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Entertainment

Met Opera Strikes Deal With Stagehands Over Pandemic Pay

The Metropolitan Opera has reached a preliminary agreement on a new contract with the union that represents its stagehands, which increases the likelihood the company will return to the stage after its longest shutdown in September.

The deal was reached early Saturday morning and the union plans to brief its leaders and members after the July 4th holiday, said a union spokesman, Local One of the International Alliance of Theatrical Stage Employees. The union and the company declined to provide details of the agreement, which union members will have to vote on.

The company’s 300 or so stagehands were locked out at the end of last year due to disagreement over the duration and duration of the pandemic pay cuts. But the opera house desperately needs workers to prepare its complex operations if it is to reopen in less than three months. The pressure on the talks increased as the two sides negotiated for almost four weeks.

The Met, which claims it has lost more than $ 150 million in revenue since the pandemic forced its closure in March 2020, has called for substantial cuts in the wages of its union members. Peter Gelb, the company’s general manager, said that in order for the company to survive the pandemic and thrive, it will need to cut labor costs for these unions by 30 percent, which is effectively lowering pay by about 20 percent. Union leaders have opposed the proposed cuts, arguing that many of their members have been unpaid for many months.

A Met spokeswoman declined to comment on the deal.

Because of Local One’s lockout, the Met outsourced some of its stage construction work to Wales and California, a move that angered union members struggling during the pandemic. These sets were shipped to New York City, where it would take long hours to get the productions up and running.

Of the other two major Met unions, one representing the orchestra is still in negotiations. The contract with the other, the American Guild of Musical Artists, which includes choir members, soloists, and stage managers, saved money by modestly cutting salaries, moving members from the Met’s health insurance to the union, and reducing the size of the regular choir. The projected savings do not correspond to Mr. Gelb’s demand for a wage cut of 30 percent.

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Health

F.D.A. Releases One other Batch of Johnson & Johnson’s Vaccine

WASHINGTON — Federal regulators on Friday cleared a batch of vaccine that could furnish up to 15 million doses of Johnson & Johnson’s one-shot coronavirus vaccine, deciding they can be safely distributed despite production failures at the factory that ruined 75 million other doses.

The move brings the total number of Johnson & Johnson doses made at the Baltimore facility and cleared by the Food and Drug Administration for distribution in the United States to roughly 40 million. But Johnson & Johnson remains far short of its commitment to deliver 100 million doses to the federal government by the end of June. European Union officials have said the company is missing its delivery targets there, as well.

The vaccine cleared on Friday is not yet bottled, and the Biden administration’s plans for it remain unclear. But with new coronavirus cases dropping and the country awash in vaccines from two other authorized manufacturers, most new Johnson & Johnson doses produced in the United States are likely destined for export.

Johnson & Johnson has been unable to produce much of its vaccine since April, when regulators shut down the Baltimore factory, operated by Emergent BioSolutions, because of major production errors. Johnson & Johnson had been relying on Emergent, its subcontractor, to produce vaccine for use in the United States as well as to meet its commitments overseas while it expanded its own plant in Leiden, the Netherlands.

Even with the newly cleared batch, Johnson & Johnson remains nearly 40 million doses short of the 100 million doses called for in its federal contract. The F.D.A. did not disclose the precise number of doses cleared Friday, but multiple people familiar with Emergent’s operation said the batch amounted to as many as 15 million doses.

Also on Friday, European regulators approved the reopening of Johnson & Johnson’s Dutch plant, a piece of good news for the company amid its supply woes. “Today’s approval represents progress in expanding our global manufacturing network to supply our Covid-19 vaccine worldwide,” the company said in a statement.

The Baltimore factory is expected to remain shuttered for at least several more weeks while Emergent tries to bring it up to standard, according to people familiar with its operation who spoke on condition of anonymity. The F.D.A. said in a statement Friday that it was not yet ready to certify that the plant was following proper manufacturing practices.

After the discovery in March that Emergent workers had contaminated a batch of Johnson & Johnson’s vaccine with a key ingredient for AstraZeneca’s Covid vaccine being made at the same plant, regulators cited Emergent for a series of regulatory violations. Emergent was forced to throw out the equivalent of 75 million doses of Johnson & Johnson vaccine. European authorities discarded another 17 million more doses, and South Africa, which is desperate for vaccine, pulled two million more.

The Biden administration also had to pivot from relying on AstraZeneca doses to fulfill its pledge to donate vaccine to poorer nations, swapping in supplies from other makers. The F.D.A. has yet to rule on whether the equivalent of more than 100 million doses of both Johnson & Johnson and AstraZeneca vaccines produced by Emergent are suitable for use.

The F.D.A. has been conducting a painstaking review of every vaccine batch from the Emergent plant, matching up records of deviations from manufacturing standards with production lots to determine whether the batches can be released. In a letter to Johnson & Johnson released late Friday, the agency said the batch it was releasing was suitable for distribution even though the factory was not adhering to proper manufacturing practices at the time it was produced.

