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World News

The Tech Chilly Warfare’s ‘Most Difficult Machine’ That’s Out of China’s Attain

SAN FRANCISCO — President Biden and many lawmakers in Washington are worried these days about computer chips and China’s ambitions with the foundational technology.

But a massive machine sold by a Dutch company has emerged as a key lever for policymakers — and illustrates how any country’s hopes of building a completely self-sufficient supply chain in semiconductor technology are unrealistic.

The machine is made by ASML Holding, based in Veldhoven. Its system uses a different kind of light to define ultrasmall circuitry on chips, packing more performance into the small slices of silicon. The tool, which took decades to develop and was introduced for high-volume manufacturing in 2017, costs more than $150 million. Shipping it to customers requires 40 shipping containers, 20 trucks and three Boeing 747s.

The complex machine is widely acknowledged as necessary for making the most advanced chips, an ability with geopolitical implications. The Trump administration successfully lobbied the Dutch government to block shipments of such a machine to China in 2019, and the Biden administration has shown no signs of reversing that stance.

Manufacturers can’t produce leading-edge chips without the system, and “it is only made by the Dutch firm ASML,” said Will Hunt, a research analyst at Georgetown University’s Center for Security and Emerging Technology, which has concluded that it would take China at least a decade to build its own similar equipment. “From China’s perspective, that is a frustrating thing.”

ASML’s machine has effectively turned into a choke point in the supply chain for chips, which act as the brains of computers and other digital devices. The tool’s three-continent development and production — using expertise and parts from Japan, the United States and Germany — is also a reminder of just how global that supply chain is, providing a reality check for any country that wants to leap ahead in semiconductors by itself.

That includes not only China but the United States, where Congress is debating plans to spend more than $50 billion to reduce reliance on foreign chip manufacturers. Many branches of the federal government, particularly the Pentagon, have been worried about the U.S. dependence on Taiwan’s leading chip manufacturer and the island’s proximity to China.

A study this spring by Boston Consulting Group and the Semiconductor Industry Association estimated that creating a self-sufficient chip supply chain would take at least $1 trillion and sharply increase prices for chips and products made with them.

That goal is “completely unrealistic” for anybody, said Willy Shih, a management professor at Harvard Business School who studies supply chains. ASML’s technology “is a great example of why you have global trade.”

The situation underscores the crucial role played by ASML, a once obscure company whose market value now exceeds $285 billion. It is “the most important company you never heard of,” said C.J. Muse, an analyst at Evercore ISI.

Created in 1984 by the electronics giant Philips and another toolmaker, Advanced Semiconductor Materials International, ASML became an independent company and by far the biggest supplier of chip-manufacturing equipment that involves a process called lithography.

Using lithography, manufacturers repeatedly project patterns of chip circuitry onto silicon wafers. The more tiny transistors and other components that can be added to an individual chip, the more powerful it becomes and the more data it can store. The pace of that miniaturization is known as Moore’s Law, named after Gordon Moore, a co-founder of the chip giant Intel.

In 1997, ASML began studying a shift to using extreme ultraviolet, or EUV, light. Such light has ultrasmall wavelengths that can create much tinier circuitry than is possible with conventional lithography. The company later decided to make machines based on the technology, an effort that has cost $8 billion since the late 1990s.

The development process quickly went global. ASML now assembles the advanced machines using mirrors from Germany and hardware developed in San Diego that generates light by blasting tin droplets with a laser. Key chemicals and components come from Japan.

Peter Wennink, ASML’s chief executive, said a lack of money in the company’s early years had led it to integrate inventions from specialty suppliers, creating what he calls a “collaborative knowledge network” that innovates quickly.

“We were forced to not do ourselves what other people do better,” he said.

ASML built on other international cooperation. In the early 1980s, researchers in the United States, Japan and Europe began considering the radical shift in light sources. The concept was taken up by a consortium that included Intel and two other U.S. chip makers, as well as Department of Energy labs.

ASML joined in 1999 after more than a year of negotiations, said Martin van den Brink, ASML’s president and chief technology officer. Other partners of the company included the Imec research center in Belgium and another U.S. consortium, Sematech. ASML later attracted big investments from Intel, Samsung Electronics and Taiwan Semiconductor Manufacturing Company to help fund development.

