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Health

Hong Kong biotech start-up Prenetics plans $1.three billion SPAC merger

Signage for Prenetics, a Hong Kong-based biotechnology company, at the company’s laboratory in Hong Kong, China, on Jan. 26, 2018.

Anthony Kwan| Bloomberg | Getty Images

Hong Kong biotech company Prenetics is set to merge with Artisan Acquisition, a special purpose acquisition company, in a deal that will value the new entity at $1.3 billion or more, according to a source close to the deal.

The transaction is expected to close by the end of this year. The SPAC is already traded on the Nasdaq under the ticker ARTU.

SPACs are shell companies set up to raise money through an initial public offering — their sole purpose is to merge with or acquire an existing private company and to take it public. They bypass Wall Street’s traditional IPO process.

Artisan Acquisition is backed by Adrian Cheng, the CEO and Executive Vice Chairman of Hong Kong-listed New World Development, a conglomerate with $88 billion in assets.

Prenetics is a diagnostic and genetic testing company with significant operations in Hong Kong and the U.K. It was founded by serial entrepreneur Danny Yeung and will become the first billion-dollar start-up in Hong Kong to go public.

A technician handles a sample at a Prenetics laboratory in Hong Kong, China, on Jan. 26, 2018.

Anthony Kwan | Bloomberg | Getty Images

UBS, Citi, Credit Suisse and CICC are financial advisors on the potential de-SPAC transaction.

Artisan raised $339 million in the SPAC, and has signed a further $60 million forward purchase agreements with investment firm Aspex and PAG, a private asset manager for institutional investors, according to the source who requested anonymity as that person was not allowed to discuss the information publicly.

Talks with additional pipe investors are said to be ongoing, with strong initial demand, the source said.

The company has grown significantly since its founding in 2014, and 2021 revenue is projected to surpass $200 million. That would mark 400% growth over the year prior, according to the source.

Annual revenue is expected to reach $600 million by 2025, said the source.

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World News

Constructing moral AI merchandise can put companies at aggressive benefit

An Ubtech Walker X Robot plays Chinese chess during the World Artificial Intelligence Conference (WAIC) 2021 at the Shanghai World Expo Center on July 8, 2021 in Shanghai, China.

VCG | VCG via Getty Images

SINGAPORE – Ensuring that AI-powered services and products are ethical and trustworthy could become a competitive strength for businesses, experts said on Wednesday.

Artificial intelligence systems are already changing companies. You’ll be able to automate repetitive tasks, analyze large amounts of data, recommend content, translate languages, and even play games.

But the current scope of things AI can do is relatively narrow. Some experts say the technology is far from becoming what is known as artificial general intelligence, or AGI – which indicates the AI’s hypothetical ability to understand or learn any human intellectual task.

However, others have pointed out that despite its current limited capabilities, AI raises a number of ethical questions – such as whether the data fed into AI programs is unbiased and whether AI can be held responsible if something goes wrong.

To build trustworthy AI systems, countries and various stakeholders need to work together, said Wonki Min, a former vice minister in South Korea’s science and technology ministry who spearheaded the country’s national AI strategy.

That means working with neighboring countries as well as industry experts, academics and ordinary people who use these technologies, Min said during a panel discussion on AI governance at the Asia Tech x Singapore conference.

Requirements for building trust

Experts previously warned that inherently biased AI programs can create serious problems and compromise people’s trust in these systems. For example, facial recognition software can contain accidental racial and gender biases that can pose a threat to a specific group of people.

Trust is fundamental to getting a technology up and running to its fullest, said Andrew Wyckoff, director of the science, technology and innovation directorate at OECD who was part of the panel.

Artificial intelligence creates competitive strength for industry.

Ieva Martinkenaite

Vice President at Telenor Research

He pointed out that there are several “essential” elements to building trust in AI systems. These include: being able to transparently explain how a program works, ensuring that the program is robust, secure, secure and accountable.

Regulators are faced with the daunting task of finding a balance to encourage further AI developments and manage the risks involved. Some researchers say it is too early for politics to impose new strict rules on technology.

For their part, the OECD Principles on AI promote artificial intelligence that is “innovative, trustworthy and respects human rights and democratic values” and makes recommendations to policy makers and other stakeholders.

A competitive advantage

According to Hiroaki Kitano, President and CEO of Sony Computer Science Laboratories, building trustworthy and ethical AI systems and the governance that surrounds them could potentially become a competitive strength for companies.

