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Health

Florida, Texas open Covid antibody remedy facilities as delta surge overwhelms hospitals

Florida Governor Ron DeSantis holds a press conference to announce the opening of a monoclonal antibody treatment center to help recover COVID-19 patients at Camping World Stadium in Orlando.

Paul Hennessy | LightRakete | Getty Images

Florida and Texas are opening free monoclonal antibody centers to treat a surge in Covid-19 patients in both states in the hopes that early intervention will help keep people out of hospitals and save more lives – even if they do The governors of both states are fighting local officials with mask and vaccination regulations.

Texas is building nine antibody infusion centers, Governor Greg Abbott announced on Friday, while Florida opened its fifth site on Wednesday. With the delta variant spike, coronavirus patients were occupied by more than 46% of Texas intensive care beds and more than half of Florida intensive care units as of Thursday, compared with 27% nationwide, according to the Department of Health and Social Affairs.

“What takes you to the hospital is the inflammation. People get inflammation in their lungs,” said Dr. Arturo Casadevall, Chair of Molecular Microbiology and Immunology at the Bloomberg School of Public Health at Johns Hopkins University, told CNBC in an interview. “So what these antibodies do is, if you give them to a patient early, they neutralize the virus.”

Abbott has firsthand experience of the treatment. His office announced Tuesday that he was receiving monoclonal antibody treatment from Regeneron after testing positive for Covid despite being fully vaccinated.

Although monoclonal antibodies like Regeneron and GlaxoSmithKline treatments are one of the few proven ways to fight the virus and reduce hospital stays, they were rarely used during the pandemic because they are awkward to administer. Monoclonal antibody treatments must be injected directly into the vein via an IV infusion, which requires time and dedicated medical staff, often using the same equipment reserved for chemotherapy patients.

The Food and Drug Administration issued emergency clearances to Regeneron’s treatment in November, saying it reduced hospital admissions for Covid “in patients at high risk for disease progression within 28 days of treatment.” GlaxoSmithKline just received emergency approval for its treatment with Vir Biotechnology in May and said it has reduced hospital stays and deaths in high-risk patients by about 85%.

The FDA approved both companies’ treatments for use in patients 12 years of age and older.

“Many patients who are examined by their doctors and referred for a monoclonal antibody infusion are less likely to be hospitalized,” said Teresa Farfan, spokeswoman for the Texas Division of Emergency Management, in an email to CNBC . “This will help ensure that resources are available in the hospitals to treat those with the most severe cases of the virus.”

Treatment centers couldn’t get there early enough as the Delta variant is driving cases to record highs in Florida. The state, which publishes its cases once a week on Fridays, last reported a record seven-day average of nearly 21,700 new infections, 12.6% more than a week ago, according to a CNBC analysis of data compiled by Hopkins.

Texas has been moving closer and closer to its record highs of more than 23,000 average cases per day in January in recent weeks, reporting a seven-day average of just over 15,400 new infections on Thursday, up from a seven-day average of around 3,000 a last month.

“Let me be very clear on this – both monoclonal and vaccines save lives,” said Christina Pushaw, spokeswoman for Florida Governor Ron DeSantis, in an email to CNBC. “They certainly aren’t mutually exclusive.”

More than 34% of the 50,706 registered inpatients in Florida have the coronavirus, as does over a quarter of the 51,337 registered inpatients in Texas, as measured Thursday. Abbott called 2,500 medical workers from across the country last week to help fight the virus and urged hospitals to build capacity by postponing election procedures.

A box and vial of the Regeneron monoclonal antibody can be seen at a new COVID-19 treatment site opened by Florida Governor Ron DeSantis at Camping World Stadium in Orlando following a press conference.

Paul Hennessy | LightRakete | Getty Images

While both Abbott and DeSantis have urged residents to get vaccinated, they still strictly oppose mask or vaccination regulations, saying it violates personal freedoms. Republican governors have banned local governments and school districts from requiring face-covering. Abbott has threatened $ 1,000 fines for those who fail to comply, and DeSantis said it will withhold pay from educators who prescribe masks.

