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Social Inequities Clarify Racial Gaps in Pandemic, Research Discover

When Dr. Gbenga Ogedegbe began researching coronavirus infections in black and Hispanic patients, believed he knew what to find. Infected black and Hispanic patients would be hospitalized and dying more often compared to white patients.

But that’s not how it turned out.

Dr. Ogedegbe, the director of the Department of Health and Behavior at New York University’s Grossman School of Medicine, and colleagues reviewed the medical records of 11,547 patients in NYU’s Langone Health system between March 1 and April 8 have been tested for coronavirus infections.

After considering various differences, Dr. Ogedegbe found that infected black and Hispanic patients were no more hospitalized than white patients. Black patients had a slightly lower risk of death in the hospital.

“We were surprised,” said Dr. Ogedegbe.

The study was published in the journal JAMA Network Open. Three other recent large studies have come to similarly surprising results.

The new findings don’t contradict a massive body of research showing that black and Hispanic Americans are more likely to be affected by the pandemic compared to whites. Coronavirus is more prevalent in minority communities, and infections, diseases and deaths have emerged in disproportionate numbers in these groups.

However, the new studies suggest that there is no innate susceptibility to the virus in Black and Hispanic Americans, said Dr. Ogedegbe and other experts. Instead, these groups are more exposed due to social and ecological factors.

“We hear this all the time – ‘Blacks are more susceptible,'” said Dr. Ogedegbe. “It’s all about the exposure. It’s about where people live. It has nothing to do with genes. “

Black and Hispanic communities and households tend to be overcrowded, along with many other security vulnerabilities. Many people work in jobs that require frequent contact with others and rely on public transport. Access to health care is poorer than that of white Americans, and the basic conditions are much higher.

“To me, these results make it clear that the differences in mortality we see are even more appalling,” said Jon Zelner, an epidemiologist at the University of Michigan who led one of the new studies.

The toll on Black and Hispanic Americans “could easily have been alleviated before the pandemic through a less worn and gruesome approach to social welfare and health care in the US,” he added. “Even if it hadn’t worked, so much of it could have been avoided.”

For example, the federal government could have protected citizens from risky work situations by providing income subsidies that allowed them to stay at home, said Dr. Zelner. The government could have provided workers in nursing homes and long-term care facilities with adequate protective equipment.

Dr. From March to June, Zelner and his colleagues examined data on 49,701 coronavirus patients in Michigan who were and were not hospitalized. In this population, the death rate in black and white patients was the same: 11 percent.

(The high rate reflects the fact that Michigan incidence was dominated by the elderly at the beginning of the epidemic, Dr. Zelner said. The data pertains to detected cases rather than all infections during that period, when it was much less Tests gave.)

A study of patients in Veterans Affairs hospitals led by Dr. Christopher Rentsch of the London School of Hygiene and Tropical Medicine and VA researchers analyzed the health records of more than five million patients in more than 1,200 facilities.

About 16,317 tested positive for the coronavirus. Dr. Rentsch found that among them there was no difference in the death rate between white, black, or Hispanic patients.

The researchers had expected that underlying health conditions would result in higher death rates in Black and Hispanic patients, who are more likely to suffer from obesity and high blood pressure, which increase their risk for severe Covid-19.

However, when analyzing the death rate, these conditions “hardly moved,” said Dr. Rentsch. However, overall health differences between VA patients by race tend to be smaller than that of Americans, he warned.

A New Orleans study led by Dr. Eboni Price-Haywood, director of the Ochsner Center for Outcomes and Health Services Research, included the 3,481 patients who tested positive for the coronavirus between March 1 and April 11.

She and her colleagues found that black and white patients had the same death rate.

“It’s always confusing when people read the paper,” said Dr. Price-Haywood in an interview. But, she added, when someone was sick enough to be hospitalized, race became irrelevant.

“If you were fragile enough to be admitted, you were fragile enough to die,” said Dr. Price-Haywood.

The four studies confirmed large differences in the incidence of coronavirus infections between minority and white patients.

In the study by Dr. Ogedegbe, black and Hispanic patients were 60 to 70 percent more likely than whites to get infected. In research in Michigan, the incidence of infection in blacks was four times higher than that of whites.

“If you were to replace the white incidence rates with the black, it would reduce mortality by 83 percent,” said Dr. Zelner.

In the VA study, nine out of 1,000 white veterans had a positive coronavirus test, compared with 16.4 out of 1,000 for black patients. In New Orleans, black patients made up 76.9 percent of patients hospitalized with Covid-19, even though they made up only 31 percent of the healthcare system population.

These differences are fully explained by socioeconomic factors, researchers said.

“The bigger problem is the role of social determinants of health,” said Dr. Price-Haywood. “Race is a social construct, not a biological one.”

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Health

For a Nation on Edge, Antacids Turn into Exhausting to Discover

At first it was toilet paper. Then it was meat.

Now it’s antacids.

People who search for over-the-counter belly pacifiers online or in stores are finding that parts of the country cannot simply buy antacids like tums, pepcid, and the generic version famotidine. A few weeks ago Wegmans Food Markets took the step of restricting buyers to two packets of famotidine products per trip.

During a hoarding pandemic, this can be the most unexpected.