The Japanese conglomerate uses AI in a variety of its products, including cameras.

For Norwegian telecommunications giant Telenor, ethical AI is “a responsible business emerging” according to Ieva Martinkenaite, Vice President at Telenor Research. She pointed out that many of the next generation telecommunications networks will be powered by AI-embedded software and that technology will be critical to new growth opportunities.

According to Martinkenaite, this requires a set of global rules and trust principles built on top of AI that are followed not only by telecommunications companies but also by global providers to whom they outsource parts of their operations. Vendors can include stakeholders such as device vendors, software companies and service companies, he added.

“Artificial intelligence creates competitive strength for the industry,” she said.

Wonki Min, currently president of the State University of New York, Korea, added that if companies fail to meet ethical standards surrounding AI, they will not survive in the marketplace. Unless governments can create a trustworthy AI environment, they would not be maximizing the benefits of the technology.

“This is why building trustworthy AI is important in order to maximize the potential benefits of AI technology, and the way we should be doing this is a global, multi-stakeholder approach,” said Min.

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Health

Tapping Into the Mind to Assist a Paralyzed Man Communicate

For years, Pancho communicated by spelling out words on a computer using a pointer attached to a baseball cap, an arduous method that allowed him to type about five correct words per minute.

“I had to bend/lean my head forward, down, and poke a key letter one-by-one to write,” he emailed.

Last year, the researchers gave him another device involving a head-controlled mouse, but it is still not nearly as fast as the brain electrodes in the research sessions.

Through the electrodes, Pancho communicated 15 to 18 words per minute. That was the maximum rate the study allowed because the computer waited between prompts. Dr. Chang says faster decoding is possible, although it’s unclear if it will approach the pace of typical conversational speech: about 150 words per minute. Speed is a key reason the project focuses on speaking, tapping directly into the brain’s word production system rather than hand movements involved in typing or writing.

“It’s the most natural way for people to communicate,” he said.

Pancho’s buoyant personality has helped the researchers navigate challenges, but also occasionally makes speech recognition uneven.

“I sometimes can’t control my emotions and laugh a lot and don’t do too good with the experiment,” he emailed.

Dr. Chang recalled times when, after the algorithm successfully identified a sentence, “you could see him visibly shaking and it looked like he was kind of giggling.” When that happened or when, during the repetitive tasks, he’d yawn or get distracted, “it didn’t work very well because he wasn’t really focused on getting those words. So, we’ve got some things to work on because we obviously want it to work all the time.”

The algorithm sometimes confused words with similar phonetic sounds, identifying “going” as “bring,” “do” as “you,” and words beginning with “F” — “faith,” “family,” “feel” — as a V-word, “very.”

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Politics

Invoice to Change How Navy Prosecutes Felonies Faces Resistance

WASHINGTON – After years of opposition from Pentagon leaders, New York Democrat Senator Kirsten Gillibrand appeared to be nearing victory over a fundamental change in the way the military handles sexual assault cases. However, their emphasis on including all serious crimes in the measure for reasons of racial justice now threatens to weaken their support.

Ms. Gillibrand’s push to remove commanders from decisions in prosecuting sexual assault cases had received bipartisan support despite opposition from military leaders. Last month, President Biden and Secretary of Defense Lloyd J. Austin III endorsed a similar change recommended by an independent military body.

But Mr. Austin and some of Mrs. Gillibrand’s strongest allies in Congress on this issue are reluctant to make broader changes to the military justice system. Some lawmakers say they only recently focused on the details of the measure after months of discussion.

“Your bill is much broader than I thought,” said Senator Susan Collins, Republican of Maine and an early proponent of Ms. Gillibrand’s move. “I believe she has made a compelling case for sexual assault and related allegations to be removed from the chain of command.”

But Ms. Collins said she didn’t think there was any justification for removing other alleged crimes from the military justice system.

Ms. Gillibrand’s bill would overturn the decision to prosecute serious crimes such as sexual assault and other crimes such as murder from military commanders to military prosecutors. The Pentagon panel proposed a more limited change: that a special victim unit should be set up within the military for cases of sexual assault and some other crimes.

But Ms. Gillibrand argues that this would create an unequal system and has said that her proposal would also help fight racial injustice.

A bill that would cover most crimes is “necessary,” she said in the Senate on Tuesday, “because the current military justice system simply does not provide justice, especially for soldiers of color.”