As deliveries of Johnson & Johnson’s vaccine stalled, the Biden administration ended up relying almost entirely on doses made by Pfizer-BioNTech and Moderna. With the pandemic now waning in the United States, demand for shots has plummeted. Johnson & Johnson has teamed up with the pharmaceutical giant Merck to make more doses, but the factory they intend to use is not expected to start operating until the fall.

Although the Johnson & Johnson vaccine was once considered a game changer in the nation’s vaccination campaign, state health officials have struggled to use up even the limited supply they received in the spring. Roughly 12.5 million people in the United States have taken the vaccine, accounting for a little more than half of the available supply, and millions of doses are set to expire by August. It is still being used in doctors’ offices and at smaller events, state officials said.

Enthusiasm for the Johnson & Johnson vaccine dropped in part because of a federally recommended pause in its use in April after a rare blood-clotting disorder was discovered in a few recipients.

But federal health officials are still hoping that surplus doses of Johnson & Johnson’s vaccine will be useful overseas, where vaccine doses remain desperately scarce. White House officials said this week that some countries had requested the vaccine because it is easier to store and transport than the others, and because some people prefer a one-shot regimen. The vaccine has been deployed in 27 countries so far.

On Thursday, Johnson & Johnson reported that early results of unpublished studies showed that its vaccine was effective against the highly contagious Delta variant, even eight months after inoculation. That was a reassuring finding for those who have gotten the company’s shot.

The news came after earlier data showed Pfizer’s and Moderna’s mRNA vaccines as effective against the Delta variant, which is much more contagious than previous variants and is expected to quickly become the dominant version of the virus in the United States. Because Johnson & Johnson’s vaccine rolled out more slowly, information about its effectiveness against variants has also lagged.

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Politics

Pentagon Seeks to Soften Blow of U.S. Withdrawal From Afghanistan

The August date also gives the government more time to find places to relocate thousands of Afghans and their family members who helped Americans during the Twenty Years’ War. The White House has come under severe pressure to protect its Afghan allies from Taliban revenge attacks and to speed up the lengthy and complex process of issuing special immigrant visas.

“We cannot turn our backs and let them die,” said Texas MP Michael McCaul, the top Republican on the House Foreign Affairs Committee, on Fox News Sunday. “They are being slaughtered by the Taliban.”

Administration officials previously said they would consider Guam as a possible location, but State Department officials say they will need multiple locations. The Foreign Ministers of Tajikistan and Uzbekistan were in Washington last week and the issue of Afghan security was raised at their meetings with Mr. Austin and Foreign Secretary Antony J. Blinken.

After all, General Miller’s stay for a few more weeks and the extension of the security umbrella at least until August should give the oppressed Afghan troops a boost. Pentagon officials said leaving Bagram Air Base and leaving General Miller at the same time would have been a devastating blow to Afghan morale.

“A safe, orderly exit allows us to maintain an ongoing diplomatic presence, assist the Afghan people and government, and prevent Afghanistan from becoming a safe haven again for terrorists threatening our homeland,” Kirby said.

The White House joined the calming campaign on Friday – up to a point. Mr Biden said that while the United States still retained the ability to conduct air strikes in order to protect the Afghan government, no withdrawal of the withdrawal was on the table.

“We have developed a capacity beyond the horizon,” he said, speaking of American fighter jets and armed Reaper drones stationed mostly in the Persian Gulf, “but the Afghans have to do it themselves with the air force that they have.” . “

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World News

The Tech Chilly Warfare’s ‘Most Difficult Machine’ That’s Out of China’s Attain

SAN FRANCISCO — President Biden and many lawmakers in Washington are worried these days about computer chips and China’s ambitions with the foundational technology.

But a massive machine sold by a Dutch company has emerged as a key lever for policymakers — and illustrates how any country’s hopes of building a completely self-sufficient supply chain in semiconductor technology are unrealistic.

The machine is made by ASML Holding, based in Veldhoven. Its system uses a different kind of light to define ultrasmall circuitry on chips, packing more performance into the small slices of silicon. The tool, which took decades to develop and was introduced for high-volume manufacturing in 2017, costs more than $150 million. Shipping it to customers requires 40 shipping containers, 20 trucks and three Boeing 747s.

The complex machine is widely acknowledged as necessary for making the most advanced chips, an ability with geopolitical implications. The Trump administration successfully lobbied the Dutch government to block shipments of such a machine to China in 2019, and the Biden administration has shown no signs of reversing that stance.

Manufacturers can’t produce leading-edge chips without the system, and “it is only made by the Dutch firm ASML,” said Will Hunt, a research analyst at Georgetown University’s Center for Security and Emerging Technology, which has concluded that it would take China at least a decade to build its own similar equipment. “From China’s perspective, that is a frustrating thing.”

ASML’s machine has effectively turned into a choke point in the supply chain for chips, which act as the brains of computers and other digital devices. The tool’s three-continent development and production — using expertise and parts from Japan, the United States and Germany — is also a reminder of just how global that supply chain is, providing a reality check for any country that wants to leap ahead in semiconductors by itself.

