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Flip Your Telephone Right into a Health Coach

Ready to go outside and get fit this summer? The hardware of your smartphone, its software and an app store full of programs can help you with this. Here are instructions on how to get the most out of your device.

Remember that medical data is sensitive information. So, be sure to read the privacy policy of any app that tracks it or tracks you. Consult your doctor before making any major changes to your diet or exercise routine.

In 2014, Apple and Google announced both dashboard apps to track personal health and wellbeing, and the companies have improved these apps since then.

The Google Fit app works on the Android and iOS operating systems. (It can also import health data from Wear OS, Apple Watches, and third-party apps.) Working with the American Heart Association, Google Fit helps users set activity goals to collect Heart Points for better cardiovascular health. That year, Google announced that the app could also use the phone’s camera to measure heart and respiratory rates for informational purposes (but not as a medical diagnosis); Google’s own Pixel phones were the first to get this feature.

Both Apple Health and Google Fit include basic tools like a pedometer that uses the phone’s motion sensor to track your steps, but fitness and food apps can provide more detailed information.

If you’re looking for a workout app for a workout plan that goes beyond step counting, your options are plenty. Most of the popular programs are available for both Android and iOS. These include the Jefit Workout Planner and the Skimble Workout Trainer; Both offer instructions on specific exercises and routines for low subscription fees.

The Peloton app ($ 13 per month) offers video-controlled workouts, and Google Fit has a curated list of free workout videos on YouTube. For those in the Apple ecosystem, the Apple Fitness + service costs $ 10 per month and requires an Apple Watch with your iPhone to monitor your vital signs.

Recognition…overfly; Google

Runners and cyclists looking to measure their progress have a variety of apps to consider. For beginners, the $ 3 Couch to 5K app offers a workout plan for more stationary newbies to work their way up to a solid running routine. Runkeeper and MapMyRun use the phone’s location services to record and track routes; both are free with in-app purchases. Cyclemeter and Strava are also affordable apps that track running, cycling, and more.

If you want to focus on diet adjustments – eat more protein, consume less sodium, shed a few pandemic pounds – and don’t want to manually log food labels, consider a dedicated nutrition app. Many of these are free to download, but offer in-app subscriptions for personalized nutrition planning, community support, and other features.

Recognition…Lose it! / MyFitnessPal

Among the apps in this category is Lose It! focuses on calorie counting and weight loss and can share its data with Apple Health, Google Fit and other apps. Lose it! has a huge database of nutritional information for millions of items and can scan packaging labels to add new foods. MyFitnessPal is a similar program with a database of 11 million foods, a huge online community, and the ability to sync and share data with 50 other fitness apps and devices.

Your phone’s Maps app can help you get more active in general. For example, just type “gyms near me” to see where you can work out or “hike” to find hiking trails nearby.

Over the past year, both Apple Maps and Google Maps added new features for urban cyclists, including bike routes in specific cities, the location of bike rental docks in the city, and elevation information. In Google Maps for Android and iOS, you can also tap the Layers button to view bike routes and terrain – so you’re really prepared for any non-metaphorical climbs on your trip.

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How CRISPR gene enhancing will deal with illness: Intellia founder Doudna

The gene editing technology CRISPR reached an important milestone last weekend and completed its first systemic drug delivery to the human body.

CRISPR, or clustered, regularly spaced short palindromic repeats, cuts genomes and cuts DNA effectively to treat genetic diseases.

The latest breakthrough, the result of a study between biotech company Regeneron and Boston startup Intellia Therapeutics, treats a rare disease after it has been given as an IV infusion. Previously, other uses of CRISPR technology have been limited to ex vivo therapy, or where cells are removed from the body for genetic manipulation in a laboratory and then returned to the body.

Jennifer Doudna, who was awarded the Nobel Prize in Chemistry in 2020 for her work on CRISPR gene editing and is the co-founder of Intellia, recently told CNBC about the development of the technology from the publication of her early work to clinical studies showing its effectiveness at treating disease in less than 10 years means “one of the fastest rollouts in my opinion of technology from basic, initial science to actual application.”

“This is mainly because the technology comes at a time when there is a huge demand for genome editing and a lot of knowledge about genomes,” said Doudna at the recent CNBC Global Evolve Summit in mid-June.

As for next, Doudna highlighted several challenges and opportunities that CRISPR has on the horizon.

Deploying CRISPR remains a major challenge

As technology continues to advance, the task of getting the processed molecules in the body to the cells in the areas where they are needed remains a challenge.

“This is a particular issue in clinical medicine where the ability to manipulate brain cells, heart cells or muscle cells has incredible potential, but right now we don’t really have the tools to introduce the editors to those cells,” said Doudna. “We have the editors; we just don’t know how to get them where they need to go.”

Sickle cell anemia was an early focus

Much of the success of CRISPR’s previous applications has been in ex vivo therapy, in which extracted cells are manipulated in a laboratory and then returned to a patient.

Sickle cell anemia, which is genetically inherited and affects approximately 100,000 Americans, according to the CDC, was a particularly good target for the technology because blood stem cells “can be harvested, processed, and then returned to patients,” Doudna said.

Genetic eye diseases were also a focus for CRISPR applications, as Doudna said, “It is certainly easier to get into the eye than other parts of the body.”

The delivery of the processed cells to the liver has also proven to be easier so far. “A liver is an organ that naturally accepts molecules in the body,” she said.

Any advance in eradicating the 100+ liver diseases could have a huge impact on the lives of Americans. According to the American Liver Foundation, at least 30 million people, or one in ten Americans, have liver disease.