Americans are stressed out. They are concerned about the rising number of coronavirus cases. They care about their work. Distance learning is a nightmare, and grocery shopping is no walk in the park. Not to mention the elections. And now the holidays are coming. The result is that some people are experiencing “pandemic stomach,” acid-generating episodes that increase the demand for over-the-counter and prescription antacids.

And antacids are also popular with people who are new to indigestion or heartburn. People started stocking up on them after preliminary studies suggested that famotidine could relieve symptoms of the coronavirus. Another wave of purchases hit this fall when President Trump was under treatment for coronavirus and White House officials said he was given famotidine along with zinc and vitamin D.

For those in need of relief, the bottlenecks are insane.

When 24-year-old Maia Callahan, a young early education graduate who teaches families and teaches distance learning in Greenfield, Massachusetts, attempted to put her usual order of Pepcid in her online Stop & Shop shopping cart in early September, it said again and again that the product is out of stock.

“I thought, OK, I’m going to place an order through Amazon,” said Ms. Callahan, who has an autoimmune disease and has been taking medication to treat her heartburn since she was 17. “That was the worst. One of the heartburn drugs was three times as expensive as usual. I took Tums for two weeks.”

Doctors said when the quarantines were lifted this spring, they noticed more patients reporting symptoms of heartburn and acid reflux.

“I think part of that is the stress of everything that’s going on in the world,” said Dr. Lauren Bleich, a gastroenterologist in Acton, Massachusetts, about 25 miles northwest of Boston, who said she saw a 25 percent increase in patients reporting heartburn and similar symptoms.

But she also said that the coronavirus, which has uprooted people’s normal lives and forced many to work from home, has led to many “dietary indiscretions” that trigger these symptoms.

“We are more relaxed than before with alcohol, sweets or our comfort food,” said Dr. Pale. “And then there is a lack of activity or movement. Weight gain definitely contributes to heartburn and acid reflux. “

Another perpetrator appeared in early November.

“We had many people with upset stomachs, heartburn and indigestion related to the elections,” she said.

Dr. Atul Maini, the medical director of the Heartburn Center at St. Joseph’s Health in Syracuse, NY, said that while the specialized center did not see an increase in patients, it did see a huge difference between the patients it has treated since the coronavirus quarantines have been lifted.

“The heartburn patients were now very anxious and depressed,” he said. “Something else had changed.”

Companies that make over-the-counter drugs are trying to meet demand.

“We are aware that there may be supply shortages,” said a spokeswoman for GlaxoSmithKline, which manufactures Tums, in an email.

However, for some antacids, the surge in demand may be linked to various preliminary studies suggesting that famotidine, the main ingredient in Pepcid, may reduce symptoms of the coronavirus.

In the spring, some patients with Covid-19 at Northwell Health in the New York City area received intravenous famotidine as part of a clinical trial following reports of use in China. The study was halted in May as patient volumes decreased and no conclusions were drawn. An observational study published earlier this fall by Hartford Hospital in Connecticut found positive results were also seen in coronavirus patients given famotidine.

Of the roughly 900 Hartford Hospital patients treated for coronavirus this spring, 83 were given famotidine at some point during their hospital stay. Those who received famotidine had lower hospital death rates and needed less help breathing a ventilator, the hospital said in its research report.

Still, the medical community is cautious about early results. In late June, the Infectious Diseases Society of America recommended the use of famotidine unless it was done in a clinical trial due to insufficient data.

Even before the preliminary research reports were published, demand for famotidine and Pepcid had risen sharply after the Food and Drug Administration asked companies to stop selling all forms of the heartburn drug Zantac in April and recommended consumers take it over the counter have version known as ranitidine, stop that. Small amounts of a carcinogenic chemical have been found in samples of the drug.

As consumers and doctors switched from Zantac to generic famotidine and pepcid, drug makers struggled to keep up. Some manufacturers reported drug shortages to the FDA earlier this year.

Johnson & Johnson, makers of Pepcid, did not respond to a request for comment. In July, company executives announced that US over-the-counter drug sales rose 30 percent in the second quarter, driven by strong demand for Tylenol, Pepcid, and other adult products.

For those who have taken Pepcid or generic versions of Famotidine, the past few months have been a struggle.

“I got a bottle in February but haven’t had one since,” said Mackenzie Doyle, a 21-year-old student at the University of Nebraska at Lincoln who is taking Pepcid with prescription strength to treat her immune disease. It will also be difficult to find over-the-counter Pepcid this spring, she said. When she visited her parents in Alabama during the spring break, Pepcid was sold out in the four stores she visited.

“When the first round of panic buying went on, it was impossible to find Pepcid,” said Ms. Doyle, who eventually found a generic famotidine at Walgreens and took double the dose to reach her prescription strength.

Ms. Doyle admits she has mixed feelings about the pre-studies on famotidine and coronavirus. While assisting the research, she wonders if the names of the drugs used could be withheld until more became known.

And then there are the just-in-case hoarders.

“They make me a little angry,” said Ms. Doyle. “There are so many people who have my immune disorder and who are worse than me and who need these drugs to stay alive. Having people buy it and keep it in their bathroom cabinet and never open the bottle makes me nervous. “