order to maintain water supplies. Network operators have also urged residents to limit electricity usage to avoid blackouts as forest fires scorched the state, including the Dixie Fire, which has been burning for more than three weeks and decimated the gold rush town of Greenville.

“Falling reservoir levels are another example of why it is so important for all Californians to conserve water,” said Nemeth.

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World News

Yuan Longping, Plant Scientist Who Helped Curb Famine, Dies at 90

After graduating in 1953, Mr. Yuan took a job as a teacher in an agricultural college in Hunan Province, keeping up his interest in crop genetics. His commitment to the field took on greater urgency from the late 1950s, when Mao’s so-called Great Leap Forward — his frenzied effort to collectivize agriculture and jump-start steel production — plunged China into the worst famine of modern times, killing tens of millions. Mr. Yuan said he saw the bodies of at least five people who had died of starvation by the roadside or in fields.

“Famished, you would eat whatever there was to eat, even grass roots and tree bark,” Mr. Yuan recalled in his memoir. “At that time I became even more determined to solve the problem of how to increase food production so that ordinary people would not starve.”

Mr. Yuan soon settled on researching rice, the staple food for many Chinese people, searching for hybrid varieties that could boost yields and traveling to Beijing to immerse himself in scientific journals that were unavailable in his small college. He plowed on with his research even as the Cultural Revolution threw China into deadly political infighting.

In recent decades, the Communist Party came to celebrate Mr. Yuan as a model scientist: patriotic, dedicated to solving practical problems, and relentlessly hard-working even in old age. At 77, he even carried the Olympic torch near Changsha for a segment of its route to the Beijing Olympics in 2008.

Unusually for such a prominent figure, though, Mr. Yuan never joined the Chinese Communist Party. “I don’t understand politics,” he told a Chinese magazine in 2013.

Even so, the Xinhua state news agency honored him this weekend as a “comrade,” and his death brought an outpouring of public mourning in China. In 2019, he was one of eight Chinese individuals awarded the Medal of the Republic, China’s highest official honor, by Xi Jinping, the national leader.

Mr. Yuan is survived by his wife of 57 years, Deng Zhe, as well as three sons. His funeral, scheduled for Monday morning in Changsha, is likely to bring a new burst of official condolences.

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Business

Staff at plant that ruined hundreds of thousands of J&J Covid vaccine doses did not bathe, change garments

Employees work in a laboratory at Emergent Biosolutions in Baltimore, Maryland on February 8, 2021.

Michael Robinson Chavez | The Washington Post | Getty Images

Some employees at the Emergent BioSolutions Baltimore plant were unable to shower or change clothes, which is necessary to work at the factory, and it likely helped ruin millions of Covid-19 cans from Johnson & Johnson’s key committee.

Inspections of the Bayview facility carried out last year also revealed mold problems, poor disinfection of facility equipment and inadequate staff training, employees of the selected coronavirus crisis subcommittee said in the memo. The committee is holding a hearing on Wednesday examining the biopharmaceutical company’s role in the destruction of the J&J recordings.

Although inspectors found poor conditions at the plant, top executives received hundreds of thousands of dollars in bonuses last year and were commended for their leadership by the company’s board of directors. This is evident from other documents published by the committee.

According to one document, aspiring CEO Robert Kramer received a bonus of $ 1.2 million last year, while three other executives received payments of more than $ 400,000.

The U.S. government awarded the company a $ 628 million contract to manufacture coronavirus vaccines last year.

Emergent did not immediately respond to CNBC’s request for comment.

Wednesday’s hearing comes more than a month after the Biden government hired J&J to run the Baltimore plant after US officials learned that Emergent, a federal company that makes key ingredients for J&J and AstraZeneca had produced contaminated contaminated ingredients for the two shots.

During the hearing, Kramer said the FDA is holding over 100 million J&J Covid-19 vaccine doses for further testing.

“There are a significant number of doses that we have manufactured. Here, too, we manufacture the mass drugs,” Kramer told the legislature. “It has been reported by a number of news outlets that there are likely over 100 million doses of the J&J vaccine we make that are now under FDA review for possible release and availability.”

