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Novavax Says U.S. Will Pause Funding for Manufacturing of Its Vaccine

WASHINGTON – Novavax, the Maryland company that won a federal $ 1.75 billion contract to develop and manufacture a coronavirus vaccine, said Thursday that the federal government will not fund further production of its vaccine until the company does has dispelled the concerns of the federal supervisory authorities about its work.

The company’s disclosure was made in a quarterly filing with the Securities and Exchange Commission. The Trump administration agreed to purchase 110 million doses of vaccine from Novavax as part of its crash vaccine development program.

Although the company reported in June that its vaccine was 90 percent effective against symptomatic Covid-19 cases and 100 percent against serious illnesses, Novavax has been battling mass production of its product for months. His vaccine has not been approved for sale in the United States, and federal officials said it was unclear when or if it would.

Four people familiar with Novavax operations said the company has not yet been able to demonstrate that its production process complies with Food and Drug Administration standards. They spoke on condition of anonymity to discuss sensitive contractual issues.

In its SEC filing on Thursday, Novavax said, “The US government recently directed the company to prioritize coordination with the US Food and Drug Administration on the company’s analytical methods before engaging in additional US productions. and has further advised that the US government will not allocate additional funding to US production until such an agreement is reached. “

An official with the Department of Health and Human Services overseeing Novavax’s federal contract said the government wanted the company to step up its testing and quality controls. The officer spoke on condition of anonymity to discuss confidential negotiations with the company.

Novavax said in a statement that the federal government is continuing to fund other ongoing work, including clinical trials. “We do not anticipate any impact on our funding agreement with the US government to support the overall development and production of 110 million doses of our vaccine candidate,” the company said.

The company’s manufacturing problems are on top of lost production at a government-funded vaccine-making factory in Baltimore operated by Emergent BioSolutions.

Federal regulators suspended production at that facility for more than three months this year until the company resolved quality control issues, including a failure to prevent contamination that ruined tens of millions of cans. The plant had made Johnson & Johnson and AstraZeneca vaccines but now only makes doses for Johnson & Johnson.

Chris Hamby contributed to the coverage.

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Charts present how far delta variant has unfold all over the world

A sign warning people to stay separated due to Covid-19 can be seen in Mevagissey, UK on July 29, 2021.

Finnbarr Webster | Getty Images News | Getty Images

More than a year after the Covid-19 pandemic, the world is struggling with a highly transmissible Delta variant, which has led to a renewed increase in infections in countries from the UK and the US. to those in Africa and Asia.

The Delta variant, which was first discovered in India last October, has been found in more than 130 countries around the world, according to the World Health Organization.

Delta is the most commonly transmitted variant of the coronavirus, which first appeared in China in late 2019, said Dr. Maria Van Kerkhove, epidemiologist and technical director for Covid-19 at the WHO.

“The virus itself is, as it begins, a dangerous virus, a highly transmissible virus. The Delta variant is even more – it is twice more transmissible than the ancestral strain, it is 50% more transmissible than the Alpha strain, ”she said at a WHO press conference last week.

The alpha variant was first discovered in Great Britain

Globally, the number of reported Covid-19 cases exceeded 200 million on Wednesday and more than 4.2 million people have died from it, data compiled by Johns Hopkins University showed.

Delta variant prevalence

Delta is one of four “Concerning Variants” listed by the WHO. Such variants are considered to be more contagious, more resistant to current vaccines and treatments, or could cause more serious illness.

The delta variant has become the dominant Covid-19 pathogen in many countries.

According to genetically sequenced coronavirus samples collected by GISAID, around 65 countries have discovered cases of Covid caused by the Delta variant in the four weeks leading up to August 5.

GISAID is a platform for scientists to share information about viruses, and their data is widely used by the global scientific community, including the WHO.

Data on the prevalence of the Covid Delta variant likely underestimate the real situation as some countries do not share sequenced samples with GISAID, while others may not have the ability and resources to perform virus sequencing.

In 55 of these countries, the delta variant accounted for more than half of the virus samples submitted, according to data compiled by GISAID.

Effectiveness of the vaccine

The Covid Delta variant has not spared countries with some of the highest vaccination rates in the world.

Israel, where more than 62% of the population is fully vaccinated, reported an increase in daily cases last month as Delta became the dominant strain in the country.

When the Delta variant spread in Israel, the Ministry of Health found that the effectiveness of the Covid vaccine dropped to just 39% with two doses of Pfizer-BioNTech, although protection against serious illnesses remained high. The country has started giving booster shots to people over the age of 60.

But a study in the UK, where the Delta variant is also fueling a surge in infections, found that two doses of Pfizer-BioNTech or the AstraZeneca-Oxford University vaccine were almost as effective against Delta as against the Alpha variant.