Next, let’s focus on the brain, heart, muscles

The next step for innovation around CRISPR will be to move these cells to other parts of the body like the brain, heart and muscles, Doudna said.

“There are already some technologies that make some of this possible, for example with different types of viruses or virus-like particles, and I look forward to the innovations that will come in this regard over the next few years,” she said.

Treatment costs are a problem

But as technology improves and scientists become able to fight disease throughout the body, Doudna said that CRISPR technology needs to be cheaper in order for it to have “widespread effects.”

Treating sickle cell anemia with CRISPR therapy costs about $ 2 million per patient, according to Doudna.

“That is clearly not a price point that makes this available to most of the people who can benefit from it,” she said.

While addressing delivery challenges can also help reduce costs, the medical community needs to figure out how “to scale molecule production so that we can cut costs,” said Doudna.

Applying CRISPR to Agriculture

The advancement of CRISPR technology may have an impact on other industries as well, with agriculture being one of the first to benefit.

Rather than addressing genetic problems through breeding, which can take months to years, or through current methods of genetically modifying crops that have seen a boom over the past few decades but that incorporate biological material from other species, CRISPR technology can address the Genes from plants “without touch” manipulate everything else, “said Doudna.

“This opens the door to a lot of things that can be done now to both address the challenges of climate change, manage drought, and introduce properties into the plants that will protect them from pests,” she said.

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Las vacunas de Pfizer y Moderna podrían generar una inmunidad duradera, según científicos

Las vacunas fabricadas por Pfizer-BioNTech y Moderna generan una reacción inmunitaria persistente en el organismo que puede proteger contra el coronavirus durante años, informó el lunes un grupo de científicos.

Los hallazgos se suman a la creciente evidencia de que la mayoría de las personas inmunizadas con las vacunas de ARNm podrían no necesitar refuerzos, siempre y cuando el virus y sus variantes no evolucionen mucho más allá de sus formas actuales, algo que no está garantizado. Es posible que las personas que se recuperaron de COVID-19 antes de ser vacunadas no necesiten refuerzos incluso si el virus realiza una transformación significativa.

“Es una buena señal de lo durable que es nuestra inmunidad proveniente de esta vacuna”, dijo Ali Ellebedy, inmunólogo de la Universidad de Washington en Saint Louis que dirigió el estudio, publicado en la revista Nature.

El estudio no incluyó a la vacuna fabricada por Johnson & Johnson, sin embargo, el doctor Ellebedy dijo que esperaba que la respuesta inmunitaria sea menos durable que la que producen las vacunas de ARN mensajero.

Ellebedy y sus colegas reportaron el mes pasado que en quienes sobreviven a la COVID-19, las células inmunitarias que reconocen al virus permanecen inactivas (durmientes) en la médula ósea durante al menos ocho meses después de la infección. Un estudio de otro equipo indicó que las llamadas células B de memoria siguen madurando y fortaleciéndose durante al menos un año tras la infección.

Los investigadores, con fundamento en esos hallazgos, sugirieron que la inmunidad podría durar por años y tal vez toda la vida en las personas que contrajeron el coronavirus y luego fueron vacunadas. Pero no quedó muy claro si es posible conseguir un efecto tan duradero solo con la vacunación.

El equipo de Ellebedy buscó resolver esa pregunta al examinar la fuente de las células de memoria: los nódulos linfáticos, donde las células inmunitarias se entrenan para reconocer y combatir el virus.

Después de una infección o la vacunación, se forma una estructura especializada llamada centro germinal en los ganglios linfáticos. Esta estructura es una suerte de escuela de élite para las células B, un campo de entrenamiento donde se vuelven cada vez más sofisticadas y aprenden a reconocer un conjunto diverso de secuencias genéticas virales.

Es más probable que estas células logren frustrar a las variantes del virus que puedan surgir si disponen de más tiempo y rango para practicar.

“Todos se enfocan siempre en la evolución del virus; esto muestra que las células B están haciendo lo mismo”, dijo Marion Pepper, inmunóloga de la Universidad de Washington en Seattle. “Y va a proteger contra la evolución en curso del virus, lo cual es realmente alentador”.

Después de contraer el coronavirus, se forma el centro germinal en los pulmones. Pero después de la vacunación, la educación de las células sucede en los nódulos linfáticos de las axilas, al alcance de los investigadores.

Ellebedy y sus colegas reclutaron a 41 personas, incluidas ocho con antecedentes de infección por el virus, que fueron inmunizadas con dos dosis de la vacuna Pfizer-BioNTech. De 14 de estas personas, el equipo extrajo muestras de los ganglios linfáticos a las tres, cuatro, cinco, siete y 15 semanas después de la primera dosis.

Ese laborioso trabajo es lo que hace que este sea un “estudio heróico”, comentó Akiko Iwasaki, inmunólogo de Yale. “Este tipo de análisis cuidadoso de series de tiempo en humanos es muy difícil de realizar”.

El equipo de Ellebedy encontró que a las 15 semanas de recibir la primera dosis de la vacuna, el centro germinal seguía altamente activo en los 14 participantes y que la cantidad de células de memoria capaces de reconocer al coronavirus no había disminuido.

“Que las reacciones continuaran casi cuatro meses después de la vacunación, es una señal muy muy buena”, comentó Ellebedy. Los centro germinales suelen tener su máxima expresión una o dos semanas después de la inmunización y luego declinan.