An inspection by the Food and Drug Administration later revealed that the facility was unsanitary and unsuitable for making the shots. In a 13-page report, the inspectors wrote that the facility used to manufacture the vaccine “was not kept in a clean and sanitary condition” and “was not of the appropriate size, design and location for cleaning, maintenance and to facilitate proper operation. “”

FDA inspectors said they observed paint peeling in multiple areas and damaging walls, which could affect “Emergent’s ability to adequately clean and disinfect”. They also found that when handling waste or materials used to make vaccines, employees did not follow standard operating procedures to ensure they were not contaminated.

The facility has not been approved by the FDA to manufacture or distribute Johnson & Johnson’s Covid-19 vaccine, and none of the factory-made doses have been marketed for use in the United States. Emergent has agreed to cease production of materials until the issues identified by the FDA are resolved.

Emergent said at the time it was required to work with the FDA and J&J to resolve the issues.

“While we are never satisfied with defects in our production facilities or processes, these can be corrected and we will take quick action to correct them,” it said in a statement on April 21.

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Health

FDA finds poor situations at Baltimore plant that ruined J&J doses

A detail of Janssen Johnson & Johnson’s COVID-19 vaccine that is not currently being issued because it has been on hold.

Allen J. Cockroaches | Los Angeles Times | Getty Images

The Food and Drug Administration said Wednesday a facility in Baltimore that ruined millions of Johnson & Johnson Covid-19 vaccine doses was unsanitary and unsuitable for making the shots.

The FDA asked Emergent BioSolutions, which operates the facility, to temporarily suspend production of materials for Covid-19 vaccines earlier this month as the U.S. agency initiated an inspection.

“The company has not adequately trained personnel involved in manufacturing operations, quality control sampling, weighing and dispensing, and engineering operations to prevent drug cross-contamination,” FDA investigators wrote in the report.

The eight-day inspection earlier this month revealed a number of alarming quality issues throughout the facility.

In a 13-page report, the inspectors wrote that the facility used to manufacture the vaccine “was not kept in a clean and sanitary condition” and “was not of the appropriate size, design and location for cleaning, maintenance and to facilitate proper operation. “”

FDA inspectors said paint was peeling in multiple places and walls were damaged, which could affect the facility’s “ability to adequately clean and disinfect.” They also found that when handling waste or materials used to make vaccines, employees did not follow standard operating procedures to ensure they were not contaminated.

The facility has not been approved by the FDA to manufacture or distribute Johnson & Johnson’s Covid-19 vaccine, and none of the doses manufactured at this facility have been marketed for use in the United States.

In a statement, J&J said it had “stepped up its oversight of drug manufacturing at the Emergent BioSolutions Bayview facility, including additional controls and personnel, to ensure that the quality standards of our company and the US Food & Drug Administration ( FDA) are complied with. “”

“Johnson & Johnson will exercise its regulatory authority to ensure that all FDA observations are promptly and fully considered,” it said.

Robert Califf, former FDA commissioner under the Obama administration, said that while the problems at the Baltimore plant appear “troubling”, manufacturing issues are emerging and one reason FDA oversight is so important.

“Supply chain and manufacturing are really complicated issues, but that’s why you need an FDA and inspections, and it’s the shared responsibility of the FDA and the companies themselves,” he told CNBC in a telephone interview.

Earlier this month, the Biden administration hired J&J to run the Baltimore facility after US officials learned that Emergent, a contract manufacturer that made vaccines for J&J and AstraZeneca, mixed the ingredients for the two shots would have. Officials also stopped production of the AstraZeneca vaccine.

The interruption in production of new materials is the most recent setback for J & J. Last week, the FDA and Centers for Disease Control and Prevention advised states to temporarily discontinue use of J & J’s vaccine “out of caution” after six Women had developed a rare but potentially life-threatening bleeding disorder in which one person was dead and one was in critical condition. A key CDC panel is due to meet on Friday to make a recommendation on how to use the vaccine.

The FDA said Wednesday that its actions at the Baltimore facility had nothing to do with the ongoing evaluation of the coagulation cases.

This is a developing story. Please try again.

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Health

FDA asks Emergent plant to pause manufacturing throughout probe of botched Covid vaccines

The Emergent BioSolutions facility, a manufacturing partner for Johnson & Johnson’s Covid-19 vaccine, on April 9, 2021 in Baltimore, Maryland.