The study, published in the New England Journal of Medicine, used real world data and found that two doses of the Pfizer BioNTech vaccine were 88% effective against the Delta variant. That’s compared to 93.7% versus the Alpha strain, it said.

According to the study, the AstraZeneca-Oxford vaccine was found to be 67% effective against Delta, compared to 74.5% effectiveness against the Alpha variant.

However, vaccination progress has remained inconsistent around the world. Many poorer developing countries are lagging behind due to their lack of access to Covid-19 vaccines.

On Wednesday, WHO urged rich nations to stop distributing booster vaccines, highlighting global injustice in vaccines.

Aside from getting more people vaccinated, WHO’s Van Kerkhove said there are steps individuals can take to better protect themselves from the Delta variant. That includes wearing a mask, keeping your hands clean, and spending more time outdoors than indoors, she said last week.

“This won’t be the last variant of the virus you will hear us talk about,” she added. “The virus is likely to become more transmissible because viruses do just that – they evolve, they change over time, and so we have to do everything we can to contain it.”

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Abebech Gobena, the ‘Mom Teresa’ of Africa, Dies at 85

Abebech Gobena was returning from a pilgrimage to the holy site of Gishen Mariam, about 300 miles north of the Ethiopian capital, Addis Ababa, when she saw the woman and her baby.

It was 1980, and Ms. Gobena was passing through an area recently stricken by drought and an accompanying famine. All along the road were bodies — many dead, some dying, some still able to sit up and ask for food.

“There were so many of these hungry people sprawled all over, you could not even walk,” she said in a 2010 interview with CNN. She handed out what little she had — a loaf of bread, a few liters of water.

At first, Ms. Gobena thought the woman was asleep, and she watched as the baby tried to suckle at her breast. Then she realized the mother was dead.

A man nearby was collecting bodies. He told her he was waiting for the child, a girl, to die.

Without thinking further, Ms. Gobena picked up the baby, wrapped her in a cloth and took her home to Addis Ababa. She returned the next day with more food and water.

“One of the men dying by the side of the road said to me, ‘This is my child. She is dying. I am dying. Please save my child,’” she recalled. “It was a terrible famine. There were no authorities. The government at that time did not want the famine to be public knowledge. So I had to pretend the children were mine and smuggle them out.”

By the end of the year she had 21 children living with her and her husband, Kebede Yikoster. At first supportive, he eventually gave her an ultimatum: him or the children.

Ms. Gobena left him, and most of her possessions, taking the children to live with her in a shack in the woods. She sold her jewelry to raise money, then eked out an income selling injera bread and honey wine. Unable to pay the children’s school fees, she found a tutor to visit the shack.

She took in more children, and after years of battling government bureaucracy in Ethiopia, in 1986 she managed to register her organization — Abebech Gobena Children’s Care and Development Association — as a nonprofit, enabling her to raise money and accept grants.

She bought farmland outside Addis Ababa, where she and the orphans worked, and sold the produce to fund the orphanage. They also built dozens of latrines, public kitchens and water points around the city.

Today the organization, known by its acronym in Amharic, Agohelma, is one of the largest nonprofits in Ethiopia. Along with its orphanage, it provides free school for hundreds of children, HIV/AIDS prevention and maternal health care — according to its own estimate, some 1.5 million Ethiopians have benefited from its services since 1980. They and many others call her the “Mother Teresa of Africa.”

In June Ms. Gobena contracted Covid-19. She entered the intensive care unit at St. Paul’s Hospital in Addis Ababa, where she died on July 4. She was 85. Yitbarek Tekalign, a spokesman for Agohelma, confirmed her death.

“Abebech Gobena was one of the most selfless and pure-hearted people I ever met,” Tedros Adhanom Ghebreyesus, the director-general of the World Health Organization and a former Ethiopian minister of health, said in a statement. “She helped many children not only to survive, but succeed in life.”

Abebech Gobena Heye was born on Oct. 20, 1935, in Shebel Abo, a village north of Addis Ababa in what was then Shewa Province. That same month, Italian forces in Eritrea invaded Ethiopia, setting off the Second Italo-Ethiopian War. Her father, Gofe Heye, was a farmer who died in the fighting.

Ms. Gobena and her mother, Wosene Biru, went to live with her grandparents. When she was 10 her family arranged for her to marry a much older man, but she ran home soon after the ceremony. Her family returned her to her husband, who kept her locked in a room at night.

Ms. Gobena managed to escape through a hole in the roof and made her way to Addis Ababa, where she found a family to take her in. She attended school and later found work as a quality control inspector with a company that exported coffee and grain.

The job afforded her a stable, middle-class life, but after establishing Agohelma she lived in near poverty. She never took a salary, and her bedroom was attached to one of the orphanage dormitories.

Ms. Gobena — known to many as Emaye, an Amharic word that loosely translates as “Wonderful Mother” — did not simply raise the children under her charge. Along with their classroom education, she made sure that they learned marketable skills, like metalworking, embroidery and, more recently, photography. She gave the older children seed money to start their own businesses.

