Categories
World News

Covid-19 and Vaccine Information: Dwell International Updates

Here’s what you need to know:

Credit…Atul Loke for The New York Times

As a second wave of the pandemic rages in India, which set a global record new cases for the fifth consecutive day on Monday, countries around the world are trying to help. But their efforts to send oxygen and other critical aid are unlikely to plug enough holes in India’s sinking health care system to end its deadly catastrophe.

The Indian health ministry reported almost 353,000 new cases and 2,812 deaths on Monday. Enormous funeral pyres have spilled into parking lots and city parks. Experts say that India’s reported overall toll of more than 195,000 deaths could be a vast undercount.

The emergency in India, where a worrying virus variant is spreading rapidly, has global implications for potential infections worldwide, as well as for countries relying on India for the AstraZeneca vaccine, millions of doses of which are manufactured there.

“It’s a desperate situation out there,” said Ramanan Laxminarayan, the founder and director of the Center for Disease Dynamics, Economics & Policy, adding that donations will be welcome, but may make only a “dent on the problem.”

Scientists fear that part of the problem is the emergence of a virus variant known as the “double mutant,” B.1.617, because it contains genetic mutations found in two other difficult-to-control versions of the coronavirus. One of the mutations is present in the highly contagious variant that ripped through California earlier this year. The other mutation is similar to one found in the variant dominant in South Africa and is believed to make the virus more resistant to vaccines.

Still, scientists caution it is too early to know with certainty how pernicious the new variant emerging in India really is.

In the early months of 2021, the government of Prime Minister Narendra Modi acted as if the coronavirus battle had been won, holding huge campaign rallies and permitting thousands to gather for a Hindu religious festival.

Now, Mr. Modi is striking a far more sober tone. He said in a nationwide radio address on Sunday that India has been “shaken” by a “storm.” And countries, companies and powerful members of the diaspora have pledged to pitch in.

Patients are suffocating in the capital, New Delhi, and other cities because hospitals’ oxygen supplies have run out. Frantic relatives have appealed on social media for leads on intensive-care-unit beds and experimental drugs. The government has extended New Delhi’s lockdown by another week.

India’s Supreme Court last week ordered the government to come up with a “national plan” for distributing oxygen supplies.

The problems in India’s hospitals go beyond oxygen shortages. In the western state of Gujarat, more than a dozen patients were evacuated from a hospital on Sunday night after an air-conditioning unit caught fire, the Press Trust of India reported, the third accident involving virus patients in India in the past seven days.

Mr. Modi appears to be looking to the rest of the world to help India quell the wave. Saudi Arabia and the United Arab Emirates have promised oxygen generators. The United States has pledged raw material for coronavirus vaccines and intends to share up to 60 million doses of the AstraZeneca vaccine with other nations, so long as the doses clear a safety review conducted by the Food and Drug Administration, officials said Monday. Indian-American businessmen have pledged millions in cash from the companies they lead.

At a news conference on Monday, Dr. Tedros Adhanom Ghebreyesus, the director general of the World Health Organization, called the situation in India “beyond heartbreaking.” He said the organization has deployed 2,600 staff to India to provide surveillance and vaccination help.

A global coronavirus surge, driven largely by the devastation in India, continues to break daily records and run rampant in much of the world, even as vaccinations ramp up in wealthy countries. More than one billion shots have now been administered globally.

On Sunday, the world’s seven-day average of new cases hit 774,404, according to a New York Times database, higher than the peak average during the last global surge, in January. Despite the number of shots given around the world, far too small a percentage of the global population of nearly eight billion have been vaccinated to slow the virus’s steady spread.

United States › United StatesOn Apr. 25 14-day change
New cases 33,662 –16%
New deaths 282 –3%
World › WorldOn Apr. 25 14-day change
New cases 378,263 +15%
New deaths 7,655 +4%

U.S. vaccinations ›

Where states are reporting vaccines given

People getting vaccinated at a government hospital in Mumbai, India, this month.Credit…Atul Loke for The New York Times

President Biden, under intense pressure to do more to address the surging pandemic abroad, including a humanitarian crisis in India, intends to make up to 60 million doses of the AstraZeneca vaccine available to other countries, so long as federal regulators deem the doses safe, officials said Monday.

The announcement came after Mr. Biden spoke with Prime Minister Narendra Modi of India and the two pledged to “work closely together in the fight against Covid-19.” It is a significant, albeit limited, shift for the White House, which has until now been reluctant to make excess doses of coronavirus vaccine available in large amounts.

But the commitment is a tricky one to make: The AstraZeneca doses are manufactured at the Baltimore plant owned by Emergent BioSolutions, where production has been halted amid fears of contamination. The New York Times has reported extensively on problems at the plant, which had to throw out millions of doses of AstraZeneca vaccine between October and January, and later discarded up to 15 million doses of the vaccine developed by Johnson & Johnson, also because of concern about possible contamination.

AstraZeneca’s vaccine, unlike those of Pfizer, Moderna and Johnson & Johnson, has also not been granted emergency use authorization by the Food and Drug Administration. And the administration would not specify which countries will receive the vaccine.

Jen Psaki, the White House press secretary, cautioned at a news conference that the donations of doses would not happen right away. She said about 10 million doses could be released “in the coming weeks” if the F.D.A. determines that the vaccine meets “our own bar and our own guidelines,” and that another 50 million doses are in various stages of production.

“Right now we have zero doses available of AstraZeneca,” Ms. Psaki said.

In a statement, a spokesperson for AstraZeneca said that the company would not comment on specifics but that “the doses are part of AstraZeneca’s supply commitments to the U.S. government. Decisions to send U.S. supply to other countries are made by the U.S. government.”

Correction: April 26, 2021

An earlier version of this article referred incorrectly to a safety review that the Food and Drug Administration is required to conduct before AstraZeneca coronavirus vaccine doses are shared with other nations. The doses themselves must clear an F.D.A. safety review, not the plant where the doses are manufactured.

A Sputnik V vaccine production line in Saint Petersburg, Russia in February. Brazil’s health regulator rejected the Sputnik Covid-19 vaccine on Monday, citing safety concerns.Credit…Emile Ducke for The New York Times

Brazil’s health authority, Anvisa, said late on Monday that it would not recommend importing Sputnik V, the Covid-19 vaccine developed by Russia.

Anvisa said that important safety tests had not been performed, and that questions remained about the vaccine’s development, safety and manufacturing.

Data about the vaccine’s efficacy were “uncertain,” Gustavo Mendes Lima Santos, Anvisa’s manager of medicine and biological products, said in a lengthy presentation explaining the health authority’s decision.

A tweet from the official Sputnik V Twitter account — in Portuguese — pushed back on Monday, saying that the vaccine’s developers had shared “all the necessary information and documentation” with Anvisa. In another tweet, it urged Anvisa that “we have no time to waste — let us start saving lives in Brazil. Together.”

Russia is using Sputnik V in its mass vaccination campaign, and the vaccine has been approved for emergency use in dozens of other countries. Its rollout has been entangled in politics and propaganda, with President Vladimir V. Putin announcing its approval for use even before late-stage trials began. For months, it was pilloried by Western scientists.

The Gamaleya Research Institute, part of Russia’s Ministry of Health, developed the vaccine, also known as Gam-Covid-Vac. A peer-reviewed study published in The Lancet in February said the vaccine had an efficacy rate of 91.6 percent.

Skepticism from Western experts has focused mostly on its early approval, not the vaccine’s design, which grew out of decades of research on adenovirus-based vaccines. Other Covid-19 vaccines are also based on adenoviruses, such as one from Johnson & Johnson using Ad26, and one by the University of Oxford and AstraZeneca using a chimpanzee adenovirus.

While Sputnik V’s developers have yet to release detailed data on adverse events observed during the trials, the Russian government has been using the vaccine to inoculate its own citizens for months. Russia has also exported Sputnik V to Belarus, Argentina and other countries, suggesting that any harmful side effects overlooked during trials would by now have come to light.

As vaccine supply woes in Europe worsened, the European Union’s drug regulator announced last month that it was reviewing the Sputnik V vaccine after member nations began announcing they would acquire the shot on their own.

Video

transcript

Back

transcript

E.U. Sues AstraZeneca

The European Union has sued AstraZeneca over its failure to deliver hundreds of millions of Covid vaccination doses by the end of June as promised.

Indeed, the commission has started last Friday a legal action against the company AstraZeneca on the basis of breaches of the advance purchase agreement. The reason indeed being that the terms of the contract or some terms of the contract have not been respected, and the company has not been in a position to come up with a reliable strategy to ensure the timely delivery of those. What matters to us in this case is that we want to make sure that there’s a speedy delivery of a sufficient number of doses that the European citizens are entitled to and which have been promised on the basis of the contract. So the commission has indeed started legal action on its own behalf and on behalf of the 27 member states that are fully aligned in their support for this procedure.

Video player loadingThe European Union has sued AstraZeneca over its failure to deliver hundreds of millions of Covid vaccination doses by the end of June as promised.CreditCredit…Alessandro Grassani for The New York Times

The European Union has sued AstraZeneca over what the bloc has described as delays in shipping hundreds of millions of doses of coronavirus vaccines, a sharp escalation of a longstanding dispute between the bloc and the maker of one of the world’s most important vaccines.

AstraZeneca has said that it would be able to deliver only a third of the 300 million doses that European officials had been expecting by the end of June. As a result, European officials said on Monday that they believed AstraZeneca had broken its contract, and that they were seeking speedier deliveries than the company said it could muster.

The two sides’ relationship had grown acrimonious in January when AstraZeneca slashed its expected deliveries for the first quarter of the year, setting back the bloc’s vaccination campaign by weeks as cases picked up across the continent and political leaders faced scorching criticism for inadequate planning.

For AstraZeneca, whose cheap and easy-to-store shot is being used by 135 countries, the lawsuit could create further difficulties in a bruising stretch. No company had been as instrumental in the race to vaccinate poorer countries around the world, but AstraZeneca has been buffeted in recent weeks by the discovery of an exceedingly rare, though serious, side effect that has prompted restrictions on its use in parts of Europe.

At issue in the legal dispute was whether AstraZeneca had done everything in its power to meet its delivery schedule. Pascal Soriot, the company’s chief executive, has said that the contract required only that it make its “best efforts” to deliver the purchased doses on time.

Vaccine production is a notoriously fickle science, with live cultures needing time to grow inside bioreactors, for instance. In an effort to supply doses not only to richer nations that had purchased them well in advance, but also to poorer nations, AstraZeneca had partnered with manufacturing sites around the world, rather than relying on only a few factories, as Pfizer and Moderna have.

AstraZeneca, which developed the vaccine with the University of Oxford, has also said that the European Commission, the bloc’s executive branch, finalized its contract months after Britain did, giving the company less time to iron out any manufacturing difficulties.

Legal experts said that the “best efforts” language in the contract raised the burden on the Europeans to prove that AstraZeneca did not act diligently enough to supply the promised doses. But they also said that it did not entirely insulate the company from being deemed in breach of contract.

GLOBAL ROUNDUP

Men walk on an empty street after a coronavirus curfew in Istanbul, Turkey, on Thursday.Credit…Chris Mcgrath/Getty Images

President Recep Tayyip Erdogan of Turkey ordered a national lockdown for three weeks, closing nonessential businesses and sending all students home, as the nation struggles to contain the latest surge in cases of the coronavirus.

Turkey ranks fourth in the world in new daily cases per person, averaging 63 cases per 100,000 people, according to a New York Times database. Its seven-day average for deaths ranks 11th in the world.

The lockdown starts on April 29 and will end on May 17, coinciding with Eid al-Fitr, the end of the holy month of Ramadan, Mr. Erdogan said after meeting with his cabinet. Schools and restaurants will close and travel within Turkey will require a permit, he said. Government employees will either work from home or in shifts. Essential businesses like those in the food, manufacturing and health sectors will be exempt, Mr. Erdogan said.

“In a period where Europe is opening up, we have to pull the number of cases’’ lower, Mr. Erdogan said. “Otherwise, it would be inevitable to face a heavy cost from tourism to trade to education.’’

So far, about 16 percent of its total population has received at least one dose of the vaccine from Sinovac or Pfizer-BioNTech, according to data from the Our World in Data project at the University of Oxford.

Turkey reported about 63,000 new cases on April 16, its highest daily tally since the start of the pandemic.

In other updates from around the world:

  • Brazil’s health regulator rejected the use of Russia’s Sputnik V vaccine late on Monday, citing “inherent risks” and a lack of information about the vaccine’s safety and quality, Reuters reported.

  • The governments of Singapore and Hong Kong said on Monday that a long-delayed travel bubble between the two Asian financial centers would begin next month, allowing travelers on designated flights to bypass quarantine. The travel arrangement, which was originally supposed to begin last November, was suspended at the last minute when Hong Kong experienced a sudden surge in cases.

  • The Philippines surpassed the one million mark on Monday in the total number of coronavirus cases it has reported, as the country struggles with newer, deadlier forms of the virus. The Philippines reported very few cases last year, and did not see a significant surge until recently. In response, Manila and four other suburbs went into lockdown earlier this month.

  • For the first time in nearly nine months, Portugal’s health authority on Monday reported no coronavirus-related deaths in the last 24 hours, according to Reuters. Portugal has reported nearly 17,000 Covid-19 deaths and more than 830,000 cases.

  • Health authorities in Germany will allow all adults to sign up for vaccine appointments beginning in June, Chancellor Angela Merkel said on Monday. The announcement came after a meeting with lawmakers to discuss lifting social restrictions for fully vaccinated people, a sign that Germany may be moving closer to emerging from its latest lockdown.

  • More than 78,000 people attended an Australian rules football match in Melbourne on Sunday night in what is believed to be the world’s biggest crowd at a sporting event since the coronavirus pandemic began. Just three days earlier, the government of the state of Victoria, of which Melbourne is the capital, had increased the attendance cap for the 100,000-capacity venue, the Melbourne Cricket Ground, to 85 percent from 75 percent.

A pub in Glasgow, Scotland on Monday.Credit…Andy Buchanan/Agence France-Presse — Getty Images

Scotland and Wales reopened restaurants, cafes, and nonessential shops on Monday, marking the next phase of a gradual relaxation of coronavirus restrictions that have been in place for months.

In Scotland, restaurants can serve food but not alcohol indoors until 8 p.m., and they can serve food and alcohol outdoors without restrictions. Stores, beauty salons, museums and galleries also reopened, and people are permitted to book travel in the rest of Britain.

The first minister of Scotland, Nicola Sturgeon, said she was hopeful that the country would continue its progress and lift more restrictions by the summer. But she cautioned that the virus was more infectious now than it had been in earlier waves and, therefore, “We must stick to the rules.” Free rapid tests will be available to the public.

In Wales, places of worship and retail stores reopened, and restaurants resumed outdoor service. Outdoor wedding receptions with up to 30 people can take place.

Cases remain low in Britain, with more than 40 percent of the population having received at least one dose of a vaccine. On Sunday, the country reported just over 1,700 new cases and 11 deaths, according to a New York Times database.

Health care workers prepared doses of a Covid-19 vaccine in Buffalo, W.Va., last month. Gov. Jim Justice announced a plan to give savings bonds to young people who get vaccinated.Credit…Stephen Zenner/Getty Images

West Virginia will give $100 savings bonds to 16- to 35-year-olds who get a Covid-19 vaccine, Gov. Jim Justice said on Monday.

There are roughly 380,000 West Virginians in that age group, many of whom have already gotten at least one shot, but Mr. Justice said he hoped the money would motivate the rest to get inoculated, as “they’re not taking the vaccines as fast as we’d like them to take them.”

The state will use federal funds from the CARES Act to pay for the bonds, Mr. Justice, a Republican, said at a news conference, adding that he had “vetted this every way that we possibly can” to ensure that the unconventional use of the funds was allowed.

The bonds will be also be available to anyone in that age group who has already been vaccinated, Mr. Justice said.

