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Novavax’s Vaccine Works Properly — Besides on Variant First Present in South Africa

“This is really worrying,” said Dr. Peter Hotez, vaccine expert at Baylor College of Medicine and inventor of a coronavirus vaccine. “We need to vaccinate the American people by late spring or early summer to prevent the South African and British variants from adopting.”

Drug manufacturers could update their vaccines and offer new ones on a regular basis, similar to the flu vaccine.

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Answers to your vaccine questions

Am I eligible for the Covid vaccine in my state?

Currently more than 150 million people – almost half of the population – can be vaccinated. But each state makes the final decision on who goes first. The country’s 21 million healthcare workers and three million long-term care residents were the first to qualify. In mid-January, federal officials asked all states to open eligibility to anyone over the age of 65 and adults of any age with medical conditions that are at high risk of becoming seriously ill or dying of Covid-19. Adults in the general population are at the end of the line. If federal and state health authorities can remove bottlenecks in the distribution of vaccines, everyone over the age of 16 is eligible as early as spring or early summer. The vaccine has not been approved in children, although studies are ongoing. It can take months before a vaccine is available to anyone under the age of 16. For the latest information on vaccination guidelines in your area, see your state health website

Is the Vaccine Free?

You shouldn’t have to pay anything out of pocket to get the vaccine, despite being asked for insurance information. If you don’t have insurance, you should still get the vaccine for free. Congress passed law this spring banning insurers from applying cost-sharing such as a co-payment or deductible. It consisted of additional safeguards prohibiting pharmacies, doctors, and hospitals from charging patients, including uninsured patients. Even so, health experts fear that patients will end up in loopholes that make them prone to surprise bills. This could be the case for people who are charged a doctor’s visit fee with their vaccine or for Americans who have certain types of health insurance that are not covered by the new regulations. If you received your vaccine from a doctor’s office or emergency clinic, talk to them about possible hidden costs. To make sure you don’t get a surprise invoice, it is best to get your vaccine at a Department of Health vaccination center or local pharmacy as soon as the shots become more widely available.

Can I choose which vaccine to get?How long does the vaccine last? Do I need another next year?

That is to be determined. It is possible that Covid-19 vaccinations will become an annual event just like the flu vaccination. Or the vaccine may last longer than a year. We’ll have to wait and see how durable the protection from the vaccines is. To determine this, researchers will track down vaccinated people to look for “breakthrough cases” – those people who get Covid-19 despite being vaccinated. This is a sign of a weakening of protection and gives researchers an indication of how long the vaccine will last. They will also monitor the levels of antibodies and T cells in the blood of people who have been vaccinated to see if and when a booster shot might be needed. It is conceivable that people might need boosters every few months, once a year, or just every few years. It’s just a matter of waiting for the data.

Does my employer need vaccinations?Where can I find out more?

“This virus is throwing us curve balls every day. I think we just need to be prepared and realize that the first generation of vaccines may need to be updated,” said Dr. Jesse L. Goodman, professor of medicine and infectious diseases medicine at Georgetown University.

The Novavax study in the UK tested how many volunteers developed symptoms of Covid-19 a week after receiving a second dose. The company said Thursday that its initial analysis found that of 62 participants who got the disease, 56 had received a placebo and 6 had received the vaccine. According to Novavax, the newer, more contagious variant, first identified in the UK, caused about 50 percent of the cases in the study.

If these results were reflected in the larger clinical trial in the United States and Mexico, which involved approximately 16,000 out of 30,000 people, it would equate the vaccine with the Moderna and Pfizer-BioNTech vaccines, which were shown to be about 95 percent are effective.

But the news in South Africa was not that encouraging. Novavax’s smaller study found the vaccine to have an overall effectiveness of 49.4 percent. (The company reported that about 6 percent of the study participants were HIV positive, and for those who weren’t HIV positive, the vaccine had an effectiveness of 60 percent.) The company said the study was conducted from September through September The recording of cases of Covid-19 began midway through this month when the more contagious variant was widespread. According to Novavax, 44 study participants developed Covid-19 and sequenced the genetic lineage of 27 cases. Of these, 25 cases were caused by the more contagious version of the virus.

The company also said that about a third of study participants in South Africa had previously developed Covid-19 after being infected with the original form of the virus, and that their results showed that these previous infections did not protect them from the new variant. The company said its vaccine offered some protection for those who had previously contracted the disease, but did not include that group in its analysis.

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Health

Biden to limit journey with South Africa, U.Okay., Brazil to sluggish new Covid strains

On January 22, 2021, U.S. President Joe Biden signs Executive Orders for economic relief for families and businesses affected by Covid in the State Dining Room of the White House in Washington, DC.

Nicholas Comb | AFP | Getty Images

President Joe Biden will sign a travel ban on Monday for most non-U.S. Citizens entering the country that was recently in South Africa, where a new strain of Covid-19 was identified, a person familiar with the situation told CNBC .

Biden will also reintroduce travel restrictions on entry for non-US residents from the UK and Brazil, where new strains of Covid have emerged. The restrictions also apply to Ireland and much of Europe. Former President Donald Trump lifted the restrictions shortly before Biden took office.