“I don’t have words to describe Emaye; she was my everything,” said Rahel Berhanu, a former Agohelma orphan, in an interview with the magazine Addis Standard. “After getting my diploma, I started working with her. She was a mother above mothers.’’

Ms. Gobena did not leave any immediate survivors, though she might disagree.

“I have no children of my own,” she told The Times of London in 2004, “but I have a family of hundreds of thousands, and I have absolutely no regrets.”

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FDA emergency use submission delayed to This fall

Novavax announced that it will postpone filing its Covid-19 vaccine with the Food and Drug Administration for approval for emergency use until the fourth quarter.

The biotech company’s shares slipped 10% after the bell.

The company has applied for approval in India, Indonesia and the Philippines. Plans to submit the vaccine to the World Health Organization for emergency use are scheduled for August, Novavax announced.

WHO approval enables the vaccine to be distributed worldwide through vaccine exchange initiatives at the global agency.

Novavax data from clinical trials indicate that a booster dose of the candidate vaccine after two-dose treatment of an approved vaccine produces a 4-fold increase in neutralizing antibody levels.

The data also suggest that a booster dose of a Novavax vaccine six months after two-dose treatment of an approved vaccine could provide increased protection against the Delta variant and other variants.

Despite the delay in US approval, the company remains on track to produce 100 million cans per month through the end of the third quarter and 150 million per month through the end of the fourth quarter.

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Coronary heart Issues After Vaccination in U.S. Are Unusual and Quick-Lived, Researchers Say

For every one million Americans immunized with a coronavirus vaccine, about 60 develop temporary heart problems, according to a study published Wednesday in JAMA magazine.

The complications were all short-lived, the researchers found. And these heart problems are far more common in patients who develop Covid-19, as external experts have found.

When analyzing the medical records of just over 2 million people who had received at least one dose of a coronavirus vaccine by May 2021, the new study found 20 cases of myocarditis, or inflammation of the heart muscle, and 37 cases of pericarditis, an inflammation of the heart muscle membrane that surrounds the heart.

Patients who were admitted to the hospital were discharged after just a few days, none of them died.

The incidence of myocarditis in the study is 10 cases per million vaccinated, higher than the Centers for Disease Control and Prevention’s estimate of 4.8 cases per million, suggesting there may be more cases than the federal database tracking these Side effects mentioned after vaccinations.

“We see that these adverse events lead to very short and inconspicuous hospital stays,” said Dr. Jeremy Faust, an emergency doctor at Brigham and Women’s Hospital in Boston who was not involved in the study. “The same cannot be said so far of hospital stays for Covid-19 in this or any other age group.”

“When people are hospitalized for Covid, the consequences are far more severe,” added Dr. Faust added, who compared post-vaccination myocarditis rates with those in Covid-19 patients.

The researchers worked with the Providence Health System to evaluate medical records from 40 hospitals in Washington, Oregon, Montana and Los Angeles County, California.

They found that myocarditis developed a median 3.5 days after vaccination, mostly after the second dose and in people with a median age of 36 years. Three quarters of the 20 cases were men.

The 19 patients admitted to the hospital were discharged after a median of two days. About three weeks after vaccination, 13 patients had recovered from their symptoms and the remaining seven improved.

Pericarditis affected elderly patients, a mean age of 59 years and later, about 20 days after vaccination, the researchers found. Pericarditis was also more common in men. Of the 37 identified cases, 13 were hospitalized; the average stay was one day.

A separate study published online last week found that the incidence of myocarditis in boys ages 12 to 17 with Covid-19 was 876 per million; in girls of the same age group with Covid-19, the incidence was 213 cases per million.

The study has not yet been peer-reviewed or published in a scientific journal.

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Third Covid vaccine shot excessive precedence

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, listens during a Senate Fund Subcommittee hearing in Washington, DC, on Jan.

Stefani Reynolds | Swimming pool | Reuters

Federal health officials are working “ASAP” to get a third Covid-19 vaccine approved for Americans with weakened immune systems, said Dr. White House chief physician Anthony Fauci on Thursday.

It is now clear that immunocompromised populations – which include patients with cancer, HIV, or organ transplants – generally fail to generate an adequate immune response after two doses of a Covid vaccine, Fauci said.

“Immunocompromised people are vulnerable,” said Fauci during a Covid briefing at the White House. “It is extremely important for us to give these people their boosters and we are working on it now and we will do this as soon as possible. … It is a very high priority.”

Immunocompromised populations make up only about 2.7% of the adult US population. Still, they account for about 44% of hospitalized breakthrough Covid cases – an infection in a fully vaccinated person, according to data released late last month by an advisory group from the Centers for Disease Control and Prevention.