With many children returning to classrooms this fall, local officials are pushing back. Several school districts in both states have defied their governors’ orders and restored their mask mandates, with appeals courts in Dallas and San Antonio issuing injunctions last week to circumvent the ban.

The Texas Supreme Court on Sunday blocked the injunctions, sided with Abbott and prevented school districts from issuing their own guidelines. Local officials say they plan to continue fighting Abbott in court, and President Joe Biden on Wednesday directed the education secretary to intervene “to protect our children.”

“This includes using all of its regulators and, if necessary, taking legal action against governors who try to block and intimidate local school officials and educators,” said Biden.

Dr. Bruce Farber, chief of infectious diseases at Northwell Health in New York, said states that don’t allow schools to prescribe masks are at great risk this fall.

“These states are gambling as I see it,” he said in an interview. “By not allowing masking and preventing masking and leaving it to the parents, (they) are really playing with fire.”

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Entertainment

Abrons Arts Heart’s Fall Season Celebrates Trailblazers

Abrons Arts Center’s lineup for the fall season is a salute to groundbreakers and innovators in the arts, public housing and emerging technology.

“As we emerge from isolation, we wanted to focus on work that’s still been happening and developing in different ways during the pandemic,” Craig Peterson, the center’s executive artistic director, said in an interview. “Because it deserves an audience.”

Several of the productions scheduled at the 300-seat playhouse for the coming season were booked before the pandemic and postponed because of it, said Peterson, who curated the season in collaboration with Ali Rosa-Salas, the recently appointed artistic director of the center.

“Lots of them got displaced when we stopped live performance,” he said. “But we never stopped supporting artists and always intended to present them.”

The center has scheduled a free concert, “Holy Ground: Land of Two Towers,” by the jazz ensemble Onyx Collective on Sept. 11 to commemorate the 20th anniversary of the attacks on the World Trade Center.

“It felt like an appropriate way to think about the long-term impacts of historical moments like the ones we’re in now,” Rosa-Salas said.

A week later, the center will open a free outdoor photography exhibition, “Community Matriarchs of NYCHA” (for the New York City Housing Authority), celebrating five women who have transformed their neighborhood on the Lower East Side, where they organized food distribution, especially during the pandemic, to other residents of public housing. The exhibition, presented as part of the Photoville Festival 2021 in partnership with the digital storytelling platform My Projects Runway, will include portraits by Courtney Garvin and video interviews by Christopher Currence and remain on view through Dec. 1.

“I’m really excited to uplift women activists in our community and reflect on the role of public housing in our neighborhood and city,” Rosa-Salas said.

From there it’s on to Frankenstein, Bigfoot and Sasquatch as Abrons presents a streaming video adaptation of Sibyl Kempson’s “The Securely Conferred, Vouchsafed Keepsakes of Maery S.,” beginning Oct. 29. First performed as an experimental, four-part radio play in January, the production, presented by the 7 Daughters of Eve Thtr. & Perf. Co., is described as a visual journey through the layered universe of Mary Shelley, the author of “Frankenstein.” The new virtual video work will feature hand-cut collages, digital and analog animation and illustration and collaborations with more than a dozen artists. An in-person screening is also set for Halloween at the new Chocolate Factory Theater.

Closing the season from Dec. 10-12 is a live motion-capture piece, “Antidote,” created in collaboration with Pioneer Works. Directed by the Jamaican-born choreographer Marguerite Hemmings and the new-media artist LaJuné McMillian, it explores the relationship between physical movement and motion-capture technology and how the latter can be used as a tool of personal power and liberation. The project is a collaboration with six young artists from high schools on the Lower East Side and in Brooklyn’s Red Hook neighborhood.

“It’s an intergenerational experiment and a great way to end the season,” Rosa-Salas said.

The full season lineup is available at abronsartscenter.org.

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Entertainment

Lincoln Heart’s Plaza Is Going Inexperienced. Actually.

Lincoln Center, which is holding a series of outdoor performances while its theaters will remain closed due to the pandemic, announced Tuesday that it would transform the space around its fountain into a park-like setting by covering it with artificial turf.

