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CDC Covid steering should adapt to new science extra shortly

The Centers for Disease Control and Prevention must adjust their Covid recommendations faster as new scientific knowledge emerges, said Dr. Scott Gottlieb told CNBC on Monday, adding that the agency needs to do the same with more transparency.

“These guidelines have more of an economic impact than regulation,” but Gottlieb said in Squawk Box that they are much less publicly scrutinized.

The former Commissioner of the Food and Drug Administration’s comments came after the CDC changed its guidelines on social distancing in schools, not society at large, on Friday. The Public Health Agency said that with universal masking, most students can sit 3 feet apart instead of the previous 6 foot protocol. The CDC also continued to recommend a separation of at least 6 feet between adults in schools and between adults and students.

In an opinion piece in the Wall Street Journal on Sunday, Gottlieb urged the CDC to be more open about the science behind their guidelines, writing that the “exact basis for their initial view of staying 6 feet apart” remains unclear . In the Journal and on CNBC, he said initial recommendations and precautions early last year were based on the novel coronavirus, which spread like seasonal influenza.

“It was sensible to do this because we didn’t know much about the coronavirus and therefore assumed that it would behave like the flu. It didn’t behave like the flu,” said Gottlieb in “Squawk Box” and claimed it crucially led health officials to “both overestimate and underestimate this virus”.

“It’s not so much an important question: ‘Were we wrong?’ We were wrong in some ways, “added Gottlieb, who headed the FDA in the Trump administration from 2017 to 2019. “But: ‘Have we learned quickly enough and adjusted our recommendations and guidelines quickly enough?’ The answer is no. “

In a statement to CNBC, a CDC spokesman said that “during the first year of the pandemic, there were concerns about some of the CDC’s guidelines.” However, the spokesman said the agency’s new director under President Joe Biden, Dr. Rochelle Walensky, has “pledged to restore scientific credibility and public confidence in the agency” the latest science.

We underestimated the role of air quality and quality masks because we underestimated that aerosol transmission spreads this.

Dr. Scott Gottlieb

Former FDA commissioner

Gottlieb said on CNBC that health officials “have overestimated the benefits of physical distancing because the flu spreads primarily through droplet transmission, and we know droplets don’t spread more than six feet.” On the other hand, he added, “We underestimated the role of air quality and quality masks because we underestimated the fact that aerosol transmission spreads it.”

Initially, doctors had expressed some skepticism about whether advising Americans to wear face covering – especially something homemade like a scarf or headscarf – would be effective. However, in early April last year, the CDC began recommending that people wear them in public, especially in environments like grocery stores where social distancing was more difficult to maintain.

There is little debate in the public health community these days about the importance of wearing face masks, and some experts like White House Chief Medical Officer Dr. Anthony Fauci, even started to suggest that wearing two masks is probably more effective.

As early as October, the CDC recognized the spread of the coronavirus through particles in the air that “linger in the air for minutes to hours” and infect people who were more than a meter apart.

On the CDC website, titled “How COVID-19 Spreads,” the health department says it “most often” happens through close contact between people within 6 feet.

“There is evidence that, under certain conditions, people with COVID-19 appear to have infected others more than three feet away,” adds the CDC. “These transmissions took place in closed rooms with insufficient ventilation. Sometimes the infected person breathed heavily, for example when singing or exercising.”

Some of the areas where Covid risks were initially overestimated also included contaminated surfaces, Gottlieb told CNBC. The CDC updated its website in May 2020 – about two months after the World Health Organization declared the coronavirus a pandemic – to emphasize that the virus did not spread easily from a person touching a contaminated surface, according to NBC News.

Gottlieb acknowledged that in the early stages of a health crisis like the Covid pandemic, there may be a lack of quality information to use as a basis for guidelines.

“When the CDC makes recommendations, there are different levels of evidence and different levels of security behind those recommendations,” he said. “If the agency is unsure or suggests a recommendation for a less specific science, they should be really transparent about it so that we can take seriously an interpretation we want to take, but they usually don’t.”

The CDC spokesman told CNBC that “key findings” have already been implemented following the agency’s latest review, including “reviewing key guidelines for possible updates at least every three months” and “improving clarity and usability”.

Dr. Scott Gottlieb is a CNBC employee and board member of Pfizer, the genetic testing startup Tempus, healthcare technology company Aetion, and Illumina biotech. He is also co-chair of Norwegian Cruise Line Holdings and Royal Caribbean’s Healthy Sail Panel.

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AstraZeneca races to adapt Covid vaccine as South Africa halts rollout

The dose of Oxford University / AstraZeneca COVID-19 vaccine will be displayed from its box on January 2nd, 2021 at the Princess Royal Hospital, Haywards Heath, West Sussex, UK.

Gareth Fuller | Reuters

Drug maker AstraZeneca is making efforts to adapt its Covid-19 vaccine in light of new variants of the virus. The process is becoming more urgent after a small study found it less effective at protecting against the more virulent strain discovered in South Africa.

The country said it will end the use of the shot in its vaccination program after a study published on Sunday that has not yet been peer-reviewed found the vaccine offered “minimal protection” against mild to moderate illnesses caused by the South African variant will.