Studies suggest that a third shot might help people whose immune systems don’t respond as well to a first or second dose.

Four small studies cited by the CDC last month showed that 16% to 80% of people with compromised immune systems had no detectable antibodies to Covid after two shots. Among immunocompromised patients who had no detectable antibody response, 33 to 50% developed an antibody response after receiving an additional dose, according to the CDC.

“From the observational data we have made, it now appears that they are generally not giving an adequate response that we believe would be adequately protected,” Fauci said Thursday.

Other countries such as France are already giving third vaccinations to people with cancer or other immune deficiencies. Israel announced last month that it would offer booster syringes to people over the age of 60 as the syringe seems to be becoming less effective in these people.

Some doctors have pushed for the US to allow an extra dose to immunocompromised populations, and many immunocompromised Americans are already finding extra doses of the vaccines, medical experts say.

Dr. Scott Gottlieb, who headed the Food and Drug Administration during Donald Trump’s presidency from 2017 to 2019, told CNBC on Monday that he believes the elderly and immunocompromised people will receive booster shots by September or October.

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Return to Work? Not With Youngster Care Nonetheless in Limbo, Some Mother and father Say.

When the pandemic began, Brianna McCain quit her job as an office manager to take care of her two young daughters. She was ready to go back to work last spring. But she didn’t make it because her children are still at home.

She was looking for a job with flexible hours and the option to work from home, but these are hard to find, especially for new hires and hourly workers. She cannot take a personal job until the school opens for her 6-year-old, and her Portland, Oregon district has not announced its plans. She also needs childcare for her 2 year old, which costs less than she deserves, but childcare availability is well below pre-pandemic levels and prices have gone up to cover the cost of Covid security measures.

“Especially with a new job, there is no flexibility,” says Ms. McCain, whose partner, a warehouse worker, cannot work from home. “And with the unknowns from Covid, I don’t know whether my child will be pulled out of school for quarantine or whether school will end.”

Especially with the proliferation of the Delta variant, many parents of young children – those under the age of 12 who cannot yet be vaccinated – are saying that they will not be able to return to work or apply for new jobs while insecure is about when their children can safely return to full-time school or childcare.

Businesses struggle to hire and retain workers for other reasons, too, and many parents have had no choice but to work. (In a recent survey by the Census Bureau, 5 percent of parents said their children are currently not attending childcare due to pandemic-related reasons.) But for the group of parents who still have children at home – they are disproportionately black and Latinos and some have medically vulnerable family members – that’s a big challenge.

“You can’t part with childcare and the pandemic,” said AnnElizabeth Konkel, economist at Indeed Hiring Lab. “It’s important that we don’t forget the workers who wrestle with it day in and day out.”

In an Indeed poll this summer, a third of job seekers said they didn’t want to start in the next month, and a significant proportion said they would wait for schools to open. Among those who were unemployed but not looking urgently, almost a fifth said that care responsibilities were the reason. People without a college degree were more likely to give such a reason – and were less likely to be able to work from home or afford nannies.

Summer is always a challenge for working parents, and this is especially true this year. To meet safety guidelines, many camps are open with shorter schedules and fewer children. Others have closed due to a lack of staff. And many parents are uncomfortable sending their children because of the risk of exposure to Covid.

Autumn is getting more and more uncertain. Some jobs have paused reopening plans because of Delta, and parents fear schools may follow suit. Certain companies, including McDonald’s, and states like Illinois, are trying to forestall this by offering childcare allowances to help parents get back to work. According to Bright Horizons, the employer-based childcare company, 75 companies started offering additional childcare this calendar year, and others, like PayPal, expanded their expanded pandemic benefits this year.

Most school districts still say they plan to open full-time, without the shortened timetables that many had last spring. And the five largest nationwide have released plans to reopen, according to the University of Washington’s Center on Reinventing Public Education, which has been tracking districts’ responses to the pandemic. However, some plans are still sparse in detail, and the districts in which union negotiations are ongoing were unable to answer all of the parents’ questions.

“What surprised us most this summer is the lack of publicly available clarity about what to expect,” said Bree Dusseault, who leads the data work. “Families need to know so that they can structure their lives.”

Parents in districts who have already announced plans to reopen are also faced with uncertainty. Will there be pre- and post-school childcare and after-school activities? Do families have to be quarantined for two weeks if there are cases in schools? Could schools close again if cases continue to increase?

For Alexis Lohse, mother of two in St. Paul, Minnesota, Delta is one detour too much. She lived in poverty as a single mother. At 30, she was the first in her family to go to college and earn a master’s degree. She got a job in the state government, and just before the pandemic, she had the chance of a long-awaited promotion.

But when the schools closed, she couldn’t pursue it. She continued to work, but put aside all opportunities for advancement and reduced her hours. (Her husband, a postman, couldn’t do that.) Now her county is classified as Highly Vulnerable by the CDC, and with the school opening right after big gatherings at the Minnesota State Fair, she’s skeptical that full-time school will happen.