Saul Loeb | AFP | Getty Images

The Food and Drug Administration has asked Emergent BioSolutions to temporarily suspend production of materials for Covid-19 vaccines while U.S. regulators investigate their Baltimore plant, responsible for the destruction of millions of Johnson & Johnson shots, shared Emergent in a registration application filed on Monday.

The FDA initiated an inspection of the facility on April 12, asking the company to stop production four days later until the review and remediation was complete. In a filing with the Securities and Exchange Commission, the company also said it had quarantined all material produced at the facility.

Emergent stocks were down more than 9% on the news.

In a statement to CNBC, J&J said it would work with Emergent and the FDA “to clarify any results after the FDA inspection is complete”.

“Our goal remains to ensure that all drug substances for our COVID-19 vaccine meet our high quality standards and receive emergency use approval for drug substances manufactured in Emergent Bayview,” the company said. “At this point it is premature to speculate about the potential impact this may have on the timing of our vaccine shipments.”

Earlier this month, the Biden administration hired J&J to run the Baltimore facility after US officials learned that Emergent, a contract manufacturer that made vaccines for J&J and AstraZeneca, mixed the ingredients for the two shots would have. Officials also stopped production of the AstraZeneca vaccine.

The government’s move to let the facility manufacture only the J&J single-dose vaccine is intended to avoid future confusion, the New York Times reported, citing two senior federal health officials.

The production hiatus for new materials is the most recent setback for J & J. Last week, the Food and Drug Administration and Centers for Disease Control and Prevention advised states to temporarily “cease” use of J & J’s vaccine, after six women developed a rare but potentially life-threatening bleeding disorder in which one died and one was in critical condition.

The women developed the condition known as cerebral sinus thrombosis within about two weeks of receiving the shot, an official said. CVST is a rare form of stroke that occurs when a blood clot forms in the venous sinuses of the brain. It can eventually leak blood into the brain tissue and cause bleeding.

J.& J has privately asked Covid-19 vaccine rivals Pfizer and Moderna to participate in a study examining the risk of blood clots. The companies refused, however, the Wall Street Journal reported on Friday, citing people familiar with the matter.

–Reuter contributed to this report.

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Politics

Prime Official Warned That Covid Vaccine Plant Needed to Be ‘Monitored Intently’

Mr de Notaristefani, a former executive at two large pharmaceutical companies, cited “significant” staffing problems and wrote that plans to increase staff were “insufficient to enable the company to produce at the required speed”.

He also noted that audits by the FDA and individual companies hiring Emergent “highlighted the need for extensive staff training and strengthening the quality function.”

Nevertheless, he wrote: “The organization has the necessary experience / competence” to enlarge its production. He wrote that “the management is knowledgeable and appears confident” and that with adequate government oversight, “risks can be mitigated”.

At the time of the visit, Emergent was also planning to manufacture a third Covid-19 vaccine developed by Novavax. Since then, this company has partnered with another manufacturer. “Offloading the Novavax program to another facility will also help ease the burden on Emergent Bayview,” wrote de Notaristefani.

Emergent is a longtime federal entrepreneur in the biological defense field. Sales of its anthrax vaccines accounted for nearly half of Strategic National Stockpile’s annual budget of half a billion dollars for most of the past decade, The Times reported last month. This left the government with less money on items needed during a pandemic, and last year the lack of basic health care in inventory became a symbol of the government’s botched coronavirus response.

Although the original federal contract for the Baltimore plant required Emergent to demonstrate large-scale manufacture of a pandemic influenza vaccine – designated by health officials as a pressure test of its capabilities – Emergent had yet to do so, The Times reported Tuesday. The company risked default on the original contract, which set a deadline of June 2020. The company also has separate agreements with the two vaccine makers valued at more than $ 875 million.

In an effort to solve the factory’s problems, federal officials have simplified Emergent’s mission by limiting themselves to just making Johnson & Johnson’s vaccine and forcing AstraZeneca to relocate their production lines. Johnson & Johnson now also maintains direct control of manufacturing, although the workforce at the facility in southeast Baltimore remains with Emergent.