Researchers from the University of Witwatersrand and others in South Africa, as well as the University of Oxford, found the study was small, with only about 2,000 volunteers, with a mean age of 31. Oxford University said: “Protection from moderate to severe illness, hospitalization or death could not be assessed in this study because the target group was exposed to such a low risk.”

The vaccine manufacturers had already started developing second-generation Covid vaccines, which will target new variants of the virus. Experts say it shouldn’t be too difficult to tweak existing vaccines to cover mutations, and that they could be adjusted within six weeks.

Sarah Gilbert, professor of vaccinology at Oxford University who developed the vaccine with AstraZeneca, said Sunday that “efforts are being made to develop a new generation of vaccines that will allow protection on new variants as booster jabs redirect if this is the case. ” it turns out that it is necessary to do so. “

“We are working with AstraZeneca to optimize the pipeline that would be required for a strain change should one become necessary. This is the same problem all vaccine developers face and we will continue to monitor the emergence of new variants that arise in the readiness for a future change of burden.

The variant, officially known as the B.1.351 mutation, was first detected in South Africa in October 2020 and has since become dominant in the country.

Several cases have also been found elsewhere of health officials making efforts to stop the spread of the mutation, which has been found to be more contagious. There were already concerns that this variant might be more resistant to coronavirus vaccines developed last year.

With the use of the AstraZeneca-Oxford University jab stopped, the South African government will instead offer vaccines made by Johnson & Johnson and Pfizer.

In late January, Johnson & Johnson reported that its single-dose shot was 57% effective in one of its clinical trials in South Africa, where almost all Covid-19 cases (95%) were due to variant B infection. 1,351 descent. For comparison, the vaccine was found to be 72% effective in the US arm of the study.

Pfizer-BioNTech and Moderna have both reported early signs that their vaccinations offer protection against new known variants of the virus found in South Africa and the UK

On Friday, Oxford University released details of a separate study showing the vaccine was effective against a variant of the virus that was first discovered in south-east England and has now become the dominant strain in the UK

Andrew Pollard, professor of pediatric infection and immunity and lead investigator of the Oxford vaccine study, said data from studies of its vaccine in the UK “shows that the vaccine protects not only against the original pandemic virus, but also against the novel variant B.1.1 .7, which caused the rise in disease across the UK from late 2020. “

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Biden surgeon common choose says U.S. racing to adapt towards new Covid strains

Vivek Murthy, named U.S. Surgeon General by President-elect Joe Biden, speaks as Biden announces his team tasked with fighting the Covid-19 pandemic at The Queen in Wilmington, Delaware on December 8, 2020.

Jim Watson | AFP | Getty Images

WASHINGTON – President Joe Biden’s surgeon general said Sunday that the United States is in a race to adapt against the mutant coronavirus, which has spawned a number of potentially more infectious variants of Covid-19.

“The virus is basically telling us that it will keep changing and we need to be prepared for it,” said Dr. Vivek Murthy during an interview with ABC News’ This Week.

“We need to be number one, do much better genome monitoring so we can identify variants when they arise, and that means we need to double up on public health measures like masking and avoiding indoor gatherings,” Murthy said Biden’s candidate for the nation’s next surgeon general, he added.

He also called for an emphasis on treatment strategies as well as further investment in testing and contract tracking methods.

“So the bottom line is we’re in a race against these variants, the virus is going to change and it’s up to us to adapt and make sure we stay ahead,” said Murthy.

On Friday, UK Prime Minister Boris Johnson said the new variant, known as B.1.1.7, was linked to higher mortality rates. When asked, Murthy said the US needs more data on the UK variant before making the same decision.

Dr. Anthony Fauci, Biden’s top medical advisor on Covid-19, told CBS New “Face the Nation” on Sunday that the US “has every reason to believe” that the UK government is claiming the variant is more deadly.

“We must now assume that what was predominantly floating around the UK has some increase in what is known as virulence, especially the virus’ ability to do more harm, including death,” Fauci said, adding that the US will do so I want to keep access to UK health records.

Preliminary analysis of the mutant strain, first identified in the UK, suggests that it could be the culprit for the UK’s top in some cases. Johnson previously said the new variant could also be up to 70% more transferable. The UK government has also confirmed that another infectious variant of the coronavirus identified in South Africa has emerged in the UK.

Continue reading: 5 things to know about the spread of the new strain of Covid in the UK

Last month, Colorado announced the first case of the new and potentially more infectious strain, Covid-19. The Centers for Disease Control and Prevention warned last week that the British variant, already circulating in at least 10 states, could become the dominant variant in the US by March.

Fauci warned Sunday that the Covid-19 vaccines currently on the market may not be as effective against new strains of the coronavirus identified in the UK, South Africa and Brazil.

“We’re going to look at this and monitor it very, very carefully as these things move on,” said Fauci, adding that the Biden government was already planning to modify the vaccines.

“We don’t have to do this now, but the best way to prevent these mutants from developing further is to vaccinate as many people as possible with the vaccines currently available,” he said.