That includes not only China but the United States, where Congress is debating plans to spend more than $50 billion to reduce reliance on foreign chip manufacturers. Many branches of the federal government, particularly the Pentagon, have been worried about the U.S. dependence on Taiwan’s leading chip manufacturer and the island’s proximity to China.

A study this spring by Boston Consulting Group and the Semiconductor Industry Association estimated that creating a self-sufficient chip supply chain would take at least $1 trillion and sharply increase prices for chips and products made with them.

That goal is “completely unrealistic” for anybody, said Willy Shih, a management professor at Harvard Business School who studies supply chains. ASML’s technology “is a great example of why you have global trade.”

The situation underscores the crucial role played by ASML, a once obscure company whose market value now exceeds $285 billion. It is “the most important company you never heard of,” said C.J. Muse, an analyst at Evercore ISI.

Created in 1984 by the electronics giant Philips and another toolmaker, Advanced Semiconductor Materials International, ASML became an independent company and by far the biggest supplier of chip-manufacturing equipment that involves a process called lithography.

Using lithography, manufacturers repeatedly project patterns of chip circuitry onto silicon wafers. The more tiny transistors and other components that can be added to an individual chip, the more powerful it becomes and the more data it can store. The pace of that miniaturization is known as Moore’s Law, named after Gordon Moore, a co-founder of the chip giant Intel.

In 1997, ASML began studying a shift to using extreme ultraviolet, or EUV, light. Such light has ultrasmall wavelengths that can create much tinier circuitry than is possible with conventional lithography. The company later decided to make machines based on the technology, an effort that has cost $8 billion since the late 1990s.

The development process quickly went global. ASML now assembles the advanced machines using mirrors from Germany and hardware developed in San Diego that generates light by blasting tin droplets with a laser. Key chemicals and components come from Japan.

Peter Wennink, ASML’s chief executive, said a lack of money in the company’s early years had led it to integrate inventions from specialty suppliers, creating what he calls a “collaborative knowledge network” that innovates quickly.

“We were forced to not do ourselves what other people do better,” he said.

ASML built on other international cooperation. In the early 1980s, researchers in the United States, Japan and Europe began considering the radical shift in light sources. The concept was taken up by a consortium that included Intel and two other U.S. chip makers, as well as Department of Energy labs.

ASML joined in 1999 after more than a year of negotiations, said Martin van den Brink, ASML’s president and chief technology officer. Other partners of the company included the Imec research center in Belgium and another U.S. consortium, Sematech. ASML later attracted big investments from Intel, Samsung Electronics and Taiwan Semiconductor Manufacturing Company to help fund development.

That development was made trickier by the quirks of extreme ultraviolet light. Lithography machines usually focus light through lenses to project circuit patterns on wafers. But the small EUV wavelengths are absorbed by glass, so lenses won’t work. Mirrors, another common tool to direct light, have the same problem. That meant the new lithography required mirrors with complex coatings that combined to better reflect the small wavelengths.

So ASML turned to Zeiss Group, a 175-year-old German optics company and longtime partner. Its contributions included a two-ton projection system to handle extreme ultraviolet light, with six specially shaped mirrors that are ground, polished and coated over several months in an elaborate robotic process that uses ion beams to remove defects.

Generating sufficient light to project images quickly also caused delays, Mr. van den Brink said. But Cymer, a San Diego company that ASML bought in 2013, eventually improved a system that directs pulses from a high-powered laser to hit droplets of tin 50,000 times a second — once to flatten them and a second time to vaporize them — to create intense light.

The new system also required redesigned components called photomasks, which act like stencils in projecting circuit designs, as well as new chemicals deposited on wafers that generate those images when exposed to light. Japanese companies now supply most of those products.

Since ASML introduced its commercial EUV model in 2017, customers have bought about 100 of them. Buyers include Samsung and TSMC, the biggest service producing chips designed by other companies. TSMC uses the tool to make the processors designed by Apple for its latest iPhones. Intel and IBM have said EUV is crucial to their plans.

“It’s definitely the most complicated machine humans have built,” said Darío Gil, a senior vice president at IBM.

Dutch restrictions on exporting such machines to China, which have been enforced since 2019, haven’t had much financial impact on ASML since it has a backlog of orders from other countries. But about 15 percent of the company’s sales come from selling older systems in China.

In a final report to Congress and Mr. Biden in March, the National Security Commission on Artificial Intelligence proposed extending export controls to some other advanced ASML machines as well. The group, funded by Congress, seeks to limit artificial intelligence advances with military applications.

Mr. Hunt and other policy experts argued that since China was already using those machines, blocking additional sales would hurt ASML without much strategic benefit. So does the company.

“I hope common sense will prevail,” Mr. van den Brink said.

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Health

Emirates, Etihad put together for summer season amid delta Covid warnings

A Boeing 777 of the Emirates airline at Sydney International Airport on May 01, 2021 in Sydney, Australia.