This tactic has helped attract other voices to their cause.

“Racial and gender bias in the military has resulted in inadequate prosecution of sexual assault cases and excessive prosecution of black and brown officers,” said Anthony Brown, Rep. Anthony Brown, Democrat of Maryland, a veteran and former Army Attorney General an interview this week.

While there have been differences in prosecution in the military over time, he said, “I think after the tragic murder of George Floyd, it really got a lot of us to say, ‘Hey, this is a real opportunity here, this one Fix inequalities and differences. ‘“

Studies over the years have identified racial differences in the military justice system, including the way in which discipline is exercised.

The tensions over Ms. Gillibrand’s move and the closer changes recommended by the Military Commission are potentially difficult terrain for Mr. Austin. He said strengthening the fight against sexual assault, racism and extremism in the ranks is a top priority.

Many military leaders who oppose changes in sexual assault cases may also oppose the loss of other prosecutorial powers. But focusing on other crimes could also alienate some of Ms. Gillibrand’s supporters – many of whom were brought back after years of courting.

“My inclination now is to commit sexual assault,” said Senator Angus King, Maine Independent, after previously saying he would register with Ms. Gillibrand. “That has been the goal of our work for eight years.”

Among the 70 or so senators from both parties who joined this spring, Ms. Gillibrand still seems to enjoy support. Senator Ted Cruz, a Republican from Texas, has been with their side for years, while some Democrats, like Senator Tim Kaine of Virginia, recently joined their efforts.

“There are many reasons to professionalize crime-dealing,” said Kaine, who previously worked as a lawyer. “Kirsten has a bright line that was maybe a little different from the one she drew earlier. But it’s a line that makes sense for us lawyers. “

Republican Senator Josh Hawley from Missouri agreed. “As a lawyer and former prosecutor, I think there is some value in having continuity and saying that every crime is handled the same way no matter what it is. I like that as a former prosecutor and I like it as a defense attorney. For me it’s a plus. “

Both men said they support the bill in writing but welcome further debate on the proposed changes that would require a Congressional resolution.

Senator Jack Reed, Democrat of Rhode Island and chairman of the Senate Armed Forces Committee, now supports changing the prosecution for sexual assault after years of opposition. But he is a leading voice against extending this trial to other crimes.

Data on racial differences is mixed and sometimes inconclusive, in large part due to the military’s lack of consistent data on race and the justice system, several reports say.

A recent report by the Government Accountability Office found that black and Hispanic military personnel were more likely than whites to be tried in a military trial, but that race “was not a statistically significant factor in conviction.”

A report by the Air Force Inspector General last year found that black service members were 1.64 times more likely to be suspicious in Office of Special Investigations criminal cases, but said that “identifying racial differences does not automatically imply racial bias or racism available”. . “

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Health

Ease of Covid lockdown restrictions could assist diminish drug abuse, physician says

The number of deaths from drug overdose in the United States hit a dismal record as the nation battled the Covid-19 pandemic at the same time. In 2020, a total of 93,331 Americans died from drug overdoses, an increase of nearly 30% year over year, according to preliminary data from the Centers for Disease Control and Prevention.

Dr. Nora Volkow, director of the National Institute on Drug Abuse, told CNBC’s The News with Shepard Smith that she hopes the surge in drug overdoses will not last.

“One of the reasons I’m optimistic … is that one of the factors that contributed to this surge in drug use was isolation and social distancing, and that doesn’t allow you to give Narcan, which reverses overdoses,” said Volkow. “This desperation, which I hope people felt, is slowly being alleviated.”

Volkow added that people will now be able to rebuild social support systems that existed before the Covid pandemic and that health systems can focus again on treating opioid abuse disorders.

The US also had the highest number of deaths from opioid overdoses in 2020, and more than 60% of those deaths were related to fentanyl. Moderator Shepard Smith asked Volkow why fentanyl played such a role in drug overdoses. Volkow stated that it had to do with potency and pricing.

“Fentanyl is a very potent drug, and it’s actually 50 times more potent than heroin, so you need smaller amounts to get the same effects,” said Volkow. “So it is actually a big win for the illicit drug market, and it has been used to actually contaminate other drugs. So when you mix fentanyl with drugs like methamphetamine or cocaine, you make them so much more deadly. “

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World News

Mother and father Who By no means Stopped Looking out Reunite With Son Kidnapped 24 Years In the past

For nearly 24 years, the father crossed China by motorbike. With banners displaying photos of a 2-year-old boy flying from the back of his bike, he traveled more than 300,000 miles, all in pursuit of one goal: finding his kidnapped son.