Since the center was using its outdoor areas as stages this spring and summer, it turned to a set designer, Mimi Lien, to redesign its campus. She had a plan to transform the space into what she calls “The GREEN” – adding a pop of color to a palette dominated by white travertine and turning the space into the grassy oasis she hopes that she invites New Yorkers for performances and relaxation.

“I wanted to create a place where you could lie on a grassy slope all afternoon reading a book,” Lien, a MacArthur Genius Fellow, said in a statement. “Get a coffee and sit in the sun. Bring your babies and frolic in the grass. Have a picnic with colleagues. “

“Like an urban green,” she added, “a place to collect.”

The installation, which will open on May 10 and remain operational through September, will be the physical centerpiece of Restart Stages, an initiative Lincoln Center announced in February to use its outdoor areas for live performances. The initiative began last week with a New York Philharmonic performance for healthcare workers and has since continued with a blood donation and other pop-up arts programs.

The artificial turf will be green in another sense: officials said it would be made from “high soy-content, recycled, sourced entirely from US farmers”. There will also be a small snack bar and books will be available to borrow. Events that will be held in the room will be announced in the coming weeks, officials said.

The room is open from 9 a.m. to midnight. Face covering, social distancing, and other health and safety protocols are required. The place is cleaned regularly, officials said.

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Health

Biden administration to start transport Covid vaccine doses to group well being facilities

People wait outside a COVID-19 vaccine distribution center at the Kedren Community Health Center on January 28, 2021 in Los Angeles, California.

Mario Tama | Getty Images

The White House will begin delivering doses of Covid-19 vaccine doses directly to state-qualified community health centers next week in an effort to extend reach to traditionally underserved communities, Jeff Zients, White House Response Coordinator for Covid-19, announced Tuesday .

Along with other initiatives such as government-sponsored mass vaccination centers and mobile clinics, the new program aims to ensure fair adoption of the vaccine, said Zients.

“Justice is at the core of our strategy to move out of this pandemic, and justice means reaching out to everyone, especially those in underserved and rural communities,” Zients said. “But we cannot do this effectively at the federal level without our partners at the state and local levels sharing the same commitment to justice.”

Dr. Marcella Nunez-Smith, Chair of the White House’s Covid-19 Health Equity Task Force, noted that there are more than 1,300 community health centers across the country serving nearly 30 million people.

“Two-thirds of their patients live at or below the federal poverty line, and 60% of patients in community health centers identify as racial or ethnic minorities,” she noted. “Justice is our north star here. These efforts, which focus on direct referral to community health centers, are really about connecting with hard-to-reach populations across the country.”

When the program launches, the White House plans to send cans to at least one center in each state, with 1 million split between 250 centers over the coming weeks, Nunez-Smith said. She noted that the government is also working to increase public confidence in vaccines, “which we know are lower than the national average in underserved communities”.

The community health center program will be announced after the launch of the retail pharmacy program, where the federal government will begin shipping cans directly to a few hundred pharmacies across the country. Nunez-Smith said the Centers for Disease Control and Prevention are working with participating pharmacy companies to ensure they reach “socially vulnerable areas”.

The government also announced that it will again increase the number of doses it sends to states each week. The federal government will now ship 11 million cans to states every week, up from the 8.6 million it sent three weeks ago, Zients said.

“That’s a 28% increase in vaccine delivery in the first three weeks,” he said.

When asked whether there is an inevitable trade-off between equity and speed of vaccine distribution, Zients said, “I do not accept that premise at all.”

“I think we can do this in a fair, equitable and efficient way,” he said. “So efficiency and equity are at the heart of everything we do, and I don’t see any compromise between the two that I think go hand in hand.”

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Business

Disneyland as a Vaccination Website? Airports as Check Facilities? The Journey Trade Pitches In

Many corners of the travel industry are looking for a way to end the pandemic.

More than a dozen U.S. airports including Chicago O’Hare and Chicago Midway, Los Angeles International, Tampa, Newark, and Minneapolis-St. Paul. In many terminals, XpresSpa has evolved from offering airport massages and manicures to rapid coronavirus tests.