West Virginia has the 16th highest rate of new coronavirus cases per person among U.S. states and ranks 12th in hospitalizations, according to a New York Times database.

Mr. Justice said the state needed to stop the virus “dead in its tracks,” and that if it did, “these masks go away, the hospitalizations go away, the death toll and the body bags start to absolutely become minimal.”

Earlier this year, at the start of the country’s vaccination effort, West Virginia had stood out for its success in vaccinating its residents. At one point, it had administered second doses to more of its population than any other state; it was also behind only Alaska for the percent of its residents that had received a first dose.

But now West Virginia is fallen behind, ahead of only nine states for the portion of its residents that have had a first dose, according to a New York Times database tracking vaccines.

Mr. Justice said that young West Virginians could “always stand an extra dose of patriotism.” He urged them to “accept that wonderful savings bond” — which will allow the recipient to retrieve the $100, plus interest, at a later date — adding, “I hope that you keep it for a long, long, long time.”

State Senator Lora Reinbold of Alaska in Juneau in March.Credit…Pool photo by Becky Bohrer

Alaska Airlines has suspended an Alaska state lawmaker from its flights for violating its mask policies, the company said.

Lora Reinbold, a Republican state senator, was arguing with employees at Juneau International Airport about the airline’s mask rules, according to footage posted on Twitter.

“We need you to pull the mask up, or I’m not going to let you on the flight,” an employee is heard saying to Ms. Reinbold on the videos, which were posted on Thursday.

“It is up,” Ms. Reinbold responds.

“It is not,” an employee says. “It’s down below your nose. We can’t have it down.”

The airline said it had told Ms. Reinbold that she was “not permitted to fly with us for her continued refusal to comply with employee instruction regarding the current mask policy,” adding that the suspension is being reviewed.

The clash over the company’s rule was the latest to surface in the country about masks during the pandemic. Mask mandates have become a rallying cry for some activists and a divisive political talking point. Disputes about the rules have sometimes led to angry confrontations.

The European Union will ease travel restrictions for vaccinated Americans.Credit…Charlie Riedel/Associated Press

U.S. airlines have been bolstered by the return of customers eager to travel within the country or just outside its borders, but the nation’s largest carriers are still lamenting the loss of two particularly lucrative parts of the business: international and corporate travel. At least one of those could rebound this summer.

In an interview with The New York Times over the weekend, Ursula von der Leyen, the president of the European Commission, said she expected the European Union to ease travel restrictions for vaccinated American tourists, a move that could let the airline industry cash in during the year’s busiest travel season.

“Long-haul international flying represents a significant opportunity for United,” Andrew Nocella, the chief commercial officer for United Airlines, told investors last week. “We have seen in recent weeks that immediately after a country provides access with proof of a vaccine, leisure demand returns to the level of 2019 quickly.”

American Airlines and United said this month that international travel remained about 80 percent lower than in 2019. They and other airlines expect strong demand for domestic flights this summer, and the restoration of trans-Atlantic travel could provide the industry a much-needed boost as it works to generate profits again.

American, Delta Air Lines and United each reported a loss of more than $1 billion in the first three months of the year. Southwest Airlines reported a small profit, of $116 million, though its chief executive said the airline would have lost $1 billion without federal aid.

The news of the E.U. reopening to vaccinated American tourists was also welcomed by Willie Walsh, the director general of the International Air Transport Association, a global airline industry group, who said it could bode well for carriers elsewhere, too.

He said in a statement that coordination between the European Commission and the industry was essential “so that airlines can plan within the public health benchmarks and timelines that will enable unconditional travel for those vaccinated,” not just Americans but passengers from other countries as well.

A small number of guests enjoying the pool at a resort in Phuket, Thailand, this month.Credit…Adam Dean for The New York Times

Only a few weeks ago, Phuket seemed poised for a comeback. After a year of practically no foreign tourists arriving in Thailand, the national government decided that Phuket would start welcoming vaccinated visitors in July, without requiring them to go through quarantine. The project was called Phuket Sandbox.

But Thailand is now gripped by its worst Covid-19 outbreak since the pandemic began, spread in part by the well-heeled Thais who partied in Phuket and Bangkok with no social distancing. The confirmed daily caseload — albeit low by global standards — has increased from 26 on April 1 to more than 2,000 three weeks later, in a country that in early December had about 4,000 cases total.

The opening that Phuket had planned for July 1 now appears unlikely, Thailand’s tourism minister acknowledged this month.

“If you ask me how optimistic I am, I cannot say,” said Nanthasiri Ronnasiri, the director of the tourism authority’s Phuket office. “The situation changes all the time.”

The virus’s resurgence after so many months of economic hardship is devastating for the majority of Phuket’s residents, who depend on foreign tourists for their livelihoods.

Centner Academy in Miami sent teachers a letter repeating false claims that being vaccinated made people a health risk. People waited to receive a shot at Miami Dade College.Credit…Lynne Sladky/Associated Press

A private school in the fashionable Design District of Miami sent its faculty and staff a letter last week about getting vaccinated against Covid-19. But unlike institutions that have encouraged and even facilitated vaccination for teachers, the school, Centner Academy, did the opposite: One of its co-founders, Leila Centner, informed employees “with a very heavy heart” that if they chose to get a shot, they would have to stay away from students.

In an example of how misinformation threatens the nation’s effort to vaccinate enough Americans to get the coronavirus under control, Ms. Centner, who has frequently shared anti-vaccine posts on Facebook, claimed in the letter that “reports have surfaced recently of non-vaccinated people being negatively impacted by interacting with people who have been vaccinated.”

“Even among our own population, we have at least three women with menstrual cycles impacted after having spent time with a vaccinated person,” she wrote, repeating a false claim that vaccinated people can somehow pass the vaccine to others and thereby affect their reproductive systems. (They can do neither.)

In the letter, Ms. Centner gave employees three options:

  • Inform the school if they had already been vaccinated, so they could be kept physically distanced from students;

  • Let the school know if they get the vaccine before the end of the school year, “as we cannot allow recently vaccinated people to be near our students until more information is known”;

  • Wait until the school year is over to get vaccinated.

Teachers who get the vaccine over the summer will not be allowed to return, the letter said, until clinical trials on the vaccine are completed, and then only “if a position is still available at that time” — effectively making teachers’ employment contingent on avoiding the vaccine.

Credit…Romain Maurice/Getty Images for Haute Living

Ms. Centner required the faculty and staff to fill out a “confidential” form revealing whether they had received a vaccine — and if so, which one and how many doses — or planned to get vaccinated. The form requires employees to “acknowledge the School will take legal measures needed to protect the students if it is determined that I have not answered these questions accurately.”

Ms. Centner directed questions about the matter to her publicist, who said in a statement that the school’s top priority throughout the pandemic has been to keep students safe. The statement repeated false claims that vaccinated people “may be transmitting something from their bodies” leading to adverse reproductive issues among women.

“We are not 100 percent sure the Covid injections are safe and there are too many unknown variables for us to feel comfortable at this current time,” the statement said.

The Food and Drug Administration, the Centers for Disease Control and Prevention, the World Health Organization and many other authorities have concluded that the coronavirus vaccines now in emergency use in the United States are safe and effective.

The Centner Academy opened in 2019 for students in prekindergarten through eighth grade, promoting itself as a “happiness school” focused on children’s mindfulness and emotional intelligence. The school prominently advertises on its website support for “medical freedom from mandated vaccines.”

Ms. Centner founded the school with her husband, David Centner, a technology and electronic highway tolling entrepreneur. Each has donated heavily to the Republican Party and the Trump re-election campaign, while giving much smaller sums to local Democrats.

In February, the Centners welcomed a special guest to speak to students: Robert F. Kennedy Jr., the prominent antivaccine activist. (Mr. Kennedy was suspended from Instagram a few days later for promoting Covid-19 vaccine misinformation.) This month, the school hosted a Zoom talk with Dr. Lawrence Palevsky, a New York pediatrician frequently cited by anti-vaccination activists.

Kitty Bennett contributed research.

Teenagers in Scampia, a district on the outskirts of Naples, Italy.Credit…Gianni Cipriano for The New York Times

The number of students that dropped out of school in Italy because of the coronavirus pandemic is rising, aggravating what was already a crisis before the disease spread across the nation.

Italy had among the worst dropout rates in the European Union, and the southern city of Naples was particularly troubled by high numbers. When the coronavirus hit, Italy shuttered its schools more than just about all the other European Union member states, with especially long closures in the Naples region, pushing students out in even higher numbers.

While it is too early for reliable statistics, principals, advocates and social workers say they have seen a sharp increase in the number of students falling out of the system. The impact on an entire generation may be one of the pandemic’s lasting tolls.

Italy closed its schools — fully or in part — for 35 weeks in the first year of the pandemic — three times longer than France, and more than Spain or Germany.

And experts say that by doing so, the country, which has Europe’s oldest population and was already lagging behind in critical educational indicators, has risked leaving behind its youth, its greatest and rarest resource for a strong post-pandemic recovery.

Categories
Health

Covid-19 Vaccine ‘Passports,’ Passes and Apps Across the Globe

Isn’t the European Union also developing a system? Yes. The EU is expected to introduce a certificate called the Digital Green Pass on June 21st to allow people vaccinated against the coronavirus to travel more freely. According to the proposed rules, each nation within the block could decide which travel restrictions, such as B. the compulsory quarantine, owners of Digital Green should do without. But many countries, including Denmark, say they can’t afford to wait for the Digital Green Pass and are developing their own versions.

Name of the card: The green pass

Could it bring you an indoor table? Yes.

How about a concert or a sports game? That too.

Anything else? The pass allows you to enter many businesses including swimming pools, gyms, theaters and wedding halls, as well as cultural events such as concerts, sports games and religious gatherings. The passport can also mean that you may not need to be quarantined for 10-14 days after international travel.

How does it work? In late February, the Israeli Ministry of Health began offering the Green Pass to fully vaccinated residents and people who have recovered from Covid-19. When booking a table in a restaurant, many companies would ask, “Do you have a Green Pass?” Israelis can print out their certificates with a QR code, download the code to their phones or flash the app themselves.

What about this family? The app and other Green Pass materials include an animated representation of a family of three. The man is wearing shorts, a backpack and a camera around his neck, suggesting that he is on vacation. His son and wife wear masks, but their demeanor is relaxed as they pull their suitcases.

Aparna Nair, a professor of the history of science at the University of Oklahoma who maintains a collection of vaccination certificates from the 1820s, said this detail was noteworthy: “They use the vaccination card design to make visual connections to life after the pandemic is in Essentially the vaccine as a literal passport to the rest of the world. “

Categories
World News

As Covid-19 Devastates India, Deaths Go Undercounted

Todesfälle wurden übersehen oder heruntergespielt, was den menschlichen Tribut des Ausbruchs des Landes unterschätzt, der fast die Hälfte aller neuen Fälle in einem globalen Aufschwung ausmacht.

NEU-DELHI – Indiens zweite Welle des Coronavirus gerät schnell in eine verheerende Krise. Die Krankenhäuser sind unerträglich voll, die Sauerstoffversorgung geht zur Neige, verzweifelte Menschen sterben in der Schlange und warten darauf, Ärzte aufzusuchen – und es gibt immer mehr Beweise dafür, dass die tatsächliche Zahl der Todesopfer weitaus höher ist als offiziell berichtet.

Jeden Tag meldet die Regierung mehr als 300.000 Neuinfektionen, ein Weltrekord, und Indien verzeichnet derzeit mehr Neuinfektionen als jedes andere Land, fast die Hälfte aller Neufälle in einem globalen Aufschwung.

Experten sagen jedoch, dass diese Zahlen, so erstaunlich sie auch sein mögen, nur einen Bruchteil der tatsächlichen Reichweite der Ausbreitung des Virus darstellen, die dieses Land in den Notfallmodus versetzt hat. Millionen von Menschen weigern sich, überhaupt nach draußen zu gehen – ihre Angst, sich mit dem Virus zu infizieren, ist so extrem. Berichte aus dem ganzen Land berichten, dass die Kranken nach Luft schnappen müssen, während sie in chaotischen Krankenhäusern warten, denen der lebensrettende Sauerstoff ausgeht.

Der plötzliche Anstieg in den letzten Wochen, bei dem möglicherweise eine heimtückische neuere Variante eine Rolle spielt, lässt die offizielle Zahl der Todesopfer von Covid-19 in Indien von fast 200.000 in Frage stellen. Täglich sterben mehr als 2.000 Menschen.

Interviews aus Feuerbestattungsgebieten im ganzen Land, in denen die Brände niemals aufhören, zeigen ein umfangreiches Todesmuster, das weit über den offiziellen Zahlen liegt. Laut Analysten zählen nervöse Politiker und Krankenhausverwalter möglicherweise eine große Anzahl von Toten unter oder übersehen sie. Und trauernde Familien verstecken möglicherweise auch aus Scham Covid-Verbindungen, was die Verwirrung in dieser riesigen Nation von 1,4 Milliarden Menschen noch verstärkt.

“Es ist ein komplettes Massaker an Daten”, sagte Bhramar Mukherjee, ein Epidemiologe an der Universität von Michigan, der Indien genau verfolgt hat. “Nach all den Modellierungen, die wir durchgeführt haben, glauben wir, dass die tatsächliche Anzahl der Todesfälle das Zwei- bis Fünffache der gemeldeten Zahl beträgt.”

Auf einem der großen Einäscherungsgelände in Ahmedabad, einer Stadt im westindischen Bundesstaat Gujarat, erleuchten leuchtend orangefarbene Feuer den Nachthimmel und brennen 24 Stunden am Tag wie eine Industrieanlage, die niemals stillgelegt wird. Suresh Bhai, ein Arbeiter dort, sagte, er habe noch nie ein so endloses Fließband des Todes gesehen.

Aber er hat die Todesursache nicht als Covid-19 auf die dünnen Zettel geschrieben, die er den traurigen Familien übergibt, obwohl die Zahl der Toten mit dem Virus steigt.

“Krankheit, Krankheit, Krankheit”, sagte Herr Suresh. “Das schreiben wir.”

Auf die Frage nach dem Grund sagte er, es sei das, wozu er von seinen Vorgesetzten angewiesen worden sei, die nicht auf Anfragen nach Kommentaren geantwortet hätten.

Am Samstag meldeten Beamte fast 350.000 Neuinfektionen, und die Todesfälle nahmen weiter zu. In einem Krankenhaus in Neu-Delhi, der Hauptstadt, sagten Ärzte, 20 Patienten auf einer Intensivstation seien gestorben, nachdem der Sauerstoffdruck gesunken war. Die Ärzte gaben dem akuten Sauerstoffmangel in der Stadt die Schuld an den Todesfällen.

Vor Monaten schien Indien mit der Pandemie bemerkenswert gut zurechtzukommen. Nachdem Anfang letzten Jahres eine harte anfängliche Sperrung gelockert worden war, registrierte das Land nicht die erschreckenden Fallzahlen und Todeszahlen, die andere große Länder in den Krisenmodus versetzten. Viele Beamte und normale Bürger hörten auf, Vorsichtsmaßnahmen zu treffen, als wären die schlimmsten Tage vorbei.

Jetzt wenden sich unzählige Inder an soziale Medien, um herzzerreißende SOS-Nachrichten für ein Krankenhausbett, Medikamente und etwas Sauerstoff zum Atmen zu versenden. “Nationaler Notfall”, lautete eine Schlagzeile in einer der führenden Zeitungen Indiens, der Hindustan Times. In ganz Indien finden jetzt Massenverbrennungen statt. Manchmal gehen Dutzende von Bränden gleichzeitig auf.

Gleichzeitig hat Indiens Covid-Impfstoffkampagne Probleme: Weniger als 10 Prozent der Inder haben sogar eine Dosis erhalten, obwohl Indien der weltweit führende Impfstoffhersteller ist. Indiens dringende Bedürfnisse haben bereits weltweite Auswirkungen, insbesondere für ärmere Länder. Es hatte geplant, Millionen von Dosen zu versenden; Angesichts des starken Impfmangels des Landes wurden die Exporte nun im Wesentlichen eingestellt, so dass andere Nationen weitaus weniger Dosen hatten als erwartet.