“Por lo general no suele quedar mucho después de cuatro a seis semanas”, dijo Deepta Bhattacharya, inmunólogo de la Universidad de Arizona. Pero los centros germinales estimulados por las vacunas de ARNm “siguen activas a los meses y no declinan mucho en la mayoría de las personas”.

Bhattacharya indicó que la mayor parte de lo que los científicos saben sobre la persistencia de los centros germinales proviene de la investigación con animales. El nuevo estudio es el primero en mostrar lo que sucede en las personas después de la vacunación.

Los resultados sugieren que una gran mayoría de las personas vacunadas estarán protegidas a largo plazo, al menos contra las variantes de coronavirus existentes. Pero los adultos mayores, las personas con sistemas inmunitarios débiles y aquellos que toman medicamentos inmunosupresores puede que necesiten refuerzos; Es posible que las personas que sobrevivieron a la COVID-19 y luego fueron inmunizadas nunca los necesiten.

Es difícil predecir con exactitud cuánto durará la protección de las vacunas de ARN mensajero. Si no existieran las variantes que esquivan a la inmunidad, esta podría durar en teoría toda la vida. Pero el virus claramente sigue evolucionando.

“Cualquier necesidad de un refuerzo sería a causa de una variante, no de un declive de la inmunidad”, dijo Bhattacharya. “No veo que eso llegue a suceder”.

Las personas que se infectaron con el coronavirus y luego se inmunizaron experimentan un aumento importante en sus niveles de anticuerpos, muy probablemente porque sus células B de memoria, que producen anticuerpos, tuvieron muchos meses para evolucionar antes de la vacunación.

La buena noticia: la vacuna de refuerzo probablemente tendrá el mismo efecto que una infección previa en personas inmunizadas, dijo Ellebedy. “Si les brindas otra oportunidad de participar, responderán de forma masiva”, dijo, refiriéndose a las células B de memoria.

En lo que respecta a reforzar el sistema inmunológico, la vacunación es “probablemente mejor” que recuperarse de la infección real, dijo. Otros estudios han sugerido que el repertorio de células B de memoria que se producen después de la vacunación es más diverso que el generado por la infección, lo que sugiere que las vacunas protegen mejor contra variantes que la inmunidad natural por sí sola.

Ellebedy dijo que los resultados también sugieren signos de una reacción inmunitaria persistente producidos por las vacunas de ARNm, en lugar de por aquellas más tradicionales, como la de Johnson & Johnson.

Pero esa es una comparación injusta, ya que la vacuna de Johnson & Johnson se administra en una sola dosis, dijo Iwasaki: “Es probable que si la J & J tuviera una segunda dosis, podría inducir el mismo tipo de respuesta”.

Apoorva Mandavilli es reportera del Times y se enfoca en ciencia y salud global. En 2019 ganó el premio Victor Cohn a la Excelencia en Reportaje sobre Ciencias Médicas. @apoorva_nyc

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Asia faces ‘bumpy street’ forward as Covid instances stay excessive

A woman is given a dose of Covid-19 vaccine during the mass vaccination at Tanah Abang Textile Market in Jakarta, Indonesia on June 19, 2021.

Agung Kuncahya B. | Xinhua News Agency | Getty Images

Asia’s fight against the coronavirus is far from over, but an expected increase in the spread of Covid vaccines in the coming months could defuse the situation, according to investment bank HSBC.

India was the hardest hit country this year, suffering from a devastating second wave that saw cases soar between February and early May. Although the daily reported numbers of infections have dropped significantly from a peak of over 414,000 cases in a day, the South Asian nation still reports an average of 50,000 cases per day.

Countries like Indonesia, Malaysia and Nepal have seen a sharp surge in cases recently, while the numbers of infections in other places continue to rise. Nations like Singapore, South Korea, Japan, and China have also faced outbreaks recently.

“It’s easy to believe or tempting to think we’ve got through it all, but the reality is, if you look at Asia ex-India, we’re currently seeing record numbers of daily infections,” said Frederic Neumann, co-head of Asian economic research at HSBC, said on CNBC’s “Squawk Box Asia” on Wednesday.

“There are still terrible human tariffs in many parts of Southeast Asia and even in India,” he said.

Delta variant

Experts say the closely watched coronavirus mutation known as the delta variant is partly responsible for the rise in new cases in many parts of the world. First discovered in India and now present in over 80 countries, Delta is said to be more contagious than previous variants.

Although it remains unclear whether the variant is more deadly than previous strains, its increased transmissibility, especially in environments with low vaccination and minimal social distancing, means that in absolute terms it is likely to infect more people, according to analysts at political risk advisory group Eurasia Group.

“Countries with younger populations and wetter climates could therefore experience more severe outbreaks than previous waves, even if the proportion of young people with serious illnesses remains the same,” said Eurasia Group analysts in a recent statement. They added that there is a growing risk of health system overload in many emerging markets.

Asia lags far behind North America and Europe in vaccines. The data showed that just over 23% of the population received at least one Covid vaccine dose, compared to over 40% or more in the other two regions.

“We are far from finished,” said Neumann from HSBC. “That said, if we look at the third quarter, there’s still a risk that at least some glitches will get through. We just need these vaccines. We need more supply. We have to introduce them. “

Economic recovery

Neumann said that based on publicly available information, HSBC predicts that many Asian countries will not achieve herd immunity until early 2022 at the earliest.

“That means some of the restrictions, especially on travel, remain in place, and unfortunately that still means a bit of a bumpy road for the next few months,” he said.