Reuters reported on the travel restrictions for the first time on Sunday.

Dr. Anne Schuchat, assistant chief director of the Centers for Disease Control and Prevention, told the point of sale that the agency “is introducing this series of measures to protect Americans and also reduce the risk of these variants spreading and worsening the current pandemic.” . “

Before Biden took office, the new White House press secretary Jen Psaki criticized Trump’s efforts to lift international travel restrictions despite more contagious variants emerging around the world.

“We plan to step up public health measures related to international travel to further contain the spread of Covid-19,” Psaki wrote in a tweet.

Trump issued a proclamation last Monday to lift the travel restrictions his administration had put in place at the start of the pandemic for most non-US citizens living in much of Europe, the UK and Brazil as of January 26.

At that time, the US government will begin providing US air travelers, including US citizens, with the latest negative Covid-19 test results before boarding flights.

White House Health Advisor Dr. Anthony Fauci said that available vaccines against new, more contagious strains of Covid-19 appear to be less effective but likely still offer enough protection to be worth buying.

The CDC also announced on Sunday that it would remove the option for airlines flying from countries that do not have Covid-19 tests to request temporary exemptions for some travelers. The agency will implement the order on Tuesday.

The virus has infected more than 25 million people and killed at least 417,000 people in the United States since the pandemic began, according to Johns Hopkins University.

The US has not yet discovered any cases of the South African variant, but several states have discovered the British variant.

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Business

Covid variant present in South Africa ‘might evade’ Eli Lilly’s antibody drug: CEO

Dave Ricks, chairman and CEO of Eli Lilly, told CNBC on Tuesday that he expected the company’s Covid-19 antibody drug to be effective against the variant of coronavirus found in the UK

However, he said the exposure observed in South Africa is likely to be more of a challenge.

“The South African variant … is cause for concern. It has more dramatic mutations to the spike protein that these antibody drugs target,” Ricks told Squawk Box. “In theory, it could evade our drugs.”

Eli Lilly’s antibody drug was approved for emergency use by the US Food and Drug Administration in November. The drug is aimed at people recently diagnosed with Covid-19 in hopes of preventing the need for hospitalization. Regeneron’s Covid-19 antibody treatment, which President Donald Trump received after contracting the disease, has also received limited approval from the FDA.

According to Ricks, Eli Lilly wants to work with the FDA to quickly test different versions of antibodies to see if they are against virus variants like the one in South Africa.

“We actually have a large library of these antibodies now that are pre-clinical,” said Ricks. “We could think of a very expedited way to study them in a month or two and then approve their use. That seems like a smart thing because this virus is mutating.”

Discovery of variants

Coronavirus variants originally found in the UK and South Africa have received significant attention in recent weeks. They are believed to be more transmissible – but not more deadly – than previous tribes. Even so, a more contagious virus that leads to more infections could continue to weigh on healthcare systems and lead to more deaths.

The discovery of these mutations also coincides with the introduction of Covid-19 vaccines from drug companies such as Pfizer and BioNTech, as well as Moderna. It has led to some questions about whether the vaccines – along with treatments for the disease – would keep their effectiveness.

In a CNBC interview on Monday, Dr. Ugur Sahin, CEO of BioNTech, confident that his vaccine, manufactured in partnership with Pfizer, will work against the strains of the virus found in the UK and South Africa.

Daniel O’Day, CEO of Gilead Sciences, told CNBC it was testing its remdesivir treatment against these new strains, but said Monday the antiviral drug would likely be effective. Antiviral drugs like remdesivir try to prevent the virus from replicating. In contrast, antibodies like Eli Lillys bind to the virus present in the body and try to neutralize it.

There have been no confirmed cases of the variant, which was first discovered in South Africa in America, but according to the Wall Street Journal, it was discovered in countries like Japan, South Korea, and Switzerland. According to the Centers for Disease Control and Prevention, there have been around 70 confirmed cases of the coronavirus variant in the US that were originally found in the UK.

“It seems clear that Lilly’s single antibody, and likely Regeneron’s cocktail, will stop this as well as the normal variant,” said Ricks of the UK-affiliated tribe. “We haven’t done a clinical study of this effect, but we do have pre-clinical data that strongly suggests that it won’t be a problem.”

Use of antibody therapies

After the FDA approved emergency use for their antibody therapies to Eli Lilly and later Regeneron, problems arose with actually delivering the drug, which requires an intravenous infusion, to Covid patients. In mid-December, CNBC reported that between 5% and 20% of the doses delivered had been administered.

That number is “climbing” now, Ricks said on Monday. He pointed to Alabama as a state where the antibodies are widespread. Alabama “basically runs out and refills every week,” he said.

“There are quite a few” from state to state, Ricks admitted. “We want all states to learn from these practices and really be able to use this medicine, as the benefit is that patients, especially seniors, are kept out of the hospital. We know if you are a senior and have Covid-19 and end up in a hospital hospital bed, the prospects are not good. “