Covid19 vaccinations>

Answers to your vaccine questions

If I live in the US, when can I get the vaccine?

While the exact order of vaccine recipients may vary from state to state, most doctors and residents of long-term care facilities will come first. If you want to understand how this decision is made, this article will help.

When can I get back to normal life after the vaccination?

Life will only get back to normal once society as a whole receives adequate protection against the coronavirus. Once countries have approved a vaccine, they can only vaccinate a few percent of their citizens in the first few months. The unvaccinated majority remain susceptible to infection. A growing number of coronavirus vaccines show robust protection against disease. However, it is also possible that people spread the virus without knowing they are infected because they have mild symptoms or no symptoms at all. Scientists don’t yet know whether the vaccines will also block the transmission of the coronavirus. Even vaccinated people have to wear masks for the time being, avoid the crowds indoors and so on. Once enough people are vaccinated, it becomes very difficult for the coronavirus to find people at risk to become infected. Depending on how quickly we as a society achieve this goal, life could approach a normal state in autumn 2021.

Do I still have to wear a mask after the vaccination?

Yeah, but not forever. The two vaccines that may be approved this month clearly protect people from contracting Covid-19. However, the clinical trials that produced these results were not designed to determine whether vaccinated people could still spread the coronavirus without developing symptoms. That remains a possibility. We know that people who are naturally infected with the coronavirus can spread it without experiencing a cough or other symptoms. Researchers will study this question intensively when the vaccines are introduced. In the meantime, self-vaccinated people need to think of themselves as potential spreaders.

Will it hurt What are the side effects?

The vaccine against Pfizer and BioNTech, like other typical vaccines, is delivered as a shot in the arm. The injection is no different from the ones you received before. Tens of thousands of people have already received the vaccines, and none of them have reported serious health problems. However, some of them have experienced short-lived symptoms, including pain and flu-like symptoms that usually last a day. It is possible that people will have to plan to take a day off or go to school after the second shot. While these experiences are not pleasant, they are a good sign: they are the result of your own immune system’s encounter with the vaccine and a strong response that ensures lasting immunity.

Will mRNA vaccines change my genes?

No. Moderna and Pfizer vaccines use a genetic molecule to boost the immune system. This molecule, known as mRNA, is eventually destroyed by the body. The mRNA is packaged in an oily bubble that can fuse with a cell, allowing the molecule to slide inside. The cell uses the mRNA to make proteins from the coronavirus that can stimulate the immune system. At any given moment, each of our cells can contain hundreds of thousands of mRNA molecules that they produce to make their own proteins. As soon as these proteins are made, our cells use special enzymes to break down the mRNA. The mRNA molecules that our cells make can only survive a few minutes. The mRNA in vaccines is engineered to withstand the cell’s enzymes a little longer, so the cells can make extra viral proteins and trigger a stronger immune response. However, the mRNA can hold for a few days at most before it is destroyed.

The Monterey Bay Aquarium in Monterey, California has been closed to guests since March. in December they loaned one of their ultra-cold freezers to a hospital in nearby Salinas; The special freezer can maintain temperatures of minus 94 degrees Fahrenheit, which is necessary for the safe storage of some coronavirus vaccines.

During the first few weeks of the pandemic, the State Fair of West Virginia signed an agreement with the Greenbrier County Health Department that promised the use of their facilities for testing, vaccinations, and possibly even a hospital for emergencies. The site, which was closed in 2020, has since been the location for three free drive-through testing clinics and is currently operated as a vaccination center for residents.

Many of Orange County’s residents who receive their vaccination puffs at Disneyland will have coronavirus tests done at the Anaheim Convention Center, which, like convention centers across the country, stalled in March. Jay Burress, President and CEO of Visit Anaheim, estimates the freeze cost the city $ 1.9 billion in lost revenue. He responded by donating unused supplies to local nonprofits. In July, the parking lot of the congress center was converted into a mass test area.

“How do we safely open again? That was our goal all along, ”said Mr. Burress. “Marketing our goal, either as a vacation destination or as a conference destination when hotels aren’t even open for vacation travel, is turning your wheels.”