“I don’t know how to get back on track, especially with the questions out there – how schools reopen; If; Variants; the behavior of everyone else; that schools open and close at bizarre, random hours, “she said.

The safety net that she has built has been torn away, she says: “I know how difficult it is and how little infrastructure our country has to support parents. And it just feels so frustrating that I hit the same brick walls that I hit 16 years ago in the pandemic. “

Many parents of preschool children struggle with a shortage of childcare places. Research shows that a third of day care centers have never opened again; those that are still closed catered disproportionately to Asian, Latin American and black families. Those that have opened are on average 70 percent full. They struggled to hire qualified teachers; must keep classes small to limit exposure to the virus; and have raised prices to cover new health and cleaning measures.

Daphne Muller, Los Angeles mother of two and a technology company consultant, says she calls preschools almost every week to see if there is room for their youngest: “I don’t feel like I have any career plans myself. I don’t want to take a job and have to quit. “

Parents must also plan for disruptions, such as quarantine times after exposure or when the number of cases in the community increases.

Bee Thorp, a mother of two in Richmond, Virginia, said her children’s daycare closed three times for two weeks each time last year, as well as cutting cleaning times. Her husband, a lawyer, was much less flexible than she, so the extra care fell on her.

“That means I’m not really looking for a job,” she said. “I can’t ask in an interview, ‘Do you mind if I pick up two weeks without notice?’ It’s frustrating to hear comments about people not applying for jobs. Maybe people want these jobs; they just can’t. “

Other parents are not yet ready to send their unvaccinated children to school. Amy Kolev is a mother of three and a construction project manager based in Glen Burnie, Maryland. When the virtual school got too tough, she and her husband, a software programmer, decided to quit. She longs to return, but does not risk exposing her children.

“I will be back when my children are vaccinated and not the day before,” she said.

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Pfizer would require Covid shot or testing for U.S. staff

November 2020, people walk past Pfizer’s New York headquarters.

Hit by Betancur | AFP | Getty Images

Pfizer said on Wednesday all of its U.S. employees and contractors must be vaccinated against Covid-19 or have regular weekly tests.

The new initiative will “best protect the health and safety of our colleagues and the communities we serve,” Pfizer spokeswoman Pamela Eisele said in a statement to CNBC.

“Outside the US, the company strongly encourages all colleagues who can do this in their countries to get vaccinated,” added Eisele. “Colleagues with illnesses or religious objections can look for accommodation. Colleagues must continue to follow all federal, local, and Pfizer security procedures related to COVID-19 while at Pfizer. “

Pfizer, whose Covid vaccine was first approved in the US with German drug maker BioNTech, is just the youngest company to require its employees to be vaccinated. The mandates come again as coronavirus cases in the USA, fueled by the highly contagious Delta variant.

On Tuesday, New York City became the first major city in the United States to require proof of vaccination in restaurants, gyms, and other businesses.

A new CNBC All-America Economic Survey released on Wednesday found Americans are sharply divided over vaccine mandates.

The survey of 802 Americans, conducted July 24-28, found that 49% were in favor of vaccine mandates and 46% were against – a difference that is well within the survey’s margin of error of 3.5 percentage points. Five percent said they were not sure.

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Who Are the Unvaccinated in America? There’s No One Reply.

As coronavirus cases rise across the United States, the fight against the pandemic is focused on an estimated 93 million people who are eligible for shots but have chosen not to get them. These are the Americans who are most vulnerable to serious illness from the highly contagious Delta variant and most likely to carry the virus, spreading it further.

It turns out, though, that this is not a single set of Americans, but in many ways two.

In one group are those who say they are adamant in their refusal of the coronavirus vaccines; they include a mix of people but tend to be disproportionately white, rural, evangelical Christian and politically conservative, surveys show.

In the other are those who say they are open to getting a shot but have been putting it off or want to wait and see before making a decision; they are a broad range of people, but tend to be a more diverse and urban group, including many younger people, Black and Latino Americans, and Democrats.

With cases surging and hospitalizations rising, health officials are making progress in inoculating this second group, who surveys suggest account for less than half of all unvaccinated adults in the United States.

Credit…Adriana Zehbrauskas for The New York Times

“I heard a news story several weeks ago now, about the Epsilon variant, which is hitting one of the countries in South America. So, I don’t want to get a vaccine now, necessarily, if I don’t have to, and then get a different vaccine nine months from now.”

Steven Harris, 58, who said he believes that the antibodies he has from getting Covid-19 are sufficiently protective.

The problem is the same surveys show that the group firmly opposed to the vaccines outnumbers those willing to be swayed. And unless the nation finds a way to persuade the unwavering, escaping the virus’s grip will be a long way off, because they make up as much as 20 percent of the adult population.