This week, Guo Gangtang’s search finally ended. He and his wife were reunited with their son, now 26, after the police matched their DNA, according to China’s public security ministry.

In a scene captured by Chinese state television, the trio clung to each other tearfully at a news conference on Sunday in Liaocheng, Mr. Guo’s hometown in northern Shandong Province.

“My darling, my darling, my darling,” Mr. Guo’s wife, Zhang Wenge, sobbed as she embraced the young man. “We found you, my son, my son.”

“He’s been delivered into your hands, so you need to love him well,” Mr. Guo said, trying to comfort her even as his own voice shook.

The apparent happy ending captivated China, where Mr. Guo has become something of a folk hero. His cross-country odyssey, during which he said he was thrown from his bike at least once and slept outdoors when he could not afford a hotel, inspired the 2015 film “Lost and Love,” starring the renowned Hong Kong actor Andy Lau.

After the reunion, Chinese social media filled with congratulatory messages. Hashtags about the Guo family were viewed hundreds of millions of times. “Today, ‘Lost and Love’ finally has a real happy ending,” the movie’s director, Peng Sanyuan, said in a video on Douyin, a social media app.

Child abduction is a longstanding problem in China. There are no official statistics on the number of children kidnapped each year, but officials at the Ministry of Public Security said this month that they had located 2,609 missing or abducted children so far this year. Various reports estimate the number of children abducted annually in China may be as high as 70,000.

Historically, child abduction was linked, at least in part, to China’s one-child policy. At the height of the policy’s enforcement in the 1980s and 1990s, some couples resorted to buying young boys on the black market to ensure they would have a son, according to research by scholars at Xiamen University in Fujian Province. Chinese society has traditionally favored sons.

As the central government began easing enforcement of the policy in the early 2000s — before ending it in 2015 — reported abductions fell sharply. Technological advances such as a nationwide DNA database of missing children, stiffer criminal penalties and greater public awareness of child trafficking have also helped curb the problem, said Zhang Zhiwei, executive director of an anti-trafficking center at the China University of Political Science and Law.

Still, the threat of abduction continues to weigh on many Chinese. On Monday, several police departments in the eastern city of Hangzhou issued statements denying viral rumors about attempted kidnappings.

Mr. Guo’s son, named Guo Xinzhen at birth, disappeared on Sept. 21, 1997. He had been playing at the door of his home while his mother cooked inside, according to interviews the elder Mr. Guo has given over the years.

A frantic Mr. Guo and his wife, along with family, neighbors and friends, fanned out across the region to search for the boy. But after several months, the effort waned. That was when Mr. Guo attached large banners printed with his son’s photo to the back of a motorcycle and set out to find the boy on his own.

“Son, where are you?” the banners said, alongside an image of the boy in a puffy orange jacket. “Dad is looking for you to come home.”

Over the years, Mr. Guo wore out 10 motorcycles, traveling from Hainan in the south to Henan in the north, chasing down any tidbits of information, he has said. Once, on a rainy day, a rock slipped off a truck bed in front of him, sending his motorcycle toppling. He had so many near-miss traffic incidents that he lost count. But he always set out again.

“If I’m at home, the human trafficker is not going to deliver him back to me,” he said in a 2015 interview with state television.

In 2012, Mr. Guo founded an organization to help other parents find their missing children, and he said he has helped dozens of other families find their loved ones, even as his own search remained unsuccessful. His story rose to national prominence with the 2015 film. Earlier this year he also began promoting anti-trafficking awareness on the social media app Douyin, where he had gained tens of thousands of followers even before his son was found.

The latest development in Mr. Guo’s story also seemed like something straight out of a screenwriter’s imagination.

In June, law enforcement officials in Shandong received notice of a potential match for Mr. Guo’s son in Henan Province, according to the public security ministry. It was not immediately clear how officials had identified him, though they said they had used “the newest comparison and search methods.” Further blood work confirmed that the 26-year-old man, who some local news reports said was working as a teacher, was Mr. Guo’s son.