When a country reaches herd immunity, it means that the virus can no longer spread rapidly because most of the population is either fully vaccinated or would have become immune from infection.

In a release, Neumann and other HSBC analysts said they expect local demand growth in the region to pick up pace over the next six months. It is due to a large, expected surge in vaccine distribution, they said.

According to the bank, exports remain strong despite ongoing transport disruptions and supply chain bottlenecks.

“The latter should slowly subside as demand for services recalibrates and factories make up for lost time. However, the crisis has shown that there is an urgent need for more investment in capacity – expect investment to rise as the region tiptoe out of the pandemic, ”wrote the HSBC analysts.

The investment bank forecast that Asia (excluding Australia and New Zealand) will grow 6.6% year-on-year in 2021 – compared to a 0.9% decline in the previous year – and 4.6% in 2022.

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‘It’s Powerful to Get Out’: How Caribbean Medical Colleges Fail Their College students

Last summer, when Dr. Sneha Sheth went online to begin filling out applications for residency — the next stage of her training after medical school — she was hit with a jolt of disappointment.

Of the 500 residency programs she was considering, nearly half had been labeled unfriendly to international medical students, like her, by the website Match a Resident, which helps medical students abroad navigate the U.S. residency application process. Dr. Sheth submitted her applications in September and spent months on edge. Then came the distress of rejections from numerous programs, and no responses from others.

“There are 50 percent of programs that don’t want you, which is a scary feeling,” said Dr. Sheth, 28, who graduated recently from a Caribbean medical school. “It’s like, if they don’t want you, who will?”

The frustrations of the match process, which assigns graduates to programs where they can begin practicing medicine, made Dr. Sheth question whether she had been foolish to enroll in a Caribbean medical school. She had spent tens of thousands of dollars but ended up shut out of American residency programs (although she recently landed a spot in a Canadian one).

In the 1970s, a wave of medical schools began to open across the Caribbean, catering largely to American students who had not been accepted to U.S. medical schools; today there are roughly 80 of them. Unlike their U.S. counterparts, the schools are predominantly for-profit institutions, their excess revenue from tuition and fees going to investors.

Admissions standards at Caribbean schools tend to be more lax than at schools in the United States. Many do not consider scores on the standardized Medical College Admission Test as a factor in admissions. Acceptance rates at some are 10 times as high as those at American schools. They also do not guarantee as clear a career path. The residency match rate for international medical graduates is about 60 percent, compared with over 94 percent for U.S. graduates.

In 2019, Tania Jenkins, a medical sociologist, studied the composition of U.S. residency programs and found that at more than a third of the country’s biggest university-affiliated internal medicine programs, the residency population was made up overwhelmingly of U.S. medical graduates. Caribbean medical school students match into residencies at a rate 30 percentage points lower than their U.S. counterparts.

“U.S. medical school graduates enjoy tailwinds,” Ms. Jenkins said. “Caribbean medical students experience headwinds. They have a number of obstacles they have to overcome in order to be given a chance at lower-prestige and lower-quality training institutions.”

The challenges that Caribbean medical students face in career advancement have raised questions about the quality of their education. But with the rapid rise in the number of medical schools worldwide — from around 1,700 in the year 2000 to roughly 3,500 today — tracking and reporting on the quality of medical schools abroad has proved a difficult task.

In recent years, medical educators and accreditors have made a more concerted effort to evaluate the credibility of those institutions, with the goal of keeping applicants informed about subpar Caribbean schools, which charge tens of thousands of dollars in tuition and fees and sometimes fail to position their students for career success.

That effort has largely been led by the Educational Commission for Foreign Medical Graduates, which reviews and provides credentials for graduates of foreign medical schools, including documentation of their exam scores and their academic histories. In 2010, the commission announced an initiative requiring every physician applying for certification to have graduated from an accredited medical school. The group also said it would more closely scrutinize the standards for organizations that accredit medical schools around the world. The new rule will take effect by 2024.

The commission has already penalized two Caribbean medical schools — the University of Science, Arts & Technology Faculty of Medicine in Montserrat and the Atlantic University School of Medicine in Antigua and Barbuda. The group refused to grant credentials to any of those schools’ graduates, saying it had found the schools to be “egregious in terms of how they treated students and misrepresented themselves.” The medical school in Montserrat subsequently sued the commission, but the case was dismissed in a U.S. federal court. The University of Science, Arts & Technology Faculty of Medicine in Montserrat did not respond to requests for comment.

“I’m very concerned about students’ being taken advantage of by schools that may not give them proper information as to how they’re going to learn and what their opportunities are going to be when they finish school,” said Dr. William Pinsky, head of the commission.

He said he hoped that students would be better protected by 2024, when accrediting organizations plan to complete evaluations of all international medical schools through a more rigorous accreditation process.

One of the primary accrediting bodies for Caribbean medical schools is the Caribbean Accreditation Authority for Education in Medicine and Other Health Professions, known as CAAM-HP. Lorna Parkins, executive director of the organization, said that some of the key factors the group considers in denying accreditation include high attrition rates and low exam pass rates.

Credit…via Yasien Eltigani

But Caribbean schools occasionally misrepresent their accreditation status on their websites, Ms. Parkins added. She sometimes hears from students who are struggling to transfer out of lower-quality schools.

“It’s my daily concern,” Ms. Parkins said. “I know students have very high loans, and their families make great sacrifices to educate them.”