Interviews this past week with dozens of people in 17 states presented a portrait of the unvaccinated in the United States, people driven by a wide mix of sometimes overlapping fears, conspiracy theories, concern about safety and generalized skepticism of powerful institutions tied to the vaccines, including the pharmaceutical industry and the federal government.

Myrna Patterson, 85, a Democrat from Rochester, N.Y., who works at a hospital, said she could not shake her worry that the vaccines were produced too quickly. “Is it really worth me taking it?” Ms. Patterson said. “How do they know that it will kill the virus, and if it’s really good for humans to be taking this vaccine?”

Hannah Reid, 30, a mother of four and a certified sommelier in Oregon who is an unaffiliated voter, said she had long been apprehensive about vaccines: Her young children get many but not all pediatric shots. She says her Christian faith has also made her comfortable with not yet getting a Covid-19 shot, which she thinks is too new, the conversation around it too noisy and bombastic.

Alex Garcia, 25, who is not tied to any political party and works in landscaping in Texas, said he believed he was too young and healthy to need a vaccine. “My immune system could fight it,” Mr. Garcia said. He said he did not worry about infecting his unvaccinated 86-year-old grandmother, either.

About 30 percent of the adult population in the United States has yet to receive a shot, and about 58 percent of those age 12 through 17 have yet to receive a shot.

Part of the challenge is that the unvaccinated live in communities dotted throughout the United States, in both lightly and densely populated counties. Though some states like Missouri and Arkansas have significantly lagged the nation in vaccination rates, unvaccinated Americans are, to varying degrees, everywhere: In Cook County, Ill., which includes Chicago, 51 percent of residents are fully vaccinated. Los Angeles County is barely higher, at 53 percent. In Wake County, N.C., part of the liberal, high-tech Research Triangle area, the vaccination rate is 55 percent.

The rate of vaccinations across the country has slowed significantly since April, but there are signs in recent days of a new rise in shots being distributed, with upticks in vaccinations particularly in states like Arkansas, Louisiana and Missouri, where cases have grown. As of Friday, about 652,000 doses, on average, were being given each day, according to data from the Centers for Disease Control and Prevention; that was up from recent weeks, when the country hovered just above 500,000 shots a day. Nationwide, about 97 percent of people hospitalized with Covid-19 are unvaccinated, federal data shows.

How many people eventually decide to get shots could help determine the course of the virus and severity of illnesses across the country, so efforts to convince the unvaccinated — both the group that is waiting and watching and the vehemently opposed — have gained steam with advertising campaigns, incentives and new mandates. Some experts have estimated that 90 percent or more of the total population — adults and children — would need to be fully vaccinated for the country to reach a possibly elusive herd immunity threshold of protection against the coronavirus.

So far excluded from the debate over vaccination are 48 million unvaccinated children under 12, who are too young to be eligible for a shot until at least fall. They make up 15 percent of the total population in the United States. Once they are eligible, it is uncertain how many will get shots; even some vaccinated parents are hesitant to inoculate their children, surveys show.

Doctors say they are working to convince reluctant Americans, sometimes in long conversations that unravel falsehoods about vaccines.

Dr. Laolu Fayanju, a family medicine doctor in Ohio, has encountered patients on both ends of the spectrum: those who are insistent in their refusal to be vaccinated, and others who agree to a shot after he painstakingly lays out facts.

Never did he expect that so many Americans would still be resisting a shot this many months into the vaccination effort.

“I vacillate between anguish and anger,” Dr. Fayanju said. “We live in an era of unprecedented scientific breakthroughs and expertise. But we’re also stymied by the forces of misinformation that undermine the true knowledge that is out there.”

In the first weeks of the nation’s vaccination effort, health officials could not distribute shots quickly enough to millions who rushed for them, beginning with health care employees, essential workers and older Americans, who were particularly at risk of dying from the coronavirus, which has killed more than 600,000 people across the country.

Over time, the people choosing vaccines shifted markedly, according to C.D.C. data, which captures race and ethnicity for about 60 percent of vaccine recipients.

White people, who were vaccinated at a higher rate than Black and Hispanic people earlier this year, make up a larger share of the vaccinated population than the overall population, but that share has been shrinking.

Credit…Alisha Jucevic for The New York Times

“I hope this is just like the polio vaccine, where we can say, in a few years, praise God, what a gift to humanity — that this Covid vaccine saved so many people, and has proved long term to be such a good gift. So I hope that’s the case, but I think we kind of want to see it through.”

Hannah Reid, 30. If the F.D.A. approves the vaccines, she said she and her husband will feel somewhat less apprehensive but will continue to do their own research and pray.