Ärzte befürchten, dass der außer Kontrolle geratene Anstieg zumindest teilweise durch die Entstehung einer Virusvariante verursacht wird, die als „Doppelmutante“ B.1.617 bekannt ist, da sie genetische Mutationen enthält, die in zwei anderen schwer zu kontrollierenden Versionen des Coronavirus gefunden wurden. Eine der Mutationen ist in der hoch ansteckenden Variante vorhanden, die Anfang dieses Jahres durch Kalifornien gezogen ist. Die andere Mutation ähnelt der in der südafrikanischen Variante gefundenen und soll das Virus resistenter gegen Impfstoffe machen.

Dennoch warnen Wissenschaftler davor, dass es noch zu früh ist, um genau zu wissen, wie schädlich die neue Variante ist, die in Indien auftaucht.

Das Ergebnis könnte das Schlimmste aus beiden Welten sein, sich schneller ausbreiten und weniger kontrollierbar sein. Dies beunruhigt Wissenschaftler auf der ganzen Welt, die sehen, wie Menschen in gut geimpften Ländern beginnen, ihre Wachsamkeit zu lockern, obwohl große Rückschläge in Indien, Brasilien und anderen Ländern die Wahrscheinlichkeit erhöhen, dass das Coronavirus auf eine Weise mutiert, die die derzeitigen Impfstoffe überflügeln könnte.

In Bhopal, einer großen Stadt in Zentralindien, in der in den 1980er Jahren ein katastrophales Gasleck auftrat, bei dem Tausende Menschen ums Leben kamen, waren die Einäscherungsgebiete seit dieser Katastrophe nicht mehr so ​​voll.

Aktualisiert

26. April 2021, 8:25 Uhr ET

Mitte April meldeten Bhopal-Beamte an 13 Tagen 41 Todesfälle im Zusammenhang mit Covid-19. Eine Umfrage der New York Times zu den wichtigsten Einäscherungs- und Grabstätten der Stadt Covid-19, in denen Leichen nach strengen Protokollen behandelt wurden, ergab im gleichen Zeitraum insgesamt mehr als 1.000 Todesfälle.

“Viele Todesfälle werden nicht registriert und nehmen täglich zu”, sagte Dr. GC Gautam, ein in Bhopal ansässiger Kardiologe. Er sagte, dass Beamte dies taten, weil “sie keine Panik erzeugen wollen”.

Das gleiche Phänomen schien in Lucknow und Mirzapur – Großstädten im Bundesstaat Uttar Pradesh – und in ganz Gujarat aufzutreten, wo die Behörden in einem ähnlichen Zeitraum Mitte April täglich zwischen 73 und 121 Todesfälle im Zusammenhang mit Covid meldeten.

Eine detaillierte Zählung, die von einer der führenden Zeitungen Gujarats, Sandesh, zusammengestellt wurde und Reporter zu Einäscherungs- und Bestattungsplätzen im ganzen Bundesstaat schickte, ergab jedoch, dass die Zahl um ein Vielfaches höher war, etwa 610 pro Tag.

Die größten Zeitungen in Indien haben die Diskrepanzen aufgegriffen. “COVID-19-Todesfälle in Gujarat übersteigen die Regierungszahlen bei weitem”, heißt es in einer Schlagzeile auf der Titelseite in The Hindu.

Indiens Bevölkerung ist im Durchschnitt viel jünger als in den meisten westlichen Ländern. Experten sagen, dass dies der wahrscheinlichste Grund dafür ist, dass die Todesfälle pro Million in Indien relativ niedrig erschienen sind. Aber die Zahl steigt schnell.

Studien zur Übersterblichkeit zufolge wurden die Todesfälle durch Covid-19 in vielen Ländern unterschätzt, darunter in den USA und in Großbritannien.

Aber Indien ist ein viel größeres und ärmeres Land. Die Bevölkerung verteilt sich auf 28 Bundesstaaten und mehrere Bundesgebiete in einem stark dezentralisierten Regierungssystem, wobei verschiedene Bundesstaaten die Todesfälle auf unterschiedliche Weise zählen.

Selbst in einem guten Jahr, sagen Experten, wird nur etwa ein Fünftel der Todesfälle medizinisch untersucht, was bedeutet, dass die große Anzahl von Indern stirbt, ohne dass eine Todesursache bestätigt wird.

Nach Angaben der Weltgesundheitsorganisation sollte ein Todesfall als Covid-19-bedingt eingestuft werden, wenn angenommen wird, dass die Krankheit sie verursacht oder dazu beigetragen hat, selbst wenn die Person bereits an einer Krankheit wie Krebs leidet.

An vielen Orten in Indien scheint das nicht zu passieren.

Rupal Thakkar wurde Mitte April positiv auf Covid-19 getestet. Am 16. April wurde sie in Shalby Limited, ein privates Krankenhaus in ihrer Heimatstadt Ahmedabad, eingeliefert, doch ihr Sauerstoffgehalt sank plötzlich. Am nächsten Tag starb Frau Thakkar, 48.

Das Krankenhaus führte ihre Todesursache als „plötzlichen Herztod“ an, was die Familie Thakkar empörte.

“Es war ein lebenslanger Schock”, sagte ihr jüngerer Bruder Dipan Thakkar. „Warum sollte ein privates Krankenhaus mit der Regierung zusammenarbeiten, um die tatsächlichen Todeszahlen zu verbergen? Es war ein organisiertes Verbrechen. Es war eine illegale Handlung. “

Die Beamten von Shalby antworteten nicht auf Anfragen nach Kommentaren.

Nachdem ihre Situation in indischen Zeitungen weit verbreitet war, stellte das Krankenhaus eine zweite Sterbeurkunde aus, diesmal mit Covid-19 als Ursache.

Einige Familien wollen nicht, dass die Wahrheit herauskommt, sagte Dr. Mukherjee von der University of Michigan. Einige wollen ihre Angehörigen außerhalb der strengen Regierungsprotokolle von Covid-19 einäschern, und so verbergen sie die Tatsache, dass ihr Familienmitglied an dem Coronavirus gestorben ist. Andere schämen sich vielleicht dafür, einen geliebten Menschen zu verlieren, als wäre es ihre Schuld.

Eine politische Agenda könnte ebenfalls im Spiel sein, sagten Experten. Staaten, die von Indiens regierender Bharatiya Janata-Partei unter der Führung von Premierminister Narendra Modi kontrolliert werden, könnten laut einigen Analysten unter Druck geraten, zu wenig Bericht zu erstatten. Dr. Mukherjee zitierte den sehr öffentlichen Skandal im Jahr 2019, als die Regierung von Herrn Modi versuchte, Daten zu unterdrücken, die einen Anstieg der Arbeitslosenquote belegen.

In Bezug auf Covid-Daten sagte sie: “Die Zentralregierung übt einen enormen Druck auf die Landesregierungen aus, um Fortschritte zu projizieren.”

Mehrere Beamte der Regierungspartei antworteten nicht auf Nachrichten, in denen sie um einen Kommentar gebeten wurden.

Aber die Manipulation von Todeszahlen scheint auch an anderen Orten zu geschehen. Ein Beispiel ist der Bundesstaat Chhattisgarh in Zentralindien, der von der führenden Oppositionspartei Congress geführt wird.

Beamte im Bezirk Durg in Chhattisgarh, in dem sich ein großes Stahlwerk befindet, meldeten vom 15. bis 21. April mehr als 150 Todesfälle durch Covid-19. Dies geht aus Nachrichten hervor, die an lokale Medien gesendet wurden, die von The Times gesehen wurden. Der Staat meldete weniger als die Hälfte dieser Zahl für Durg.

Der Gesundheitsminister von Chhattisgarh, TS Singh Deo, bestritt jede absichtliche Unterberichterstattung. “Wir haben versucht, so transparent wie möglich zu sein”, sagte er. “Wir müssen jederzeit korrigiert werden.”

Feuerbestattungen sind ein wichtiger Bestandteil hinduistischer Bestattungsrituale, die als ein Weg gesehen werden, die Seele vom Körper zu befreien. Diejenigen, die auf dem brennenden Gelände arbeiteten, sagten, sie seien völlig erschöpft und könnten sich nie an so viele Menschen erinnern, die in so kurzer Zeit starben.

In Surat, einer Industriestadt in Gujarat, haben die zum Verbrennen von Körpern verwendeten Grills so unerbittlich funktioniert, dass das Eisen einiger tatsächlich geschmolzen ist. Am 14. April teilten die Krematorien von Covid-19 in Surat und einem anderen Distrikt, Gandhi Nagar, der Times mit, dass sie 124 Menschen eingeäschert hätten, an einem Tag, an dem die Behörden sagten, 73 seien im gesamten Bundesstaat an Covid-19 gestorben.

In Kanpur im Bundesstaat Uttar Pradesh werden derzeit in einigen Parks der Stadt Leichen verbrannt. Die Krematorien sind die gesichert.

In Ahmedabad, im Krematorium von Vadaj, pumpen riesige Schornsteine ​​schwarzen Rauch aus. Mr. Suresh, ein Angestellter, sitzt in einem winzigen Büro, die Tür fest geschlossen.

Als er telefonisch erreicht wurde, sagte er, er habe alle Sterbeurkunden mit „Beemari“ oder Krankheit auf Hindi versehen und Fragen an einen Sanitärbeamten weitergeleitet, der dann Fragen an einen anderen Beamten weiterleitete, der sich weigerte, Anrufe zu beantworten.

Herr Suresh sagte, dass sein Krematorium jeden Tag 15 bis 20 Leichen von Covid-19-Patienten behandelte. Während er am Freitag sprach, brannten drei Leichen auf getrennten Pyren neben einem großen und wachsenden Stapel frisch gehackten Holzes.

Categories
Health

Astronauts Launching to Area Are Vaccinated In opposition to Covid-19

With no hospitals or medical specialists in space, NASA and other space agencies have always been concerned about astronauts getting sick while on a mission. To minimize the likelihood of this, they usually spend the two weeks prior to launch in quarantine.

A Covid-19 superspreader event on the space station would disrupt operations.

The interior of the space station has a volume equivalent to a Boeing 747 jetliner, so infected crew members have room to isolate themselves. But space station managers certainly don’t want to worry about the spread of the virus in the station’s constantly filtered and recycled air.

During a press conference last week, Shane Kimbrough, the NASA astronaut in command of Crew-2, said that all four astronauts had received Covid vaccinations. “I think it went well,” he said. “We all have slightly different reactions, just like most people. So in that respect we are no different. But we are grateful that we have the vaccines. “

The three astronauts who launched a Soyuz rocket to the station earlier this month – Oleg Novitskiy and Pyotr Dubrov from the Russian space agency and Mark Vande Hei from NASA – were also vaccinated.

The four astronauts on the Crew 1 mission are not, as no vaccines were available when it launched last November. When they return to Earth, everyone who is not on the planet will be vaccinated against Covid-19.

Categories
World News

Covid-19 Dwell Updates: Vaccines, Variants and Instances

Here’s what you need to know:

Credit…Joao Silva/The New York Times

South Africa will resume the use of the Johnson & Johnson vaccine to inoculate health care workers next week, offering some relief to the country that has suffered a series of blows to its vaccination efforts in recent months, according to South African authorities.

The country suspended an early-access Johnson & Johnson vaccination program last week after health officials in the United States put a pause on the vaccine amid concerns of rare blood clots that emerged in a handful of people who received it.

South Africa’s decision to move forward again was the second green light this week for Johnson & Johnson. On Tuesday, the European Union drug regulator also recommended resuming the rollout of the company’s vaccine.

Now, many eyes are on Washington, where a federal advisory panel is scheduled to meet Friday to discuss whether to lift the pause in the United States.

The blood clots that led to the Johnson & Johnson suspensions were all reported in the United States. In South Africa, officials confirmed Thursday that no cases of clots have been reported among the roughly 290,000 health care workers who have received the vaccine so far.

“The temporary suspension in South Africa was in line with government’s commitment to ensure comprehensive measures are undertaken regarding vaccine rollout,” Khumbudzo Ntshavheni, a cabinet minister, told reporters on Thursday.

Health experts welcomed the resumption of the vaccine campaign in South Africa, which has recorded more coronavirus cases than any other country on the continent and has suffered serious setbacks in its attempt to combat the virus in recent months.

In February, health officials scrapped plans to use the AstraZeneca vaccine after it proved ineffective against a variant of the virus now dominant in South Africa. The decision came a week after a million doses of the vaccine arrived in the country and amid a devastating second wave of virus cases.

Though the Johnson & Johnson vaccine has not yet been approved for general use in South Africa, it has been used as part of a research study offering early access to the vaccine to the country’s 1.2 million health care workers.

South African health officials are gearing up to extend vaccinations to the general public starting in May. In a first step to launching a national rollout, the country last week opened its vaccine registration to people over 60 years old, who will be among the first to be inoculated.

That plan depends on tens of millions of doses of the Pfizer-BioNTech vaccine, which requires two doses and will be used in major cities. The single-shot Johnson & Johnson vaccine, which is easier to store and better for hard-to-reach populations, will be used in the country’s rural areas.

United States › United StatesOn Apr. 21 14-day change
New cases 64,853 –4%
New deaths 879 –1%
World › WorldOn Apr. 21 14-day change
New cases 952,928 +23%
New deaths 17,951 +14%

U.S. vaccinations ›

Where states are reporting vaccines given

People waiting in line to register for a vaccination in Brooklyn earlier this month.Credit…Spencer Platt/Getty Images

Federal health officials appear to be leaning toward lifting their recommended pause on the use of Johnson & Johnson’s coronavirus vaccine after finding only a limited number of additional cases of a rare blood clotting disorder among recipients.

Instead, the Food and Drug Administration is likely to attach a warning to the vaccine’s label to inform health practitioners — and the public — about the exceedingly uncommon, but dangerous possible side effect.

Federal health officials are waiting to act until they hear from a committee of outside experts who advise the C.D.C. The committee is scheduled to meet on Friday to discuss whether to recommend lifting, extending or modifying the pause that was initiated on April 13.

“We know that it’s not a good thing to leave the pause going for any longer than it absolutely has to go for,” Dr. Peter Marks, the Food and Drug Administration’s top vaccine regulator, said Thursday, adding that a protracted pause could contribute to greater vaccine hesitancy. “Once, essentially, the adequate discussion has occurred, we’re prepared to move as quickly as we possibly can.”

When top federal health officials abruptly decided early last week to recommend a temporary halt in the use of the shot, six women had been reported to have suffered from the disorder, a combination of clots in the brain that led to bleeding and low platelets, components of the blood that normally help to heal wounds.

That was fewer than one in a million recipients of Johnson & Johnson’s shot in the United States. But officials worried that more cases were hidden or could develop shortly as the new vaccine rolled out.

That fear has not materialized.

Dr. Marks and Dr. Janet Woodcock, the F.D.A.’s acting commissioner, said the clotting disorder appeared to be nearly as rare as they hoped it would be when they recommended the pause.

“We’ve now received more cases, but it isn’t an avalanche,” Dr. Woodcock said “We’re not seeing a big surge, which is a great relief.”

Even if the C.D.C.’s advisory committee decides Friday that the benefits of Johnson & Johnson’s single-dose vaccine outweigh its risks, the company will still face manufacturing hurdles at a Baltimore plant that regulators have refused so far to certify. That plant was supposed to deliver the bulk of the nearly 100 million doses the firm had promised to have ready by the end of May.

But it would mean a temporary surge of about 10 million shots that were effectively put on hold when the pause was announced.

A man who died of complications from the coronavirus was being cremated in Mumbai on Wednesday.Credit…Atul Loke for The New York Times

India’s rapidly worsening coronavirus outbreak is now expanding on a scale beyond any previously measured in more than a year of the pandemic: The health ministry reported more than 310,000 new infections on Thursday, the most recorded in any country on a single day.