Sharon Decker is President of the Tryon Resort, North Carolina, which includes 250 rooms and an equestrian center, plus a 300,000 square foot indoor arena on 1,600 acres at the base of the Blue Ridge Mountains. She wasn’t surprised in October when officials from Polk County, NC asked if she would be willing to donate this arena as a vaccination site, even though she knew doing so would pose logistical challenges. The site opened in mid-December.

“We have established a real partnership with public health officials,” she said. “It had to be a real public-private partnership to make this happen. But if you have common goals for a healthy economy and healthy businesses, this is the way to find out. “

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Health

At Elite Medical Facilities, Even Employees Who Don’t Qualify Are Vaccinated

A 20 year old who works on computers. A young researcher studying cancer. Technicians in basic research laboratories.

These are some of the thousands of people who have been vaccinated against the coronavirus at Columbia University, New York University, Harvard, and Vanderbilt hospitals, despite millions of frontline workers and older Americans waiting their turn.

The Centers for Disease Control and Prevention have issued recommendations to ensure the country’s vaccines reach those most at risk first: healthcare workers interacting with Covid-19 patients, residents and nursing home workers, followed by Persons aged 75 and 75 older and certain essential employees.

Each state has its own version of the guidelines, but as the rollout pace has accelerated, the pressure for a more flexible approach has increased. Officials from the CDC and the Food and Drug Administration recently suggested that it might be wiser to just relax the criteria and distribute the vaccine as widely as possible.

However, these officials did not intend that the vaccines should be given to healthy people in their twenties and thirties, in front of the elderly, important workers, or anyone else at risk. States should continue to prioritize groups that “make sense,” said Dr. Stephen Hahn, the FDA commissioner, told reporters on Friday.

But a handful of the most prestigious academic hospitals in the country have already taken the idea much further. Workers unrelated to patient care who are not 75 years of age or older were offered admissions. Some of the institutions were among the earliest recipients of the limited shipments in the United States.

“Cronyism and connections have no place in the launch of this vaccine,” said Ruth Faden, a bioethicist at Johns Hopkins University in Baltimore. “If we don’t do it right, the consequences can be pretty disastrous, so it’s very important that people here are overly sensitive to the rules of the game.”

The CDC never intended to include workers who do not interact with patients, such as administrators and graduate students, in the first tier of priority vaccinations, said Dr. Stanley Perlman, an immunologist at the University of Iowa and a member of the committee issued the recommendations.

“It all got so confusing,” he said. “Looking back, I think it probably had to be a bit more specific about what we thought because we never thought of hospital administrators.”

In Nashville, Vanderbilt University Medical Center asked all staff whether they were treating patients or not to register for the vaccination. Vaccinations began in December when the Tennessee Hospital Association approved vaccinations for all hospital workers regardless of role.

On January 6, the medical center announced plans to begin vaccinating its high-risk patients, but only after “the initial vaccine dose to well over 15,000 at the medical center,” according to an email it sent to the medical center working people had administered “patients.

“We continue to follow instructions received from the Tennessee Department of Health when we vaccinate Vanderbilt Health staff and other priority groups of patients, staff and community health workers,” said John Howser, chief communications officer for the medical center. said in a statement.

But the Tennessee Department of Health sees it differently. “Hospitals have been encouraged since the onboarding process began to use any remaining vaccines to vaccinate high priority populations,” said Bill Christian, a department spokesman.

“Some hospitals have interpreted their ‘staff’ broadly,” he added.

The Tennessee department, he said, “continues to applaud hospitals that have only prioritized their high-risk frontline staff for vaccination and made any remaining vaccinations available to meet community vaccination needs,” groups with high priority.

“I wish our elderly relatives had the vaccine before I did,” said a young Vanderbilt employee who has no contact with patients and asked not to be identified for fear of reprisals.

In Boston, Brigham and Women’s Hospital and Massachusetts General Hospital, both affiliated with Harvard University, have immunized more than 26,000 employees, including those involved in patient care, researchers who may come into contact with coronavirus samples, and those involved in clinical trials are Rich Copp, a spokesman for the hospitals.