James D. Morgan | Getty Images News | Getty Images

Emirates airline is preparing for a summer travel surge over the next two weekends, despite growing concerns about the variant delta coronavirus, which is responsible for more than a third of infections in the United Arab Emirates.

Emirates expects more than 450,000 passengers on over 1,600 flights to, from and through Terminal 3 of Dubai International Airport (DXB) in the coming days.

“The busiest days for the airline will be the next two weekends, July 2-3 and July 9-10, although high passenger traffic is expected today and will last until July 12,” Emirates said in a statement on Wednesday.

Almost 100,000 passengers will arrive in Dubai on Emirates flights over the same period to begin their summer vacation, the airline added. The seasonal surge in travel comes when temperatures heat up in the United Arab Emirates, where mercury can soar to 40 degrees Celsius and more in July.

Emirates, one of two national airlines in the United Arab Emirates, plans to increase its flight capacity to 90% of pre-pandemic levels by July. Dubai Airports also reopened Terminal 1 and Hall D on June 24th after being closed for 15 months due to the pandemic.

“All Emirates and DXB touchpoints are well prepared to cope with the increase in passenger numbers, with measures and protocols that increase the security of customers’ passage through Terminal 3,” said Emirates.

The more than half a million people who are expected to cross the UAE in the coming days correspond to almost the entire passenger volume of London’s Heathrow Airport in May of this year, according to Heathrow Airport.

A Boeing 787-9 “Dreamliner” operated by Etihad Airways displays Israeli and Emirati flags after arriving from the United Arab Emirates (UAE) at Israel’s Ben Gurion Airport near Tel Aviv on the company’s first scheduled commercial flight from Abu Dhabi landed in April 02/06/2021.

JACK GUEZ | AFP | Getty Images

Etihad Airways from Abu Dhabi also extended their “Verified to Fly” program on Wednesday. The program enables travelers to validate Covid-19 travel documents prior to arriving at the airport to improve passenger turnaround time.

“We know these are challenging times for travelers and this has been an important initiative to make our guests’ journeys as easy as possible,” said John Wright, Etihad vice president for global airports and networking, in a statement.

Delta concerns

The expected increase in summer travel comes despite new warnings about the Delta variant of the virus, which has been shown to be more transmissible, causing more hospital stays and reducing vaccine effectiveness. The Delta variant, identified for the first time in India, accounts for 33.9% of cases in the UAE, according to the UAE Ministry of Health.

The British variant accounts for 11.3% of the cases, while the South African variant still has the highest infection rate at 39.2%. The United Arab Emirates reported 1,747 new cases of the virus on Tuesday.

The US Centers for Disease Control and Prevention on Monday issued a renewed level 4 “do not travel” warning for the UAE, the highest possible category, citing concerns about the virus. The United Arab Emirates are also still on the United Kingdom’s “red list”, where they have been since the end of January.

Britons living in the United Arab Emirates have expressed confusion and anger over the decision, particularly the Red List quarantine requirements.

Forty percent of the UAE’s roughly 10 million residents are now fully vaccinated, according to Johns Hopkins University. The high local vaccination rate, new flight routes and the easing of restrictions on vacation hotspots have given locals and residents the confidence and desire to travel again despite warnings about dangerous coronavirus variants.

Emirates has vowed to adhere to strict security measures for travelers. The airline was one of the first in the world to introduce the IATA Travel Pass, which will be extended to all routes in its network in the coming weeks. Emirates has also partnered with Al Hosn, the UAE covid tracing app, to support safe passenger movement.

“Emirates customers can travel knowing that the airline and its partners have spared no effort to make their airport trip as safe and smooth as possible,” said the airline.

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Politics

Demolition of collapsed condominium tower in Florida to start Sunday night time

In this handout image dated July 2, 2021, search and rescue workers are working on the site of a collapsed Florida condominium complex in Surfside, Miami, USA.

MIAMI DADE FIRE DEPARTMENT | about REUTERS

The demolition of the partially collapsed residential tower in Surfside, Florida will begin search operations on Sunday evening once the site is safe, according to Miami-Dade County’s Mayoress Daniella Levine Cava.

The demolition will take place between 10 p.m. and 3 a.m., Levine Cava said during a press conference on Sunday evening. According to the Miami-Dade police, residents in the protection zone should stay indoors with immediate effect.

The on-site protection order will be lifted two hours after the demolition is complete, Levine Cava said. Residents should close all windows, doors and air intakes, she said.

“The demolition is limited to the immediate vicinity of the building,” said the mayor. “However, there is dust and other particles that are an inevitable by-product of all types of demolition, and as a precautionary measure, we ask residents in the immediate vicinity to stay indoors during the demolition.”

Search and rescue operations on the building were temporarily suspended on Saturday afternoon in preparation for demolition, which included drilling the building’s remaining pillars. Levine Cava said Sunday the search would resume immediately after the building is shut down and the site is believed to be safe.

“The controlled demolition of the building is critical to expanding our search area, as you know in the pile, and allowing us to search the area closest to the building, the one for the teams given the great risk to ours Teams was inaccessible. ” First responders because of the instability of the building, “said Levine Cava.