India’s total eclipsed the previous one-day high of 300,669 recorded coronavirus cases, set in the United States on Jan. 8, according to a New York Times database, though differences in testing levels from country to country, and a widespread lack of tests early in the pandemic, make comparisons difficult.

Over the past two months, the outbreak in India has exploded, with reports of superspreader gatherings, oxygen shortages and ambulances lined up outside hospitals because there were no ventilators for new patients.

As cases worldwide reach weekly records, a substantial proportion of the new infections are coming in India, a sobering reminder that the pandemic is far from over, even as infections decline and vaccinations speed ahead in the United States and other wealthy parts of the world. India has surpassed 15.6 million total reported infections so far, second-most after the United States.

The death toll has also begun to climb precipitously.

On Thursday, the Indian government recorded 2,104 deaths, and an average of more than 1,600 people have died of the virus every day for the past week. That is less than the tolls at the worst points of the pandemic in the United States or Brazil, but it is a steep increase from just two months ago, when fewer than 100 people in India were dying daily.

There are signs that the country’s health system, patchy even before the pandemic, is collapsing under the strain. On Tuesday, at least 22 people died in an accident in the central city of Nashik when a leak in a hospital’s main oxygen tank cut the flow of oxygen to Covid-19 patients.

The picture is staggeringly different from early February, when India was recording an average of just 11,000 cases a day, and domestic drug companies were pumping out millions of vaccine doses. More than 132 million Indians have received at least one dose, but supplies are running low and experts warn that the country is unlikely to meet its goal of inoculating 300 million people by the summer.

Critics say Prime Minister Narendra Modi, who imposed a harsh nationwide lockdown in March 2020 in the early stages of the pandemic, failed to prepare for a second wave or to warn Indians to remain vigilant against the virus, especially as more infectious variants began to spread.

Mr. Modi’s Hindu nationalist government has also allowed a massive Hindu festival to take place, drawing millions of pilgrims to the banks of the Ganges River, and his party has held packed political rallies in several states.

“India’s rapid slide into this unprecedented crisis is a direct result of complacency and lack of preparation by the government,” Ramanan Laxminarayan, the director of the Center for Disease Dynamics, Economics and Policy in Washington, wrote in The New York Times on Tuesday.

The hardest-hit region is Maharashtra, a populous western state that includes the financial hub of Mumbai. On Wednesday, the state’s top leader ordered government offices to operate at 15 percent capacity and imposed new restrictions on weddings and private transportation to slow the spread of the virus.

This week, Britain’s prime minister, Boris Johnson, and Japan’s prime minister, Yoshihide Suga, called off plans to visit India. On Thursday, the Australian prime minister, Scott Morrison, said that direct flights from India would be reduced by about 30 percent, and that Australians would be allowed to travel to India only in “very urgent circumstances.” Canada also suspended all direct flights from India and Pakistan starting Thursday night for 30 days.

People relaxed in the Place des Vosges in central Paris on Saturday. Prime Minister Jean Castex said that France will relax many of its coronavirus restrictions in May. Credit…Dmitry Kostyukov for The New York Times

The French government outlined plans on Thursday to gradually reopen the country starting in early May, stoking hopes that life might finally return to something close to normal after more than a year of on-and-off pandemic restrictions.

Prime Minister Jean Castex said at a news conference that primary school students would be allowed to return to classrooms on Monday, followed by middle and high school students the following week. Travel restrictions will be lifted on May 3.

Depending on how things are going at that point, Mr. Castex said, retail stores, outdoor dining, and certain cultural and sporting activities could start to reopen in mid-May.

The pandemic situation appears to be improving in France, with the daily average number of new cases falling to about 32,000 from 42,000 the week before. Hospitalizations seem to have plateaued at nearly 6,000.

“The peak of the third wave seems to be behind us,” Mr. Castex said.

The government is hoping to alleviate the deep sense of pandemic fatigue that has taken root in France. When the country went into its third lockdown at the start of April, once again closing schools and “nonessential” retail stores, the move was met with anger and some pointed protests.

Hundreds of lingerie shops across France, closed under the lockdown order, have been mailing panties to Mr. Castex since the beginning of the week, as part of a campaign called “Action Culottée,” meaning “cheeky action,” which was coordinated on Facebook.

The country’s vaccination campaign, which stumbled for months, has gathered speed recently, and is now administering about 2.5 million doses a week. More than 13 million people have received at least one dose so far, and the country aims to raise the figure to 20 million — 30 percent of the population — by mid-May. Even so, France lags far behind countries like the United States, Britain and Israel in its vaccination efforts.

To limit the spread of highly transmissible virus variants, Mr. Castex said, France will tighten testing and quarantine requirements for travelers arriving from five countries — Brazil, Chile, Argentina, South Africa and India — where the variants are circulating widely.

The Atlantic City boardwalk last July.Credit…Michelle Gustafson for The New York Times

With summer on the horizon, states are beginning to rethink social-distancing measures.

In Rhode Island, Gov. Dan McKee said that starting May 7, the state will stop requiring masks outside, and social gatherings can increase to 25 people indoors and 75 people outdoors. By May 28, the state will lift capacity limits on businesses and houses of worship; the bar areas of restaurants will be able to open; and dance floors can once again be filled.

“It’s a good day for everyone here in the Ocean State,” Mr. McKee said at a news conference Thursday. “It’s a little early to put a ‘Mission Accomplished’ sign up but we’re getting ready to order that sign.”

Mr. McKee attributed the reopening plans to the state’s vaccination rate — 48 percent of residents have received at least one shot and 33 percent are fully vaccinated, according to a New York Times database. But masks will still be required indoors.

Rhode Island is not alone.

On Monday, Gov. Ned Lamont of Connecticut announced that his state would phase out all pandemic restrictions, except the indoor mask mandate, by May 19. And in New Jersey, Gov. Phil Murphy said Wednesday that he would announce “a pretty significant amount of guidance” for summer activities next week.

“We don’t want to lurch, in other words go forward and then have to pull something back,” Mr. Murphy said at his weekly news conference. “And we don’t want to start that now. But we also owe people our best guesses for what it’s going to look like for graduation, summer, the beaches and what not.”

As more people get vaccinated and the outdoors become more appealing with spring weather and sunshine, one question persists: Do we still need to wear masks outside? Science shows that the risk of viral transmission outside is very low. The Times’ Well columnist, Tara Parker-Pope, suggests making sure your activity meets two out of the following three conditions: outdoors, distanced and masked.

Global Roundup

Police officers stood guard in Berlin as Germans demonstrated against coronavirus measures on Wednesday.Credit…Christian Mang/Reuters

BERLIN — State lawmakers in Germany approved a new version of a law on Thursday boosting the federal government’s power to enforce uniform coronavirus lockdown rules. New restrictions are expected in most districts soon after the president signs the bill into law, which could be as early as Thursday afternoon.

The law, which Chancellor Angela Merkel’s cabinet passed last week, is a response to a disjointed virus response by state governments, which previously had the ultimate say in carrying out restrictions. For months, experts have called for a lockdown to control Germany’s surging third wave of coronavirus infections.

Under the law passed by the federal council of states on Thursday, the rules would apply uniformly across the country but would depend on the rate of infection in each district, leading to more severe lockdowns in highly affected areas. There would be a curfew from 10 p.m. to 5 a.m. in districts with more than 100 new infections per 100,000 people in a week. Restaurants would remain closed, and nonessential stores would require an appointment and a negative test result in districts with more than 150 new infections per 100,000 people. Schools would close if 165 new infections per 100,000 were registered.

Germany is currently measuring 161 infections per 100,000 in a week, according to the health authorities, which also counted 29,518 new infections on Wednesday.

As many as 8,000 people, including right-wing extremists and coronavirus deniers, took to the streets in Berlin to protest the measures on Wednesday. Several lawsuits against it have already been announced.

Germany has recorded more than 80,000 deaths so far.

In other developments across the world:

  • Japan’s auto industry group canceled the biennial Tokyo Motor Show, scheduled for the fall, because of rising coronavirus cases, the Kyodo News agency reported. It was the first cancellation in the 67-year history of the event, which drew around 1.3 million people in 2019. Akio Toyoda, the chairman of the industry group and president of Toyota Motor Corp., said at a news conference that “it seems difficult to offer main programs in a safe environment.” The cancellation came as Japan reported 5,291 new infections, the highest daily total in three months. And it raised more questions about plans for the Tokyo Olympics, which organizers have insisted will begin in July even as officials plan to impose emergency measures in Tokyo and other municipalities.

  • The European Union will not order an extra 100 million vaccines from AstraZeneca foreseen in its contract, a European Commission spokesman said Thursday, underscoring the soured relationship between the pharmaceutical company and the bloc of 27 countries. The bloc could have added 100 million doses of vaccines to its existing order of 300 million from AstraZeneca but the time to do so has passed, Stefan de Keersmaecker, the spokesman, said. The European Union is embroiled in a dispute with the British-Swedish company over its inability to deliver expected doses, which has set the bloc’s vaccination efforts back significantly. They have been in a legal arbitration process for weeks, and the bloc is considering suing.

Megan Fairchild practicing in her parent’s home in Utah.Credit…Kim Raff for The New York Times

At the beginning of the pandemic, one of Megan Fairchild’s former dance teachers gave her some advice: Now would be a really great time to get pregnant. Ms. Fairchild, a principal at New York City Ballet, was aghast.

“I was like, that’s a ridiculous idea and the last thing on my mind right now,” she said. “This is going to last a couple months, and I don’t want to not be there when we get back.”

But when it became clear that her kind of live performance, dancing for thousands at Lincoln Center, would not be resuming anytime soon, the decision to have another child came to her in three words when she was meditating: Do it now.

For much of the pandemic year, Ms. Fairchild, 36, was pregnant with twins. On April 10, she gave birth to two girls.

She’s not the only one to have taken advantage of the theatrical shutdown. The dance world is experiencing a full-blown baby boom.

Federal regulators have found many shortcomings at a plant of Emergent BioSolutions in Baltimore.Credit…Saul Loeb/Agence France-Presse — Getty Images

WASHINGTON — Federal regulators have found serious flaws at the Baltimore plant that had to throw out up to 15 million possibly contaminated doses of Johnson & Johnson’s coronavirus vaccine, casting doubt on further production in the United States of a vaccine that the government once viewed as essential in fighting the pandemic.

The regulators for the Food and Drug Administration said that the company manufacturing the vaccine, Emergent BioSolutions, may have contaminated additional doses at the plant. They said the company failed to fully investigate the contamination, while also finding fault with the plant’s disinfection practices, size and design, handling of raw materials and training of workers.

The F.D.A. has not yet certified the plant, in Baltimore’s Bayview neighborhood, and no doses made there have gone to the public. All the Johnson & Johnson shots that have been administered in the United States have come from overseas.

The report amounted to a harsh rebuke of Emergent, which had long played down setbacks at the factory, and added to problems for Johnson & Johnson, whose vaccine had been seen as a game changer because it requires only one shot, can be produced in mass volume and is easily stored.

The inspection began after routine checks showed that Emergent workers had contaminated at least part of a batch of 13 million to 15 million doses of the Johnson & Johnson vaccine with the harmless virus that is used to make the AstraZeneca shot, which is not yet authorized in the United States.

The F.D.A. findings, based on an inspection that ended on Tuesday, underscore questions raised in reports by The New York Times about why Emergent did not fix problems earlier and why federal officials who oversee its lucrative contracts did not demand better performance.

In statements on Wednesday, the F.D.A., Emergent and Johnson & Johnson all said they were working to resolve the problems at the factory. There was no indication of how long that would take.

Nepal’s dethroned king, Gyanendra Shah, center, at Golden Temple in Amritsar, India, last year.Credit…Sameer Sehgal/Hindustan Times, via Getty Images

KATHMANDU, Nepal — At the beginning of this month, Nepal’s dethroned king, Gyanendra Shah, and his wife, Komal, traveled to northern India for the Kumbh Mela, a Hindu pilgrimage where millions seek a dip in the Ganges River to absolve themselves of their sins.

Gyanendra bathed in the river, and for 10 days, he and his aides mingled in crowds and met ascetics, Hindu leaders and other dignitaries. On April 18, he and Komal flew home to Nepal, where supporters welcomed them at the airport and formed a procession to escort them home, chanting pro-Hindu and pro-monarchy slogans along the way.

Three days later, the couple tested positive for the coronavirus. Now they are in quarantine at their residence in Kathmandu, the capital, while health officials in Nepal try to trace anyone who was in contact with them.

“Both king and queen have isolated themselves from other family members,” said Phani Raj Pathak, an aide to Gyanendra, who was dethroned when Nepal became a republic in 2008 and ended a two-century-old Hindu monarchy. The former ruler, who is in his 70s, retains support among some Hindus in Nepal as well as among critics of the elected government.

The infections have cast a harsh spotlight on the Kumbh Mela, where millions of Hindu pilgrims have gathered for weeks, shoulder to shoulder and often maskless, even as highly infectious variants of the coronavirus surge across South Asia. On Thursday, India reported more than 312,000 new infections, the highest daily total in any country since the pandemic began.

The Indian government has defended the gathering as safe, even as news media report thousands of infections among participants. Organizers say that attendees are required to wear masks and show proof of a negative coronavirus test, but they acknowledge that given the size of the event, many could have flouted the rules.

Now there are fears that the Kumbh Mela will cause the virus to explode in Nepal, which shares a porous border with India.

“The majority of people weren’t wearing face masks,” said Yogini Saritanandi, a pilgrim who returned to Nepal. She said she had seen “nothing other than a sea of humans on the bank of the Ganges.”

She said the authorities in the northern city of Haridwar, where the Kumbh Mela is being observed this year, began to slightly restrict entry after a few ascetics were reportedly infected and after India’s prime minister, Narendra Modi, urged organizers to observe social distancing. But it appeared to be too late.

“People got Covid one after another,” said Ms. Saritanandi, 43. “When I saw this, I thought of my 10-year-old son, and I cut my visit short to return to Nepal earlier.”

As Indian states impose new lockdowns, tens of thousands of Nepali migrant workers have returned from India without undergoing coronavirus tests. After reporting no new infections for much of January, Nepal is now averaging more than 1,100 cases a day, according to a New York Times database.

The government has closed schools and colleges in urban areas and tried to speed up vaccinations, with more than 1.7 million people having received at least one shot. But the inoculation drive was slowed after India restricted exports of vaccines to fight the outbreak at home, leaving Nepal to rely on a donation of shots from China.

A man used a self-administered coronavirus test kit in Durham, N.C., in February.Credit…Pete Kiehart for The New York Times

The health effects of Covid-19 not only can stretch for months, but also appear to increase the risk of death and chronic medical conditions even in people who were never sick enough with Covid to be hospitalized, according to a new study published Thursday in the journal Nature.

Researchers looked at medical records of more than 73,000 people across the United States who were infected with the coronavirus between March and November 2020 and did not require hospitalization. In the period from one to six months after becoming infected, those patients were 20 percent more likely to need outpatient medical care, and 60 percent more likely to die, than people who had not contracted the coronavirus.

The Covid survivors experienced a vast array of long-term medical problems that they had never had before — not just lung issues from the respiratory effects of the virus, but symptoms that could affect virtually any organ system or part of the body, from neurological to cardiovascular to gastrointestinal. They were also at greater risk of mental health problems, including anxiety and sleep disorders.

Some of the patients’ post-Covid medical issues — like diabetes, kidney disease and some heart problems — could become chronic conditions that would require treatment for the rest of their lives.

Most of the nearly 32 million people who have contracted the coronavirus in the United States have not needed hospitalization, so the findings may have wide implications. But the study sample and the control group they were compared with may not be very representative of the general public: They were Veterans Health System patients, overwhelmingly men with a median age over 60.

A pregnant woman receiving the Pfizer vaccine in Schwenksville, Pa., in February.Credit…Hannah Beier/Reuters

In an early analysis of coronavirus vaccine safety data, researchers at the Centers for Disease Control and Prevention have found no evidence that the Pfizer-BioNTech or Moderna vaccines pose serious risks during pregnancy.