The authorities later said that they had arrested a woman surnamed Tang and a man surnamed Hu. According to the state news media, Ms. Tang snatched the boy and delivered him to Mr. Hu, who then sold him. CCTV, the state broadcaster, said the two had confessed.

Ahead of the reunion, a dazed Mr. Guo and his wife bought more than 1,000 pounds of candy to distribute to neighbors in celebration. Mr. Guo also cleaned out his home, tossing out old belongings to commemorate a new beginning.

In an interview ahead of the reunion with Chen Luyu, a talk-show host, the parents veered between jubilation and paralysis. Sitting at their dining table, Ms. Zhang, Mr. Guo’s wife, broke down several times, wondering if their son would blame her for not watching him closely enough.

Mr. Guo said he bore no resentment toward the couple that had raised his son. How his son would treat that couple going forward was up to him, he said.

“If the child wants to be filial to his adopted parents, then you just need to openly and sincerely accept that,” he said.

State media reports said that the younger Mr. Guo had said he would continue living with the couple that had raised him, who he said had treated him well. But he said he would visit his birth parents often.

The elder Mr. Guo told Ms. Chen, the television host, that he was content with whatever the future brought.

“Our child has been found,” he said. “From now on, only happiness is left.”

Categories
Entertainment

Metropolis Heart Pronounces Its 2021-2022 Season

The New York City Center will resume its live performances in October with the Fall for Dance Festival, one of its premier events. The dance showcase will open the theater’s 2021-2022 season, which will also include a Twyla Tharp birthday party, the Alvin Ailey American Dance Theater’s annual Christmas engagement, and two new dance series.

“We really wanted to reaffirm our commitment to the New York audience as a very New York institution and to New York artists,” said Arlene Shuler, President and CEO of City Center, about the ambitious season.

“It’s a huge opportunity for artists,” added Stanford Makishi, vice president and artistic director of dance programs. “Those I have spoken to over the past 16 months, they are all eager not only to get back on stage, but also to actually interact with the audience.”

City Center announced four orders for this year’s Fall for Dance on Tuesday. Ayodele Casel, Lar Lubovitch and Justin Peck will create new pieces that will be distributed across the festival’s five programs; and the Verdon Fosse Legacy, an organization dedicated to preserving the work of Bob Fosse and Gwen Verdon, will reconstruct three dances for the festival. The full line-up and schedule will be released in early September.

In November Twyla Tharp celebrates her 80th birthday with “Twyla Now”, a program with two world premieres and signature works. A variety of stars including Sara Mearns and Robert Fairchild will perform, supported by an ensemble of young dancers.

The City Center’s new dance program will begin in 2022. Tiler Peck, director of the New York City Ballet, will inaugurate Artists at the Center, which allows an accomplished dancer to create a program; Peck’s program March 3-6 will include works by William Forsythe, Alonzo King, and others. The City Center Dance Festival, a spring counterpart to Fall for Dance, will follow from March 24th to April 10th. It will feature several New York ensembles, including the Martha Graham Dance Company, the Dance Theater of Harlem, and the Paul Taylor Dance Company.

The encores! The series, which revives rarely produced Broadway musicals, also returns in 2022. May), were announced last year. The coming encores! Season will be the first under the artistic direction of Lear deBessonet, who was announced as the successor to Jack Viertel in 2019.

More information is available at www.nycitycenter.org.

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Politics

Mnuchin refuses to sentence Trump election lie, Cybereason accepts Biden win

The CEO of Cybereason said he and his company accept the results of the 2020 presidential election after one of their investors, Steven Mnuchin, declined to acknowledge that ex-President Donald Trump was spreading a lie about the contest being rigged.

In an interview with CNBC’s “Squawk Box” on Wednesday morning, Mnuchin was asked several times to acknowledge that Trump was lying about the 2020 election. Each time, he dodged the question, attempting to change the subject to his firm’s investment in the Israeli cybersecurity company.

“I’m focused on our investments, our business going forward,” Mnuchin said. He said he stayed out of the 2020 campaign and its aftermath.

After he was asked about Trump’s election lie a final time, he said he believed American democracy is working – and that he hopes Trump will think about running again.

“We have a great democracy. It’s working. It worked. I hope the president [Trump] considers running again down the road,” said Mnuchin, a wealthy businessman, investor and film financier.

Trump has continued to push what has become known as “the Big Lie” in statements to the media and in interviews with sympathetic television hosts, such as Fox Business’ Maria Bartiromo.