Categories
Politics

U.S. Faucets Johnson & Johnson to Run Troubled Vaccine Plant

WASHINGTON – The Biden government on Saturday hired Johnson & Johnson to manage a troubled Baltimore manufacturing facility that ruined 15 million doses of the Johnson & Johnson coronavirus vaccine and prevented the facility from producing another vaccine from AstraZeneca manufacture.

The Department of Health and Human Services’ extraordinary move came just days after officials learned that Emergent BioSolutions, a contract manufacturer that makes both Johnson & Johnson and AstraZeneca’s vaccines, was mixing the ingredients in the two, which regulators did delayed the approval of the plant’s production lines.

By outsourcing the AstraZeneca vaccine, according to two senior federal health officials, the facility can be dedicated solely to Johnson & Johnson’s single-dose vaccine to avoid future breakdowns.

The Department of Health and Human Services directed Johnson & Johnson to establish a new leadership team to oversee all aspects of manufacturing and manufacturing at the Emergent Baltimore facility. The company said in a statement that it took “full responsibility” for the vaccine manufactured at the Emergent facility.

Given President Biden’s aggressive efforts to have enough doses for every adult by the end of May, federal officials fear the mix-up will undermine public confidence in Covid-19 vaccines. The AstraZeneca vaccine in particular has raised safety concerns. Germany, France and other European nations have temporarily discontinued use in some vaccine recipients after reports of rare cerebral blood clots.

The ingredient mix-up and the government move on Saturday is a major setback and PR debacle for Emergent, a Maryland-based biotech company that has built a profitable business by working with the federal government, largely selling its own Anthrax vaccines against the Strategic National Stockpile.

An Emergent spokesman declined to comment, except that the company will continue to manufacture AstraZeneca cans until it receives a contract amendment from the federal government.

Unlike Johnson & Johnson, AstraZeneca does not yet have an emergency approval from the Food and Drug Administration for its vaccine. With three federally approved vaccines (the other two are from Pfizer-BioNTech and Moderna), it’s not clear whether the AstraZeneca vaccine, which has had regulatory issues in the past, could even get approved in time to meet U.S. needs .

However, one of the federal officials said the Department of Health and Human Services is discussing working with AstraZeneca to adapt its vaccine to fight new coronavirus variants. AstraZeneca said in a statement that it would work with the Biden administration to find a new location to manufacture its vaccine.

To date, none of the Johnson & Johnson cans manufactured by Emergent have been cleared for distribution by the FDA. Officials have stated that it could take weeks to find out if other batches of vaccine were contaminated and that FDA inspectors are determining if the emergent facility can be cleared to release the doses it made.

Updated

April 3, 2021, 9:22 p.m. ET

Acting FDA commissioner, Dr. Janet Woodcock said in a statement on Saturday that the agency “takes its responsibility for ensuring the quality of manufacturing of vaccines and other medical products for use during this pandemic very seriously”.

However, she made it clear that the ultimate responsibility would rest with Johnson & Johnson, saying, “It is important to note that even if companies employ contract manufacturing companies, the ultimate responsibility lies with the company that has the emergency use authorization to do so ensure FDA quality standards are met. “

In another agreement brokered by the Biden administration last month, Johnson & Johnson is now working with Merck, one of the world’s largest vaccine manufacturers. Officials said Merck would help manage the Baltimore facility.

Emergent’s Baltimore facility is one of two federally designated “Centers for Innovation in Advanced Development and Manufacturing” and was built with taxpayer support. Last June, the Emergent government paid $ 628 million to reserve space as part of Operation Warp Speed, the Trump administration’s rapid initiative to develop coronavirus vaccines.

Johnson & Johnson and AstraZeneca both signed a contract with Emergent to use the space. Both vaccines are called live virus vector vaccines, which means they use a modified, harmless version of another virus as a vector or carrier to deliver instructions to the body’s immune system. The Johnson & Johnson vaccine is given in one dose, AstraZeneca in two doses.

Experts in vaccine manufacturing said the FDA has historically had a policy of preventing such mishaps by not allowing a plant to make two live viral vector vaccines as it can lead to mix-ups and contamination.

Last month, Mr Biden canceled a visit to the Emergent Baltimore plant, and his spokeswoman announced that the administration would conduct an audit of the Strategic National Stockpile, the country’s emergency medical reserve. Both measures came after an investigation by the New York Times that looked at how the company had gained oversized influence on the repository.