The findings are preliminary and cover just the first 11 weeks of the U.S. vaccination program. But the study, which included self-reported data on more than 35,000 people who received one of the vaccines during or shortly before pregnancy, is the largest yet on the safety of the coronavirus vaccines in pregnant people.

During the clinical trials of the vaccines, pregnant women were excluded. That left patients, doctors and experts unsure whether the shots were safe to administer during pregnancy.

“There’s a lot of anxiety about whether it’s safe and whether it would work and what to expect as far as side effects,” said Dr. Stephanie Gaw, a maternal-fetal medicine specialist at the University of California, San Francisco.

The new data, Dr. Gaw said, demonstrate that “a lot of pregnant people are getting the vaccine, there isn’t a significant increase in adverse pregnancy effects at this point, and that side effect profiles are very similar to nonpregnant people.”

“I think that’s all very reassuring,” she said, “and I think it will really help providers and public health officials more strongly recommend getting the vaccine in pregnancy.”

Covid-19 poses serious risks during pregnancy. Pregnant women who develop symptoms of the disease are more likely to become seriously ill, and more likely to die, than nonpregnant women with symptoms.

Because of those risks, the C.D.C. has recommended that coronavirus vaccines be made available to pregnant women, though it also suggests that they consult with their doctors when making a decision about vaccination.

The new study, which was published on Wednesday in The New England Journal of Medicine, is based largely on self-reported data from V-safe, the C.D.C.’s coronavirus vaccine safety monitoring system. Participants in the program use a smartphone app to complete regular surveys about their health, and any side effects they might be experiencing, after receiving a Covid-19 vaccine.

The researchers analyzed the side effects reported by V-safe participants who received either the Pfizer or Moderna vaccine between Dec. 14, 2020, and Feb. 28, 2021. They focused on 35,691 participants who said that they had been pregnant when they received the vaccine or became pregnant shortly thereafter.

After vaccination, pregnant participants reported the same general pattern of side effects that nonpregnant ones did, the researchers found: pain at the injection site, fatigue, headaches and muscle pain.

Women who were pregnant were slightly more likely to report injection site pain than women who were not, but less likely to report the other side effects. They were also slightly more likely to report nausea or vomiting after the second dose.

Pregnant V-safe participants were also given an opportunity to enroll in a special registry that tracked pregnancy and infant outcomes.

By the end of February, 827 of those enrolled in the pregnancy registry had completed their pregnancies, 86 percent of which resulted in a live birth. Rates of miscarriage, prematurity, low birth weight and birth defects were consistent with those reported in pregnant women before the pandemic, the researchers report.

“This study is of critical importance to pregnant individuals,” Dr. Michal Elovitz, a maternal-fetal medicine specialist at the University of Pennsylvania, said in an email. “It is very reassuring that there were no reported acute events in pregnant individuals” over the course of the study, she said.

But the report has several limitations and much more research is needed, experts said. Enrollment in the surveillance programs is voluntary and the data are self-reported.

In addition, because the study period encompassed just the first few months of the U.S. vaccination campaign, the vast majority of those enrolled in the pregnancy registry were health care workers. And there is not yet any data on pregnancy outcomes from people who were vaccinated during the first trimester of pregnancy.

“I think we can feel more confident about recommending the vaccine in pregnancy, and especially with pregnant people that are at risk of Covid,” Dr. Gaw said. “But we do need to wait for more data for complete pregnancy outcomes from vaccines early in pregnancy.”

Jackie Robinson Day at Dodger Stadium earlier this month.Credit…Kirby Lee/USA Today Sports, via Reuters

Fully vaccinated baseball fans will be granted their own section at the Los Angeles Dodgers game this weekend against the San Diego Padres.

The set-aside seats, reported by The Los Angeles Times, are part of the many incentives being offered — from doughnuts to beer — to encourage people to get vaccinated against Covid-19. The Miami Heat and the San Francisco Giants have introduced similar sections at their stadiums.

To prove they are fully vaccinated, fans will have to show government-issued I.D. and documentation like a vaccination card, according to the Dodgers’ website. Everyone 16 years and older will have to show proof that at least two weeks have passed since they were fully vaccinated. Fans younger than 16 will be required to show proof of a negative coronavirus test taken within 72 hours before admission.

Face masks will still be required, but social distancing will not. The team said spectators in the sections for the fully vaccinated will be seated directly next to each other.

The game Saturday won’t mark the first time fans have entered Dodger Stadium since the pandemic began. The team’s home opener on April 9 was attended by fans — just not all that many of them. Attendance was capped at around 11,000, about 20 percent of capacity.

In the past week, there has been an average of more than 2,300 daily coronavirus cases in the state, and Los Angeles County has seen an average of 435 daily cases — a 20 percent drop over the past two weeks, according to a New York Times database.

As of Wednesday, more than 40 percent of Californians had received at least one dose of the vaccine, and more than 20 percent had been fully vaccinated.

On April 15, Gov. Gavin Newsom loosened some restrictions in the state, permitting limited outdoor gatherings and live events, depending on a region’s Covid-19 risk level.

A 5K run organized by New York Road Runners in October.Credit…John Minchillo/Associated Press

New York Road Runners, the club that puts on the New York City Marathon, has announced the return of its first regularly scheduled race since the beginning of the pandemic.

On Thursday, the club said that it would hold the annual New York Mini 10K on June 12. The 10-kilometer, women-only race has been held annually since 1972, with the exception of last year.

“This is our first real table setting,” said Kerin Hempel, the organization’s interim chief executive. “It’s starting to feel like ‘OK, we’re back, we’re coming back.’”

This will not be the first race the club has held since the onset of the pandemic.

The organization has held a series of “return to racing” events as pilots starting last fall, allowing very small fields to run with safety protocols in place. Among other measures, the races had temperature checks, staggered starts and different corralling of runners.

Those events, Ms. Hempel said, have given N.Y.R.R. the confidence to move ahead with its first regularly scheduled race since March 2020.

The Mini 10K field will be smaller than in past years, with a cap of 1,200 runners. The race will also have safety protocols, such as requiring runners to mask up at the start and finish. (They will be strongly encouraged to wear masks during the race, too.)

It will be the first time N.Y.R.R. has welcomed elite athletes since the 2019 New York City Marathon, with 25 elite athletes expected at the starting line. The 2019 Mini 10K champion, Sara Hall, will return to defend her title.

The announcement comes as runners look ahead — with cautious optimism — to the return of major road races. Ms. Hempel anticipated the question on the minds of many: What does this mean for the New York City Marathon?

“We’ve been saying the marathon is going to happen,” she said. “It’s more about what it’s going to look like, and how many people we can accommodate on the course.”

Categories
Health

No Being pregnant Danger Discovered From 2 Covid-19 Vaccines, Preliminary Analysis Exhibits

In an early analysis of coronavirus vaccine safety data, researchers from the Centers for Disease Control and Prevention found no evidence that the Pfizer-BioNTech or Moderna vaccines posed a serious risk during pregnancy.

The results are preliminary and only cover the first 11 weeks of the US vaccination program. The study, which included self-reported data on more than 35,000 people who received any of the vaccines during or shortly before pregnancy, is the largest to date on the safety of coronavirus vaccines in pregnant women.

Pregnant women were excluded during clinical trials with the vaccines. Patients, doctors and experts were therefore unsure whether the shots could be safely administered during pregnancy.

“There is great concern about whether it is safe and whether it would work and what to expect in terms of side effects,” said Dr. Stephanie Gaw, a Maternal-Fetal Medicine Specialist at the University of California at San Francisco.

The new data, said Dr. Gaw, show that “many pregnant people receive the vaccine, there is no significant increase in adverse pregnancy effects at this point and that the side effect profiles are not very similar to pregnant people.”

“I think this is all very comforting,” she said, “and I think it will really help public health providers and officials recommend the vaccine more strongly during pregnancy.”

Covid-19 carries serious risks during pregnancy. Pregnant women who develop symptoms of the disease are more likely to become seriously ill and die more often than non-pregnant women with symptoms.

Because of these risks, the CDC has recommended providing coronavirus vaccines to pregnant women, but also suggests that they consult their doctor when deciding whether to vaccinate.

The new study, published Wednesday in the New England Journal of Medicine, is largely based on self-reported data from V-safe, the CDC’s coronavirus vaccine safety monitoring system. Participants in the program use a smartphone app to regularly conduct surveys about their health and possible side effects after receiving a Covid-19 vaccine.

The researchers analyzed the side effects of V-Safe participants who received either the Pfizer or Moderna vaccine between December 14, 2020 and February 28, 2021. They focused on 35,691 participants who said they were pregnant when they received the vaccine or became pregnant shortly afterwards.

After vaccination, pregnant participants reported the same general pattern of side effects as non-pregnant women, the researchers noted: injection site pain, fatigue, headache, and muscle pain.

What You Need To Know About The Johnson & Johnson Vaccine Break In The United States

    • On April 13, 2021, U.S. health officials called for an immediate halt to use of Johnson & Johnson’s single-dose Covid-19 vaccine after six recipients in the U.S. developed a rare blood clot disorder within one to three weeks of being vaccinated.
    • All 50 states, Washington, DC, and Puerto Rico have temporarily stopped using the vaccine or recommended providers are suspending use of the vaccine. The U.S. military, government-run vaccination centers, and a variety of private companies, including CVS, Walgreens, Rite Aid, Walmart, and Publix, also paused the injections.
    • Fewer than one in a million Johnson & Johnson vaccinations are currently being studied. If there is indeed a risk of blood clots from the vaccine – which has yet to be determined – the risk is extremely small. The risk of contracting Covid-19 in the United States is much higher.
    • The hiatus could complicate the country’s vaccination efforts at a time when many states are facing spikes in new cases and are trying to address vaccine hesitation.
    • Johnson & Johnson had also decided to delay the launch of its vaccine in Europe amid concerns about rare blood clots. However, the company later decided to continue its campaign after the European Union Medicines Agency announced the addition of a warning. South Africa, devastated by a contagious variant of the virus, stopped using the vaccine and Australia announced it would not buy doses.

Pregnant women were slightly more likely to report injection site pain than women who did not, but were less likely to report the other side effects. They were also slightly more likely to report nausea or vomiting after the second dose.

Pregnant V-safe participants also had the option of enrolling in a special register that recorded pregnancy and infant results.

By the end of February, 827 of the people on the pregnancy register had completed their pregnancies, of which 86 percent resulted in a live birth. The incidence of miscarriages, premature births, low birth weight, and birth defects were consistent with those reported in pregnant women prior to the pandemic, the researchers report.

“This study is critical for pregnant people,” said Dr. Michal Elovitz, a maternal-fetal medicine specialist at the University of Pennsylvania, in an email. “It’s very comforting that no acute events have been reported in pregnant people,” she said as the study progressed.

However, the report has several caveats, and experts say a lot more research is needed. Participation in the monitoring programs is voluntary and the data is reported by yourself.

Since the study period only spanned the first few months of the US vaccination campaign, the vast majority of those on the pregnancy registry were healthcare workers. And there is still no data on pregnancy outcomes for people vaccinated in the first trimester of pregnancy.

“I think we can feel more secure if we recommend the vaccine during pregnancy, especially in pregnant people who are at risk of Covid,” said Dr. Gaw. “But we do I will have to wait for more data to get full pregnancy results from early pregnancy vaccines. “

Categories
Health

The Covid-19 Plasma Growth Is Over. What Did We Study From It?

Scott Cohen was on a ventilator struggling for his life with Covid-19 last April when his brothers pleaded with Plainview Hospital on Long Island to infuse him with the blood plasma of a recovered patient.

The experimental treatment was hard to get but was gaining attention at a time when doctors had little else. After an online petition drew 18,000 signatures, the hospital gave Mr. Cohen, a retired Nassau County medic, an infusion of the pale yellow stuff that some called “liquid gold.”

In those terrifying early months of the pandemic, the idea that antibody-rich plasma could save lives took on a life of its own before there was evidence that it worked. The Trump administration, buoyed by proponents at elite medical institutions, seized on plasma as a good-news story at a time when there weren’t many others. It awarded more than $800 million to entities involved in its collection and administration, and put Dr. Anthony S. Fauci’s face on billboards promoting the treatment.

A coalition of companies and nonprofit groups, including the Mayo Clinic, Red Cross and Microsoft, mobilized to urge donations from people who had recovered from Covid-19, enlisting celebrities like Samuel L. Jackson and Dwayne Johnson, the actor known as the Rock. Volunteers, some dressed in superhero capes, showed up to blood banks in droves.

Mr. Cohen, who later recovered, was one of them. He went on to donate his own plasma 11 times.

But by the end of the year, good evidence for convalescent plasma had not materialized, prompting many prestigious medical centers to quietly abandon it. By February, with cases and hospitalizations dropping, demand dipped below what blood banks had stockpiled. In March, the New York Blood Center called Mr. Cohen to cancel his 12th appointment. It didn’t need any more plasma.

A year ago, when Americans were dying of Covid at an alarming rate, the federal government made a big bet on plasma. No one knew if the treatment would work, but it seemed biologically plausible and safe, and there wasn’t much else to try. All told, more than 722,000 units of plasma were distributed to hospitals thanks to the federal program, which ends this month.

The government’s bet did not result in a blockbuster treatment for Covid-19, or even a decent one. But it did give the country a real-time education in the pitfalls of testing a medical treatment in the middle of an emergency. Medical science is messy and slow. And when a treatment fails, which is often, it can be difficult for its strongest proponents to let it go.

Because the government gave plasma to so many patients outside of a controlled clinical trial, it took a long time to measure its effectiveness. Eventually, studies did emerge to suggest that under the right conditions, plasma might help. But enough evidence has now accumulated to show that the country’s broad, costly plasma campaign had little effect, especially in people whose disease was advanced enough to land them in the hospital.

In interviews, three federal health officials — Dr. Stephen M. Hahn, the former commissioner of the Food and Drug Administration; Dr. Peter Marks, a top F.D.A. regulator; and Dr. H. Clifford Lane, a clinical director at the National Institutes of Health — acknowledged that the evidence for plasma was limited.

“The data are just not that strong, and it makes it makes it hard, I think, to be enthusiastic about seeing it continue to be used,” Dr. Lane said. The N.I.H. recently halted an outpatient trial of plasma because of a lack of benefit.

Doctors have used the antibodies of recovered patients as treatments for more than a century, for diseases including diphtheria, the 1918 flu and Ebola.

So when patients began falling ill with the new coronavirus last year, doctors around the world turned to the old standby.

In the United States, two hospitals — Mount Sinai in New York City and Houston Methodist in Texas — administered the first plasma units to Covid-19 patients within hours of each other on March 28.

Dr. Nicole M. Bouvier, an infectious-disease doctor who helped set up Mount Sinai’s plasma program, said the hospital had tried the experimental treatment because blood transfusions carry a relatively low risk of harm. With a new virus spreading quickly, and no approved treatments, “nature is a much better manufacturer than we are,” she said.

As Mount Sinai prepared to infuse patients with plasma, Diana Berrent, a photographer, was recovering from Covid-19 at her home in Port Washington, N.Y. Friends began sending her Mount Sinai’s call for donors.

“I had no idea what plasma was — I haven’t taken a science class since high school,” Ms. Berrent recalled. But as she researched its history in previous disease outbreaks, she became fixated on how she could help.

She formed a Facebook group of Covid-19 survivors that grew to more than 160,000 members and eventually became a health advocacy organization, Survivor Corps. She livestreamed her own donation sessions to the Facebook group, which in turn prompted more donations.

“People were flying places to go donate plasma to each other,” she said. “It was really a beautiful thing to see.”

Around the same time, Chaim Lebovits, a shoe wholesaler from Monsey, N.Y., in hard-hit Rockland County, was spreading the word about plasma within his Orthodox Jewish community. Mr. Lebovits called several rabbis he knew, and before long, thousands of Orthodox Jewish people were getting tested for coronavirus antibodies and showing up to donate. Coordinating it all was exhausting.