The House of Representatives, including several Republican members, voted to impeach Trump for stoking the deadly Jan. 6 riot on Capitol Hill, which followed a “Stop the Steal” rally the then president headlined. The pro-Trump invaders – some of whom chanted “Hang Mike Pence,” who was vice president – delayed congressional confirmation of Joe Biden’s election victory by several hours.

The Senate acquitted Trump after he left office, although several GOP senators voted to convict.

Mnuchin was joined for the interview on “Squawk Box” by Cybereason CEO Lior Div, announcing that the former Treasury secretary’s new private equity firm is leading a $275 million investment in the company.

Div suggested in a follow-up statement to CNBC that Mnuchin’s answers were being misconstrued, and that his position would have no bearing on the company’s business relationship with the former Treasury secretary’s firm, Liberty Strategic Capital.

“Respectfully, I do not think that is what the Secretary said and, regardless, it certainly has no bearing on his relationship with Cybereason,” Div said in a statement provided to CNBC by a company spokesman on Wednesday.

“We have no political motivations and have chosen to work with Liberty because of their massive network and the understanding of the financial and government markets that Secretary Mnuchin and General Dunford bring to Cybereason. For example, the executive order issued by the Biden administration has accelerated the importance of EDR solutions like ours in the public market, and Liberty has the relationships to help accelerate our go-to-market strategy in the federal sector.”

A spokesman for Cybereason initially did not return requests for additional comment before publication.

After publication, the spokesman sent another comment from Div, in which he said the company backs the outcome of the 2020 election and President Biden’s administration.

“Cybereason supports the 2020 election results and the Biden administration. Our connection to Liberty is not political, it is a strategic partnership designed to help us further penetrate key markets, including the government,” Div said. “Both Secretary Mnuchin and General Dunford (appointed by [President] Obama to his Joint Chiefs of Staff) are part of Liberty Strategic Capital. Secretary Mnuchin will join our Board of Directors and General Dunford is joining our Advisory Board.”

Div himself also supports the 2020 election results and the new Biden administration, a spokeswoman told CNBC.

The incident is the latest example of how companies consider whether they should be speaking out on political issues, particularly if it pertains to their investors and employees.

After voting laws that have been deemed restrictive by critics were passed in Georgia, corporations felt pressured to respond. Several did, including Major League Baseball, which moved its All-Star Game from Georgia to Colorado.

In a recent example of the pressure, Toyota halted giving campaign contributions to Republican lawmakers who challenged the results of the election.

Categories
Health

Ohio Clinic Says It Will not Administer Alzheimer’s Drug to Sufferers

In a conspicuous concern about the approval of the controversial new Alzheimer’s drug Aduhelm, the Cleveland Clinic said Wednesday evening that it would not give it to patients.

The clinic, one of the largest and most respected medical centers in the country, said in a statement a panel of experts had “reviewed all available scientific evidence about this drug,” also called aducanumab.

“Based on the current data on safety and effectiveness, we have decided not to wear aducanumab at the moment,” the statement said.

A spokeswoman for the clinic said individual doctors there could prescribe Aduhelm to patients, but those patients would have to go elsewhere to get the drug, which is given as an intravenous infusion every month.

The stance of the major medical center is the latest fallout from the approval of the drug by the Food and Drug Administration on June 7, a decision that also fueled Congressional investigations.

Many Alzheimer’s experts and other scientists have said that it is unclear that the drug helps slow cognitive decline and that at best the evidence suggests only a slight slowdown while showing that Aduhelm causes brain swelling or hemorrhage could.

Recognition…Biogen, via Associated Press

The drug is also expensive. Biogen, the maker, has set its price at $ 56,000 per year.

In a recent survey of nearly 200 neurologists and primary care physicians, most said they disagreed with the FDA’s decision and did not plan to prescribe the drug to their patients.

Last week, Dr. Janet Woodcock, acting FDA commissioner, in response to growing criticism of an independent state investigation into the agency’s regulatory process, wrote, “To the extent that these concerns could undermine public confidence in the FDA’s decision, I believe” it is critically important that the disputed events are reviewed by an independent body. “

Two almost identical clinical trials with Aduhelm were stopped prematurely because an independent data monitoring committee concluded that the drug did not appear to be helping patients. A later analysis by Biogen found that participants who received the high dose of the drug in one study experienced a very slight slowdown in cognitive decline – 0.39 on an 18-point scale – that participants in the other study however, had not benefited from it at all.