Applying to medical school in the United States requires a certain level of know-how: how to study for the MCAT; how to apply for loans; and how to make yourself competitive for a select number of spots. Applicants with less access to resources and mentoring are at a disadvantage and are sometimes less aware of the drawbacks of international medical education.

Dr. Yasien Eltigani, 27, who is Sudanese and immigrated from the United Arab Emirates to the United States, said he had little assistance in navigating the obstacle course of medical school applications. He applied to only nine schools, all in Texas, not realizing that most U.S. students apply more widely, and was rejected from all of them. Two years later, when he saw a Facebook advertisement for St. George’s University in Grenada, he decided to apply.

Looking back, he says he wished he had reapplied to American schools instead of going the Caribbean route. Although he was able to match into a residency program, which he recently started, he found the process to be anxiety-inducing.

“If you fall behind in a U.S. medical school, your chances of matching are decent, whereas in a Caribbean medical school you’re at risk,” he said. “As an immigrant, I didn’t have much in the way of guidance.”

Caribbean medical school administrators say their intentions are straightforward: They aim to expand opportunities for students to go to medical school, especially those from racially, socioeconomically and geographically diverse backgrounds, to include people who might not have traditionally pursued careers in medicine.

“U.S. medical schools have more applicants than they know what to do with,” said Neil Simon, president of the American University of Antigua College of Medicine. “So why do they object to medical schools that have obtained approval and are educating a student population that is much more diverse? Wouldn’t you think they’d welcome us with open arms?”

Mr. Simon said that he was aware of the bias that A.U.A.’s graduates confront as they apply for residency positions in the United States and that he saw the stigma as unfounded. He added that international medical graduates were more likely to pursue family medicine and to work in underserved areas, especially rural communities.

But experts say that the proliferation of for-profit medical schools does not always serve the best interests of students. The Liaison Committee on Medical Education, which credentials U.S. schools, did not recognize any for-profit schools until 2013, when it changed its stance following an antitrust ruling mandating that the American Bar Association accredit for-profit law schools. Among medical educators, substantial skepticism still exists toward the for-profit model.

“If medical students are viewed as dollar signs rather than trainees that require lots of investment, support and guidance, that fundamentally changes the training experience of these students and the way their education pans out,” Ms. Jenkins said.

Some students at Caribbean medical schools said the quality of their education had declined even further in recent years as some campuses faced natural disasters.

In 2017 when Hurricane Maria hit Dominica, where Ross University School of Medicine’s campus was situated, the school decided to offer its students accommodations on a ship docked near St. Kitts. To some of the students, this sounded like an adventure. But as soon as they arrived on the boat, they realized that it did not lend itself to rigorous study.

With few study spots or electric outlets available on the ship, Kayla, a first-year-student, awoke each day at 2 a.m. to claim a place where she could study for the day. (Kayla asked to be identified by just her first name so that she could freely share her experience.) Her exams were held in a room filled with windows that looked out over the ocean waves. She and her classmates said that if they looked up from their tests, they had immediately felt nauseated. She couldn’t take Dramamine, she said, because that exacerbated her fatigue. Some of her classmates left before the semester ended because they could not handle study conditions on the ship.

“We understand that extenuating circumstances posed challenges for all,” a spokesman for Adtalem Global Education, the parent organization of Ross University School of Medicine, said in an email. “We took extraordinary measures to provide options for students to continue their studies or to take a leave of absence until campus facilities could be restored.”

But the combined challenges of these schools have given way to a saying: “It’s extremely easy to get into Caribbean schools,” said Dr. Abiola Ogunbiyi, a recent graduate of Trinity Medical Sciences University in Saint Vincent. “But it’s tough to get out.”

As accreditation standards evolve, Ms. Jenkins said one of the most critical ways to protect students was to ensure transparency from the schools. “People should go into their training with their eyes wide open,” she said.

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Walmart unveils low-price analog insulin amid rising diabetes drug prices

Walmart said Tuesday it will offer a less expensive version of insulin that could better fit into the budgets of millions of Americans who don’t have health insurance or struggle to pay for the lifesaving diabetes drug.

Starting this week, the retailer will sell an exclusive private-label version of analog insulin, ReliOn NovoLog, to adults and children who have a prescription. The drug will be available at its membership-based Sam’s Club in mid-July. The insulin will cost about $73 for a vial or about $86 for a package of prefilled insulin pens.

The insulin is the latest addition to Walmart’s private brand of diabetes products, ReliOn. It already sells a low-price version of insulin for about $25 as part of the line, but that is an older formulation that some doctors and advocates say is not as effective at managing blood sugar swings as newer versions of insulin, called analogs.

With the move, Walmart will bring its longtime focus on “everyday low price” to a drug that is a medical necessity for a growing number of Americans. More than 34 million people in the U.S. — or nearly 11% of the population — have diabetes, and about 1.5 million Americans are diagnosed every year, according to the American Diabetes Association. That percentage is about 14% among Walmart shoppers, said Warren Moore, Walmart’s vice president of health and wellness, on a call.

As the number of people with diabetes climbs, the cost of the 100-year-old drug has soared rather than fallen and drawn scrutiny from lawmakers. The annual cost of insulin for people with Type 1 diabetes in the U.S. nearly doubled from $2,900 in 2012 to $5,700 in 2016, according to the most recent data available from the Health Care Cost Institute. Some of the top manufacturers of insulin, including Sanofi and Eli Lilly, have been grilled by politicians during congressional hearings for hiking prices of the critical drug. In some cases, the companies have responded to criticism by rolling out limited, reduced price programs.