“April,” Mr. Lebovits recalled with a laugh, “was like 20 decades.”

Two developments that month further accelerated plasma’s use. With the help of $66 million in federal funding, the F.D.A. tapped the Mayo Clinic to run an expanded access program for hospitals across the country. And the government agreed to cover the administrative costs of collecting plasma, signing deals with the American Red Cross and America’s Blood Centers.

The news releases announcing those deals got none of the flashy media attention that the billion-dollar contracts for Covid-19 vaccines did when they arrived later in the summer. And the government did not disclose how much it would be investing.

That investment turned out to be significant. According to contract records, the U.S. government has paid $647 million to the American Red Cross and America’s Blood Centers since last April.

“The convalescent plasma program was intended to meet an urgent need for a potential therapy early in the pandemic,” a health department spokeswoman said in a statement. “When these contracts began, treatments weren’t available for hospitalized Covid-19 patients.”

Updated 

April 17, 2021, 11:41 a.m. ET

As spring turned to summer, the Trump administration seized on plasma — as it had with the unproven drug hydroxychloroquine — as a promising solution. In July, the administration announced an $8 million advertising campaign “imploring Americans to donate their plasma and help save lives.” The blitz included promotional radio spots and billboards featuring Dr. Fauci and Dr. Hahn, the F.D.A. commissioner.

A coalition to organize the collection of plasma was beginning to take shape, connecting researchers, federal officials, activists like Ms. Berrent and Mr. Lebovits, and major corporations like Microsoft and Anthem on regular calls that have continued to this day. Nonprofit blood banks and for-profit plasma collection companies also joined the collaboration, named the Fight Is In Us.

The group also included the Mitre Corporation, a little-known nonprofit organization that had received a $37 million government grant to promote plasma donation around the country.

The participants sometimes had conflicting interests. While the blood banks were collecting plasma to be immediately infused in hospitalized patients, the for-profit companies needed plasma donations to develop their own blood-based treatment for Covid-19. Donations at those companies’ own centers had also dropped off after national lockdowns.

“They don’t all exactly get along,” Peter Lee, the corporate vice president of research and incubations at Microsoft, said at a virtual scientific forum in March organized by Scripps Research.

Microsoft was recruited to develop a locator tool, embedded on the group’s website, for potential donors. But the company took on a broader role “as a neutral intermediary,” Dr. Lee said.

The company also provided access to its advertising agency, which created the look and feel for the Fight Is In Us campaign, which included video testimonials from celebrities.

In August, the F.D.A. authorized plasma for emergency use under pressure from President Donald J. Trump, who had chastised federal scientists for moving too slowly.

At a news conference, Dr. Hahn, the agency’s commissioner, substantially exaggerated the data, although he later corrected his remarks following criticism from the scientific community.

In a recent interview, he said that Mr. Trump’s involvement in the plasma authorization had made the topic polarizing.

“Any discussion one could have about the science and medicine behind it didn’t happen, because it became a political issue as opposed to a medical and scientific one,” Dr. Hahn said.

The authorization did away with the Mayo Clinic system and opened access to even more hospitals. As Covid-19 cases, hospitalizations and deaths skyrocketed in the fall and winter, use of plasma did, too, according to national usage data provided by the Blood Centers of America. By January of this year, when the United States was averaging more than 130,000 hospitalizations a day, hospitals were administering 25,000 units of plasma per week.

Many community hospitals serving lower-income patients, with few other options and plasma readily available, embraced the treatment. At the Integris Health system in Oklahoma, giving patients two units of plasma became standard practice between November and January.

Dr. David Chansolme, the system’s medical director of infection prevention, acknowledged that studies of plasma had showed it was “more miss than hit,” but he said his hospitals last year lacked the resources of bigger institutions, including access to the antiviral drug remdesivir. Doctors with a flood of patients — many of them Hispanic and from rural communities — were desperate to treat them with anything they could that was safe, Dr. Chansolme said.

By the fall, accumulating evidence was showing that plasma was not the miracle that some early boosters had believed it to be. In September, the Infectious Diseases Society of America recommended that plasma not be used in hospitalized patients outside of a clinical trial. (On Wednesday, the society restricted its advice further, saying plasma should not be used at all in hospitalized patients.) In January, a highly anticipated trial in Britain was halted early because there was not strong evidence of a benefit in hospitalized patients.

In February, the F.D.A. narrowed the authorization for plasma so that it applied only to people who were early in the course of their disease or who couldn’t make their own antibodies.

Dr. Marks, the F.D.A. regulator, said that in retrospect, scientists had been too slow to adapt to those recommendations. They had known from previous disease outbreaks that plasma treatment is likely to work best when given early, and when it contained high levels of antibodies, he said.

“Somehow we didn’t really take that as seriously as perhaps we should have,” he said. “If there was a lesson in this, it’s that history actually can teach you something.”

Today, several medical centers have largely stopped giving plasma to patients. At Rush University Medical Center in Chicago, researchers found that many hospitalized patients were already producing their own antibodies, so plasma treatments would be superfluous. The Cleveland Clinic no longer routinely administers plasma because of a “lack of convincing evidence of efficacy,” according to Dr. Simon Mucha, a critical care physician.

And earlier this year, Mount Sinai stopped giving plasma to patients outside of a clinical trial. Dr. Bouvier said that she had tracked the scientific literature and that there had been a “sort of piling on” of studies that showed no benefit.

“That’s what science is — it’s a process of abandoning your old hypotheses in favor of a better hypothesis,” she said. Many initially promising drugs fail in clinical trials. “That’s just the way the cookie crumbles.”

Some scientists are calling on the F.D.A. to rescind plasma’s emergency authorization. Dr. Luciana Borio, the acting chief scientist at the agency under President Barack Obama, said that disregarding the usual scientific standards in an emergency — what she called “pandemic exceptionalism” — had drained valuable time and attention from discovering other treatments.

“Pandemic exceptionalism is something we learned from prior emergencies that leads to serious unintended consequences,” she said, referring to the ways countries leaned on inadequate studies during the Ebola outbreak. With plasma, she said, “the agency forgot lessons from past emergencies.”

While scant evidence shows that plasma will help curb the pandemic, a dedicated clutch of researchers at prominent medical institutions continue to focus on the narrow circumstances in which it might work.

Dr. Arturo Casadevall, an immunologist at Johns Hopkins University, said many of the trials had not succeeded because they tested plasma on very sick patients. “If they’re treated early, the results of the trials are all consistent,” he said.

A clinical trial in Argentina found that giving plasma early to older people reduced the progression of Covid-19. And an analysis of the Mayo Clinic program found that patients who were given plasma with a high concentration of antibodies fared better than those who did not receive the treatment. Still, in March, the N.I.H. halted a trial of plasma in people who were not yet severely ill with Covid-19 because the agency said it was unlikely to help.

With most of the medical community acknowledging plasma’s limited benefit, even the Fight Is In Us has begun to shift its focus. For months, a “clinical research” page about convalescent plasma was dominated by favorable studies and news releases, omitting major articles concluding that plasma showed little benefit.

Now, the website has been redesigned to more broadly promote not only plasma, but also testing, vaccines and other treatments like monoclonal antibodies, which are synthesized in a lab and thought to be a more potent version of plasma. Its clinical research page also includes more negative studies about plasma.

Nevertheless, the Fight Is In Us is still running Facebook ads, paid for by the federal government, telling Covid-19 survivors that “There’s a hero inside you” and “Keep up the fight.” The ads urge them to donate their plasma, even though most blood banks have stopped collecting it.

Two of plasma’s early boosters, Mr. Lebovits and Ms. Berrent, have also turned their attention to monoclonal antibodies. As he had done with plasma last spring, Mr. Lebovits helped increase acceptance of monoclonals in the Orthodox Jewish community, setting up an informational hotline, running ads in Orthodox newspapers, and creating rapid testing sites that doubled as infusion centers. Coordinating with federal officials, Mr. Lebovits has since shared his strategies with leaders in the Hispanic community in El Paso and San Diego.

And Ms. Berrent has been working with a division of the insurer UnitedHealth to match the right patients — people with underlying health conditions or who are over 65 — to that treatment.

“I’m a believer in plasma for a lot of substantive reasons, but if word came back tomorrow that jelly beans worked better, we’d be promoting jelly beans,” she said. “We are here to save lives.”’

Categories
Health

Ladies and the Covid-19 Vaccine: What You Have to Know

A study by the Centers for Disease Control and Prevention published in February looked at the Pfizer-BioNTech and Moderna vaccines and found that 79 percent of the side effects reported to the agency were from women, although only 61 percent of the vaccines were administered to women.

Women could be more likely to report side effects than men, said Dr. Sabra L. Klein, Professor of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. Or, she added, women may experience side effects to a greater extent. “We’re not sure what it is,” she said.

If women actually experience more side effects than men, there may be a biological explanation: women and girls can make up to twice as many antibodies after flu shots and vaccines for measles, mumps, and rubella (MMR), and hepatitis A and B, probably due to a mixture of factors including reproductive hormones and genetic differences.

One study found that women accounted for 80 percent of all adult allergic reactions to vaccines in nearly three decades. Similarly, the CDC reported that most anaphylactic reactions to Covid-19 vaccines, although rare, occurred in women.

In a letter published in the New England Journal of Medicine describing people’s experiences with redness, itching, and swelling that began four to eleven days after the first shot of the Moderna vaccine, 10 of the 12 patients were women. However, it’s not clear if women are more prone to the problem.

If you have mild side effects like a headache or low fever, this is a good thing, said Dr. Small as it means your immune system is going up. However, a lack of side effects doesn’t mean the vaccine isn’t working.

You can share your symptoms or concerns through the CDC’s V-Safe app, which records symptoms and provides post-vaccination health check-ins. Medically important reports sent with V-safe are followed by a call from a representative.

Categories
World News

European Union Guarantees Additional Covid-19 Vaccine Doses From Pfizer

The European Union will receive an additional 50 million doses of the coronavirus vaccine developed by Pfizer and BioNTech this month, accelerating its efforts to accelerate vaccination amid difficulties with vaccines developed by AstraZeneca and Johnson & Johnson.

The announcement by Ursula von der Leyen, President of the European Commission, is part of the European Union’s tough pivot for mRNA vaccines like Pfizer, which is basing its future coronavirus response on it.

The measures come a day after Johnson & Johnson suspended rollout of its vaccine in the European Union and the block continued to suffer from the restrictions of the AstraZeneca vaccine after reports of extremely rare but serious potential side effects from both.

The 27-nation bloc has also started negotiations with Pfizer for the delivery of 1.8 billion new doses of vaccine – including booster shots to extend immunity and new vaccines to combat emerging variants – in 2022 and 2023, Ms. von der Leyen said .

In another setback for AstraZeneca, Denmark became the first country to permanently stop administering the company’s vaccine on Wednesday. The potential side effects are significant enough to do so, given that the pandemic was under control and two other vaccines could be used. from Pfizer and Moderna.

The European Union has not canceled its existing orders for the AstraZeneca and Johnson & Johnson vaccines, but has signaled that they will no longer be placing.

The European Medicines Agency, the bloc’s top medicine agency, goes on to say that the benefits of the AstraZeneca vaccine far outweigh the risks of a dangerous but extremely rare blood disorder for most people. On Wednesday, the agency said it was accelerating its investigation of “very rare cases of unusual blood clots” in recipients of the Johnson & Johnson vaccine and is expected to issue a recommendation next week.

During the ongoing evaluation, the Agency reiterated its view that it will reap the benefits Vaccine also outweigh the risks.

The European Union’s move away from AstraZeneca follows troubled months as relations between the company and the bloc deteriorated due to late deliveries and unpredictable deliveries. And since then, concerns about possible side effects have heightened skepticism about vaccines, which was already dangerously high in Europe.

These problems have contributed to the fact that Europe has lagged seriously behind vaccination campaigns in the US and UK. The block hopes the new Pfizer broadcasts will help it catch up and meet its goal of fully vaccinating 70 percent of its adult population, roughly 255 million people, by the end of the summer.

Pfizer’s commitment to move ahead with deliveries of the 50 million cans originally planned for the end of the year means the company will deliver a total of 250 million cans to the block by the end of June.

“We now have to concentrate on technologies that have proven themselves: mRNA vaccines are a clear example of this,” said Ms. von der Leyen.

Monika Pronczuk contributed to the reporting.

Categories
World News

Covid-19 Information: Dwell Updates – The New York Occasions

Here’s what you need to know:

Credit…Emily Elconin/Reuters

The Biden administration and Michigan’s Democratic governor are locked in an increasingly tense standoff over the state’s worst-in-the-nation coronavirus outbreak, with a top federal health official on Monday urging the governor to lock down her state.

As the governor, Gretchen Whitmer, publicly called again for a surge of vaccine supply, the director of the Centers for Disease Control and Prevention said at a White House news conference that securing extra doses was not the most immediate or practical solution to the outbreak. She said that Michigan — whose metro areas include 16 of the 17 worst outbreaks in the nation — needed to enact shutdown measures to stamp out the crush of infections.

“The answer is not necessarily to give vaccine,” said the director, Dr. Rochelle Walensky. “The answer to that is to really close things down, to go back to our basics, to go back to where we were last spring, last summer, and to shut things down.”

Michigan’s outbreak — driven by a highly infectious virus variant, loosened restrictions, travel, youth sporting events and uneven compliance with the remaining rules — is by far the worst in the country. The state is averaging seven times as many cases each day as it was in late February, and hospitalizations have roughly doubled in the past two weeks. Nonetheless, Ms. Whitmer has stopped well short of the far-reaching shutdowns that made her a political lightning rod last summer, with armed protesters storming the Statehouse to demand an end to coronavirus restrictions.

The Biden administration, however, has held fast to distributing vaccines by state population, not by triage, shying away from anything that could look like inequitable distribution or political favoritism at a time when vaccine supply remains tight in many places.

“It’s important to understand how we’ve approached vaccine distribution from the beginning: It’s done with equity in mind. It’s done with the adult population in mind,” the White House press secretary, Jen Psaki, said Monday. “We don’t pick by our friends. We don’t pick through a political prism.”

Michigan’s renewed fight with the virus was a warning for other states seeing new increases in cases and could have far-reaching consequences. Reports of new cases have increased by 45 percent in Illinois over the past two weeks, with especially high infection rates around Peoria. And as new, more contagious variants spread, caseloads are rising in Minnesota, Pennsylvania and several other states.

In an interview on Sunday with CBS’s “60 Minutes,” the Federal Reserve chair, Jerome H. Powell, said the American economy had “brightened substantially” as more people have been vaccinated and businesses have reopened. But he cautioned that “there really are risks out there,” specifically coronavirus flare-ups, if Americans return to normal life too quickly.

“The principal risk to our economy right now really is that the disease would spread again more quickly,” Mr. Powell said.

In recent days, Ms. Whitmer, an ally of President Biden’s, has diverged repeatedly from the president, asking him in a private call last week for extra vaccines, and, after being turned down, continuing to press her case in public that vaccination is the answer.

Bobby Leddy, a spokesman for Ms. Whitmer, said the state was suffering not from a failure of policymaking, but from the new variants that are more contagious and from Michiganders who are not complying with the governor’s orders. “Which is why it’s important for us to ramp up vaccinations as quickly as possible,” he said.

Ms. Whitmer was joined in the call for more vaccines by Representatives Fred Upton, a Republican, and Debbie Dingell, a Democrat, who sent a letter last week to Mr. Biden pleading for extra doses for their state.

Ms. Whitmer, who called last week for voluntary pauses to indoor dining, youth sports and in-person high school, said on Monday that she planned to extend existing restrictions on in-person officework for six more months. She has also appealed to Michigan residents to take more “personal responsibility,” language that echoed Republican governors and contrasted sharply with her own response to earlier surges.