That development was made trickier by the quirks of extreme ultraviolet light. Lithography machines usually focus light through lenses to project circuit patterns on wafers. But the small EUV wavelengths are absorbed by glass, so lenses won’t work. Mirrors, another common tool to direct light, have the same problem. That meant the new lithography required mirrors with complex coatings that combined to better reflect the small wavelengths.

So ASML turned to Zeiss Group, a 175-year-old German optics company and longtime partner. Its contributions included a two-ton projection system to handle extreme ultraviolet light, with six specially shaped mirrors that are ground, polished and coated over several months in an elaborate robotic process that uses ion beams to remove defects.

Generating sufficient light to project images quickly also caused delays, Mr. van den Brink said. But Cymer, a San Diego company that ASML bought in 2013, eventually improved a system that directs pulses from a high-powered laser to hit droplets of tin 50,000 times a second — once to flatten them and a second time to vaporize them — to create intense light.

The new system also required redesigned components called photomasks, which act like stencils in projecting circuit designs, as well as new chemicals deposited on wafers that generate those images when exposed to light. Japanese companies now supply most of those products.

Since ASML introduced its commercial EUV model in 2017, customers have bought about 100 of them. Buyers include Samsung and TSMC, the biggest service producing chips designed by other companies. TSMC uses the tool to make the processors designed by Apple for its latest iPhones. Intel and IBM have said EUV is crucial to their plans.

“It’s definitely the most complicated machine humans have built,” said Darío Gil, a senior vice president at IBM.

Dutch restrictions on exporting such machines to China, which have been enforced since 2019, haven’t had much financial impact on ASML since it has a backlog of orders from other countries. But about 15 percent of the company’s sales come from selling older systems in China.

In a final report to Congress and Mr. Biden in March, the National Security Commission on Artificial Intelligence proposed extending export controls to some other advanced ASML machines as well. The group, funded by Congress, seeks to limit artificial intelligence advances with military applications.

Mr. Hunt and other policy experts argued that since China was already using those machines, blocking additional sales would hurt ASML without much strategic benefit. So does the company.

“I hope common sense will prevail,” Mr. van den Brink said.

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Health

Chilly Tooth Ache’s Mysterious Molecular Perpetrator

There’s nothing like the strange, bone-shaking reaction of a damaged tooth exposed to something cold: a bite of ice or a cold drink and suddenly that sharp, searing sensation, like a needle piercing a nerve.

Researchers have known for years that this phenomenon is due to damage to the outer protective layer of the tooth. But how the message gets from the outside of your tooth to the nerves inside has been difficult to detect. On Friday, biologists reported in Science Advances magazine that they identified an unexpected player for this painful sensation: a protein embedded in the surface of cells inside teeth. The discovery offers insight into the connection between the outside world and the inside of a tooth and could one day guide the development of treatments for toothache.

More than a decade ago, Dr. Katharina Zimmerman, now a professor at Friedrich-Alexander-Universität in Germany, discovered that cells that produce a protein called TRPC5 are sensitive to cold. When it got cold, TRPC5 opened and formed a channel for ions to flow across the cell membrane.

Ion channels like TRPC5 are distributed throughout our bodies, said Dr. Zimmerman, and they are behind some surprisingly familiar sensations. For example, if your eyes feel cold and dry in cold air, an ion channel in the cornea is activated. She wondered what other parts of the body might be using a cold receptor like TRPC5. And it occurred to her that “the most sensitive tissue in the human body can be teeth” when it comes to cold sensations.

In the protective covering of their enamel, teeth are made of a hard substance called dentin that is threaded through tiny tunnels. The heart of dentin is the soft pulp of the tooth, in which nerve cells and cells, so-called odontoblasts, that make dentin, are intertwined.

The prevailing theory of how teeth perceive cold was that changes in temperature put pressure on the fluid in dentin tunnels and somehow provoke a response in those hidden nerves. But there was little detail on how exactly that could happen and what could bridge the gap between them.