No one has been rescued since the first hours after the Champlain Towers South collapsed 11 days ago. The death toll rose to 24 by Saturday, 121 are still missing. Florida’s Governor Ron DeSantis said during a press conference early Saturday that the state will pay for all costs of the demolition.

The demolition is carried out through a technique called “energetic felling,” which relies on gravity to demolish the building with small designations and limit the collapse to the area of ​​the building, according to Levine Cava.

The officials initially thought it could take weeks to demolish. Plans to demolish the remaining structure were accelerated, however, amid concerns that the effects of the weather from Tropical Storm Elsa could hit Florida early next week and further threaten the unstable structure with heavy rains and winds.

The cause of the collapse of the Champlain Towers South, built in the 1980s, is still unknown. However, an engineering firm filed a 2018 report warning of cracks and major structural damage under the building’s pool deck.

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Health

Ought to Folks With Immune Issues Get Third Vaccine Doses?

When it came to coronavirus vaccination, the third time was the charm for Esther Jones, a dialysis nurse in rural Oregon. After two doses of the Pfizer-BioNTech vaccine failed to jolt her immune system into producing antibodies, she sought out a third, this time the Moderna shot.

It worked. Blood tests revealed a reasonable antibody response, although lower than what would be detected in healthy people. She received a fourth dose last month in hopes of boosting the levels even more.

Ms. Jones, 45, had a kidney transplant in 2010. To prevent rejection of the organ, she has taken drugs that suppress the immune response ever since. She expected to have trouble responding to a coronavirus vaccine, and enrolled in one of the few studies so far to test the utility of a third dose in people with weak immune systems.

Since April, health care providers in France have routinely given a third dose of a two-dose vaccine to people with certain immune conditions. The number of organ transplant recipients who had antibodies increased to 68 percent four weeks after the third dose from 40 percent after the second dose, one team of French researchers recently reported.

The study in which Ms. Jones enrolled has turned up similar results in 30 organ transplant recipients who procured third doses on their own.

Being vulnerable to infection even after inoculation is “very scary and frustrating” for immunocompromised people, said Dr. Dorry Segev, a transplant surgeon at Johns Hopkins University who led the study. “They have to continue to act unvaccinated until we figure out a way to give them better immunity.”

But in the United States, there is no concerted effort by federal agencies or vaccine manufacturers to test this approach, leaving people with low immunity with more questions than answers. The Centers for Disease Control and Prevention, the Food and Drug Administration and the National Institutes of Health in fact recommend even against testing to find out who is protected. And academic scientists are stymied by the rules that limit access to the vaccines.

“There should be already a national study looking at post-transplant patients getting booster shots,” said Dr. Balazs Halmos, an oncologist at the Montefiore Medical Center in the Bronx, who led a study showing that some cancer patients did not respond to the vaccines. “It shouldn’t be our little team here in the Bronx trying to figure this out.”

An estimated 5 percent of the population is considered to be immunocompromised. The list of causes is long: some cancers, organ transplants, chronic liver disease, kidney failure and dialysis, and drugs like Rituxan, steroids and methotrexate, which are taken by roughly 5 million people for disorders from rheumatoid arthritis and psoriasis to some forms of cancer.

“These are the people being left behind,” said Dr. Jose U. Scher, a rheumatologist at NYU Langone Health who led a study of methotrexate’s effect on the vaccines.

Not everyone who has one of these risk factors is affected. But without more research, it’s impossible to know who might need extra doses of the vaccines, and how many. Besides the risk of Covid-19, there is also evidence that low immunity may allow the virus to continue to replicate in the body for long periods, potentially leading to new variants.

An infusion of monoclonal antibodies may help some people who don’t produce antibodies on their own — but again, the idea is not being thoroughly explored, said John Moore, a virologist at Weill Cornell Medicine in New York.

Use of monoclonal antibodies “makes great sense for this group of people, so I would like to see the companies be more active in this area,” he said. “Government support or pressure would also help.”

Updated 

July 4, 2021, 4:20 p.m. ET

The third-dose approach has widespread support among researchers because there is clear precedent. Immunocompromised people are given booster doses of vaccines for hepatitis B and influenza, for example. And discontinuing methotrexate after getting a flu vaccine is known to improve the vaccine’s potency — evidence that compelled the American College of Rheumatology to recommend pausing methotrexate use for one week before being immunized against the coronavirus.

Several studies have indicated that a third coronavirus vaccine dose might succeed in patients who did not have detectable antibodies after the first or second dose. But research has lagged.

Moderna is gearing up to test a third dose in 120 organ transplant recipients, and Pfizer — which produces some immunosuppressant medications — is planning a study of 180 adults and 180 children with an immune condition.

The companies turned down at least two independent teams who hoped to study the effects of a third dose.

The N.I.H. is recruiting 400 immunocompromised people for a trial that would track their levels of antibodies and immune cells for up to 24 months — but has no trials looking at a third dose.