The daily vaccination rate per capita among Asian Americans started out comparable to that among white people, then accelerated when availability opened to all age groups, and now slightly surpasses white people. Black and Hispanic people were being vaccinated at a lower per capita rate than other groups at the beginning, but since April, the vaccination rate for Hispanic people began to rise above other groups.

Asian Americans, Pacific Islanders, Native Americans and Alaskan Natives, who make up a smaller proportion of the overall population, have surpassed other groups in total percentage vaccinated, but still include large numbers of unvaccinated people.

Figuring out exactly who is not vaccinated is more complicated; federal authorities have mainly tracked the people getting shots — not those who have not gotten them. But several surveys of adults — from the Kaiser Family Foundation, AP-NORC, Morning Consult, Civis Analytics, the Ad Council and the Census Bureau — together present a sense of the range of who the unvaccinated are, an essential set of data as health officials seek to convince reluctant Americans.

Updated 

Aug. 4, 2021, 9:35 p.m. ET

About 10 percent of American adults have made it clear in interviews, discussions with family members and conversations with survey researchers that under certain circumstances, they are open to be convinced to get a vaccine.

With the help of a friend who is a nurse, Lakeshia Drew, 41, of Kansas City, Mo., has been on her own journey for weeks. Ms. Drew, who voted for President Biden but is unaffiliated with a political party, said she was learning all she could about the risks that the coronavirus carries, and how a vaccine could protect her from getting critically ill.

As the Delta variant has spiked case numbers in her area, she has decided that her family will need to get vaccinated before receiving every last answer to its questions.

“It’s gone from ‘We aren’t getting it’ to ‘OK, if I get more information I’m going to get it,’” she said of the shot. “I would rather get it than to bury any one of my children or to have them bury me.”

Ms. Drew and other people in the so-called wait-and-see group tend to be younger and harbor more concerns about the safety of the vaccines. They may be worried that the vaccines are too new, or about what friends have told them about side effects.

In one Kaiser survey, 44 percent said they would be more likely to get a vaccine once it is fully approved by the Food and Drug Administration. Currently, the three coronavirus vaccines being offered in the United States have only been granted an emergency use authorization, a step short of full approval.

“It’s kind of like the known versus the unknown for some of those people,” said Mollyann Brodie, an executive vice president at the Kaiser Family Foundation, who runs the group’s survey research. “Fear is a hard thing to overcome, and there has been a lot of fearmongering with relation to the vaccine, and there is a lot of stuff that isn’t known about it.”

Some adults under 50, in particular, suggest that the risk of an unknown vaccine feels greater than the uncertainty of its benefits.

Don Driscoll, 38, who is from Pittsburgh and calls himself a socially liberal Republican, said he has opted for now against vaccination because of safety concerns.

“I don’t think there’s a conspiracy, I don’t think Bill Gates is shooting microchips into my veins,” he said. “I don’t think the Democrats want to kill half the population. I am just not an early adopter of anything, really.”

Some people who have yet to get vaccinated say they have encountered obstacles to obtaining shots, are worried about hidden costs or are waiting until they can get a shot from someone they trust. But the share of unvaccinated Americans who are held up because of issues of convenience is shrinking, survey research shows.

Understand the State of Vaccine Mandates in the U.S.

For some Latino immigrants, fear of immigration authorities has been a roadblock.

For instance, grass-roots organizers recently hosted a vaccine clinic at a supermarket in Merced, a city in California’s fertile Central Valley that draws farmworkers from Mexico. But some residents say they were turned away by the health care workers administering the vaccines because they did not have government-issued IDs — although officials have said that only proof of age should be required.

“For the undocumented, their fears are not the vaccine but the record keeping that goes along with it,” said Dr. Richard Pan, a pediatrician and Democratic state senator in California who has gone into neighborhoods to knock on doors and urge people to get inoculated.

A substantial share of the wait-and-see group — more than 40 percent in the Kaiser survey — says it would be motivated by vaccine mandates.

But San Francisco became one of the first cities to impose a vaccine mandate for its nearly 35,000 city workers, and immediately encountered resistance from labor unions and other organizations.

“I don’t believe in mandates of any kind,” said Sherman Tillman, the president of the San Francisco Black Firefighters Association, who described himself as a conservative Democrat. “I don’t believe that governments should force our workers to do anything about their bodies and health. I think it’s an individual choice.”

Credit…Chase Castor for The New York Times

“If it was really a pandemic, we wouldn’t have to be reminded daily of it. If we were in a pandemic, we would know it automatically. We wouldn’t have to have it shoved down our throats 24/7.”

Reba Dilts, 28, who cited her history of health issues as part of her reason to not get vaccinated. She also had Covid-19 and said she believes that the pandemic was not the crisis others said it was.

Other people who have skipped vaccinations so far but said they might be persuaded said they planned to rely on advice from their own doctors — whenever their next checkup might be.