Dr. Cheryl Pegus, Walmart’s executive vice president of health and wellness, said Walmart’s version of the drug will expand access to care as it undercuts the typical price and puts analog insulin within reach of more people. She said Walmart worked directly with manufacturer Novo Nordisk to reduce costs. The price difference with branded competitors will be as much as $101 per vial of insulin or up to $251 per pack of prefilled insulin pens, Pegus said.

“This price point, we hope, will improve and hopefully revolutionize the accessibility and affordability of insulin,” she said on a call with reporters. “We know that many people with diabetes struggle to manage this chronic condition because of its financial burden.”

Walmart, already the nation’s largest employer and grocer, has made a bigger push into health care as it tries to leverage its massive reach for other money-making opportunities. It has opened 20 clinics next to its stores with budget-friendly medical care, such as $30 annual checkups or $25 dental cleanings. It bought a telehealth company, MeMD, in May for an undisclosed amount as a way to provide care virtually. And it has pressured the pharmacy industry on price before by launching a prescription program that sells monthly supplies of many widely used generic drugs for $4.

Yet the retail giant is treading in a complex industry that has tripped up other large, influential corporate players. Haven, a joint venture of Amazon, Berkshire Hathaway and JPMorgan Chase, disbanded early this year about three years after the companies heralded plans to disrupt health care with lower costs and improved outcomes.

Walmart has lost some of the key talent it recruited to lead and expand its health and wellness efforts, including Sean Slovenski, formerly senior vice president of Walmart health and wellness; and Dr. Tom Van Gilder, who had become its first full-time chief medical officer.

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Masks Once more? Delta Variant’s Unfold Prompts Reconsideration of Precautions.

Throughout the pandemic, masks were among the most controversial public health measures in the United States, symbolizing a bitter partisan divide over the role of government and individual freedoms.

Now, with a new variant of the coronavirus spreading rapidly around the world, masks are once again the focus of conflicting views and fears about how the pandemic will unfold and the constraints needed to cope with it.

The renewed concerns follow forest fire growth of the Delta variant, a highly infectious form of the virus first discovered in India and later identified in at least 85 countries. It now accounts for one in five infections in the United States.

In May, federal health officials said fully vaccinated people no longer need to mask themselves, even indoors. The council marked a fundamental change in American life and set the stage for a national reopening that continues to gain momentum.

But that was before the delta variant spread. Concerned about a global surge in cases, the World Health Organization reiterated its long-standing recommendation last week that everyone – including those who have been vaccinated – wear masks to contain the spread of the virus.

Los Angeles County health officials followed on Monday, recommending that “everyone, regardless of vaccination status, should wear masks as a precaution in public places indoors.”

Barbara Ferrer, the county’s public health director, said the new recommendation was because of the increase in infections, an increase in cases due to the worrying Delta variant, and the continued high numbers of unvaccinated residents, especially children, black and Latin American residents, and important workers.

About half of Los Angeles County’s residents are fully vaccinated, and about 60 percent have received at least one dose. While the number of positive tests in the county is still below 1 percent, the rate has increased, added Dr. Ferrer added, and the number of reinfections in residents who were previously infected and not vaccinated has increased.

As far as Los Angeles County has managed to control the pandemic, it was due to a multi-faceted strategy that combined vaccinations with health restrictions to curb new infections, said Dr. Ferrer. Natural immunity among those already infected has also kept transmission low, she noted, but it is not clear how long the natural immunity will last.

“We don’t want to go back to lockdown or disruptive mandates here,” said Dr. Ferrer. “We want to stay on the path we are currently on, which keeps the transmission by the community very low.”

Health officials in Chicago and New York City said Tuesday that they had no plans to re-examine masking requirements. Officials from the Centers for Disease Control and Prevention declined to comment but did not signal any intention to revise or re-examine the masking recommendations for fully vaccinated individuals.

“When the CDC made the recommendation To stop masking, it didn’t anticipate that we might be in a situation where we might need to recommend masking again, ”said Angela Rasmussen, researcher at the Vaccines and Infectious Disease Organization at the University of Saskatchewan in Canada .

“Nobody will want to do it. The people understandably accuse them of having moved the goal posts. “

But the Delta variant’s trajectory outside of the United States suggests that concerns are likely to increase.

Even Israel – which has one of the highest vaccination rates in the world and aggressively immunizes young adolescents and teenagers who qualify – has reintroduced the mask requirement in indoor public spaces and at large outdoor public gatherings after hundreds of new Covid-19 cases were discovered in the past few days, including in people who received both doses of the Pfizer BioNTech vaccine.

This isn’t the first time the world has been consumed by a more contagious variant of the coronavirus. The alpha variant rolled over the UK and brought the rest of Europe to a standstill earlier this year. Alpha quickly became the dominant variety in the United States by late March, but the rapid pace of vaccination slowed its spread and saved the nation a huge surge in infections.

But Delta is considered even more terrifying. Much of what is known about the variant is based on its distribution in India and the UK, but early evidence suggests it is perhaps twice as contagious as the original virus and at least 20 percent more contagious than Alpha.

Updated

June 29, 2021 at 5:38 p.m. ET

In many Indian states and European nations, Delta has quickly overtaken Alpha and has become the dominant version of the virus. It is well on its way to do the same in the United States.

Among the many mutations in the variant are some that can help the virus to partially evade the immune system. Several studies have shown that while the current vaccines are effective against Delta, they are slightly less effective than most other variants. In people who received only one dose of a two-dose regimen, protection against the variant is significantly reduced compared to effectiveness against other forms of the virus.