“It takes time, unfortunately, especially as a government agency,” said Emily Ricotta, an epidemiologist at the National Institute of Allergy and Infectious Diseases. “We have to go through a lot of regulatory and approval processes to do these sorts of projects.”

But that explanation does not satisfy some researchers. Many medical centers already have groups of patients who did not respond to the vaccines, so federal agencies could organize a clinical trial without too much difficulty, Dr. Scher noted. “It’s a very simple study,” he said. “There’s no rocket science here.”

Earlier studies suggested that many people with cancer would not respond to the vaccines, but those analyses were done after the patients had received a single dose. A new study published this month by Dr. Halmos of Montefiore Medical Center and his colleagues laid some of those fears to rest. The vaccines seem to work well in patients with a wide range of solid and liquid tumors, according to the large analysis.

But 15 percent of those who had blood cancers and 30 percent of those who took drugs that suppress the immune system had no detectable antibodies after the second dose. Dr. Halmos said he and his colleagues were eager to test whether a third dose could benefit those individuals, but have not yet been able to gain access to the vaccines.

Dr. Segev’s team found in an earlier study that less than half of 658 organ transplant recipients had measurable antibodies after both doses of an mRNA vaccine made by Pfizer-BioNTech or Moderna. But to follow up on the finding, they had to resort to recruiting volunteers like Ms. Jones who had obtained third doses on their own.

The scientists found that a third dose amped up antibody levels in all 30 organ transplant recipients who had low or undetectable levels of antibodies.

Ms. Jones said many people like her felt they had been abandoned by the federal government — especially with the threat of more contagious variants circulating in the United States.

Some members of a Facebook group for immunocompromised people desperate for protection have gotten a third dose at mass vaccination sites where providers don’t check records, or have even crossed state lines, she said. Even so, most continue to wear masks to protect themselves — and have sometimes had to endure harassment as a result.

“It really saddens me that so many people in this world have made masking like, this super political thing when it should never have been,” she said. “It makes it so it’s harder for us to take care of ourselves.”

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Entertainment

10 Influences That Clarify Why ‘Concern Road’ Appears Acquainted

In the film trilogy “Fear Street”, a killer is on the loose. But this Netflix horror extravaganza not only leaves a sizable amount of blood, it also sprays the screen with a torrent of pop culture references.

The trilogy mainly takes place in the fictional town of Shadyside and is based on the books by RL Stine when the town was a village. (The episodes premier on three consecutive Fridays starting July 2.) The trilogy speeds through characters, moods, and genres, including teen romance and full-on slasher. The movies are in a way like a Netflix algorithm of styles all wrapped up in a bingeable package.

Amid the many twists and turns, the films follow the city and the oversized murder problem that it has had for generations. Is witchcraft involved? Could it be satan? Or are the people just mean? The director Leigh Janiak wants to keep the audience on their toes, at the same time hum catchy tunes and think of both Halloween and “Halloween”.

Below is a look at 10 influences horror and comedy fans alike can spot.

In the first film, set in 1994, mall culture (including B. Dalton) is alive and well. So it is almost every song a teenager or college student might have heard at the time. The needle drops bounce from Nine Inch Nails to Bush to, damn it, Sophie B. Hawkins. The songs are used a little the way Quentin Tarantino could do: to project the thoughts of characters, including lead actress Deena (Kiana Madeira), who in a moment of dissatisfaction with Garbag’s “I’m Only Happy When It Rains” is presented.

While there is no DeLorean here, the spirit of adventure and decades of understanding of revelation are reminiscent of Robert Zemeckis’ “Back to the Future” films. The third part of both trilogies takes us a long way back – to the Wild West in “Back to the Future” and to the season of the witch from the 17th century in “Fear Street”.

While the “Fear Street” films delve into all sorts of supernatural lore, knives and axes are the deepest elements of the threat. The 1978 summer camp backdrop can’t help but remind us of some good old-fashioned “Friday the 13th” Crystal Lake mayhem. The Netflix entry ticks off some creative kills that would make both Jason from those films and Michael Myers from “Halloween” proud.

“Fear Street” has a certain “meddling child” aspect to it, where a group of outsiders come together to solve age-old secrets. As the characters explore the city’s history and its often unsolved murders, you can feel Daphne and Fred from Scooby-Doo just outside the frame. Deena exudes Velma vibes and the film has its own shaggy in the character of Simon (Fred Hechinger), a slacker and trickster who finds himself in a few zoinks! Moments.

In recent years, a handful of celebratory romances with women have taken center stage, such as “Portrait of a Lady on Fire” and “Ammonite”. The trend was remarkable enough to be parodied on “Saturday Night Live”. Add Fear Street to the list of the emerging relationship between Sarah Fier (also played by Madeira) and Hannah Miller (Olivia Scott Welch) in 1666. The two keep their passions a secret, but their chemistry is as strong as the accents of time.