The reason? Some laboratory scientists may be needed in the hospitals if the coronavirus returns. “Our experience in the first wave showed that some members of the research community may need to be redeployed to support work in patient care with Covid,” said Copp.

Still, the medical centers have announced plans to immunize the rest of their staff from Monday.

In New York State, only a fraction of the estimated 2.1 million front-line workers were vaccinated. Governor Andrew Cuomo has threatened to impose fines of up to $ 100,000 on hospitals for not vaccinating fast enough to use their doses.

At Columbia University, the news quickly spread to research laboratories far removed from patient care: If you showed up at Millstein Hospital, the university’s primary medical center, you could get vaccinated, regardless of whether your work involved patients had to do.

According to information from several university employees, doctoral students, postdocs and researchers were soon lining up in the hospital auditorium. Almost everyone in a cancer research center affiliated with the hospital received the vaccine.

Hospital officials said that at some point they became aware of emails directing people to the auditorium, but that anyone who didn’t need the vaccine was turned away.

“We have worked to vaccinate tens of thousands of employees, starting with those with patient contact, and we are constantly striving to improve our vaccination process,” said Kate Spaziani, vice president of communications at the hospital.

She added, “We will do this until everyone gets a vaccine. We follow all guidelines from the New York State Department of Health on vaccine priority. “

However, some recipients were upset to learn that they did not qualify according to state guidelines.

“My understanding now is that it wasn’t our turn and I feel terrible if I get out of line,” said a young researcher whose work has no bearing on Covid-19. “I’m also honestly a little angry at the hospital and the university for not controlling it properly.”

At NYU’s Langone Medical Center, contact with non-patient staff was more conscious.

“We currently only offer the Covid-19 vaccine to frontline employees,” the center’s website says. “We will send a message to our patients as soon as we have the vaccine available for patients.”

In an email to staff on December 28, Dr. Anil Rustgi, Dean of the Faculties of Health Sciences and Medicine, said the center has completed vaccinating its 15,000 patient-interacting staff and will begin vaccinating all other staff. Elderly adults or other New York State priority groups were not mentioned.

An email sent Tuesday to NYU Medical Center employees who hadn’t yet signed up for a vaccination said, “As a health care worker, you have the opportunity to get a vaccine that millions across the country want – and You can have it: right now. “

In a tacit admission that these employees would not qualify for the vaccine anytime soon, the email warned that once the eligibility criteria are expanded, the state may have to wait weeks, if not months, to get it based on demand and Maintain availability. ”

State officials were dismayed that both NYU and Columbia had opened vaccinations for low-risk employees before millions of citizens needed the shots.

On Friday, New York expanded its guidelines on vaccination to include key workers and those over 75.

The guidelines “do not, however, provide a license to vaccinate all hospital staff regardless of their role,” said Gary Holmes, a spokesman for the state health department. “While we don’t know all the facts here, DOH will investigate if there is a violation.”

In private, some state officials were furious. Institutions should instead have asked the state what to do next once the immunization of frontline workers is complete, one official said on condition of anonymity as he was not empowered to discuss the matter.

“The only reason they have as much vaccine as they do is because they were vaccine administrators – because they have a cold store,” the official said. “It wasn’t NYU’s vaccine for NYU”

The problem is not limited to academic medical centers. Some hospitals have carried out so few checks that many people have been able to circumvent the line with false claims about the vaccines.

For example, in Maricopa County, Arizona, an online form recommends that applicants use a personal email address instead of one associated with a hospital, and not require employee identification numbers.

“Yes, we want people to be vaccinated, but we need to make sure the high-risk groups get access,” said Saskia Popescu, an epidemiologist at the University of Arizona Hospital. When the process is so disorganized, “trust in the process damages public health, and I think it’s just really heartbreaking.”

Some university employees, including some who unknowingly wrongly accepted the vaccine, were also dissatisfied with what they viewed as an unjust and unfair trial.

“It’s such a naked display of privilege, you know?” said a Columbia faculty member who failed to receive the vaccine and asked not to be identified for fear of retaliation by administrators. “It’s because we’re in elite universities and medical centers.”