The WHO rationale for keeping masking is that while vaccines are very effective at preventing serious illness and death, it is not known to what extent vaccines prevent mild or asymptomatic infections. (CDC officials disagree and say the risk is minimal.)

The WHO claims that vaccinated people should wear masks in crowded, narrow and poorly ventilated areas and take other preventive measures like social distancing.

“What we are saying is, ‘Once you are fully vaccinated, keep playing it safe because you could end up being part of a chain of transmission. You may not be fully protected, ‘”said Dr. Bruce Aylward, a senior adviser to WHO, at a news conference last week.

Even in countries with relatively high vaccination rates, there has been an increase in infections from the delta variant. Great Britain, where around two-thirds of the population have received at least one dose of the Pfizer-BioNTech or AstraZeneca vaccine and almost half two doses, is still struggling with a sharp increase in infections from the variant.

It is not certain which course the delta variant will take in the USA. The coronavirus infections have been falling for months, as have been hospital admissions and deaths. But dr. Anthony S. Fauci, the nation’s leading infectious disease doctor, has described the variant as “the greatest threat” to eliminating the virus in the United States.

When CDC officials lifted masking recommendations in May, they cited research showing that fully vaccinated individuals are unlikely to become infected with the virus, even with asymptomatic infections.

But the partial immune evasion variant’s talent makes researchers nervous, as it suggests that fully vaccinated people sometimes get asymptomatic infections and unwittingly pass the virus on to others, even if they never get the disease.

The Delta variant can infect people who have been vaccinated, although its ability to do so is very limited, said Bill Hanage, an epidemiologist at Harvard TH Chan School of Public Health. “If you’re in a fall-climbing place, wearing a mask indoors in crowded public spaces is a way to keep yourself from contributing to the spread of Delta,” he said.

Other scientists do not recommend that fully vaccinated people always wear masks indoors, but some are now suggesting that this may be appropriate depending on local circumstances – for example, anywhere the virus is circulating in high numbers or vaccination rates are very low.

“Masking in closed public spaces must continue after vaccination until we can all be vaccinated or get a new vaccine that is more effective against delta transmission,” said Dr. Ravindra Gupta, a virologist at the University of Cambridge in the United Kingdom.

Even now, around half of Americans are not vaccinated, and much of the country remains vulnerable to outbreaks of the virus and its variants. Vaccinations for children under the age of 12 are expected to be approved in autumn at the earliest.

In Saskatchewan, Canada, the reopening took place in stages tied to the vaccination rates of the population and the percentage of people vaccinated in specific age groups.

The province moves to step 3 of re-entry on July 11, but can maintain indoor mask requirements and congregation size restrictions, said Dr. Rasmussen from the University of Saskatchewan. The strategy “makes a lot more sense than just saying, ‘When you are fully vaccinated, take off your mask,'” she said.

However, some scientists fear that it will be nearly impossible to reintroduce masking requirements and other precautions, even in places where it might be a good idea.

“It’s hard to get that back,” said David Michaels, an epidemiologist and professor at the George Washington School of Public Health, referring to the CDC advice. But with the advent of the delta variant, it is also “extremely dangerous to continue the cultural norm that nobody wears a mask”.

Dr. Ezekiel Emanuel, vice president of global initiative at the University of Pennsylvania, said introducing the variant should lead to a reconsideration of the mask requirement.

He still wears a mask in public places like grocery stores and even on crowded sidewalks. “We don’t even know the long-term consequences of a slight infection,” he said, referring to so-called long Covid. “Is it worth a little more insurance by wearing a mask? Yes.”

Monroe Harmon, 60, had coffee outside the Whole Foods Market in downtown Los Angeles Tuesday morning and said he thought a step back on masking requirements for everyone is a good idea.

“There are so many people who say they just want their lives back,” said Mr. Harmon, who works for a security company. “I think you kind of roll the dice if you decide, ‘I want my life back, I won’t wear a mask, I won’t distance myself.'”

Jill Cowan and Ana Facio-Krajcer contributed the coverage from Los Angeles.

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Eli Lilly CEO says drugmaker will preserve trying to lower insulin prices

An Eli Lilly & Co. logo is seen on a box of insulin medication in this arranged photograph at a pharmacy in Princeton, Illinois.

Daniel Acker | Bloomberg | Getty Images

Eli Lilly CEO David Ricks said he welcomes new competition from Walmart, even as the retailer undercuts the drugmaker’s prices on fast-acting insulin.

Walmart announced Tuesday that it will sell a lower-price version of the notoriously expensive diabetes drug, starting this week.

“Any efforts to smash through that and deliver better value to patients, I’m for,” Ricks said in an interview Tuesday on CNBC’s “Squawk on the Street.”

Walmart developed the less expensive version of analog insulin with Novo Nordisk. The fast-acting insulin will cost about $73 for a vial or about $86 for a package of prefilled insulin pens. It will be available exclusively at Walmart and Sam’s Club for adults and children with a prescription.

Insulin has become a focal point in lawmakers’ debate over soaring drug prices — especially since it is a 100-year-old medication and one that can be lifesaving for millions of Americans diagnosed with diabetes. Eli Lilly is among the companies that have faced pushback for its prices by politicians on both sides of the aisle, including former President Donald Trump.

Ricks said the company’s leaders “welcome anyone who wants to lower the price of insulin” — including the big-box retailer.