While there isn’t an ’80s entry on the series, John Hughes’ influence here is hard to shake, as Fear Street highlights and puts the underdogs at the fore. With her disaffected one-handed attitude, Deena is reminiscent of Allison Reynolds, Ally Sheedy’s dejected character from “The Breakfast Club”. And literal gamer Josh (Benjamin Flores Jr.) on Fear Street has a lot in common with Hughes creation Brian Johnson, played with classic geekiness from Anthony Michael Hall.

A horror staple, obsession – by ghosts, witches, or something worse – can add an interesting crease to a narrative. How can you argue with a murderer when he’s obsessed? (Answer: You can’t.) “Fear Street” has fun with this premise by turning some characters harmlessly into bloodthirsty ones from a moment on.

In the 1978 episode, the bloody prom prank from Stephen King’s novel (and the subsequent Brian De Palma film) stars in the mocked but resilient Ziggy Berman (Sadie Sink) who seeks revenge on those who wronged her the act one. But in “Fear Street” pig blood is replaced by a much stronger alternative. Nonetheless, Ziggy Carrie has qualities as an outsider who is often subjected to ridicule by other campers and who develops ways to defend himself. She doesn’t have to turn up the vengeance all the way to Carrie levels, however. The killer on the rampage can do that.

While the 1978 episode has its share of revenge and editing, there are plenty of exhilarating moments too. With its short shorts, rowdy advisors and crazy gimmicks, the film owes a lot of comedies such as Ivan Reitman’s “Meatballs”, David Wain’s “Wet Hot American Summer” and Ron Maxwell’s “Little Darlings”.

Janiak, the director, has said that her shooting style for the 1666 episode was inspired by Terrence Malick’s The New World. In fact, some of the open air ensemble scenes are reminiscent of the 2005 drama about the founding of Jamestown. But the rural setting, early English accents, and looming witchcraft are more reminiscent of “The Witch,” Robert Eggers’ meticulous and sober horror mystery from 2016. With dingy, candle-lit interiors and a dark but terrifying relationship with animals ( this time an uncomfortable handling of a pig instead of Eggers’ use of a creepy goat) this entry in “Fear Street” makes life in the 17th century look tedious and desolate.

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Health

U.S. celebrates as nation emerges from pandemic

Residents line up with chairs on the side of the street as they watch an Independence Day celebration parade on July 4, 2021 in Brighton, Michigan.

Emily Elconin | Getty Images News | Getty Images

Americans are set to celebrate the Fourth of July after the coronavirus pandemic forced the cancellation of most events last year, raising hopes that life is on the road to a semblance of normalcy as cases and deaths from Covid-19 near record lows.

The White House has encouraged people to come together and watch fireworks displays to mark the country’s “independence” from the virus. Businesses and restaurants are reopening across the country as restrictions are being relaxed and air travel briefly surpassed 2019 levels at the start of the holiday weekend.

President Joe Biden is even set to host an Independence Day party on Sunday with 1,000 essential workers and military families on the South Lawn of the White House, marking the first large-scale event held by the president.

He will deliver remarks at 7:30 p.m. ET.

Though the country has made significant progress against the pandemic due to the vaccination rollout, the Fourth of July weekend also comes as U.S. health officials monitor spread of the Covid delta variant, which is believed to be more transmissible than other strains earlier in the pandemic.

Coronavirus cases are much lower than the peak in January, when the country saw more than 300,000 new cases on a single day, according to a CNBC analysis of Johns Hopkins University data.

Still, cases have been trending upward in the recent days and some health officials warn that the U.S. shouldn’t declare victory over the pandemic yet due to the delta variant, which now comprises about a quarter of infections among mostly unvaccinated people.

As of Sunday, the seven-day average of new daily Covid cases in the U.S. is 13,196, an 11% increase over the last week, according to CNBC’s analysis of JHU data.

Deaths in the U.S. have been slowing for months. The seven-day average of new Covid deaths is 225, down 23% from one week prior, according to CNBC’s analysis.

More than 600,000 people in the U.S. have died over the course of the pandemic.

White House Covid czar Jeff Zients on Sunday defended the Biden administration’s upcoming Fourth of July party and said the U.S. has “a lot to celebrate,” citing that two out of three adult Americans have received at least one dose of the vaccine.

“We are much further along than I think anyone anticipated in this fight against the pandemic,” Zients said during an interview on ABC’s “This Week.”

In fact, the administration narrowly missed its goal to fully immunize 160 million Americans and have 70% of adults with at least one shot by the Fourth of July. But nearly 156 million Americans are now fully vaccinated and more than 182 million have received at least one dose, according to the Centers for Disease Control and Prevention.

Dr. Scott Gottlieb told CNBC on Friday that most people should feel comfortable gathering over Independence Day weekend, citing high vaccination rates and low virus infection levels in much of the country.

“There’s very low prevalence around the country. You have to judge based on where you are,” Gottlieb said on “Squawk Box.” “In some parts of the country where you see prevalence rising … I think people should exercise more caution.”