Dr. Zimmerman and her colleagues examined whether mice that lacked the TRPC5 channel still experienced toothache, as did normal mice. They were intrigued to find that when these mice damaged their teeth, they didn’t act like something was wrong. In fact, they looked something like they’d been given an anti-inflammatory pain reliever, said Dr. Zimmerman.

Your co-author Dr. Jochen Lennerz, a pathologist at Massachusetts General Hospital, examined human teeth for signs of the ion channel and found them in their nerves and other cells. This suggested that the channel might play a role in a person’s perception of cold.

Over many years, the researchers developed a method to precisely measure the nerve signals emerging from a mouse’s damaged molar. They tested their ideas with molecules that could block the activity of various channels, including TRPC5.

The picture they slowly compiled is that TRPC5 is active in the odontoblasts. That was a bit of a surprise, as these support cells are best known for making and maintaining dentin without aiding the perception. Inside the odontoblasts, said Dr. Lennerz, TRPC5 opens when the cold signal comes through the dentinal tunnel, and this causes a message to be sent to the nerves.

One substance that prevents TRPC5 from opening is eugenol, the main ingredient in clove oil, a traditional treatment for toothache. Although the US Food and Drug Administration does not clearly assess the effectiveness of eugenol, it may be due to the effects of TRPC5 in relieving pain in some people.

Perhaps knowing that this canal is at the heart of cold-induced pain will lead to better treatments for toothache in the future – better ways to keep this message from becoming overwhelming.

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Business

Why SPACs May Go away Buyers within the Chilly

The misalignments are severe.

SPAC sponsors say they are putting their reputation on the line, especially if they plan to repeat the process. This applies to series sponsors such as tech investor Chamath Palihapitiya, experienced banker Michael Klein and buyout specialist Alec Gores. In some cases, sponsors invest some of their own money in the business they are acquiring to better align their interests. But remember that often they have already received 20 percent of the business, so they are partially playing with house money.

SPAC sponsors also try to attract established brand investors to their launch, which gives legitimacy to the empty shell. For some of these investors, however, it’s all about financial engineering. They don’t have a unique interest in a SPAC as they have the ability to repay their investment plus interest for a modest but predictable rate of return, almost regardless of what happens to the acquisition. If the deal turns out to be a big winner, it’s a bonus.

What is unique is that the sponsor has no fiduciary duty towards the investors in the acquired company. Very few sponsors seek fairness opinions from third parties to confirm the price they are paying for an acquisition. And while mainstream investors increasingly pump additional funds into SPACs at the time of a merger, they typically do so at a lower cost than less-connected investors.

SPACs seek to differentiate themselves by nurturing their managers’ experience and the relationships with companies they may acquire. In most cases, however, the sponsor must use the money raised in a SPAC or be forced to return it within two years. This is an incentive to get a deal instead of getting the right deal at the right price and at the right time.

According to data service SPAC Research, there are currently more than 300 SPACs with a cash volume of around 100 billion US dollars seeking acquisitions. Since SPACs typically buy companies five times their size thanks to outside investment, that translates into potential purchasing power of about $ 500 billion.

“We have a massive problem with the imbalance between supply and demand. It’s inevitable, ”said Kawaja. “We know how it will end.”

None of this means that the traditional IPO process is better than the SPAC process. Both have advantages and disadvantages. It is possible for SPACs to become routine for certain types of companies to go public.

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Health

Easy methods to Train Outside in Chilly Climate

Along the way, start with a base layer made of merino wool, polypropylene, or a material that will wick away water and sweat. These include glove liners, socks and hats that can get wet with sweat and freeze. Next, add a slightly thicker layer of fleece or light wool and top it off with something that breaks the wind. Sunglasses or goggles, as well as a buff, ties that can be pulled over the mouth and nose, protect the face. There are a variety of winter boot options. So be sure to check the temperature rating and traction.

“I buy hand and toe warmers in bulk and have them in my pockets,” said Dr. Katie Eichten, cross-country skier and emergency doctor at the Hayward Area Memorial Hospital in Wisconsin. “I also put one on the back of my phone and put both of them in a medium pocket to make the battery last longer.”