United States › United StatesOn Apr. 11 14-day change
New cases 48,271 +11%
New deaths 300 –26%
World › WorldOn Apr. 11 14-day change
New cases 711,671 +21%
New deaths 8,750 +23%

U.S. vaccinations ›

Where states are reporting vaccines given

Students lining up to enter Clara Barton High School in Crown Heights last month.Credit…Anna Watts for The New York Times

Starting later this month, about 51,000 New York City public school students who have been learning remotely for the past year will be able to return to classrooms, Mayor Bill de Blasio announced on Monday, including middle and high school students.

The announcement marks one of the most significant changes prompted by last month’s guidance from the Centers for Disease Control and Prevention that schools could reduce social distancing between students in classrooms to three feet from six. For now, only elementary schools will switch to three feet.

Students in all grades who signed up for in-person classes over the last several weeks will be able to return starting April 26, Mr. de Blasio said. Previously, the city had committed only to bringing back elementary school students who wanted to switch to in-person classes.

Though a large number of families are eager for their children to return to classrooms, the families of about 650,000 of the city’s roughly 1 million students have decided to have them continue learning from home through the end of the school year in June. The families have made that choice even though the city schools have had very low transmission, and tens of thousands of educators are fully vaccinated. Last week, the city also eased a school closure rule that had led to frequent temporary closures, which frustrated many parents.

It is difficult to generalize why hundreds of thousands of families have kept their children home. Some parents may prefer to keep a remote schedule for the next few months for the sake of consistency. Other families have expressed concern about relatively high test positivity rates in New York City’s wider population. Some parents of high school students in particular are concerned that their students would be learning from their laptops even in classrooms.

Mr. de Blasio has said he expects most schools to offer full-time in-person instruction for all or most students for the final months of the school year. The mayor said the school system would be operating at full capacity come September, with all students able to attend school full-time.

Waiting to ride the Staten Island Ferry in New York last month.Credit…Carlo Allegri/Reuters

New York City health officials said on Monday that infections with the coronavirus variant that first emerged in Britain, B.1.1.7, have been increasing in every borough, but slightly more in southern Brooklyn, eastern Queens, and Staten Island. Genetic analysis shows that B.1.1.7 now accounts for about 30 percent of cases sequenced citywide.

The data, which was included in new maps and a report released by the city, represents the first time officials have offered a ZIP-code level look at how worrisome variants have been spreading in New York, overtaking original versions of virus and clustering in some parts of the city more than others.

The report and maps, which were published Monday afternoon on the city’s health department website, also show that a variant first emerged in New York City, B.1.526, has been increasing at even a faster clip, and now represents some 45 percent of cases genetically sequenced in the city. The maps released Monday show that while B.1.526 is found in all five boroughs, it is slightly more common in the Bronx and parts of Queens.

Overall, more than 70 percent of genetically sequenced coronavirus cases now circulating in the city represent worrisome variants. The data, which spans January 1 to March 27, represents less than 5 percent of all positive test results in the city, as sequencing capabilities remain limited. As a result, it only provides a glimpse of the full picture of how the variants are impacting each community.

New York City has remained at a high plateau of coronavirus cases since February, with some 3,000 to 4,000 new cases reported per day, according to city data. The spread of these variants is likely a key reason that cases have not fallen more even as vaccinations rise, the city’s health department said in the report.

Hospitalizations have been falling, but very gradually, as the most vulnerable get vaccinated. Deaths have also been declining, but at a slower than desired pace, and have been averaging about 50 per day.

The United States has seen an exponential rise of B.1.1.7, which is now the most dominant variant across the country, according to the Centers for Disease Control and Prevention. That variant is about 60 percent more contagious and 67 percent more deadly than the original form of the coronavirus, according to the most recent estimates.

It has slammed Europe and helped fuel the worst-in-the-nation outbreak in Michigan. Until recently, the variant’s rise in the United States was somewhat camouflaged by falling infection rates overall, leading some political leaders to relax restrictions on indoor dining, social distancing and other measures. The C.D.C.’s efforts to track down the variants have greatly improved in recent weeks and will continue to grow, though Britain, which has a more centralized health care system, began a highly promoted sequencing program last year that allowed it to track the spread of the B.1.1.7 variant.

Vaccines do appear to be effective against the variant.

Less is known about the B.1.526 variant, which was first documented by researchers in the Upper Manhattan area of New York City last November and has since spread widely through the city and beyond. City officials have said that the variant may be more transmissible, and is outpacing even B.1.1.7 in some neighborhoods.

But it is still unknown whether the variant has an impact on disease severity, re-infection, or vaccine effectiveness. The city said it has no evidence that it does, but that it is studying those possibilities.

The city also warned on Monday that the P.1 variant, which was first identified in Brazil, is increasing its presence, though its incidence as a percentage of total cases remains very low.

The city did not release data or a map showing where P.1 cases have been identified. It has previously said that the variant accounted for 1.3 percent of sequenced samples as of late March — just 24 total cases of P.1. The variant maps released on Monday also excluded all ZIP codes where the total number of sequenced cases was fewer than three.

P.1 is also more transmissible than original versions of the virus, and there is some evidence of immunity evasion among both people who previously had Covid-19 and fully vaccinated people. It is spreading widely in South America and has appeared in many states.

The city’s report did not mention the B.1.351 variant, first found in South Africa, which can partially dodge the body’s immune system response. The city had previously reported sequencing 6 total cases of B.1.351.

People drinking at a pub in South London on Monday, as Britain begins to re-emerge from one of the longest lockdowns in the world.Credit…Andrew Testa for The New York Times

On Monday, Britain’s lockdown — one of the longest and most stringent in the world — finally began drawing to an end.

For people across Europe, struggling with yet another wave of the pandemic and demoralized by a vaccine rollout that, outside of Britain, has been deeply troubled, this is hardly a time to rejoice.

And Britons — who have lost more than 150,000 people to the pandemic — know better than anyone that they are facing a wily adversary, a shape-shifter of a virus that spins off variants that can threaten medical advances with a few mutations.

But just past the stroke of midnight on Monday, a few select establishments in England served their first drinks since being forced to close in December and January, and more than a year after the first of three national lockdowns was imposed to limit the spread of the virus.

Later in the morning, thousands of gyms, salons and retail stores opened their doors for the first time in months, bringing a frisson of life to streets long frozen in a state of suspended animation. Friends reunited, and families shared a meal at outdoor cafes for the first time in months.

The weather may have been chilly — there were even some snow flurries — and pubs were limited to outdoor service. But the moment was embraced with an enthusiasm born of more than a year of on-and-off deprivation and uncertainty, one in which a once-unimaginable level of government decree became a way of life.

Prime Minister Boris Johnson called it “a major step forward in our road map to freedom.”

Monday was the start of a phased reopening that is scheduled to culminate on June 21, when the government says it hopes to lift almost all restrictions in England. Scotland, Wales and Northern Ireland are following separate but similar timetables, which means that some of the restrictions eased on Monday in England will remain in place a while longer in those places.

Lockdowns of one form or another have become so commonplace around the world that it can be hard to recall a time when they did not exist. The word began entering the popular lexicon in the weeks and months after the virus first emerged in China and the authorities there moved aggressively to restrict the movement of its citizens.

While no country matched China’s draconian measures, liberal democracies have been engaged in a yearlong effort to balance economic, political and public health concerns. Last spring, that meant about four billion people — half of humanity — living under some form of stay-at-home order.

Britain, which held out longer than many of its European neighbors, entered its first national lockdown on March 26, 2020.

At the height of the epidemic in January, Britain was averaging almost 60,000 new coronavirus infections and more than 1,200 Covid-19 deaths each day. In the past week, the daily averages were about 2,500 cases and 36 fatalities.

On Monday, as Britons flocked to stores and restaurants, there was widespread hope that after so many false dawns, there will be no going back.

John F. Kennedy Airport in New York in January.Credit…Spencer Platt/Getty Images

New York will no longer require international travelers arriving in the state to quarantine though it continues to recommend they do so, according to new guidance released by the Health Department.

The change was intended to bring the state in line with travel recommendations issued earlier this month by the Centers for Disease Control and Prevention.

In that guidance for international and domestic travel, the C.D.C. said that people fully vaccinated against the coronavirus could travel safely “at low risk to themselves” but should still follow health precautions in public such as wearing masks. Federal health officials also said that they preferred all people avoid travel while the threat of the virus remained so high in the United States. The C.D.C. also cited a lack of vaccine coverage in other countries, and concern about the potential introduction and spread of new variants of the virus that are more prevalent overseas.

The C.D.C. requires all international travelers arriving in the United States to show proof of a recent negative test result before boarding their flights. When fully vaccinated Americans travel abroad, they only need to get a coronavirus test or quarantine if the country they are going to requires it. However, the guidance says they must have a negative coronavirus test before boarding a flight back to the United States, and they should get tested again three to five days after their return.

New York State health officials said in their guidance, released Saturday, that they still recommend all international travelers get tested three to five days after arriving in the state.

They also suggested that unvaccinated travelers should self-quarantine for as many as 10 days and avoid people at risk of serious illness from the virus for two weeks.

The new international guidance came after the state also ended its requirement that domestic travelers to New York quarantine upon arrival. At the time, Gov. Andrew M. Cuomo traced the decision to the pace of vaccinations and a decline in virus figures across the state, though the state was adding new cases at a higher rate than the country as a whole.

As of Sunday, the state’s average daily positivity test rate over the previous week was at 3.27 percent. Virus-related hospitalizations were at 4,083, their lowest number since Dec. 2, according to Mr. Cuomo’s office.

According to a New York Times database, New York State is adding new virus cases at the fifth-highest rate in the country. As of Sunday, the state was reporting an average of 37 new virus cases a day for every 100,000 residents over the last week. The nation as a whole was averaging 21 new cases per 100,000 people.

Allegheny Health Network hosted a vaccine clinic last week in Coraopolis, a suburb of Pittsburgh.Credit…Emily Matthews/Pittsburgh Post-Gazette, via Associated Press

The state of Pennsylvania and the city of Los Angeles are accelerating plans for wider Covid-19 vaccine eligibility this week, as the United States approaches universal eligibility for adults.

Most states and U.S. territories have already expanded access to include anyone over 16. Others, including Massachusetts, New Jersey, Oregon and Washington State, have plans in place for universal adult access to start in the next few days. All states are expected to get there by Monday, a deadline set by President Biden.

Some states have local variations in eligibility, including Illinois, where Chicago did not join a statewide expansion that began Monday.

California as a whole has set Thursday as its date, but Mayor Eric Garcetti of Los Angeles said on Sunday that all residents age 16 or older in his city, the nation’s second largest, would become eligible two days earlier. In Pennsylvania, Gov. Tom Wolf said on Monday that all adults there would be eligible on Tuesday, six days earlier than previously planned.

“We need to maintain acceleration of the vaccine rollout, especially as case counts and hospitalization rates have increased,” Mr. Wolf said in a statement.

Expanded eligibility has not always brought immediate access. Demand for vaccination continues to outstrip supply in much of the nation, with people scrambling to book scarce appointments as they become available. And supplies of Johnson & Johnson’s one-dose vaccine will be extremely limited until federal regulators approve production at a Baltimore manufacturing plant with a pattern of quality-control lapses, the White House’s pandemic response coordinator said on Friday.

“We urge patience as we continue to ramp up our operations, obtain more doses, and enter this new phase of our campaign to end the pandemic,” Mr. Garcetti said.

More than 120 million people — or more than one-third of the U.S. population — have now received at least one dose of a Covid-19 vaccine, according to the Centers for Disease Control and Prevention. The nation is administering about 3.2 million doses a day on average.

Two of the three vaccines authorized for use in the U.S. — those made by Moderna and Johnson & Johnson — are authorized for use in adults. The third, from Pfizer-BioNTech, is authorized for anyone 16 or older, and the company is seeking to expand that range to include youths 12 to 15. No vaccine has yet been authorized for use in younger children.

Global Roundup

Devotees in the Ganges River during Kumbh Mela, or pitcher festival, one of the most sacred pilgrimages in Hinduism, in Haridwar, northern state of Uttarakhand, India, on Monday.Credit…Karma Sonam/Associated Press

Even as India hit a record for daily coronavirus infections, and its total caseload rose to second in the world behind the United States, the images that dominated Indian news media on Monday were of a crowded religious festival along the banks of the Ganges River.

The dissonance was a clear manifestation of the confusing messages sent by the authorities just as India’s coronavirus epidemic is spiraling, with a daily high of 168,000 cases and 900 deaths reported on Monday.

Yet millions of devotees have thronged the holy city of Haridwar for the monthlong Kumbh Mela, or pitcher festival, when Hindu pilgrims seek absolution by bathing in the Ganges. Officials have said that about one million people will participate every day, and as many as five million during the most auspicious days, all crowded into a narrow stretch along the river and searching for the holiest spot to take a dip.

Already, fears are running high that one of the most sacred pilgrimages in Hinduism could turn into a superspreading event.

Dr. S. K. Jha, a local health officer, said that an average of about 250 new cases had been registered each day recently. Experts have warned that many more infections are going unrecorded, and that devotees could unwittingly carry the virus with them as they return to their homes across the country.

India is in the grip of the world’s fastest growing outbreak, with more and more jurisdictions going back into varying stages of lockdown. Infections are spreading particularly fast in Mumbai, the country’s financial hub, and the surrounding state of Maharashtra, where the government has announced a partial weekday lockdown and near-total closure over the weekends.

The situation is also worsening in the capital, New Delhi, which reported more than 10,000 new cases on Sunday, surpassing the previous daily high of nearly 8,500. The state government has imposed a curfew and ordered restaurants and public transport systems to run at half capacity. Arvind Kejriwal, Delhi’s top official, has said more restrictions may follow.

Hospitals in several states are reporting shortages of oxygen, ventilators and coronavirus testing kits, and some are also running low on remdesivir, a drug used in serious Covid-19 cases. India has halted the export of remdesivir until the situation improves.

India is also trying to ramp up its vaccination drive, with about three million people being inoculated daily and 104 million doses administered so far. But with many vaccination centers nationwide expressing concern over possible shortages, India’s large pharmaceutical industry has sharply reduced its exports of the AstraZeneca vaccine in order to keep more doses at home, creating serious challenges for other countries that had been relying on those shipments.

On Monday, Indian experts recommended the use of Russia’s Sputnik-V coronavirus vaccine, which would become the third available in the country if approved by the authorities.

After months of lower-than-expected infections and deaths from the virus, critics say Indian officials have sent dissonant messages about the seriousness of the crisis. Police officers are enforcing curfew and mask rules, sometimes resorting to beatings captured on videos shared across social media. But senior political leaders, including the prime minister, Narendra Modi, have been holding large rallies for local elections.

Mr. Modi’s Hindu nationalist government has also allowed the religious festival to proceed — in contrast to what happened last spring, at the start of the pandemic, when India’s health ministry blamed an Islamic seminary for fanning a far smaller outbreak. Critics say rhetoric from members of Mr. Modi’s party contributed to a spate of attacks against Muslims, a minority of about 200 million people in a Hindu-dominated country of 1.3 billion.

In other news around the world:

  • Bangladesh has announced a weeklong lockdown, closing offices, factories and transport services starting Wednesday, and banning domestic and international flights. The country is facing its severest coronavirus outbreak so far, averaging nearly 7,000 daily new infections, according to a New York Times database, as the virus sweeps across South Asia.

  • In France, all people over 55 are eligible to receive the AstraZeneca and Johnson & Johnson vaccines starting Monday, as the authorities try to ramp up their vaccination campaign after a sluggish start. Health Minister Olivier Véran said on Sunday that France would also extend the period between the first and second shots of the Pfizer and Moderna vaccines to six weeks from four, echoing Britain’s strategy. Over 14 million people have received a first injection.

  • High schools reopened in Greece on Monday after five months closed. The reopening only applies to senior high-school classes, and pupils and teachers will have to take a virus test twice a week before returning to classrooms. Thousands did so at home on Sunday, with just 613 positives out of some 380,000, a rate of 0.16 percent, according to state television. Stores in the country reopened last week.