Roughly 1,000 counties in the U.S., mostly located in the Southeast and Midwest, have vaccination coverage of less than 30%, according to the CDC. And in some counties, the delta variant rates are as high as 50%.

Dr. Anthony Fauci, the country’s top infectious disease expert, said on Sunday that people in areas with low vaccination rates, such as Mississippi, should “go the extra mile” and wear a mask even if they’re vaccinated.

“If you put yourself in an environment in which you have a high level of viral dynamics and a very low level of vaccine, you might want to go the extra step … even though the vaccines themselves are highly effective,” Fauci said during an interview on NBC’s “Meet the Press.”

The Pfizer-BioNTech and Moderna vaccines were authorized by the Food and Drug Administration for emergency use in December, followed by the Johnson & Johnson vaccine in February.

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World News

France’s structural issues have been uncovered by the pandemic

A couple, one of them on their smartphone, is enjoying the view of the Eiffel Tower at sunset in Paris on February 23, 2021.

Ludovic Marin | AFP | Getty Images

France may still be in the middle of the coronavirus pandemic as the Delta variant is spreading rapidly, but officials and business leaders are looking to a period of recovery and reflecting the broader prospects for France’s political and economic future.

“The recovery is very steep, but even steeper than last year. So we are very happy with it,” said Agnès Bénassy-Quéré, chief economist at the French finance ministry, to CNBC on Sunday, pointing out that the national statistics office is raising its growth forecast for France to 6% in 2021.

“The official forecast for 2021 is still 5% because we are still cautious about autumn. As you said, there is a Delta variant and we kept some restrictions until the end of the year. So already in spring, when this forecast was made, it contained some restrictions, slight restrictions of the second half of the year. So far we haven’t changed that forecast, then we’ll see what happens when we have to do the 2022 budget, “he said, speaking with CNBC’s Charlotte Reed while attending an economic forum in Aix-en-Provence.

Of course, the Covid-19 pandemic has left a lot of devastation and no less in France, where over 5.8 million infections and over 111,000 deaths have so far been recorded, according to Johns Hopkins University.

Like other countries, France put in place emergency measures to support the economy, businesses and employment during the pandemic, and there are now some concerns that reducing that support could lead to job losses and the closure of some businesses.

Bénassy-Quéré said the government has been “very cautious” but the labor market is currently resilient.

“There is a rejuvenation, a gradual phasing out of support, the emergency aid, which comes gradually over the course of the summer. And there will still be some support, for example [the] Long-term unemployment scheme, which also applies in the fall for activities like [the] Aircraft industry where we really want to keep the skills in the industry and so there will be some retraining programs. “

However, he found that while activity in some industries was above pre-crisis levels, some lagged behind, such as tourism. In addition to the uneven recovery, another problem for the government is that France’s mountain of debt has soared to a record high due to huge borrowing. At the beginning of the year, the French statistical office Insee reported that the national debt was 115.7% of GDP at the end of 2020, compared to 97.6% in 2019.

How France will pay off this mountain of debt is uncertain for now, as the government under President Emmanuel Macron will raise taxes just 10 months before the presidential elections. Whether Macron will undertake ambitious (and unpopular) reforms to modernize and simplify France’s sluggish pension system is also uncertain, given the pandemic situation.

So far, two rounds of regional elections in the last few weeks have dispelled expectations that the far-right National Rally – formerly known as the Front National – could do well in the national vote next year after a poor showing in the regions. Turnout was low on both rounds, leading some analysts to express concern about the level of voter dissatisfaction in France.

Valérie Rabault, President of the Socialist Group in the National Assembly, who also attended the Economic Assembly in Aix-en-Provence, told CNBC on Sunday that “French society has broken”, as evidenced by the low turnout in regional votes.

“We had local elections and less than 35% of the people voted, so that’s very low. This was the first time in France that so few people vote in local elections. For me it reflects … a kind of indifference on the part of the population to build a common project for France, for society, and that is the great challenge for us as politicians to be able to and have to tackle this issue [a] more positive message after the crisis, “she said, adding,” We have to define something, a common project that can unite people. “

Structural problems

Business leaders who attended the Aix-en-Provence Economic Forum told CNBC that there were structural problems in France that would not be easy to fix.

“The rifts that existed in French society are still there, be it the territorial divide, the generational divide and the very low percentage of voters as we saw in the last elections,” Pierre-André de Chalendar, Chairman of French building materials group Saint-Gobain, said CNBC on Saturday.

“The priorities are clear, (they are) the energy transition, reindustrialization – which is the best way to overcome this territorial gap – and to place more emphasis on the youth, on education. The question is how do we do it, and I think the problem in France is that the state as a whole is too big and not efficient enough. “

Ross McInnes, Chairman of Safran, agreed that “two important structural issues” should be addressed in France, the most important being the quality of education in France.

“When it comes to education, our school system has let us collectively,” he told CNBC. “Hundreds of thousands of young French people … drop out of secondary school with no good math, you know, the three ‘Rs’ of reading, writing, and arithmetic. And we urgently need to fix that in order to be able to recruit talent for good jobs. “