“We always look at new solutions ourselves, and this is an interesting development and we’ll look at further options,” he said. “If we can reach one more patient with more affordable insulin, we’re going to try to do that.”

Ricks said Eli Lilly continues to seek ways to reduce costs for people with diabetes. He pointed to two related efforts: The launch of a half-price, generic version of insulin, called insulin lispro, in early 2019 and the cap on out-of-pocket cost for insulin at $35 per month, which began as many Americans struggled with finances during the coronavirus pandemic.

Those moves, in part, were a response to fierce criticism by lawmakers and a subpoena by the state of New York.

Eli Lilly’s generic version costs nearly twice the price of Walmart’s at $137.35 per vial.

Over the past 20 years, the number of adults diagnosed with diabetes has more than doubled, according to the Centers for Disease Control and Prevention. About 34.2 million U.S. adults have the disease, which ranks as the seventh-leading cause of death in the country, the CDC said.

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Wash Fruits and Greens

By and large, the American food supply is quite safe, but food safety specialists keep their eyes on certain pathogens, both bacteria and viruses, that have been associated with dangerous outbreaks tied to produce. For example, E. coli O157:H7, a bacterium found in the intestines of cattle and other animals, also turns up in leafy greens and, if ingested, can cause nausea, vomiting and diarrhea. Certain groups, such as the very young and the very old, are particularly prone to developing severe symptoms and potentially deadly kidney failure.

“We see a number of outbreaks caused by viruses in produce,” said Dr. DiCaprio. “So, when we talk about food-borne viruses, primarily it’s hepatitis A virus and norovirus. We see those viruses causing a number of outbreaks in soft berries because often these commodities are harvested by hand, so we as humans can cross-contaminate those berries during harvest.”

If you see dirt, sand or grit on your produce — for example, in the grooves of a celery stalk —you’d certainly want to remove that material. But it’s also important to rinse off dust and other small debris that you may not see but that can also contain harmful germs.

Early fears about the possible transmission of coronavirus on foods were not borne out, though other viruses may be spread by the dirty hands of other customers. So wash any fruits or vegetables you pull off the shelves or produce stand, including leafy greens, whole fruits and raw vegetables. Washing won’t completely decontaminate a piece of produce, Dr. DiCaprio said, but generally removes 90 percent to 99 percent of the microorganisms. Ingesting fewer microbes makes it less likely you’ll get sick.

There’s no need to rewash greens or other items that say “pre-washed” on the package. In fact, washing them could raise the risk of cross-contamination with other foods, such as raw meat, that you may be preparing — a concern whenever you are washing any foods, so take care to keep work surfaces clean.

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Moderna says Covid vaccine exhibits promise in a lab setting towards variants, together with delta

A healthcare worker prepares a dose of Moderna Inc.’s Covid-19 vaccine on Tuesday February 9, 2021 at the Pacheco Vaccination Center in Brussels, Belgium.

Geert Vanden Wijngaert | Bloomberg | Getty Images

Moderna said Tuesday that its Covid-19 vaccine showed promise against coronavirus variants, including the highly contagious Delta variant, first identified in India in a laboratory setting.

The two-dose mRNA vaccine produced neutralizing antibodies against Delta as well as Beta and Eta, variants that Moderna said were first found in South Africa and Nigeria, respectively.

The company said the results were based on blood serum from eight participants one week after receiving the second dose of the vaccine. The data has not yet been reviewed by experts. The results, while promising, may not reflect how the vaccines actually perform against the variants in real-world scenarios.

Moderna shares rose more than 4% in intraday trading after the lab results were announced.

“We continue to strive to investigate new variants, generate data and share them as they become available,” said Stephane Bancel, CEO of Moderna, in a press release. “These new data are encouraging and reinforce our belief that the Moderna COVID-19 vaccine should continue to protect against newly discovered variants.”

Moderna’s update comes days after World Health Organization officials urged fully vaccinated people to continue wearing masks, maintain social distance, and practice other pandemic safety measures as the delta spreads rapidly across the world.

Delta, now present in at least 92 countries including the United States, is expected to become the predominant variant of the disease worldwide. In the US, the prevalence of the variant doubles about every two weeks.

WHO officials said Friday that they are urging fully vaccinated people to continue to “play it safe” as much of the world remains unvaccinated and highly contagious variants like Delta spread in many countries and cause outbreaks.

The comments were a departure from the Centers for Disease Control and Prevention, which said fully vaccinated Americans can be maskless in most environments.

“People can’t feel safe just because they got the two doses. They still need to protect themselves,” said Dr. Mariangela Simao, WHO Deputy Director General for Access to Medicines and Health Products, during a press conference.

Approved vaccines from Moderna, Pfizer-BioNTech, and Johnson & Johnson have been shown to be highly effective in preventing Covid, particularly against serious illness and death.

Some variants, including Delta, have shown the vaccines to be slightly less effective, and WHO officials said they fear people vaccinated could become part of the chains of transmission.

The Wall Street Journal reported Friday that about half of the adults infected in a Delta variant outbreak in Israel were fully vaccinated with the Pfizer vaccine, prompting the local government to reintroduce indoor masking and other measures.

In the United States, President Joe Biden warned that unvaccinated people are particularly at risk of contracting Delta.

He said the number of Covid deaths would continue to increase across the country due to the spread of the “dangerous” variant, calling this a “serious concern”.

“More than six hundred thousand Americans have died, and with this variant of the Delta, you know there will be others too. You know it will happen. We need to vaccinate young people,” Biden said Thursday at a community center in Raleigh, NC