  • The world’s wealthy nations should commit $30 billion to a global mass vaccination campaign, Gordon Brown, a former prime minister of Britain, said on Monday. Lower-income countries’ inoculation efforts are trailing far behind richer nations’ and the divide has led to allegations of a “vaccine apartheid,” Mr. Brown warned in an op-ed for The Guardian. “The costs may still be in billions, but the benefit will be in trillions,” he wrote.

Anna Schaverien, Constant Méheut and Niki Kitsantonis contributed reporting.

Eric Doulman taking a photo of his graduating daughter, Hannah, in front of photos of her graduating class outside James Madison High School in Brooklyn last May.Credit…James Estrin/The New York Times

Schools and colleges across New York State will be allowed to hold graduation ceremonies for students this spring, with restrictions depending on type of venue or its capacity, Gov. Andrew M. Cuomo said on Monday.

Outdoor ceremonies with more than 500 people, for example, must not exceed 20 percent of the venue’s capacity, and attendees must have proof of vaccination or a recent negative coronavirus test result. Indoor ceremonies with fewer than 100 people cannot exceed 50 percent of the venue’s capacity, though the vaccination or test requirement in that case will be optional, Mr. Cuomo said.

After the pandemic hit last spring, officials in New York and across the nation warned that graduation ceremonies could fuel the virus’s spread, and many such events were canceled.

Colleges and universities began experiencing major outbreaks after students returned in the fall, and more than 120,000 cases have been linked to U.S. colleges and universities since Jan. 1. As they’ve been shuttled back and forth to campuses, depending on whether they’ve been open or closed, scientists have feared students were spreading the virus.

This spring, vaccinations have tracked upward, but dangerous virus variants are spreading and case counts remain high in many places. That has left colleges struggling to find a consensus on how best to mark commencement.

Mr. Cuomo said that New York State’s new rules on graduation will take effect on May 1. But he said officials are still encouraging drive-through or virtual graduation ceremonies as safer options, and he warned that the pandemic was far from over.

According to a New York Times database, New York State is adding new virus cases at the fifth-highest rate in the country. As of Sunday, the state was reporting an average of 37 new virus cases a day for every 100,000 residents over the last week. The nation as a whole was averaging 21 new cases per 100,000 people.

Scientists working at a Regeneron facility in New York State in 2020.Credit…Regeneron, via Associated Press

A monoclonal antibody cocktail developed by the drug maker Regeneron offered strong protection against Covid-19 when given to people living with someone infected with the coronavirus, according to clinical trial results announced on Monday. The drug, if authorized, could offer another line of defense against the disease for people who are not protected by vaccination.

The findings are the latest evidence that such lab-made drugs not only prevent the worst outcomes of the disease when given early enough, but also help prevent people from getting sick in the first place.

Using the cumbersome drugs preventively on a large scale won’t be necessary: Vaccines are sufficient for the vast majority of people and are increasingly available.

Still, antibody drugs like Regeneron’s could give doctors a new way to protect high-risk people who haven’t been inoculated or who may not respond well to vaccination, such as those taking drugs that weaken their immune system. That could be an important tool as rising coronavirus cases and dangerous virus variants threaten to outpace vaccinations.

Regeneron said in a news release that it would ask the Food and Drug Administration to expand the drug’s emergency authorization — currently for high-risk people who already have Covid but are not hospitalized — to allow it to be given for preventive purposes in “appropriate populations.”

There’s “a very substantial number of people” in the United States and globally who could be a good fit to receive these drugs for preventive purposes, said Dr. Myron Cohen, a University of North Carolina researcher who leads monoclonal antibody efforts for the Covid Prevention Network, a National Institutes of Health-sponsored initiative that helped to oversee the trial.

“Not everyone’s going to take a vaccine, no matter what we do, and not everyone’s going to respond to a vaccine,” Dr. Cohen said.

Regeneron’s new data come from a clinical trial that enrolled more than 1,500 people who lived in the same household as someone who had tested positive for the virus within four days. Those who got an injection of Regeneron’s drug were 81 percent less likely to get sick with Covid compared to volunteers who got a placebo.

Dr. Rajesh Gandhi, an infectious diseases physician at Massachusetts General Hospital who was an investigator for the study, said the data were “promising” for people who have not yet been vaccinated. (An earlier version of this item incorrectly said that Dr. Gandhi was not involved in the study.)

Even so, he said, the study did not enroll the type of patients that would be needed to assess whether the drug should be used preventively for immunocompromised patients. “I would say we don’t yet know that,” Dr. Gandhi said.

Regeneron’s cocktail, a combination of two drugs designed to mimic the antibodies generated naturally when the immune system fends off the virus, got a publicity boost last fall when it was given to President Donald J. Trump after he got sick with Covid.

The treatment received emergency authorization in November. Doctors are using it, as well as another antibody cocktail from Eli Lilly, for high-risk Covid patients.

But use of the antibody drugs has been slowed not by a shortage of doses, but by other challenges, though access has improved in recent months. Many patients don’t know to ask for the drugs or where to find them.

Many hospitals and clinics have not made the treatments a priority because they have been time-consuming and difficult to administer, in large part because they must be given via intravenous infusion. Regeneron plans to ask the F.D.A. to allow its drug to be given via an injection, as it was administered in the results of the study announced on Monday, which would allow it to be given more quickly and easily.

The positivity rate for Covid tests in Gaza has been running very high, a sign of rapid community spread. A health worker collected a nasal swab sample from a man in Gaza City on Monday.Credit…Mohammed Abed/Agence France-Presse — Getty Images

Severe and critical cases of Covid-19 have hit record highs this week in the blockaded Gaza Strip, a development that health experts attributed to the proliferation of the highly transmissible coronavirus variant first identified in Britain.

Medical officials in the Hamas-run Health Ministry estimated that the variant now accounts for four out of five new cases in Gaza. They detected it in the densely populated territory for the first time in late March.

“We are in a dangerous place,” said Dr. Majdi Dhair, the director of the ministry’s preventive medicine department. “We expect more people to become infected and more people to enter hospitals. We ask God to pull us out of this situation.”

Over the past three weeks, severe cases — typically when a patient’s oxygen level falls to 94 percent or less — have risen to 219 from 58, according to ministry data. Critical cases, which can involve respiratory failure, septic shock or multiple organ dysfunction, jumped to 58 from 17.

On top of that, the ministry said on Monday that about 38 percent of the 4,700 virus test results it had received over the preceding 24 hours were positive — one of the highest rates in the past month.

Dr. Dhair said he believed that hospitals in Gaza were prepared to handle more severe and critical cases, but that they would probably have to postpone some surgical procedures to free up intensive care beds.

Devastated by years of conflict, Gaza’s hospitals were already dealing with challenging circumstances before the first cases of community transmission of the virus were discovered in the territory in August.

Gaza’s population is overwhelmingly young, and less than 1 percent of residents have been vaccinated so far.

The sharp rise in severe and critical cases has come just before the Muslim holy month of Ramadan, which begins on Tuesday. Traditionally during Ramadan, many Palestinians in Gaza would gather for large meals after sunset, pack streets in popular commercial districts and crowd into mosques for special evening prayers. But a number of those traditions will be prohibited this year because of the pandemic, the authorities said.

A QR code in a London cafe, for use with the British government’s contact tracing app.Credit…Neil Hall/EPA, via Shutterstock

An update to the contact tracing app used in England and Wales has been blocked from release by Apple and Google because of privacy concerns, renewing a feud between the British government and the two tech giants about how smartphones can be used to track Covid-19 cases.

In an attempt to trace possible infections, the update to the app would have allowed a person who tests positive for the virus to upload a list of restaurants, shops and other venues they recently visited, data that would be used by health officials for contact tracing. But collecting such location information violates the terms of service that Google and Apple forced governments to agree to in exchange for making contact tracing apps available on their app stores.

The dispute, first reported by the BBC, highlights the supernational role that Apple and Google have played responding to the virus. The companies, which control the software of nearly every smartphone in the world, have forced governments to design contact tracing apps to their privacy specifications, or risk not having the tracking apps made available to the public. The gatekeeper role has frustrated policymakers in Britain, France and elsewhere, who have argued those public health decisions are for governments, not private companies to make.

The release of the app update was to coincide with England’s relaxation of lockdown rules. On Monday, the country began loosening months of Covid-related restrictions, allowing nonessential shops to reopen, and pubs and restaurants to serve customers outdoors.

An older version of the contact tracing app continues to work, but the data is stored on a person’s device, rather than being kept in a centralized database.

To use the app, visitors to a store or restaurant take a photo of a poster with a QR code displayed in the business, and the software keeps a record of the visit in case someone at the same location later tests positive.

Apple and Google are blocking the update that would let people upload the history of the locations they have checked into directly to health authorities.

The Department of Health and Social Care said it is in discussions with Apple and Google to “provide beneficial updates to the app which protect the public.”

Apple and Google declined to comment.

A vaccination center at the Royal Exhibition Building in Melbourne, Australia, last month.Credit…James Ross/EPA, via Shutterstock

Australia has given up on the goal of vaccinating its entire population against Covid-19 by the end of the year, following updated advice from health officials that younger people should not receive the AstraZeneca vaccine, as well as delays in the delivery of doses.

The Australian government said last week that it had accepted a recommendation by a panel of health experts that people under 50 receive the Pfizer-BioNTech vaccine instead of the one developed by AstraZeneca, which had been the centerpiece of Australia’s vaccination program. The change in guidance came after European regulators found links between the AstraZeneca vaccine and rare blood clots, prompting several countries to restrict use of the shot.

Prime Minister Scott Morrison said Friday that the government had ordered another 20 million doses of the Pfizer vaccine, doubling what it had already purchased. But they are not expected to be available until the fourth quarter of this year, dealing a blow to the government’s previously stated goal of inoculating all of its 25 million people by then.

Mr. Morrison appeared to acknowledge the change in timeline in a Facebook post on Sunday.

“The government has also not set, nor has any plans to set any new targets for completing first doses,” Mr. Morrison said. “While we would like to see these doses completed before the end of the year, it is not possible to set such targets given the many uncertainties involved.”

Public health experts have criticized Mr. Morrison’s government for relying too heavily on the AstraZeneca vaccine, a relatively cheap and easy-to-use shot but one whose troubles have jeopardized inoculation efforts in multiple countries. They said the setback to Australia’s vaccination program risked undermining the country’s success in containing the spread of the coronavirus since recording its first case in January 2020.

“We’re in a position a year later where that hard-won success is jeopardized by a completely incompetent approach to a vaccine rollout,” said Bill Bowtell, a public health policy expert and adjunct professor at the University of New South Wales in Sydney.

Australia has made four separate agreements for the supply of Covid-19 vaccines that would give it a total of 170 million doses, enough to inoculate its population more than three times over. Plans to manufacture almost all of its 54 million AstraZeneca doses domestically were approved last month.

But the Australian government has been under fire for weeks over the sluggish pace of its vaccination rollout, which began in late February. By the end of March, when the government had aimed to vaccinate four million people, only about 600,000 had actually been inoculated. As of Sunday, Australia had administered fewer than 1.2 million doses.

Australian officials have attributed the slow rollout to delays in the delivery of millions of vaccine doses manufactured in the European Union, which has curbed exports amid its own supply shortages. The export restrictions mainly affect the AstraZeneca vaccine.

After enduring strict lockdowns for much of the past year, Australians are now enjoying relatively normal life in a country that has all but stamped out the virus. But public health experts warn that until more of the population is vaccinated, those freedoms are precarious.

“Having eliminated Covid, they thought a mass vaccination campaign would lock that in,” Mr. Bowtell said of the Australian public. “Now they are being deeply disillusioned.”

Covid-19 vaccinations at a monastery in Bangkok this month.Credit…Adam Dean for The New York Times

Thailand is facing its worst coronavirus outbreak just as millions of people head to their home provinces during the country’s biggest travel holiday.

The latest wave of infections, which has sent at least eight cabinet members into isolation, is centered in a Bangkok nightlife district said to be popular with government officials and wealthy partygoers. The country, which until now has largely kept the virus under control, set a record Monday for new daily cases with 985.

One top health official warned that Thailand could soon face as many as 28,000 new cases a day in the worst-case scenario. The government announced it would set up field hospitals as Covid-19 wards at existing facilities begin to fill up.

Officials ordered the closure of hundreds of bars and nightclubs, but critics say the government has been inconsistent in its efforts to bring the outbreak under control. The prime minister, Prayuth Chan-ocha, stopped short of banning travel between provinces for the Songkran holiday, which begins on Tuesday and marks the beginning of the Thai New Year.

“Whatever will be, will be,” he said last week in explaining his decision. “The reason is it’s a matter that involves a huge number of people. The government will have to try to cope with that later.”

Dozens of provinces have imposed their own restrictions on travelers coming from Bangkok and other affected areas, prompting many Thais to cancel their trips. But many others set off over the weekend.

During earlier outbreaks, the government often acted quickly to require face masks, ban foreign tourists, impose quarantine restrictions and lock down hard-hit areas. It has reported fewer than 34,000 cases — mostly from a January surge traced to a seafood market near Bangkok — and just 97 deaths.

But it has been lax in testing and slow to vaccinate. So far, it has procured about 2.2 million doses and given at least one to about 500,000 people. Thailand’s population is 70 million.

Vaccine production is not expected to begin in earnest until June, when a manufacturer in Thailand is scheduled to begin producing 10 million doses a month of the AstraZeneca vaccine.

Health officials were alarmed by the recent discovery of dozens of cases of the highly infectious coronavirus variant first identified in Britain. The finding highlighted the inadequacy of Thailand’s virus testing and suggested that its quarantine procedures have not been as effective as officials believed.

Tourism operators have been especially angered by the government’s lackadaisical approach to obtaining vaccine supplies. The tourism industry, which normally accounts for about 20 percent of the nation’s economy, is highly dependent on foreign visitors and has been calling for widespread vaccinations to speed its recovery.

The outbreak in Bangkok has also prompted questions about the activities of some top officials and their aides.

The transportation minister, Saksayam Chidchob, who was hospitalized with Covid-19, was criticized for not being forthcoming about his whereabouts during times when he may have been exposed to the virus. He denied visiting the gentlemen’s club at the center of the outbreak and said he believed he had contracted the virus from an aide.

Eyan Gallegos, 11, a middle schooler in Washington, completing his homework in his room.Credit…Gabriella Demczuk for The New York Times

Parents with school-age children have struggled to combine their usual work and family responsibilities this past year with at least some degree of home-schooling.

But mothers and fathers of middle-schoolers — the parenting cohort long known to researchers as the most angst-ridden and unhappy — are connecting now in a specific sort of common misery: the pressing fear that their children, at a vital point in their academic and social lives, have tripped over some key developmental milestones and may never quite find their footing.

Experts say some of their worries are justified — up to a point. The pandemic has taken a major toll on many adolescents’ emotional well-being.

Yet as the nation begins to pivot from trauma to recovery, many mental-health experts and educators are trying to spread the message that parents, too, need a reset. If adults want to guide their children toward resilience, these experts say, then they need to get their own minds out of crisis mode.

Early adolescence is considered a critical period, a time of brain changes so rapid and far-reaching that they rival the plasticity and growth that take place in the newborn to 3-year-old phase.

These changes make children more capable of higher-level thinking and reasoning. They also make them crave social contact, attention and approval.

Remote learning and social distancing are in many ways the opposite of what children in this age group want and need.

It’s been hardest on middle schoolers,” said Phyllis Fagell, a therapist and school counselor who wrote the 2019 book “Middle School Matters.” “It is their job to pull away from parents, to use these years to really focus on figuring out where they are in the pecking order. And all of that hard work that has to happen in these years was just put on hold.”

Yet Ms. Fagell and many other experts in adolescent development were adamant that parents should not panic — and that the spread of the “lost year” narrative needed to stop.

Getting a full picture of what’s going on with middle schoolers, they agreed, requires holding two seemingly contradictory ideas simultaneously in mind: The past year has been terrible. And most middle schoolers will be fine.