Candice Nelson, a personal assistant in Spartanburg, S.C., has suffered medical challenges before. She is a cancer survivor who endured chemotherapy. And she had Covid-19 several months ago, spending three days in a hospital to recover.

Yet she is in no hurry to receive a vaccine — until she can discuss it with the doctor who treated her cancer at their next appointment. Her employer has asked her to be vaccinated and is pressuring her for an answer.

“I’ll go with what my doctor says,” she said, adding that she would also be responsive to a requirement at her job.

The C.D.C. recommends vaccines even for people who have been infected with the virus. Some evidence suggests a prior infection offers less protection than a vaccine, particularly against variants like Delta.

For Troy Maturin, from Abbeville, La., the rapid spread of the Delta variant through his state does not make him more interested in getting the vaccine. To the contrary: He takes it as further evidence, he said, that the vaccines are a government plot.

“They’d have to Taser me, drag me out, and give it to me while I’m unaware of it,” Mr. Maturin, a 50-year-old auto parts salesman who described himself as conservative, said at the suggestion of a mandate.

Mr. Maturin belongs to the group of unvaccinated Americans who are unlikely to say they could be persuaded with improved convenience or even requirements. They are far less concerned about getting seriously ill with Covid-19, and much more likely to say they do not trust the government or the pharmaceutical companies that have developed the shots. They are not opposed to all vaccinations, but very few of them get annual flu shots.

Several studies have suggested that a Republican Party affiliation is among the best predictors of membership in this group. But the demographics of the group also overlap with key Republican constituencies. People who say they will never get a Covid-19 vaccine are disproportionately likely to be white and to live in rural areas. They are overrepresented in the South and the Midwest.

Pete Sims, 82, recalls ducking mandatory vaccines during his time in the Air Force in the late 1950s.

Servicemen would periodically line up, hold out a vaccination card, get it stamped and when their turn came, hold out their arms.

Moments before the injection, Mr. Sims always managed to take a bathroom break. He said he would emerge after his turn had passed.

Now he lives in Houston and identifies as more of a libertarian than a Republican, though he voted for Donald J. Trump in November. But Mr. Sims was emphatic that his politics have not shaped his near lifelong antipathy to vaccines.

“It has to do with my civil rights,” he said. “The United States government’s main job is to protect me from foreign and domestic enemies. Not my health. I’m in charge of my health.”

Angelique White, 28, a hairstylist in Romulus, Mich., is firm in her decision not to be vaccinated, despite pressure from her boyfriend to get the shot. Ms. White, who is a Jehovah’s Witness and does not vote, had several cousins who died from Covid-19. But she believes that years ago, when she and her twin sister became violently ill, they were reacting to a flu shot. They never got another vaccine.

“I wear my mask, I sanitize my hands and do it like that,” Ms. White said. “I think I’ll be fine.”

She has not spoken with her doctor or pastor about the vaccines. There is no need, she said: Her mind is made up and she has moved on.

Reporting was contributed by Sophie Kasakove, Rick Rojas, Albert Sun, Ashley Wu, Ana Facio-Krajcer, Danielle Ivory and Amy Schoenfeld Walker. Kitty Bennett contributed research.

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Health

Illinois Gov. Pritzker introduces masks mandate for colleges as Covid circumstances surge

Illinois Gov. J.B. Pritzker

Brian Cassella | Chicago Tribune | Tribune News Service via Getty Images)

Illinois Gov. JB Pritzker announced a mask mandate for all state students regardless of their vaccination status at a news conference Wednesday, requiring facial coverings in all indoor settings from preschool through high school.

Pritzker noted that the new order would impact 1.8 million unvaccinated children under the age of 12. In addition to requiring masks in schools, Pritzker mandated facial coverings in all long-term care facilities in state, as well as in state-run corrections facilities, veterans homes, psychiatric hospitals and developmental centers.

“Preventing outbreaks from the start also prevents kids from having to stay home because they’re sick or in quarantine,” Pritzker said.

The move comes as the coronavirus delta variant spreads rapidly across the state and the nation.

Illinois experienced a 46% increase in cases last week, a seven-day average of almost 1,669 new coronavirus cases, according to data from Johns Hopkins University.

Pritzker’s announcement also comes as state and local governments continue to introduce health measures to mitigate the spread of the infectious disease. On Monday, seven counties in Northern California issued a mask mandate for all indoor settings, elevating a facial covering advisory issued in July to a requirement.

That same day, Louisiana issued a new statewide mask mandate for residents in public indoor settings until at least Sept. 1, a measure that includes students from kindergarten to college. Nevada revived its mask mandate for indoor public spaces on July 27, though it applies only to counties with elevated Covid transmission rates.

And on Tuesday, New York City mandated vaccinations for employees and patrons of the city’s restaurants, gyms, and entertainment centers, an order that will take effect in September. Mayor Bill de Blasio also said in June that city schools would keep their mask mandates in place.