If you are driving into the mountains, your phone can be an especially powerful tool. Dustin Dyer, owner and director of the Kent Mountain Adventure Center, suggests downloading a navigation app like Avenza Maps, Powder Project or Trailforks that contains offline digital maps and uses your phone’s built-in GPS to locate you even if you are not there offer.

SAFETY FIRST Depending on your winter outdoor activity, you should consider special safety training.

Mr. Dyer, who leads backcountry skiers, snowboarders, and ice climbers, recommends CPR training for everyone.

“If you’re an hour away from grooming, spending several days outdoors, or really going offline, you should have Wilderness First Aid,” he said of the certification course. “And everyone who goes to the mountains in winter needs some kind of avalanche training. For most people, avalanche awareness focused on avoidance will be adequate. “

WARM UP (AND COOL DOWN) If you exercise in cold temperatures, your muscles will not be as flexible and you are at increased risk of injury and stress. The cold air also causes the upper airways to narrow, making it difficult to breathe. Breathing through your nose and covering your nose and mouth with a scarf or mask can warm the air before it reaches the lower airway. But both the muscles and the lungs need to warm up for at least 10 to 15 minutes.

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Politics

Job Seekers With Trump White Home on Their Résumés Face a Chilly Actuality

Others are still weighing their options.

Hope Hicks, a senior advisor who left the White House in 2018 and got an important job as Fox Corporation’s chief communications officer before returning in March, has told people near her that she is planning an extended vacation.

Hogan Gidley, a former White House deputy press secretary and campaign spokesman whose duties recently included naming Mr. Trump on Fox News the “manliest” president in American history, said he was considering “various things” and not concerned about the search before him.

“I think it’s an exaggeration,” said Gidley of the challenges he and his colleagues may face in the months ahead. But then he paused. “Let me put it this way, I hope it’s an exaggeration.”

While former advisers ponder their future in Washington, a small group of advisors will stay with Mr. Trump in Florida and assist him in building his post-presidency presence.

The group of loyalists who have followed him include Dan Scavino, a former White House deputy chief of staff for communications, and Nick Luna, the former personal bird of Mr. Trump. A larger group of aides, including Brian Jack, the former White House political director, are considering staying in Trump country but have not yet made any final decisions.

Others, including Margo Martin, a former press office worker, and Molly Michael, an assistant to Mr. Trump, are government employees who are paid by the General Services Administration and will help Mr. Trump with the transition process.

While her former colleagues spent the weekend grappling with the cold reality of life in a Washington state where the Democrats are now in charge, Ms. Martin posted a photo of her surroundings in Mar-a-Lago, Mr. Trump’s sun-drenched resort in, on Instagram Palm Beach, Florida.

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Health

Coronavirus Will Resemble the Widespread Chilly, Scientists Predict

Other experts said this scenario is not only plausible, it is likely.

“I fully agree with the overall intellectual construct of the paper,” said Shane Crotty, a virologist at the La Jolla Institute of Immunology in San Diego.

If the vaccines prevent people from transmitting the virus, “it’s much more like the measles scenario where you vaccinate everyone, including children, and the virus really doesn’t infect people,” said Dr. Crotty.

It’s more plausible that the vaccines prevent disease – but not necessarily infection and transmission, he added. And that means the coronavirus will continue to circulate.

“The vaccines we currently have are unlikely to offer sterilizing immunity,” said Jennifer Gommerman, an immunologist at the University of Toronto.

A natural infection with the coronavirus leads to a strong immune response in the nose and throat. But with the current vaccines, Dr. Gommerman: “You don’t get a natural immune response in the actual upper airways, you get an injection in your arm.” This increases the likelihood that infections will still occur after vaccination.

Ultimately, Dr. Lavine’s model on the assumption that the new coronavirus is similar to the common cold coronavirus. That assumption might not be true, however, warned Marc Lipsitch, an epidemiologist at Harvard TH Chan School of Public Health in Boston.

“Other coronavirus infections may or may not be applicable because we haven’t seen what these coronaviruses can do to an elderly, naive person,” said Dr. Lipsitch. (Naive refers to an adult whose immune system has not been exposed to the virus.)