About 40 percent of study participants developed cerebral hemorrhage or swelling, and while most of these cases were mild or manageable, about 6 percent of participants dropped out because of serious side effects from these conditions.

After reviewing the data late last year, an FDA advisory committee strongly recommended outside experts against approval, and three of its members resigned in protest last month when the agency defied the advice of the advisory committee. The American Geriatrics Society had also urged the agency not to approve the drug because it was “premature in the absence of sufficient evidence.”

In response to widespread criticism that Aduhelm was approved for anyone with Alzheimer’s, the FDA last week severely restricted the drug’s recommended use, saying that it should only be used for people with mild memory or thinking problems as it doesn’t have any Data on the use of Aduhelm gave later stages of Alzheimer’s disease.

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Health

Covid circumstances are surging once more in Latin America and the U.S., WHO officers warn

People hold their arms after receiving the Johnson & Johnson vaccine for coronavirus disease (COVID-19) as part of a government plan to vaccinate Mexican border residents on the common border with the United States in Tijuana, Mexico, Dec. June 2021.

Jorge Duenes | Reuters

Covid infections are rapidly picking up again in the United States and Latin America as more contagious variants spread, putting the entire region at risk, World Health Organization officials said in a briefing Wednesday.

Renewed spikes of infection also exacerbate instability and violence in several Latin American and Caribbean countries, officials said, noting political upheaval in Haiti, Cuba and other nations as the Delta variant takes hold in America.

“Many countries, including the United States, are seeing a resurgence of infections in North America, the United States and Mexico are reporting spikes in new infections in most states, and many Central American nations are also seeing cases,” said Dr. Carissa Etienne, director of the Pan American Health Organization, WHO’s regional office for America, said Wednesday.

Central American and Caribbean countries such as El Salvador, Guatemala, Cuba and the Virgin Islands are also seeing an increase in new infections.

Thousands of protesters in Cuba took to the streets this week over frustrations over a troubled economy hit by food and electricity shortages. The rare protests, the largest the communist country has seen since the 1990s, come as the government struggles to contain the coronavirus pandemic and marginalize the island’s fragile health system.

US Secretary of State Antony Blinken told reporters on Monday that Cubans were “tired of the mismanagement of the Cuban economy, lack of adequate food and of course an adequate response to the Covid-19 pandemic”.

The seven-day average of new cases in Cuba has more than quadrupled in the last month to 5,659 in the past seven days from an average of 1,256 per day in mid-June, according to analysis of data from CNBC compiled by Johns Hopkins University . The number of deaths in the small island nation has also increased from around 10 a day a month ago to around 32, the data shows.

Overall, deaths and hospital admissions in South America have decreased in recent weeks. However, as cases pick up again, officials expect hospitalizations and deaths, often delayed by a few weeks, could soon follow.

The cases in Argentina and Colombia are at record highs as new infections surpass the level at the beginning of the pandemic, according to Etienne. Neighboring countries like Honduras and Guatemala haven’t secured enough vaccine doses to immunize even 1% of their population, which could be disastrous if increasing infections spill over from nearby countries, she said.

Colombia, along with Brazil, Cuba and Haiti, are experiencing situations where political unrest and waves of protests make it even more difficult for health workers and residents to access life-saving resources and maintain public notices promoting vaccinations.

“Increasing violence, instability and overcrowded accommodation could become active hotspots for the transmission of Covid,” said Etienne. “Limited care and violence also hamper the ability of health workers to safely care for patients in need. In some cases, patients may avoid doing so for safety concerns.”

PAHO officials are working to bring vaccines to Haiti, where the island has not yet started vaccinating its residents, despite having received 760,000 doses of the vaccines from AstraZeneca through the COVAX Facility, a WHO-supported distribution initiative of doses to low-income countries in low-income countries of the world, according to the Washington Post. Violence broke out there following the assassination of President Jovenel Moise last week.

PAHO also cautioned countries reopening their economies too early, warning that countries that have successfully deterred early waves of infection are ignoring normally necessary public health measures such as masks and social distancing and opening up to a renewed surge in cases of variant who can bypass the vaccine protection.

“In the context of Covid-19, health and well-being must be prerequisites for reactivating the economy, because if the pandemic is not brought under control, economic reactivation will be very difficult,” said Etienne.

– CNBC’s Amanda Macias contributed to this article.